Navigation Links
Computer modeling technique goes viral at Brandeis
Date:6/18/2013

It's not a hacker lab. At Brandeis University, sophisticated computational models and advances in graphical processing units are helping scientists understand the complex interplay between genomic data, virus structure and the formation of the virus' outer "shell" critical for replication.

"We hope that some of what we are finding will help researchers alter virus assembly, leaving viruses unable to replicate," says post-doctoral fellow Jason Perlmutter, first author of the scientific paper describing the technique, published in the open access journal eLife.

Scientists know that many viruses are able to hijack the genetic machinery of host cells to produce copies of themselves and spread infection from cell to cell. For many virus families, a key part of this process is the formation of a protein "shell," called a capsid, around the viral genome during the assembly process.

The physics of this assembly process, which involves interactions between the negatively charged nucleic acid genome and the positively charged capsid protein, depends on a number of factors related to the structure of the virus genome.

"Changing all these critical genomic parameters in a live virus and looking at how capsid formation behaves is impossible given the speed of the process and our current imaging techniques," says associate professor of physics Michael Hagan, whose lab conducted the study.

That's why the team's modeling approach the most realistic developed to date is so important to scientists who are interested in how the virus capsid protein assembles around its genome in the cell. The Brandeis team used their modeling tool to calculate the optimal genome for a number of specific capsids which vary in size, shape and surface properties.

"If you take the model and apply it to biological viruses, we are able to predict within a narrow range key structural features of the virus genome and, by extension, ho
'/>"/>

Contact: Ellen de Graffenreid
edegraff@brandeis.edu
781-736-4213
Brandeis University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Computer simulations help explain why HIV cure remains elusive
2. Patel recognized with NSF Career Award for computer-modeling research on cell membranes
3. Computer scientists develop an interactive field guide app for birders
4. Computer model pinpoints prime materials for efficient carbon capture
5. 2 NASA visualizations selected for computers graphics showcase
6. RIKEN and Fujitsu complete operational testing of the K computer
7. 3-D motion of cold virus offers hope for improved drugs using Australias fastest supercomputer
8. Computers can predict effects of HIV policies
9. Eco-computer with a natural wood look
10. Molecular economics: New computer models calculate systems-wide costs of gene expression
11. NPointer from Neurotechnology Uses Hand Gestures to Control and Navigate Computer Programs Without a Mouse or Touchpad
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... DURHAM, N.C. -- Scientists have identified the developmental on-off ... microbes that produce more than two-thirds of the world,s ... would be to see whether it is possible to ... efficient. , The study, appearing August 28 in ... a small molecule called cyclic-di-GMP and a larger protein ...
(Date:8/28/2014)... compounds that could positively impact the global ... possible, thanks to researchers in Penn State,s ... suppository made from the seaweed-derived food ingredient ... Tenofovir provides a woman-initiated, drug-delivery vehicle that ... transmitted infections during unprotected heterosexual intercourse, the ...
(Date:8/28/2014)... good examples of complex systems. Their infrastructure equipment ... for cooling, transport to supply fuel, and ICT ... the network chain is interconnected with a wider ... team of UK-based scientists has studied various aspects ... have been published in EPJ B by Gaihua ...
Breaking Biology News(10 mins):Small molecule acts as on-off switch for nature's antibiotic factory 2Small molecule acts as on-off switch for nature's antibiotic factory 3Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 3Inter-dependent networks stress test 2
... 251 million years ago was preceded by elevated extinction rates ... recovery that lasted for millions of years. New research by ... in atmospheric oxygen levels was likely a major reason for ... , Earth's land at the time was still massed in ...
... measurement techniques from a high-altitude aircraft, scientists detected two ... of rain forest near the Kilauea Volcano in the ... of the Carnegie Institution's Department of Global Ecology, explained: ... used them to tell which species dominated specific areas. ...
... Helsinki, show that atomic structures can reveal evolutionary history ... for the dinosaurs and reptiles. Their article is published ... , These "molecular fossils" also revealed that viruses and ... plausible explanation may be that viral building blocks served ...
Cached Biology News:Scientists reveal the shape of a protein that helps retroviruses break into cells 2Scientists reveal the shape of a protein that helps retroviruses break into cells 3Finding hidden invaders in a Hawaiian rain forest 2Finding hidden invaders in a Hawaiian rain forest 3
(Date:8/28/2014)... USA (PRWEB) August 28, 2014 SPIE ... of Physics and Optical Science and Director of the ... of North Carolina at Charlotte, and co-founder and Chairman ... to serve as the 2015 Vice President of SPIE, ... 2014 President Philip Stahl announced recent election results at ...
(Date:8/28/2014)... new research platform uses a laser to ... undergoing stress and heating, an approach likely ... microelectronics and batteries., This new technique, called ... heating and the surface stress of microscale ... discussed the merits of surface-stress influence on ...
(Date:8/28/2014)... Aug. 28, 2014  Next month, executives from clinical trial ... industry events beginning with Patient-Centered Clinical Trials 2014 , ... Boston , September 4-5. Patient recruitment experts ... Aaron Fleishman will share insights on the benefits of ... of tactics – from media to mobile apps – can ...
(Date:8/28/2014)... new work by a Florida State University research team ... take your temperature, emit white light, and convert photon ... looks like a butterfly. , Biwu Ma, associate professor ... the FAMU-FSU College of Engineering, created the molecule in ... to discover that his creation has many other unique ...
Breaking Biology Technology:Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3BBK Worldwide Leads Sessions at Key September Events 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2
... HOUSTON, April 14 SeqWright Inc., a leading ... increase the breadth of its next,generation offerings and ... solutions. The GS FLX(TM) system will complement,SeqWright,s current ... offer,a more diverse array of next generation services, ...
... April 11 /PRNewswire-FirstCall/ - YM BioSciences Inc.,(AMEX: ... company that identifies,develops and commercializes differentiated products for ... on two of its,anti-cancer drugs, nimotuzumab and tesmilifene, ... Research (AACR) Annual Meeting held from,April 12-16, 2008 ...
... ), a leading Los Angeles branding and web ... biomedical research,institute. (http://www.liai.org ), "This is ... content to the user with,high-impact visuals and user-centric content, ... Allergy & Immunology,s dedication to,Finding Cures Faster, in a ...
Cached Biology Technology:SeqWright Expands Next Generation Lineup with the Addition of 454's GS FLX(TM) System 2YM BIOSCIENCES ANNOUNCES PRESENTATIONS FOR TWO OF ITS ANTI-CANCER DRUGS AT AACR ANNUAL MEETING 2YM BIOSCIENCES ANNOUNCES PRESENTATIONS FOR TWO OF ITS ANTI-CANCER DRUGS AT AACR ANNUAL MEETING 3La Jolla Institute for Allergy & Immunology Wows With New Website 2
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
quantitation of phosphatase activity, evaluation of hits and leads from HTS...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Biology Products: