Navigation Links
Computer modeling reveals how surprisingly potent hepatitis C drug works
Date:2/20/2013

ould greatly enhance our ability to design optimal drug therapies and ultimately cure this disease," said Alan Perelson, senior author on the paper and a senior fellow at Los Alamos National Laboratory.

A mathematical method called "viral kinetic modeling" aims to characterize the main mechanisms that govern the virologic response to treatment. It is instrumental in understanding HCV pathogenesis and in guiding development of a variety of anti-HCV agents.

Until now, viral kinetic models did not take into account the intracellular events during viral replication and infected cells were considered as "black boxes" whose viral production was partially shut down by treatment.

The researchers demonstrated that understanding the effects of daclatasvir in vivo requires a novel modeling approach that incorporates drug effects on the HCV intracellular lifecycle. They used this new model to characterize the viral kinetics during daclatasvir therapy and they showed that this compound efficiently blocked two distinct processes, namely the synthesis of new viral genomes (like other antivirals) but also the release of the virus from infected cells.

As a consequence of this unique mode of action, the viral decline observed during treatment with daclatasvir allowed for more precise estimation of the HCV half-life in serum, about 45 minutes, instead of the previously estimated 2.7 hours. This implies that the daily viral production; and thus the risk of mutations conferring drug resistance, is four times larger than previously thought.


'/>"/>

Contact: Nancy Ambrosiano
nwa@lanl.gov
505-699-1149
DOE/Los Alamos National Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. New supercomputer to aid genomics research
2. New supercomputer coming to EMSL this summer, supplied by Atipa Technologies
3. Virginia Tech computer scientists develop new way to study molecular networks
4. Iowa State computer, electrical engineers working to help biologists cope with big data
5. How computers push on the molecules they simulate
6. Total donates high-speed computer cluster to UH
7. A better thought-controlled computer cursor
8. Computers taught to ID regulating gene sequences
9. Computer simulations for multiscale systems can be faster, better, more reliable
10. Computer viruses could take a lesson from showy peacocks
11. NPointer from Neurotechnology Uses Hand Gestures to Control and Navigate Computer Programs Without a Mouse or Touchpad
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... referred for evaluation of suspected genetic conditions, whole-exome ... percent, including detection of a number of rare ... according to a study appearing in JAMA ... with the American Society of Human Genetics annual ... coding regions of thousands of genes simultaneously using ...
(Date:10/17/2014)... is available in German . ... very few drugs. When treating overdoses, doctors are often limited ... difficult if there is a combination of drugs involved. So ... accidentally swallows his grandmother,s pills? ETH professor Jean-Christophe Leroux from ... find an answer to this question. "The task was to ...
(Date:10/16/2014)... cultivated efficiently, they are anything but sustainable: environmental ... cultivation is becoming increasingly evident. Despite their disadvantages, ... are regarded as the sole possibility of achieving ... finds Bernhard Schmid, an ecology professor at the ... of agriculture and forestry. After all, a new ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Emergency aid for overdoses 2Emergency aid for overdoses 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
... Researchers have discovered an isolated, self-sustaining, bacterial community living ... surface in a South African gold mine. It is ... on geologically produced sulfur and hydrogen and one of ... depend on energy from the Sun in any way. ...
... risks of a manned flight to Mars ranks the possibility ... the brains of astronauts, leaving them in a vegetative state, ... NASA's Mars scientists, the cosmic radiation risk remains a show-stopper ... too heavy to reach Mars, which, at its closest, is ...
... iguanas on the Galápagos Islands live without predators - at ... Since then they have been confronted with cats and dogs ... therefore a suitable model of study in order to discover ... behaviour and endocrine stress response to novel predation threats. Scientists ...
Cached Biology News:Otherworldly bacteria discovered two miles down 2Mars mission Risk 29: Scientists research ways to reduce radiation-induced brain damage 2Mars mission Risk 29: Scientists research ways to reduce radiation-induced brain damage 3Mars mission Risk 29: Scientists research ways to reduce radiation-induced brain damage 4Too mellow for our predatory world 2Too mellow for our predatory world 3Too mellow for our predatory world 4
(Date:10/20/2014)... Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced four new ... and provides a good start to Q4.  The orders are for ... and one in the Middle East . ... Peter Bruijns , President & CEO. "Total bidding activity and ... have been for any complete year since the company has tracked ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 ... Partners LLC, announced today that Ellen Teplitzky, an ... support for the pharmaceutical industry, has joined the ... of its legal services practice. NDA Partners ... expert witness and testimony, to top law firms ...
(Date:10/19/2014)... The Asia-Pacific Bromine Market report defines and ... and forecast of revenue. , Browse through the ... to get an idea of the in-depth analysis ... segmentation in the Asia-Pacific bromine market, and is ... http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is a volatile ...
(Date:10/19/2014)... The report "Unmanned Ground Vehicle Market by Application ... & by Geography - Forecasts & Analysis 2014–2020", ... market into various sub segments with an in-depth ... also identifies the factors driving this market, various ... adoption trends. , The unmanned ground vehicle market ...
Breaking Biology Technology:NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5
... Germany , June 16, 2010 ,The medical devices company joimax(R) GmbH is ... had already been the motto of,the last company move back in 2005. , ... The US market has an enormous ... to Irvine, California , one,of high-tech industry centers in the United States ...
... This release is avaiable in French . ... of high-tech products such as computer displays or solar ... chemical composition as inorganic materials, preventing scientists from using ... of researchers led by McGill,s Dr. Dmitrii Perepichka and ...
... June 15 BioMed Realty Trust, Inc. (NYSE: BMR ) ... of $0.15 per share of common stock, representing a 7.1% increase over ... is equivalent to an annualized dividend of $0.60 per common share. ... BioMed also announced that its board of directors ...
Cached Biology Technology:joimax(R) Moves Into Larger Premises 2Organic nanoelectronics a step closer 2BioMed Realty Trust Declares Second Quarter 2010 Common Stock and Preferred Stock Dividends 2BioMed Realty Trust Declares Second Quarter 2010 Common Stock and Preferred Stock Dividends 3
Goat polyclonal to MLH3 Immunogen: Synthetic peptide: RQSLQQSMPPCEPP (Human) from C Terminus of the protein sequence according to NP_055196....
Rabbit polyclonal to NMDAR1 e/f/g/h ( Abpromise for all tested applications)....
Polyclonal Antibody to Coronin / CORO1C This antibody was developed against synthetic peptides corresponding to amino acids 407-420 of human CORO1C....
Peptide-affinity Purified Polyclonal Antibody to Retinoic Acid-Induced 3 (RAI3/RAIG1)...
Biology Products: