Navigation Links
Computer modeling technique goes viral at Brandeis
Date:6/18/2013

It's not a hacker lab. At Brandeis University, sophisticated computational models and advances in graphical processing units are helping scientists understand the complex interplay between genomic data, virus structure and the formation of the virus' outer "shell" critical for replication.

"We hope that some of what we are finding will help researchers alter virus assembly, leaving viruses unable to replicate," says post-doctoral fellow Jason Perlmutter, first author of the scientific paper describing the technique, published in the open access journal eLife.

Scientists know that many viruses are able to hijack the genetic machinery of host cells to produce copies of themselves and spread infection from cell to cell. For many virus families, a key part of this process is the formation of a protein "shell," called a capsid, around the viral genome during the assembly process.

The physics of this assembly process, which involves interactions between the negatively charged nucleic acid genome and the positively charged capsid protein, depends on a number of factors related to the structure of the virus genome.

"Changing all these critical genomic parameters in a live virus and looking at how capsid formation behaves is impossible given the speed of the process and our current imaging techniques," says associate professor of physics Michael Hagan, whose lab conducted the study.

That's why the team's modeling approach the most realistic developed to date is so important to scientists who are interested in how the virus capsid protein assembles around its genome in the cell. The Brandeis team used their modeling tool to calculate the optimal genome for a number of specific capsids which vary in size, shape and surface properties.

"If you take the model and apply it to biological viruses, we are able to predict within a narrow range key structural features of the virus genome and, by extension, how these parameters control whether the capsid assembles or misassembles and what misassembly looks like," says Perlmutter.

"Our tool should help scientists better understand the relationship between viral structure and packaging, making it easier to develop antiviral agents as well as aid the redesign of viruses for use in gene therapy and drug delivery."


'/>"/>

Contact: Ellen de Graffenreid
edegraff@brandeis.edu
781-736-4213
Brandeis University
Source:Eurekalert

Related biology news :

1. Computer simulations help explain why HIV cure remains elusive
2. Patel recognized with NSF Career Award for computer-modeling research on cell membranes
3. Computer scientists develop an interactive field guide app for birders
4. Computer model pinpoints prime materials for efficient carbon capture
5. 2 NASA visualizations selected for computers graphics showcase
6. RIKEN and Fujitsu complete operational testing of the K computer
7. 3-D motion of cold virus offers hope for improved drugs using Australias fastest supercomputer
8. Computers can predict effects of HIV policies
9. Eco-computer with a natural wood look
10. Molecular economics: New computer models calculate systems-wide costs of gene expression
11. NPointer from Neurotechnology Uses Hand Gestures to Control and Navigate Computer Programs Without a Mouse or Touchpad
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2017)... , May 5, 2017 ... just announced a new breakthrough in biometric authentication ... exploits quantum mechanical properties to perform biometric authentication. These ... smart semiconductor material created by Ram Group and ... finance, entertainment, transportation, supply chains and security. Ram ...
(Date:4/17/2017)... Florida , April 17, 2017 NXT-ID, ... technology company, announces the filing of its 2016 Annual Report on ... and Exchange Commission. ... on Form 10-K is available in the Investor Relations section of ... as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... , Apr. 11, 2017 Research and ... Market 2017-2021" report to their offering. ... The global eye tracking market to grow at a ... report, Global Eye Tracking Market 2017-2021, has been prepared based on ... covers the market landscape and its growth prospects over the coming ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder ... local San Diego Rotary Club. The event entitled “Stem Cells and ... had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: ...
(Date:10/10/2017)... Oct. 10, 2017 SomaGenics announced the receipt ... to develop RealSeq®-SC (Single Cell), expected to be the ... RNAs (including microRNAs) from single cells using NGS methods. ... need to accelerate development of approaches to analyze the ... "New techniques for measuring levels of mRNAs in ...
(Date:10/10/2017)... PA (PRWEB) , ... October 10, 2017 , ... ... year’s recipients of 13 prestigious awards honoring scientists who have ... presented in a scheduled symposium during Pittcon 2018, the world’s leading conference and ...
(Date:10/9/2017)... ... , ... The award-winning American Farmer television series will feature 3 Bar Biologics ... at 8:30aET on RFD-TV. , With global population estimates nearing ten billion people ... to feed a growing nation. At the same time, many of our valuable resources ...
Breaking Biology Technology: