Navigation Links
Conserved nuclear envelope protein uses a shuttle service to travel between job sites
Date:2/10/2014

directly at the Mps3 protein inside living cells and watch for its interactions with Ndc1. To monitor Mps3's interaction with Ndc1, the researchers attached a fluorescent red tag to Ndc1 and a fluorescent green for Mps3. They then focused their microscope on a specific point within a living cell, and watched for green- or red-tagged proteins to enter or leave that space. Their observations would reveal whether Ndc1 and Mps3 were moving independently within the cell, or whether they were physically linked.

"This allowed us to look inside living yeast cells to study the complexes in real time, in the context of the nuclear envelope. We could just sit there and watch, rather than touching or breaking open the cells," Jaspersen says. The imaging not only confirmed the interaction between Mps3 and Ndc1, it allowed the team to track exactly where it occurred.

Although she and her colleagues expected to see Mps3 associate with Ndc1 either at nuclear pore complexes or at the cell's spindle pole bodies, neither turned out to be true. Instead, Mps3 and Ndc1 came together in the nuclear envelope, but away from the two structures the team had set out to study. This led them to speculate that Mps3 might help shuttle Ndc1 to the sites where it is needed, controlling the distribution of nuclear pore complexes and spindle pole bodies. Jaspersen team is now planning further experiments to test how Ndc1 and Mps3 maintain the appropriate balance of these critical structures.


'/>"/>

Contact: Gina Kirchweger
gxk@stowers.org
816-806-1036
Stowers Institute for Medical Research
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. American Chemical Society podcast: Detecting radioactive material in nuclear waste water
2. Bone marrow mononuclear stem cells show no new gains in heart function says TIME study
3. Improving detection of radioactive material in nuclear waste water
4. Volume of nuclear waste could be reduced by 90 percent, says new research
5. CNIO researchers identify a new gene that is essential for nuclear reprogramming
6. Invention could make spent nuclear fuel useful for irradiation purposes
7. UT MD Anderson scientists uncover the nuclear life of actin
8. Fallout from nuclear testing shows that the Achilles tendon cant heal itself
9. Biologists map rare case of fitness-reducing interaction in nuclear, mitochondrial DNA
10. How to make stem cells - nuclear reprogramming moves a step forward
11. University of Tennessee, ORNL lead national team to study nuclear fusion reactors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Conserved nuclear envelope protein uses a shuttle service to travel between job sites
(Date:12/19/2014)...  23andMe, Inc., the leading personal genetics company, today ... differences in genetic ancestry of individuals from across ... immigrants first arrived more than four hundred years ago, ... as a meeting place for peoples from different continents. ... mixing of peoples with African, European, and American origins ...
(Date:12/17/2014)... YORK , Dec. 15, 2014  HITLAB ... Good Clinical Practices (GCP) audit to confirm its ... (FDA) regulations. This accomplishment enables HITLAB to conduct ... utilizing the highest principles for patient safety and ... improve global healthcare access, quality, and delivery with ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research ... announced the addition of the "Global Facial ... http://photos.prnewswire.com/prnh/20130307/600769 ... the identification of individuals. Facial recognition system measures ... as nose, jaw edges, mouth, and the distance ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... many areas of the United States, scientists in Minnesota are ... clean-burning energy source of the future may consume up ... appeared in ACS, journal Environmental Science & Technology . ... that annual bioethanol production in the U.S. is currently about ...
... , WEST CHESTER, Pa., Aug. 4 ... video analytics and control products, solutions and services, today announced ... provide critical hardware, software and systems integration for a Maritime ... ComCam CEO Don Gilbreath stated, "Our two companies ...
... Researchers at the University of Pittsburgh School of Medicine ... immune response against a protein that is made in ... head and neck cancers. The finding suggests that a ... individuals. Mice that were vaccinated to boost their ...
Cached Biology News:ComCam Selected by ePortation on New Maritime Domain Awareness Project 2Pitt researchers find promising candidate protein for cancer prevention vaccines 2
(Date:12/24/2014)... Dec. 23, 2014 Vermillion, Inc. (Nasdaq: ... gynecologic disease, announced today that investors including Oracle ... Fund LLC and several Vermillion directors have agreed ... of Vermillion,s common stock and warrants to purchase ... private placement.  Under the terms ...
(Date:12/22/2014)... 2014 The Center for Professional ... technical training across the life sciences industry, has partnered ... (SCDM) to provide the organization's members with discounted classroom ... to the more than 350 sessions across 80 course ... off when registering for a public course ...
(Date:12/22/2014)...  ( www.competitivehealth.com ) — Competitive Health is pleased ... and advocacy service, has signed an agreement to become ... health services marketplace. 63% of Americans have ... expected to pay. As part of an ongoing effort ... is pleased to offer medical bill review and negotiation ...
(Date:12/19/2014)... December 19, 2014 Charm Sciences is ... for the Detection of Aflatoxin M1 in raw commingled ... independent third party validation. The peer reviewed report of ... the Institute for Agricultural and Fisheries Research (ILVO-T&V) has ... , Aflatoxin B1, the most toxic aflatoxin and a ...
Breaking Biology Technology:Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2
... ... India, CJP is all set to hold 5 Days Global Jatropha ... Training Programme 2010-- the Most Authoritative platform shall introduce the A-Z ... technologies, including utilization of Jatropha Crude Oil and Seedcake; besides introducing ...
... [Brown University] Creating catalysts that can operate efficiently and ... fuel-cell technology from the lab bench to the assembly line. ... researchers, but platinum has two major downsides: It is expensive, ... In a new study, chemists at Brown University report a ...
... May 24 Epeius Biotechnologies Corporation ( www.epeiusbiotech.com ) ... Phase I/II Study of Intravenous Rexin-G and Reximmune-C for Cancer ... June 6, 2010 . The presentation will be made ... Cancer Institute and Bioethics Committee-Philippine General Hospital, and Principal Investigator ...
Cached Biology Technology:JatrophaWorld Training Programme Slated for India September 20-24, 2010 2JatrophaWorld Training Programme Slated for India September 20-24, 2010 3JatrophaWorld Training Programme Slated for India September 20-24, 2010 4Brown chemists report promising advance in fuel-cell technology 2Tumor-Targeted Nanoparticle-based Gene Delivery Provides Evidence of Therapeutic Vaccination in Patients with Metastatic Cancer (ASCO 2010) 2Tumor-Targeted Nanoparticle-based Gene Delivery Provides Evidence of Therapeutic Vaccination in Patients with Metastatic Cancer (ASCO 2010) 3
Rabbit polyclonal to Methionine Aminopeptidase 2 ( Abpromise for all tested applications). entrezGeneID: 10988 SwissProtID: P50579...
Mouse monoclonal [TU-20] to beta III Tubulin (FITC) ( Abpromise for all tested applications). entrezGeneID: 10381 SwissProtID: Q13509...
Chlamydia pneumoniae (TWAR)...
Sheep polyclonal to Methaqualone ( Abpromise for all tested applications). Antigen: Methaqualone(5') conjugated to BSA...
Biology Products: