Navigation Links
Conserved nuclear envelope protein uses a shuttle service to travel between job sites
Date:2/10/2014

directly at the Mps3 protein inside living cells and watch for its interactions with Ndc1. To monitor Mps3's interaction with Ndc1, the researchers attached a fluorescent red tag to Ndc1 and a fluorescent green for Mps3. They then focused their microscope on a specific point within a living cell, and watched for green- or red-tagged proteins to enter or leave that space. Their observations would reveal whether Ndc1 and Mps3 were moving independently within the cell, or whether they were physically linked.

"This allowed us to look inside living yeast cells to study the complexes in real time, in the context of the nuclear envelope. We could just sit there and watch, rather than touching or breaking open the cells," Jaspersen says. The imaging not only confirmed the interaction between Mps3 and Ndc1, it allowed the team to track exactly where it occurred.

Although she and her colleagues expected to see Mps3 associate with Ndc1 either at nuclear pore complexes or at the cell's spindle pole bodies, neither turned out to be true. Instead, Mps3 and Ndc1 came together in the nuclear envelope, but away from the two structures the team had set out to study. This led them to speculate that Mps3 might help shuttle Ndc1 to the sites where it is needed, controlling the distribution of nuclear pore complexes and spindle pole bodies. Jaspersen team is now planning further experiments to test how Ndc1 and Mps3 maintain the appropriate balance of these critical structures.


'/>"/>

Contact: Gina Kirchweger
gxk@stowers.org
816-806-1036
Stowers Institute for Medical Research
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. American Chemical Society podcast: Detecting radioactive material in nuclear waste water
2. Bone marrow mononuclear stem cells show no new gains in heart function says TIME study
3. Improving detection of radioactive material in nuclear waste water
4. Volume of nuclear waste could be reduced by 90 percent, says new research
5. CNIO researchers identify a new gene that is essential for nuclear reprogramming
6. Invention could make spent nuclear fuel useful for irradiation purposes
7. UT MD Anderson scientists uncover the nuclear life of actin
8. Fallout from nuclear testing shows that the Achilles tendon cant heal itself
9. Biologists map rare case of fitness-reducing interaction in nuclear, mitochondrial DNA
10. How to make stem cells - nuclear reprogramming moves a step forward
11. University of Tennessee, ORNL lead national team to study nuclear fusion reactors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Conserved nuclear envelope protein uses a shuttle service to travel between job sites
(Date:2/5/2015)... 2015 New Market Research Reports ... Forecasts To 2020 has Been Added to GrandViewReseach.com Report ... expected to reach USD 5.10 billion by 2020, according ... IR cameras help identify the site of tissue damage ... surging demand in medical imaging applications. They have been ...
(Date:2/5/2015)... Jan. 30, 2015  It is gratifying to see ... potential for genomic science as a means to better ... and treatment.  I was honored to participate in today,s ... medicine program. Since the 1980s my ... genomics—from the first sequenced genome of a free living ...
(Date:1/22/2015)... , Jan. 9, 2015 Valid S.A. ("Company") (BM&FBOVESPA: ... market in general the State of Washington,s ... for a new enrollment and central issuance system for driver,s ... The project planning and development will start in ...
Breaking Biology News(10 mins):IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 3J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2Valid USA Signs Contract For Washington Driver's License Issuance 2
... comprehensive geological review ever undertaken of the upper U.S. Gulf ... rivers could flood large swaths of wetlands this century in ... terms of sea-level increases and river sediments flowing into the ... conditions they last saw in the Holocene, from about 9,600 ...
... dog to salivate in anticipation of food when a ... behaviors when enticed with different smells. Researchers at the ... Hong Kong and the National Institute of Standards and ... interval between the signal, or odor, and the rewarddelicious ...
... European industries have updated the planning of the preparatory ... October 2008 for the GOCE satellite. On 7 ... the Plesetsk Cosmodrome in northern Russia were stopped by ... the units of the guidance and navigation subsystem of ...
Cached Biology News:Bays on US Gulf Coast vulnerable to flooding 2Moths with a nose for learning 2
(Date:3/3/2015)... March 3, 2015 AtheroNova Inc. (OTCQB: AHRO) today ... filed voluntary petitions under Chapter 11 of the U.S. Bankruptcy ... California , Santa Ana ... Chapter 11 cases are expected to be jointly administered. ... Court supervised asset sale process, for all or substantially all ...
(Date:3/3/2015)... 03, 2015 Cambridge Semantics, the leading ... technology, today announced that it has been named to ... in Knowledge Management.’ , To create the list ... analysts and system integrators who identify organizations dedicated to ... right information to the right people at the right ...
(Date:3/3/2015)... , March 3, 2015  Johnson & Johnson ... South San Francisco (JLABS @SSF), a ... South San Francisco, Calif. The ... up to 50 startups from across the healthcare spectrum ... The first resident startups have been ...
(Date:3/3/2015)... /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ), ... it has initiated commissioning activities for its 30,000 MT ... Ontario , Canada.  Commissioning and ... the facility being in commercial operation in Q3 2015.  ... months and it is carrying out commissioning and start-up ...
Breaking Biology Technology:AtheroNova and its Subsidiary File for Chapter 11 Bankruptcy Protection 2AtheroNova and its Subsidiary File for Chapter 11 Bankruptcy Protection 3AtheroNova and its Subsidiary File for Chapter 11 Bankruptcy Protection 4Cambridge Semantics Named to KMWorld’s 2015 ‘100 Companies That Matter in Knowledge Management’ 2Johnson & Johnson Innovation Opens JLABS @South San Francisco and Announces First Five Resident Startups 2Johnson & Johnson Innovation Opens JLABS @South San Francisco and Announces First Five Resident Startups 3Johnson & Johnson Innovation Opens JLABS @South San Francisco and Announces First Five Resident Startups 4Johnson & Johnson Innovation Opens JLABS @South San Francisco and Announces First Five Resident Startups 5BioAmber Begins Commissioning of Sarnia Commercial Plant 2BioAmber Begins Commissioning of Sarnia Commercial Plant 3
... devices are brighter now thanks to a new study ... Lawrence Berkeley National Laboratory (Berkeley Lab). Working at the ... has provided the first experimental determination of the pathways ... an organic thin film. Their results also show how ...
...  Watson Pharmaceuticals, Inc. (NYSE: WPI ) today ... approval from the United States Food and Drug Administration ... 150mg tablets, the generic equivalent to Roche,s BONIVA® tablets. ... second quarter. BONIVA® 150mg tablets had total U.S. sales ...
... 2012  Frank A. Critz, M.D., founder and medical director of ... hero,s welcome this April when he returns to Fulton, Miss.  ... event will be April 14, 2012 at the Holiday Inn ... noon until 3 p.m., and lunch will be served. ...
Cached Biology Technology:Better organic electronics 2Better organic electronics 3Watson's Generic BONIVA® 150mg Receives FDA Approval 2Radiotherapy Clinics of Georgia's Founder Returns Home to Celebrate Cancer Survivors and Receive Lifetime Achievement Award 2
TRIS-EDTA based buffer prepared from RNase-free water suitable for storage and dilution of siRNA, pH 8, store at 4 C ...
Request Info...
Ultra-sensitive, non-radioactive detection of rat Osteopontin...
Request Info...
Biology Products: