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Computer simulations yield clues to how cells interact with surroundings
Date:3/22/2013

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They also discovered an interesting pattern in which integrins fluctuate. Two integrin sections, one that spans the cell membrane and one that protrudes from the cell, are connected by a hinge-like region. This hinge swings about when the protein is forced to vibrate as a result of frequent kicks from other molecules around it, such as water molecules, lipids, and ions.

These computationally obtained insights could guide new experiments designed to uncover how integrins do their job.

"Our research sets up an avenue for future studies by offering a hypothesis that relates integrin activation and clustering," says Mofrad.


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Contact: Dan Krotz
dakrotz@lbl.gov
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert

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