Navigation Links
Computer modeling technique goes viral at Brandeis
Date:6/18/2013

It's not a hacker lab. At Brandeis University, sophisticated computational models and advances in graphical processing units are helping scientists understand the complex interplay between genomic data, virus structure and the formation of the virus' outer "shell" critical for replication.

"We hope that some of what we are finding will help researchers alter virus assembly, leaving viruses unable to replicate," says post-doctoral fellow Jason Perlmutter, first author of the scientific paper describing the technique, published in the open access journal eLife.

Scientists know that many viruses are able to hijack the genetic machinery of host cells to produce copies of themselves and spread infection from cell to cell. For many virus families, a key part of this process is the formation of a protein "shell," called a capsid, around the viral genome during the assembly process.

The physics of this assembly process, which involves interactions between the negatively charged nucleic acid genome and the positively charged capsid protein, depends on a number of factors related to the structure of the virus genome.

"Changing all these critical genomic parameters in a live virus and looking at how capsid formation behaves is impossible given the speed of the process and our current imaging techniques," says associate professor of physics Michael Hagan, whose lab conducted the study.

That's why the team's modeling approach the most realistic developed to date is so important to scientists who are interested in how the virus capsid protein assembles around its genome in the cell. The Brandeis team used their modeling tool to calculate the optimal genome for a number of specific capsids which vary in size, shape and surface properties.

"If you take the model and apply it to biological viruses, we are able to predict within a narrow range key structural features of the virus genome and, by extension, ho
'/>"/>

Contact: Ellen de Graffenreid
edegraff@brandeis.edu
781-736-4213
Brandeis University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Computer simulations help explain why HIV cure remains elusive
2. Patel recognized with NSF Career Award for computer-modeling research on cell membranes
3. Computer scientists develop an interactive field guide app for birders
4. Computer model pinpoints prime materials for efficient carbon capture
5. 2 NASA visualizations selected for computers graphics showcase
6. RIKEN and Fujitsu complete operational testing of the K computer
7. 3-D motion of cold virus offers hope for improved drugs using Australias fastest supercomputer
8. Computers can predict effects of HIV policies
9. Eco-computer with a natural wood look
10. Molecular economics: New computer models calculate systems-wide costs of gene expression
11. NPointer from Neurotechnology Uses Hand Gestures to Control and Navigate Computer Programs Without a Mouse or Touchpad
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... French and German . ... other mammals, the difference between sexes depends on one single element ... males, where the two sexual chromosomes are X and Y, whereas ... for all the morphological and physiological differences between males and females. ... long time ago, the X and Y were identical, until the ...
(Date:4/23/2014)... their mid-thirties and forties, face a devastating prognosis: ... decades. "Mutant" protein clusters, long blamed for the ... primary focus of therapies in development by pharmaceutical ... Gerardo Lederkremer and Dr. Julia Leitman of Tel ... in collaboration with Prof. Ulrich Hartl of the ...
(Date:4/23/2014)... (Apr. 23 2014) A team of ... cells (hNSCs) into the brains of nonhuman primates ... and 24 months found that the hNSCs had ... not cause tumors. , The study will be ... Transplantation but is currently freely available on-line ...
Breaking Biology News(10 mins):Male or female? 2Male or female? 3On the defensive 2On the defensive 3Study finds long-term survival of human neural stem cells transplanted into primate brain 2
... from males can damage relationships between females is revealed in ... Centre for Research in Animal Behaviour at the University of ... B , the research uncovers the effect of sexual harassment ... with each other. The study focused on guppies, a ...
... 2009Exploring the psychology of human-nature relationships and understanding the ... at the core of the evolving discipline called ecopsychology ... journal, Ecopsychology , published by Mary Ann Liebert, ... free online at www.liebertpub.com/eco The goal ...
... has announced the university teams who won the annual ... award competition encourages college students to apply technology in ... designs must be economically profitable, which is why each ... designs. "Scientific innovation has long been a ...
Cached Biology News:Sexual harassment from males prevents female bonding, says study 2Premier issue of Ecopsychology launched by Mary Ann Liebert Inc. publishers 2Premier issue of Ecopsychology launched by Mary Ann Liebert Inc. publishers 3EPA's P3 award winners celebrate a green future 2
(Date:1/15/2014)... Two champions of science, technology, engineering, and ... annual competition for middle and high school students designed ... study. The competition presents students with real-world problems experienced ... Mathematics, and Sciences is a program administered by ...
(Date:1/15/2014)... January 15, 2014 AudioNotch is the ... therapy for the treatment of tinnitus. Patients listen to ... and over a period of weeks to months, their tinnitus ... in two forms: Notched Music and Notched White Noise. Now, ...
(Date:1/14/2014)...  3D Communications, a leading provider of strategic communications services to corporations ... in the United States and ... , JD, is returning to the firm,s Washington, D.C. ... after more than two years of service as Associate Commissioner for ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management software, ... Strategy. In this role, Michelle will work with current and ... the development of iLab products. Her main goal will be ... the scientific community by offering the most advanced, user-friendly, and ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... -- GE Healthcare reported Monday that it ... Virginia Health System to develop new, minimally ... will use GE Healthcare's surgical navigation tools, the InstaTrak ... invasive methods of therapeutic and surgical intervention for the ...
... - Gov. Jim Doyle on Monday expressed hope ... Majority Leader Bill Frist's recent decision to support removal ... , ,Doyle made his comments at the groundbreaking of ... also praised Wisconsin's medical development scene. , ,In remarks ...
... -- Dr. Carlos Perez has been appointed to the ... Madison. Perez is a former president of the American ... years of experience in radiation oncology. , ,Perez ... at Mallinckrodt Institute of Radiology, Siteman Cancer Center, Washington ...
Cached Biology Technology:Doyle praises Frist's new stem cell research position 2Doyle praises Frist's new stem cell research position 3
Rabbit polyclonal to HMGB1 (rating: ****) ( Abpromise for all tested applications). entrezGeneID: 3146 SwissProtID: P09429...
Pooled normal sreum with 0.1% sodium azide as preservative...
Mouse CXCR3 Allophycocyanin MAb (Clone 220803)...
Mouse P-Selectin/CD62P MAb (Clone 127933)...
Biology Products: