Navigation Links
Computer modeling technique goes viral at Brandeis
Date:6/18/2013

It's not a hacker lab. At Brandeis University, sophisticated computational models and advances in graphical processing units are helping scientists understand the complex interplay between genomic data, virus structure and the formation of the virus' outer "shell" critical for replication.

"We hope that some of what we are finding will help researchers alter virus assembly, leaving viruses unable to replicate," says post-doctoral fellow Jason Perlmutter, first author of the scientific paper describing the technique, published in the open access journal eLife.

Scientists know that many viruses are able to hijack the genetic machinery of host cells to produce copies of themselves and spread infection from cell to cell. For many virus families, a key part of this process is the formation of a protein "shell," called a capsid, around the viral genome during the assembly process.

The physics of this assembly process, which involves interactions between the negatively charged nucleic acid genome and the positively charged capsid protein, depends on a number of factors related to the structure of the virus genome.

"Changing all these critical genomic parameters in a live virus and looking at how capsid formation behaves is impossible given the speed of the process and our current imaging techniques," says associate professor of physics Michael Hagan, whose lab conducted the study.

That's why the team's modeling approach the most realistic developed to date is so important to scientists who are interested in how the virus capsid protein assembles around its genome in the cell. The Brandeis team used their modeling tool to calculate the optimal genome for a number of specific capsids which vary in size, shape and surface properties.

"If you take the model and apply it to biological viruses, we are able to predict within a narrow range key structural features of the virus genome and, by extension, ho
'/>"/>

Contact: Ellen de Graffenreid
edegraff@brandeis.edu
781-736-4213
Brandeis University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Computer simulations help explain why HIV cure remains elusive
2. Patel recognized with NSF Career Award for computer-modeling research on cell membranes
3. Computer scientists develop an interactive field guide app for birders
4. Computer model pinpoints prime materials for efficient carbon capture
5. 2 NASA visualizations selected for computers graphics showcase
6. RIKEN and Fujitsu complete operational testing of the K computer
7. 3-D motion of cold virus offers hope for improved drugs using Australias fastest supercomputer
8. Computers can predict effects of HIV policies
9. Eco-computer with a natural wood look
10. Molecular economics: New computer models calculate systems-wide costs of gene expression
11. NPointer from Neurotechnology Uses Hand Gestures to Control and Navigate Computer Programs Without a Mouse or Touchpad
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... wages war on the human body. Battles are ... In pancreatic cancer, this stalemate—known as tumor dormancy—can ... malignant, a phenomena that is poorly understood. ... laboratory of Salvatore Torquato, a Professor of Chemistry ... surrounding tumor dormancy and the switch to a ...
(Date:10/16/2014)... a new synthesis of recent research findings to inform ... the two states. , The Ecology and Management ... A Synthesis of the Relevant Biophysical Science and Implications ... by the U.S. Forest Service,s Pacific Northwest Research Station, ... for a synthesis of the large body of scientific ...
(Date:10/16/2014)... monocultures can be cultivated efficiently, they are anything ... caused by monoculture cultivation is becoming increasingly evident. ... crop form and are regarded as the sole ... – quite wrongfully, finds Bernhard Schmid, an ecology ... a novel form of agriculture and forestry. After ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2New report synthesizes best available science on management of moist mixed-conifer forests 2Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
... government builds on its $1 billion investment to clean up ... developed innovative new maps of both environmental threats and benefits ... world,s largest fresh water resource. Writing this week (Dec. ... of Science ( PNAS ), a group led by ...
... with pollutants from Asia, transpacific dust plumes deliver vast ... manuscript published online ahead of print in the journal ... detected thousands of unique microbial species, many of which ... David J. Smith, a graduate student at the University ...
... common reed, grows rapidly into dense stands of tall plants ... Early treatment is the key to controlling Phragmites . ... they take over their environment if we don,t know where ... from Michigan Technological University,s Michigan Tech Research Institute (MTRI), the ...
Cached Biology News:Mapping effort charts restoration tack for Great Lakes 2Mapping effort charts restoration tack for Great Lakes 3Dust-plumes power intercontinental microbial migrations 2Following Phragmites home 2
(Date:10/18/2014)... According to a new market research report ... Global Trends & Forecasts up till 2017”, hydraulic fracturing ... This value is expected to increase from $40 billion ... CAGR during the same period. North America is expected ... terms of hydraulic horse power supplied by the year ...
(Date:10/18/2014)... The “Global Diagnostic Electrocardiograph (ECG) ... End-user (Hospitals, Home/Ambulatory, Research Center, Physician Office, Nursing ... Forecast to 2020” provides a detailed overview of ... trends, and strategies impacting the global diagnostic ECG ... the revenue and share analysis. , The global ...
(Date:10/17/2014)... looking-glass to Wonderland, mirrors in the real world can ... new class of mirror that works like no other. ... (OSA) new high-impact journal Optica , ... type of mirror that forgoes a familiar shiny metallic ... unusual magnetic property of a non-metallic metamaterial. , ...
(Date:10/17/2014)... (PRWEB) October 17, 2014 For ... top employers, as published in today’s print issue ... Careers’ annual Top Employers Survey polled employees in ... the 20 best employers. Rankings were determined ... asked to rate their companies on 23 characteristics, ...
Breaking Biology Technology:Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 2Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 4The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 2The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 3The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 4The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 5Magnetic mirrors enable new technologies by reflecting light in uncanny ways 2Magnetic mirrors enable new technologies by reflecting light in uncanny ways 3Magnetic mirrors enable new technologies by reflecting light in uncanny ways 4DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3
... Advanced Cell Technology, Inc. ("ACT"; OTCBB: ACTC), a ... that it has filed a clinical trial application (CTA) ... (MHRA) seeking clearance to initiate its Phase 1/2 clinical ... human embryonic stem cells (hESCs) to treat patients with ...
... Calif., April 20, 2011 Clontech Laboratories, Inc., ... announced the release of the iDimerize inducible ... ARGENT™ technology developed by ARIAD Pharmaceuticals, ... systems enable precise, real-time control of protein-protein interactions ...
... Practice Fusion, the leading EHR and healthcare community ... Paul Willard as Vice President of Marketing and Liz ... of the expanded executive team follows a $23 million ... Health Record system , led by Founders Fund earlier ...
Cached Biology Technology:ACT Files European Clinical Trial Application for Phase 1/2 Study Using Embryonic Stem Cells to Treat Macular Degeneration 2ACT Files European Clinical Trial Application for Phase 1/2 Study Using Embryonic Stem Cells to Treat Macular Degeneration 3ACT Files European Clinical Trial Application for Phase 1/2 Study Using Embryonic Stem Cells to Treat Macular Degeneration 4Announcement - Clontech Laboratories, Inc. Releases the iDimerize™ Cell Signaling and Expression Systems 2Announcement - Clontech Laboratories, Inc. Releases the iDimerize™ Cell Signaling and Expression Systems 3Announcement - Clontech Laboratories, Inc. Releases the iDimerize™ Cell Signaling and Expression Systems 4Practice Fusion Expands Executive Team with New VP of Marketing and Senior Business Development Director 2Practice Fusion Expands Executive Team with New VP of Marketing and Senior Business Development Director 3Practice Fusion Expands Executive Team with New VP of Marketing and Senior Business Development Director 4
...
D.R. Harper and C. Grose (1994) • Includes: virus structure & replication, fundamental virology, immunology and pathogenesis, vaccines and antiviral drugs, novel diagnostic techniques, cloning a...
IHC Polymer Detection Kit (Rabbit DAB)150 slides...
...
Biology Products: