Navigation Links
Common congenital defect a prickly problem for the kidney
Date:2/21/2011

One of the most common congenital defects in humans it is detected in approximately 0.5% of fetuses analyzed by routine antenatal sonography is a kidney abnormality known as hydronephrosis. Hydronephrosis arises because the flow of urine from the kidney to the bladder is impeded. By studying kidney development in mice, Norman Rosenblum and colleagues, at the Hospital for Sick Children, Toronto, have identified a new cellular mechanism underlying hydronephrosis, something that they hope might lead to better therapeutics for the condition and improved diagnosis of its severity.

Rosenblum and colleagues found that the Hedgehog signaling pathway controls the development of two populations of cells required for the initiation and transmission of coordinated contractions of the tract that links the kidney and the bladder (the ureter). Thus, genetic mutations in mice that disrupted the Hedgehog signaling pathway impaired urine flow from the kidney to the bladder, causing hydronephrosis. As noted by both the authors and Doris Herzlinger, in an accompanying commentary, these data have the potential to lead to the development of novel therapeutics for the treatment of hydronephrosis. Further, they suggest that it might be possible to develop genetic tests that discriminate between cases of hydronephrosis that spontaneously resolve (as approximately 70-80% of cases do) and those that do not.


'/>"/>

Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related biology news :

1. APS to adopt Creative Commons licensing, publish open access articles and journals
2. Research links 29 genome regions with common form of inflammatory bowel disease
3. Free radicals in cornea may contribute to Fuchs dystrophy, most common cause of corneal transplants
4. Study finds common ground for ecosystems and fishing in Northwest Mexico
5. 2 bacterial enzymes confer resistanceto common herbicide, say MU researchers
6. Common antibiotics and blood pressure medication may result in hospitalization
7. New research contains solutions to common pear disease
8. UGA researchers develop rapid diagnostic test for common type of pneumonia
9. Genetic variants linked to increased risk of common gynecological disease
10. Study finds anti-microbials a common cause of drug-induced liver injury and failure
11. Reading the signs: Plants and animals found common ground in response to microbial threats
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/12/2014)... GARDENS, Fla. , Nov. 12, 2014 ... announced today that its U.are.U ® fingerprint readers ... bakery chain in Central Mexico . ... June 2014 to eliminate payroll issues caused by employees ... to installing the U.are.U fingerprint readers, Montparnasse relied on ...
(Date:11/10/2014)... store shelves in early 2010, and people have used ... can be tossed into a washing machine without ever ... convenience, though, has come with risks for young children. ... Hospital found that from 2012 through 2013, U.S. poison ... 6 years of age swallowing, inhaling, or otherwise being ...
(Date:11/7/2014)... 2014  In conjunction with the Glendale ... Community Foundation of the Verdugos has announced the " ... a $250,000 initiative to keep the Verdugo Regional Crime Lab ... six months of existence, the Lab has processed more than ... law enforcement. "Because our number one priority is ...
Breaking Biology News(10 mins):Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Study finds laundry detergent pods, serious poisoning risk for children 2Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2
... bacteria in the root of a tropical grass whose ... industries. These bacteria seem to promote the production of ... of the oil, giving it different flavours and properties: ... of the tropical Vetiver grass through interdisciplinary research, the ...
... of all food allergies are not food allergies at ... allergologists from Wrzburg University, concluded in a study with ... Deutsches rzteblatt International (Dtsch Arztebl Int 2008; ... allergy testing, food allergy was only confirmed in 214 ...
... at the Helmholtz-Zentrum fr Infektionsforschung (HZI) in Braunschweig, ... understanding metabolic pathways in bacteria and their use. ... working group, headed up by Vtor Martins dos ... for increasing the production of biosynthetics in the ...
Cached Biology News:Bacteria manage perfume oil production from grass 2Biosynthetics production with detours 2
(Date:11/21/2014)... (PRWEB) November 21, 2014 2014 ... Ferrocyanide Industry” is a professional and in-depth research ... Sodium ferrocyanide information, like its definition, classification, ... industry overview. This report covers the international market ... global (such as the US, Europe, Asia, China, ...
(Date:11/21/2014)... 20, 2014 Polaris Group announced today ... its Phase 1 trial of ADI-PEG 20 in ... of malignant pleural mesothelioma (MPM) and non-squamous non-small ... trials on ADI-PEG 20, both as monotherapy and ... of several other indications, including breast cancer, melanomas, ...
(Date:11/21/2014)... , Nov. 20, 2014  Cytori Therapeutics (NASDAQ: ... Hedrick , M.D. will present live at VirtualInvestorConferences.com on December ... TIME:    11:15 am PT / 2:15 pm ET ... into your browser,s address bar: http://bit.ly/1B2KGaL ... receive event updates. This will be a ...
(Date:11/18/2014)... Calif. , Nov. 18, 2014 Cord ... platinum sponsor of the 10th Annual World Stem Cell Summit, ... medicine stakeholders. The 2014 World Stem Cell Summit will be ... San Antonio, Texas . The ... and development of lifesaving cures and therapies, convening the most ...
Breaking Biology Technology:Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 4Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3
... A. Oclassen to Join Sleep Experts in Panel Hosted by Natixis ... ... Transcept Pharmaceuticals,Inc. today announced that Glenn A. Oclassen, President and Chief Executive,Officer, ... Bleichroeder "Hidden Gems" Healthcare Conference. Date: Monday, October 8, ...
... 1 Advanced Instruments, Inc., (http://www.aicompanies.com ) ... to the biotechnology industry. The revolutionary high ... about 35 minutes. Designed to automate ... cell,culture process optimization, the high throughput Multi-Sample ...
... developed by a team led by University at ... manipulates the single spin of an electron, overcoming ... spintronics and spin-based quantum computing., Published online this ... brings closer to reality electronic devices based on ...
Cached Biology Technology:Transcept Pharmaceuticals to Participate in Middle-of-the-Night (MOTN) Insomnia Investor Panel 2Advanced Instruments Introduces World's Fastest High Throughput Freezing Point Osmometer 2Advanced Instruments Introduces World's Fastest High Throughput Freezing Point Osmometer 3Quantum device traps, detects and manipulates the spin of single electrons 2
Human VEGF-D Biotinylated MAb (Clone 78923)...
Mouse Wnt-11 Affinity Purified Polyclonal Ab...
...
[14C]Polyethylene glycol 4000, 9.25 MBq, 250 uCi. Aqueous solution containing 3% ethanol, sterilized. 370-740 MBq/g, 10-20 mCi/g.1.85 MBq/ml, 50 uCi/ml. Category: Radiochemicals &Radiation Safety, ...
Biology Products: