Navigation Links
Compound may provide drug therapy approach for Huntington's disease
Date:6/23/2011

DALLAS June 23, 2011 UT Southwestern Medical Center researchers have identified compounds that appear to inhibit a signaling pathway in Huntington's disease, a finding that may eventually lead to a potential drug therapy to help slow the progression of degenerative nerve disorders.

"Our studies have uncovered a new therapeutic target for Huntington's disease treatment and possibly for other neurodegenerative diseases," said Dr. Ilya Bezprozvanny, professor of physiology and senior author of the study, published in today's issue of Chemistry and Biology. "In addition, we now have this new series of compounds that gives us a tool to study the pathogenesis of Huntington's disease."

Huntington's disease is a fatal genetic disorder in which certain brain cells waste away. More than 250,000 people in the U.S. have the disorder or are at risk for it. The most common form is adult-onset, with symptoms usually developing in patients in their mid-30s and 40s.

The disease results in uncontrolled movements, psychiatric disturbance, gradual dementia and eventually death. There is no therapy available currently to slow the progression of the disease.

Scientists at UT Southwestern found that quinazoline-derived compounds effectively block what is known as the store-operated calcium entry signaling pathway, which was never before implicated in Huntington nerve cells but that might be a therapeutic target in the disease.

Dr. Bezprozvanny's laboratory research has contributed to growing scientific evidence that suggests abnormalities in neuronal calcium signaling play an important role in the development of Huntington's disease. UT Southwestern researchers demonstrated in the current study that the quinoline compounds supplied by EnVivo protected brain cells.

"If this holds, this compound can be considered to have potential therapeutic application for Huntington's," he said. "As we ultimately seek a cure, we a
'/>"/>

Contact: Robin Russell
robin.russell@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Toxic compounds in groundwater
2. TGen study identifies compounds that could slow down Alzheimers disease
3. Mushroom compound suppresses prostate tumors
4. Scientists find new class of compounds with great potential for research and drug development
5. URI scientist discovers 54 beneficial compounds in pure maple syrup
6. New data published in Nature Genetics demonstrate that tiny LNA-based compounds developed by Santaris Pharma A/S inhibit entire disease-associated microRNA families
7. Rockefeller Scientists discover new compound that rids cells of Alzheimer protein debris
8. Compound useful for studying birth defects may also have anti-tumor properties
9. Chemical compounds in trees can fight deadly staph infections in humans
10. Antifungal compound found on tropical seaweed has promising antimalarial properties
11. UT researchers link algae to harmful estrogen-like compound in water
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2015)... -- ATL Technology, LLC, a top provider of electromechanical contract ... solutions, headquartered in Springville, Utah , has ... corporation with locations in Santa Clara, ... ). This acquisition will incorporate MedConx,s manufacturing ... Technology,s existing facility in Costa Rica , ...
(Date:6/25/2015)... N.J. , June 25, 2015  TAKE Solutions ... a patent by the United States Patent and Trademark ... Standardization". This process leverages TAKE Solutions, Clinical Accelerators to ... over 50% (when compared to standardization without the accelerators), ... At the heart of ...
(Date:6/24/2015)... JOSE, Calif. , June 24, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that ... sensor to provide secure authentication for its latest ... recently reached more than 200 million shipments of ... with Sharp reinforces Synaptics, strength, scalability and leadership ...
Breaking Biology News(10 mins):ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2TAKE Solutions Awarded Patent By USPTO 2Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2
... exposed to low doses of atrazine, a widely used herbicide, ... through puberty later than non-exposed animals. The research adds to ... used to control weeds and grasses in crops such as ... to be relatively persistent in the environment, potentially finding their ...
... current issue of Deutsches rzteblatt International (Dtsch ... pharmacologist, and coauthors present the PRISCUS List: a list ... effects when given to elderly patients. The authors ... Germany in the setting of a joint project entitled ...
... Chinese on EurekAlert! Chinese . ... Medicine, Hershey, Pennsylvania have discovered that the Opioid Growth ... important system with potent antitumor properties, has controlled entry ... passage of OGF-OGFr is critical to cell proliferation and ...
Cached Biology News:Atrazine causes prostate inflammation in male rats and delays puberty 2Regulation of cell proliferation is dependent on nucleocytoplasmic trafficking 2Regulation of cell proliferation is dependent on nucleocytoplasmic trafficking 3
(Date:6/29/2015)... ... June 29, 2015 , ... MediVet Biologics today announced ... agreement, MediVet will acquire the rights to a portfolio of cultures, products and ... development as a potential next-generation treatment for various musculoskeletal and internal medicine conditions ...
(Date:6/29/2015)... 29, 2015  Neuralstem, Inc. (NYSE MKT: CUR), a ... small molecule and cell therapy treatments for central nervous ... for listing on the NASDAQ Capital Market under the ... trade on the NYSE MKT until the market close ... Market is expected to commence on July 13, 2015. ...
(Date:6/29/2015)... , June 29, 2015 ... and medical information products and services, today announced the ... According to the 2014 Journal Citation Reports® (JCR) published ... Impact Factors increase from 2013 to 2014, ahead of ... occupied the top rank in 62 subject categories, up ...
(Date:6/26/2015)... -- A San Francisco company, Pembient, recently announced it will ... beer in China and skin ... to the emerging industry, two leading rhino conservation organizations ... rhino horn.  The International Rhino ... (SRI) released a joint statement calling ...
Breaking Biology Technology:MediVet Biologics Acquires Exclusive Patent License from Kansas State University 2MediVet Biologics Acquires Exclusive Patent License from Kansas State University 3Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 2Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 3Elsevier Announces 2014 Citation Impact Highlights 2Elsevier Announces 2014 Citation Impact Highlights 3Rhino Experts Oppose Synthetic Rhino Horn as Solution to Poaching Crisis 2
... students Steven T. Evans, Tobias Voitl, Gabriel R. Rodriguez-Rivera, ... MADISON - Carbon monoxide, or CO, has long been ... fuel cells. But now, chemical and biological engineers at ... barrier - they also have discovered a method to ...
... have mercy, otherwise, our produce will not be discovered and ... day. The festivities are full steam ahead, the skateboarding mathematicians ... sticks while sipping champagne, and they are now calculating the ... ,Looking from a wider angle, it seems that the big ...
... Thursday with Capital Data, Inc. , an ... services, according to TeraMEDICA's executive vice president, Paul ... bundle TeraMEDICA's TI2m archive solution into its own ... that includes Wisconsin, Minnesota, North Dakota, South Dakota, ...
Cached Biology Technology:UW engineers clear bottleneck in hydrogen production 2Lord of the Engines 2Lord of the Engines 3TeraMEDICA and Capital Data enter into diagnostic imaging agreement 2
... Serum • Cyno serum is collected off the clot ... years of age. Available Anticoagulants: ... N-06: K2EDTA N-08: Potassium Oxalate ... N-05: ACD N-07: CPD N-09: ...
Marmoset plasma and serum - various quantities available...
DNA Purification...
EPH electrode, cathode, 1. Category: Electrophoresis Systems & Standards & Reagents, IEF & SDS-PAGE & 2-D Electrophoresis, Multiphor II Kits & Components and Accessories....
Biology Products: