Navigation Links
Computer simulations yield clues to how cells interact with surroundings
Date:3/22/2013

target="_blank" href="http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002948">http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002948

Their "molecular dynamics" model is the latest example of computational biology, in which scientists use computers to analyze biological phenomena for insights that may not be available via experiment. As you'd expect from a model that accounts for the activities of half a million atoms at once, the integrin model takes a lot of computing horsepower to pull off. Some of its simulations require 48 hours of run time on 600 parallel processors at the U.S. Department of Energy's (DOE) National Energy Research Scientific Computing Center (NERSC), which is located at Berkeley Lab.

The model is already shedding light on what makes integrin tick, such as how they "know" to respond to more force with greater numbers. When activated by an external force, integrins cluster together on a cell's surface and join other proteins to form structures called focal adhesions. These adhesions recruit more integrins when they're subjected to higher forces. As the model indicates, this ability to pull in more integrins on demand may be due to the fact that a subunit of integrin is connected to actin filaments, which form a cell's skeleton.

"We found that if actin filaments sustain more forces, they automatically bring more integrins together, forming a larger cluster," says Mehrbod.

The model may also help answer a longstanding question: Do integrins interact with each other immediately after they're activated? Or do they not interact with each other at all, even as they cluster together?

To find out, the scientists ran simulations that explored whether it's physically possible for integrins to interact when they're embedded in the plasma membrane. They found that interactions are likely to occur only between one compartment of integrin called the β-subun
'/>"/>

Contact: Dan Krotz
dakrotz@lbl.gov
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Computer model may help athletes and soldiers avoid brain damage and concussions
2. Computer modeling reveals how surprisingly potent hepatitis C drug works
3. New supercomputer to aid genomics research
4. New supercomputer coming to EMSL this summer, supplied by Atipa Technologies
5. Virginia Tech computer scientists develop new way to study molecular networks
6. Iowa State computer, electrical engineers working to help biologists cope with big data
7. How computers push on the molecules they simulate
8. Total donates high-speed computer cluster to UH
9. A better thought-controlled computer cursor
10. Computers taught to ID regulating gene sequences
11. Computer simulations for multiscale systems can be faster, better, more reliable
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... YORK , Nov. 19, 2014  Earlier this ... at New York College, and one of the most ... biosensor signals that are transmitted from Smartphones to third ... were Smartphones and has one of the earliest known ... discussing its usage in the military, child care, elder ...
(Date:11/18/2014)... 2014   News Highlights: ... develop The Partners Data Lake, an agile data ... Lake will allow researcher and clinicians to explore ... the lives of patients , The Partners ... across the Partners system, breaking down physical barriers ...
(Date:11/11/2014)... -- Forensicon, Inc., a Chicago -based digital ... promotion of Yaniv Schiff from Senior Computer ... new role as Director, he will lead company efforts ... and provide leadership within the company,s digital forensics practice ... Schiff joined Forensicon in 2006 and ...
Breaking Biology News(10 mins):Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2
... The genome of Medicago , a close relative of alfalfa ... been sequenced by an international team of scientists, capturing around 94 ... insights into the evolution of the Papilionoid subfamily of ... Plants in this family can house and work with ...
... SALT LAKE CITY While previous studies have linked ... disease, new research at the Intermountain Medical Center Heart ... to the onset of a dangerous heart condition known ... the flagship facility for the Intermountain Healthcare system, studied ...
... Ditching the diet for Thanksgiving? Turkey with all ... to miss their goals, according to a new Cornell ... subconsciously bending willpower every day. "We,re slaves to ... and of psychology at Cornell, who co-authored the article ...
Cached Biology News:Genome sequence sheds new light on how plants evolved nitrogen-fixing symbioses 2New study links excessive amounts of vitamin D to onset of atrial fibrillation 2New study links excessive amounts of vitamin D to onset of atrial fibrillation 3
(Date:11/21/2014)... November 20, 2014 Offering a complete ... Sartorius Entris Balance promotion . The Sartorius Entris Balance ... durable, high accuracy, and easy-to-maintain balance entry level balance. ... It was designed to help customer’s bridge the gap ... balance that is very durable. Sartorius is the second ...
(Date:11/21/2014)... 2014 The report, "Synthetic ... Enzymes, Cloning kits), Technology (Bioinformatics, Nanotechnology, Gene ... Biomaterials, Bioremediation) - Global Forecast to 2018", ... threats, opportunities, and challenges. , Browse 99 ... through 185 pages and in-depth TOC of ...
(Date:11/21/2014)... 21, 2014 Why did Stephen Hawking ... Einstein so instantly recognizable? Why have they become icons ... and author Hilton Ratcliffe seeks out the answers to ... all to do with science. In " Stephen Hawking ... November 21, 2014), Ratcliffe puts it plainly: , ...
(Date:11/21/2014)... , Nov. 20, 2014 Polaris ... been dosed in its Phase 1 trial of ... for the treatment of malignant pleural mesothelioma (MPM) ... is conducting clinical trials on ADI-PEG 20, both ... for the treatment of several other indications, including ...
Breaking Biology Technology:Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 4“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2
... /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY ... Eastland as Chief Financial Officer and Vice President, ... responsibilities will include financial management, investor relations and ... than 25 years of financial management experience to ...
... -- Chemists at Indiana University Bloomington have designed a molecule ... to release the ions in the presence of ultraviolet light. ... Society today (online), IU Bloomington chemist Amar Flood and ... how it works and, just as importantly, how they know ...
... Innovations (MBI) will be showcasing Zequanox ,™ ... at the International Conference on Aquatic Invasive Species ... September 2, 2010.  The conference is attended by participants ... and other stakeholders involved in the issues of aquatic ...
Cached Biology Technology:ONCOTHYREON APPOINTS JULIE M. EASTLAND AS CHIEF FINANCIAL OFFICER 2IU chemists develop new 'light switch' chloride binder 2IU chemists develop new 'light switch' chloride binder 3Marrone Bio Innovations to Present Invasive Mussel Control Solution 2
... Drosophila S2 cells are used ... Expression System (DES). The S2 cell ... late stage (20-24 hours old) Drosophila melanogaster ... grows rapidly at room temperature without CO2 and ...
ACS Reagent Grade C 19 H 14 O 5 S Formula Weight: 354.38 PRODUCT SPECIFICATIONS Form: Rust/red crystalline powder Clarity of Solution: Passes test Visual Transition Interval: pH 6.8 - Yellow pH 8.2...
... tool for investigating dynamic events in cells ... been limited at wavelengths longer than 370 ... in the deep UV. HORIBA Jobin Yvon, ... filter-based confocal system (the DynaMic) to measure ...
... Optically clear dishes with stacking feature for ... new product number, created to easily match Cornings ... order under the old Sigma-Aldrich number (Z70,947-6) or ... low binding surface Comp Dim: surface area 55 ...
Biology Products: