Navigation Links
Conserved nuclear envelope protein uses a shuttle service to travel between job sites
Date:2/10/2014

KANSAS CITY, MOResearchers at the Stowers Institute for Medical Research have glimpsed two proteins working together inside living cells to facilitate communication between the cell's nucleus and its exterior compartment, the cytoplasm. The research provides new clues into how a crucial protein that is found in organisms from yeast to humans does its work.

The study, led by Stowers Investigator Sue Jaspersen, Ph.D., focused on a protein called Ndc1, which controls when and where a cell inserts holes into the double-walled membrane that surrounds its nucleus. In yeast, these holes become the sites for two essential structures: passageways called nuclear pore complexes, and spindle pole bodies, which anchor the cytoskeletal filaments that pull chromosomes to opposite sides of a dividing cell.

"Too many or too few insertion sites will have disastrous consequences," Jaspersen says, explaining that new nuclear pore complexes and spindle pole bodies must be created each time a cell prepares to divide to ensure genetic material can be properly distributed and daughter cells are equipped for gene activation and protein production. Her team's findings on Ndc1's interactions with a protein called Mps3, which appears to govern Ndc1's distribution on the nuclear envelope, are described in the February 10, 2014 issue of the Journal of Cell Biology.

Jaspersen and her colleagues set out to study Ndc1 because it is absolutely crucial for cell survival. They knew that in yeast, Ndc1 is embedded in the nuclear envelope and is needed for the insertion of both nuclear pore complexes and spindle pole bodies. But because cells are so sensitive to changes in Ndc1, scientists had been unable to learn much about how the protein functions.

Traditional genetic strategies of eliminating, altering, or increasing Ndc1 to test its function typically killed cells. "Having the exact right amount of Ndc1 is really critical," Jaspersen says. "Tha
'/>"/>

Contact: Gina Kirchweger
gxk@stowers.org
816-806-1036
Stowers Institute for Medical Research
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. American Chemical Society podcast: Detecting radioactive material in nuclear waste water
2. Bone marrow mononuclear stem cells show no new gains in heart function says TIME study
3. Improving detection of radioactive material in nuclear waste water
4. Volume of nuclear waste could be reduced by 90 percent, says new research
5. CNIO researchers identify a new gene that is essential for nuclear reprogramming
6. Invention could make spent nuclear fuel useful for irradiation purposes
7. UT MD Anderson scientists uncover the nuclear life of actin
8. Fallout from nuclear testing shows that the Achilles tendon cant heal itself
9. Biologists map rare case of fitness-reducing interaction in nuclear, mitochondrial DNA
10. How to make stem cells - nuclear reprogramming moves a step forward
11. University of Tennessee, ORNL lead national team to study nuclear fusion reactors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Conserved nuclear envelope protein uses a shuttle service to travel between job sites
(Date:8/29/2014)... University of Texas Medical Branch at Galveston has gone on ... completely protect monkeys against a lethal dose of Ebola virus ... the disease is severe. , Thomas Geisbert, professor of microbiology ... discussing advances in Ebola treatment research. The filoviruses known as ... of pathogens, with fatality rates of up to 90 percent. ...
(Date:8/29/2014)... connections in transcription factor networks (TFNs) to evaluate the ... in PLOS Computational Biology in August. ... a network,s resilience against mutations. , "In simulations, ... models has a greater effect on robustness than varying ... Dov A. Pechenick, PhD, lead author and former researcher ...
(Date:8/29/2014)... This news release is available in German . ... of chemical signals between organisms is considered the oldest ... social interactions between conspecifics, for example, the sexual attraction ... trigger social responses and to coordinate reproductive behavior in ... at the University of the Algarve in Faro, Portugal, ...
Breaking Biology News(10 mins):Leading Ebola researcher at UTMB says there's an effective treatment for Ebola 2Assortativity signatures of transcription factor networks contribute to robustness 2Ready for mating at the right time 2Ready for mating at the right time 3
... The most common cause of a mare,s reduced fertility is ... caused by the bacteria , Streptococcus equi subspecies ... negative for streptococci have a dormant infection without showing clinical ... to reduce the fertility of the mares," says Professor Anders ...
... Researchers at the Johns Hopkins University in Baltimore, Md., ... have found that nonself-donated cells (allografts) better survive implantation ... grafts are injected into the striatum (STR) of the ... region. In their study, all FM grafts were ...
... being passive wallflowers, are "secret gardeners" that actively engineer their ... team of scientists from Duke University and the University of ... that the distribution of plants within a marsh is a ... that,s where conditions like soil aeration and salinity best meet ...
Cached Biology News:Researchers make racehorses fertile 2Impact of stem cell transplantation location in brain a crucial factor for cell survival 2Marsh plants actively engineer their landscape 2
(Date:8/28/2014)... (PRWEB) August 28, 2014 SPIE Fellow ... Physics and Optical Science and Director of the Center ... North Carolina at Charlotte, and co-founder and Chairman of ... serve as the 2015 Vice President of SPIE, the ... President Philip Stahl announced recent election results at the ...
(Date:8/28/2014)... are important devices in spintronics, an electronic which ... electrons but also on their spin and the ... electric into magnetic signals and vice versa. Recently, ... the Institute of Physics at Johannes Gutenberg University ... Prague, and Japan, has for the first time ...
(Date:8/28/2014)... 2014 Sterlitech is proud to announce ... its stable of products . These additional ... and include membrane filters with surface charges. ... demand for our membrane process testing equipment, and correspondingly, ... sheet membranes,” explains Sterlitech President Mark Spatz. “The ...
(Date:8/28/2014)... this month, a report was created by Colorado ... Force on the performance of vehicles using an eco-friendly, ... fuel made from mustard seeds, offered great potential as ... friendly future. In fact, every branch of the U.S. ... foreign oil over the next few years. They will ...
Breaking Biology Technology:Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5
... U.S. Asthma Control, RESEARCH TRIANGLE PARK, N.C. and ... with asthma and more than a quarter of,children with ... have their disease well controlled, according to the Asthma ... of the American,Thoracic Society meeting in Toronto., The ...
... May 20 PreViser Corporation,( http://www.previser.com ), a ... assessment technology to the dental profession,announced today the ... (OHI) Ltd ( http://www.previser.co.uk ) of Birmingham, England ... Kingdom and the,Republic of Ireland., OHI Ltd ...
... living computers by genetically altering bacteria. The findings of ... of Biological Engineering, demonstrate that computing in living cells ... applications including data storage and as a tool for ... from the biology and the mathematics departments of Davidson ...
Cached Biology Technology:Asthma Uncontrolled in More Than 40 Percent of Adults With the Disease, New Landmark Survey Shows 2Asthma Uncontrolled in More Than 40 Percent of Adults With the Disease, New Landmark Survey Shows 3PreViser and Oral Health Innovations Ltd Form UK Partnership to Provide Oral Health Scoring and Risk Analysis 2Researchers bring new meaning to the term 'computer bug' 2
Goat polyclonal to MLH3 Immunogen: Synthetic peptide: RQSLQQSMPPCEPP (Human) from C Terminus of the protein sequence according to NP_055196....
Polyclonal Antibody to SHPRH...
Rabbit polyclonal to TetR ( Abpromise for all tested applications). Antigen: Synthetic peptide: AQKLGVEQPTLYWHVKNKR, corresponding to amino acids 31 - 49 of TetR...
Biotin anti-mouse Ly-49C/F/I/H...
Biology Products: