Navigation Links
Common congenital defect a prickly problem for the kidney
Date:2/21/2011

One of the most common congenital defects in humans it is detected in approximately 0.5% of fetuses analyzed by routine antenatal sonography is a kidney abnormality known as hydronephrosis. Hydronephrosis arises because the flow of urine from the kidney to the bladder is impeded. By studying kidney development in mice, Norman Rosenblum and colleagues, at the Hospital for Sick Children, Toronto, have identified a new cellular mechanism underlying hydronephrosis, something that they hope might lead to better therapeutics for the condition and improved diagnosis of its severity.

Rosenblum and colleagues found that the Hedgehog signaling pathway controls the development of two populations of cells required for the initiation and transmission of coordinated contractions of the tract that links the kidney and the bladder (the ureter). Thus, genetic mutations in mice that disrupted the Hedgehog signaling pathway impaired urine flow from the kidney to the bladder, causing hydronephrosis. As noted by both the authors and Doris Herzlinger, in an accompanying commentary, these data have the potential to lead to the development of novel therapeutics for the treatment of hydronephrosis. Further, they suggest that it might be possible to develop genetic tests that discriminate between cases of hydronephrosis that spontaneously resolve (as approximately 70-80% of cases do) and those that do not.


'/>"/>

Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related biology news :

1. APS to adopt Creative Commons licensing, publish open access articles and journals
2. Research links 29 genome regions with common form of inflammatory bowel disease
3. Free radicals in cornea may contribute to Fuchs dystrophy, most common cause of corneal transplants
4. Study finds common ground for ecosystems and fishing in Northwest Mexico
5. 2 bacterial enzymes confer resistanceto common herbicide, say MU researchers
6. Common antibiotics and blood pressure medication may result in hospitalization
7. New research contains solutions to common pear disease
8. UGA researchers develop rapid diagnostic test for common type of pneumonia
9. Genetic variants linked to increased risk of common gynecological disease
10. Study finds anti-microbials a common cause of drug-induced liver injury and failure
11. Reading the signs: Plants and animals found common ground in response to microbial threats
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2015)... , Aug. 19, 2015  VOXX International ... it has entered into a Definitive Agreement to ... of iris authentication market leader EyeLock through an ... will have a controlling interest in the acquiring ... to completion of due diligence.  Expanding on its ...
(Date:8/17/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market and creator of the Wocket® smart ... The new marketing campaign is being spearheaded by an ... ( http://amplitudemarketing.com/ ) and TPMG ( http://tmpg.com/ ). ... driven marketing and brand awareness and has a client ...
(Date:8/12/2015)...  New research unveiled at Black Hat 2015 ... steal users, fingerprints. Information released today by HYPR ... on mobile devices, making the security of this ... mobile devices, HYPR Corp. recently released a biometric ... with strong cryptographic security. More information on this ...
Breaking Biology News(10 mins):VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 2VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 4VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 5NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3
... (SACRAMENTO, Calif.) Smokers who don,t quit before ... neck cancers fair significantly worse than those who do, ... Allen Chen, an assistant professor in the Department ... found that head- and neck-cancer patients who continue to ...
... This press release is available in French . ... most deadly parasitic diseases in the world. It affects more than ... it kills 50 000 people each year. A reliable and rapid ... now, this has been next to impossible. Dr. Momar Ndao and ...
... America needs more vitamin D. It,s one more reason to ... at the Experimental Biology conference in Anaheim, California. Milk is ... supplying nearly half of all of the much-needed vitamin D. ... what more than 16,000 Americans ages two and older eat, ...
Cached Biology News:Smoking during radiation therapy for head and neck cancers linked to poorer outcomes 2Smoking during radiation therapy for head and neck cancers linked to poorer outcomes 3Major breakthrough in the diagnosis of parasitic diseases 2
(Date:8/31/2015)... ... August 31, 2015 , ... ... of its properties such as low carbon footprints and compostability. These properties can ... petroleum based plastics. On the basis of applications, the market for biodegradable plastics ...
(Date:8/31/2015)... Aug. 31, 2015 Research and Markets ( ... "Mexico Biomedical Sensors Market - Growth, Trends & Forecasts ... The Mexico Biomedical Sensors market is estimated at ... over the period 2014-2020 The near future ... genetic formulation of each individual. These sensors can be ...
(Date:8/31/2015)... , Aug. 31, 2015  For people with ... brighten their day. The biotechnology company, located in the ... one of the best potential therapies yet for people ... entitled, " Correction of Down syndrome and Edwards syndrome ... journal DNA Research . Elixirgen plans to develop ...
(Date:8/31/2015)... , Aug. 31, 2015  US-Australian drug ... NVGN ) today confirmed its comprehensive scientific review ... technology platforms in areas of unmet patient need. ... the remaining preclinical projects prior to entering into ... compounds. Acting Chief Executive Officer, ...
Breaking Biology Technology:Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 4Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 5Mexico Biomedical Sensors Market Report 2015-2020 2New Down syndrome therapy discovered 2Novogen Announces The Outcome Of A Comprehensive Science Review 2Novogen Announces The Outcome Of A Comprehensive Science Review 3Novogen Announces The Outcome Of A Comprehensive Science Review 4Novogen Announces The Outcome Of A Comprehensive Science Review 5Novogen Announces The Outcome Of A Comprehensive Science Review 6
... A new test developed by Japanese scientists may revolutionize ... a research report published online in The FASEB ... proteins in the spinal fluid known to be one ... impairment in Alzheimer,s patients: high molecular weight A-Beta oligomers. ...
... nuclear reactors may one day become a reality ... National Laboratory scientists. In a paper appearing ... Alamos researchers report a surprising mechanism that allows ... damage. Nanocrystalline materials are those created from nanosized ...
... ... by the Small Business Commerce Association (SBCA). The SBCA 2009 Award Program recognizes the top ... , ... 2010 -- BioSoteria, Inc ., a drug safety services and education firm, announced today ...
Cached Biology Technology:New test takes guesswork out of diagnosing early stage Alzheimer's disease 2Safer nuclear reactors could result from Los Alamos research 2Safer nuclear reactors could result from Los Alamos research 3Drug Safety Firm BioSoteria Receives 2009 Best of Business Award 2