Navigation Links
Compromised skin barrier function plays a role in psorasis development
Date:1/25/2009

Researchers at the Genome Institute of Singapore (GIS) and the Anhui Medical University, China, have identified genes that play an important role in the development of psoriasis, a common chronic skin disease.

The research, led by GIS Human Genetics Group Leader and Associate Prof. Liu Jianjun, will be published online on 25 Jan. 2009 in the journal Nature Genetics.

Studying genetic variants in the human genomes of a large cohort of patients with psorasis and healthy controls in the Chinese population, Dr. Liu and his colleagues, who are one of the three independent teams that have been simultaneously performing genetic studies on psoriasis, found that a genetic variant within what is known as the LCE gene cluster is able to provide protection against the development of psoriasis.

One of the LCE genes' functions is to code proteins that are part of cells located in the outermost layers of skin. These proteins are important for maintaining skin's barrier function.

"Together with the findings from the other two studies," said Dr Liu, "our finding suggests that compromised skin barrier function play a role in the development of psoriasis. This is a very important find, as it advances our understanding of the genetic basis of psoriasis, which in turn is important for early diagnosis and prediction of an individual's risk to the disease."

While Dr Liu's team focused on a Chinese population, the other two studies were conducted on Western populations. Dr Liu added, "Our team's work is also important because it is the first study ever done on a Chinese population all other studies on psoriasis so far have focused on western populations."

All three independent studies will be published by Nature Genetics at the same time.

Psoriasis is a common chronic, auto-immune and hyper-proliferative skin disease, usually characterized by red scaly patches on the skin. Affecting about one percent of ind
'/>"/>

Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2

Related biology news :

1. CMV infections affect more than just patients with compromised immune systems, researchers find
2. Text focuses on diagnosing infections in immunocompromised patients
3. Auto immune response creates barrier to fertility; could be a step in speciation
4. Leading experts cite poor health and nutrition as major barrier to education in developing world
5. Scientists from the UGR prove that rivers do not act as barriers for groundwater flow
6. Building the blood-brain barrier
7. Fear of hypoglycemia a barrier to exercise for type 1 diabetics
8. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
9. Device helps patients survive, regain function til transplant
10. Specific brain protein required for nerve cell connections to form and function
11. Systems Biology poised to revolutionize the understanding of cell function and disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... researcher has shed light on how an estimated one ... outback have become reviled as pests and culled on ... and Sustainability Institute at the University of Exeter,s Penryn ... from their historic role helping to create the country,s ... , The deserts of the Australian outback are a ...
(Date:4/23/2014)... mammals, ravens form different types of social relationships ... also form strict dominance relations. From a cognitive perspective, ... ability in daily social life ("knowing who is nice ... have with each other sets the stage for "political" ... this study have been published in the scientific journal ...
(Date:4/23/2014)... a 2 million Food Standards Agency (FSA) project to ... industry workers. , Norovirus outbreaks can rapidly affect ... of frozen strawberries infected 11,000 people in Germany, but ... which strains cause infection and which foods are the ... Researchers will produce data that will help the FSA ...
Breaking Biology News(10 mins):How Australia got the hump with 1 million feral camels 2How Australia got the hump with 1 million feral camels 3Ravens understand the relations among others 2
... to promote company,s highly secure, do it ... smartTOUCH(R) finger activated products, JERICHO, N.Y., Sept. 16 ... it has hired Debbe Dunning as,the company,s new spokesperson ... advertising campaign directed at the Home Improvement,market., (Photo: ...
... 16, 2008)- A team of scientists headed by neuroscientist Dr. ... the National Institute of Health (NIH), to develop a technique that ... Chiba, a professor at the University of Miami,s Department of Biology, ... to enhance synapse formation or nerve regeneration., ...
... , Researchers at McGill University and the affiliated Lady ... with colleagues at the University of Ottawa and the Ottawa ... use of viruses to target and destroy cancer cells, a ... the September early edition of the Proceedings of the ...
Cached Biology News:'Home Improvement' Star Debbe Dunning is New smartTOUCH Spokesperson 2'Home Improvement' Star Debbe Dunning is New smartTOUCH Spokesperson 3NIH EUREKA grant awarded to University of Miami scientist 2Viral 'magic bullet' targets cancer cells with help of new compound 2
(Date:1/14/2014)... iLab Solutions, the leader in core facility management ... Product Strategy. In this role, Michelle will work with current ... in the development of iLab products. Her main goal will ... to the scientific community by offering the most advanced, user-friendly, ...
(Date:1/14/2014)... Rockville, MD (PRWEB) January 14, 2014 ... dedicated to developing innovative information technology solutions for ... other health care stakeholders, announced today the signing ... the US Food and Drug Administration (FDA). ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Kerr Corporation, a ... video and additional how-to information about dual arch impressions on ... with Dual Arch Impressions,” the blog entry serves up a ... and houses a step-by-step demonstration by Dr. David Little as ...
(Date:1/14/2014)... January 14, 2014 BioMedomics, Inc. , ... POC diagnostic platforms and novel disease specific POC tests, announced ... financing netting a total of $690,000. The investment is from ... the company. This group of private investors has significant successful ...
Breaking Biology Technology:iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2BioMedomics, Inc. Closes $690K Round of Financing 2
... Pursues Additional Approvals Globally for Dialysis and Earlier Stage ... Chronic Kidney ... GENZ ) today announced the U.S. launch of the ... progress in its international efforts to secure additional,approvals for the ...
... PharmAthene, Inc., a,biodefense company specializing in the ... biological threats, announced,today that it has completed the ... spectrum chemical nerve agent prophylaxis., The PK ... used the final,pegylated version of rBChE for the ...
... - Continues Consolidation of Competitors in Key Markets ... China Nepstar,Chain Drugstore Ltd. (NYSE: NPD ) ... in China based on the number of directly ... a definitive agreement,with DongGuan Hui Ren Tang Pharmaceutical ...
Cached Biology Technology:Genzyme Launches Renvela(R) in the U.S. for Dialysis Patients 2Genzyme Launches Renvela(R) in the U.S. for Dialysis Patients 3Genzyme Launches Renvela(R) in the U.S. for Dialysis Patients 4Genzyme Launches Renvela(R) in the U.S. for Dialysis Patients 5PharmAthene Completes Pharmacokinetic Studies of Protexia(R); Program on Target for IND Filing in 2008 2PharmAthene Completes Pharmacokinetic Studies of Protexia(R); Program on Target for IND Filing in 2008 3PharmAthene Completes Pharmacokinetic Studies of Protexia(R); Program on Target for IND Filing in 2008 4China Nepstar Chain Drugstore to Acquire 18 Stores from Dongguan Hui Ren Tang Pharmaceutical Co. 2China Nepstar Chain Drugstore to Acquire 18 Stores from Dongguan Hui Ren Tang Pharmaceutical Co. 3China Nepstar Chain Drugstore to Acquire 18 Stores from Dongguan Hui Ren Tang Pharmaceutical Co. 4
... Application: A tracking dye for ... polyacrylamide gels including DNA sequencing. Preparation ... 0.05% is recommended. A 2% stock ... 5-10 buffer. Chem comp: Dye ...
... The VSOS-4 Orbital Shaker is designed to ... provide a uniform motion that is both mixing ... VSOS-4 Orbital Shaker provides a smooth, quiet, reproducible ... a wide range of laboratory applications such as ...
... The Biometra TProfessional Thermocycler combines top performance ... block achieves high speed and unparalleled temperature ... display providing programming in a spreadsheet or ... Performance Smart Lid opens on the push ...
... The Synaptic Vesicles Isolation Kit provides ... an enriched synaptic vesicle fraction. The ... lysis of the synaptosomes, and differential ... gradient. The kit also contains an ...
Biology Products: