Navigation Links
Common congenital defect a prickly problem for the kidney
Date:2/21/2011

One of the most common congenital defects in humans it is detected in approximately 0.5% of fetuses analyzed by routine antenatal sonography is a kidney abnormality known as hydronephrosis. Hydronephrosis arises because the flow of urine from the kidney to the bladder is impeded. By studying kidney development in mice, Norman Rosenblum and colleagues, at the Hospital for Sick Children, Toronto, have identified a new cellular mechanism underlying hydronephrosis, something that they hope might lead to better therapeutics for the condition and improved diagnosis of its severity.

Rosenblum and colleagues found that the Hedgehog signaling pathway controls the development of two populations of cells required for the initiation and transmission of coordinated contractions of the tract that links the kidney and the bladder (the ureter). Thus, genetic mutations in mice that disrupted the Hedgehog signaling pathway impaired urine flow from the kidney to the bladder, causing hydronephrosis. As noted by both the authors and Doris Herzlinger, in an accompanying commentary, these data have the potential to lead to the development of novel therapeutics for the treatment of hydronephrosis. Further, they suggest that it might be possible to develop genetic tests that discriminate between cases of hydronephrosis that spontaneously resolve (as approximately 70-80% of cases do) and those that do not.


'/>"/>

Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related biology news :

1. APS to adopt Creative Commons licensing, publish open access articles and journals
2. Research links 29 genome regions with common form of inflammatory bowel disease
3. Free radicals in cornea may contribute to Fuchs dystrophy, most common cause of corneal transplants
4. Study finds common ground for ecosystems and fishing in Northwest Mexico
5. 2 bacterial enzymes confer resistanceto common herbicide, say MU researchers
6. Common antibiotics and blood pressure medication may result in hospitalization
7. New research contains solutions to common pear disease
8. UGA researchers develop rapid diagnostic test for common type of pneumonia
9. Genetic variants linked to increased risk of common gynecological disease
10. Study finds anti-microbials a common cause of drug-induced liver injury and failure
11. Reading the signs: Plants and animals found common ground in response to microbial threats
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
(Date:4/26/2016)... BANGALORE, India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a ... ), and Onegini today announced a partnership to ... banking solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... banks to provide their customers enhanced security to ...
(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... /PRNewswire/ - FACIT has announced the creation of ... company, Propellon Therapeutics Inc. ("Propellon" or "the Company"), ... portfolio of first-in-class WDR5 inhibitors for the treatment ... represent an exciting class of therapies, possessing the ... cancer patients. Substantial advances have been achieved with ...
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)... June 23, 2016  The Prostate Cancer Foundation (PCF) is pleased ... and faster cures for prostate cancer. Members of the Class of 2016 were ... Read More About the Class of 2016 PCF Young ... ... ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
Breaking Biology Technology: