Navigation Links
Common European MRSA originated in Africa
Date:8/25/2014

The predominant strain of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infecting people in Europe, the Middle East and northern Africa derived from a single sub-Saharan ancestor, a team of international researchers reported this week in mBio, the online open-access journal of the American Society for Microbiology.

CA-MRSA refers to MRSA infections occurring in healthy people with no recent hospitalizations. The infections, which are typically skin infections, can be transmitted through close person-to-person contact or contact with a contaminated item like a towel or clothing.

"With increasing levels of CA-MRSA reported from most parts of the Western world, there is a great interest in understanding the origin and factors associated with the emergence of these epidemic lineages," said lead study author Marc Stegger, PhD, of the Department of Microbiology and Infection Control at the Statens Serum Institut in Denmark. "Our study determined that a single descendant of a methicillin-sensitive ancestor circulating in sub-Saharan Africa rose to become the dominant CA-MRSA clone in Europe, the Middle East and north Africa."

In Europe, the predominant CA-MRSA strain belongs to a family called clonal complex 80 (CC80), which are resistant to the antibiotics kanamycin/amikacin, tetracyclin and fusidic acid, in addition to beta-lactams. It was first identified sporadically in the late 1990s, but has since been identified throughout northern Africa, the Middle East and Europe, with only sporadic reports from Asia, Australia and South America.

For the study, Stegger and colleagues at 19 other institutions around the world analyzed 97 S. aureus CC80 samples from 22 countries in Europe, North Africa, sub-Saharan Africa, the Middle East and Asia isolated between 1993 and 2010. Twenty-three samples were sensitive to methicillin while 74 were resistant to methicillin. The investigators performed whole genome sequencing, a technique that determines the complete DNA sequence of an organism's genetic material at a single time, and other tests to trace the origin, evolution and dissemination pattern of the European CA-MRSA clone CC80.

Within the samples, the team identified two distinct groups of S. aureus: a methicillin-sensitive clone from sub-Saharan Africa that was susceptible to all antibiotics, and the rest from all other areas that were MRSA and most often resistant to other antibiotics. Studying family trees among the bacteria, they found that the European CC80 clone evolved from the strain from sub-Saharan Africa. They also noted that in the transition from a methicillin-sensitive line to a CA-MRSA clone, the bacteria simultaneously acquired two highly specific genetic elements making them resistant to methicillin and became resistant to fusidic acid.

The methicillin-sensitive S. aureus resided in sub-Saharan Western Africa, potentially as a result of the local human migration patterns, Stegger said. The investigators hypothesize that CC80 moved to other countries starting in the mid-1980s due to several factors, including increased migration from sub-Saharan Africa in search of better economics, and as a result of an increase in European tourism to this region of Africa, he said. The simultaneous acquisition of methicillin and fusidic acid resistance determinants and their stability in the European CA-MRSA could be a result of a higher selective pressure in North Africa and Europe.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Commonly used herbicides seen as threat to endangered butterflies
2. Common North American frog identified as carrier of deadly amphibian disease
3. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
4. New research about facial recognition turns common wisdom on its head
5. Commonly used diabetes drug may help to prevent primary liver cancer
6. Loyola study debunks common myth that urine is sterile
7. Dental X-rays linked to common brain tumor
8. Women & Infants participating in study of treatment of common viral infection in pregnancy
9. Clusters of cooperating tumor-suppressor genes are found in large regions deleted in common cancers
10. Modest alcohol intake associated with less inflammation in patients with common liver disease
11. Sulphur and iron compounds common in old shipwrecks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/21/2016)... , June 21, 2016 NuData ... the new role of principal product architect and ... the director of customer development. Both will report ... technical officer. The moves reflect NuData,s strategic growth ... response to high customer demand and customer focus ...
(Date:6/9/2016)... 2016  Perkotek an innovation leader in attendance control systems is proud to announce ... for employers to make sure the right employees are actually signing in, and to ... ... ... ...
(Date:6/2/2016)... 2, 2016 The Department of Transport ... the 44 million US Dollar project, for the , ... including Personalization, Enrolment, and IT Infrastructure , to ... production and implementation of Identity Management Solutions. Numerous renowned international ... Decatur was selected for the most compliant ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... YORK , June 23, 2016 ... trading session at 4,833.32, down 0.22%; the Dow Jones Industrial ... S&P 500 closed at 2,085.45, down 0.17%. Stock-Callers.com has initiated ... INFI ), Nektar Therapeutics (NASDAQ: NKTR ), ... Therapeutics Inc. (NASDAQ: BIND ). Learn more about ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory ... technical consulting, provides a free webinar on Performing Quality Investigations: Getting ... at 12pm CT at no charge. , Incomplete investigations are still a major ...
(Date:6/23/2016)... , June 22, 2016  Amgen (NASDAQ: ... the QB3@953 life sciences incubator to accelerate ... The shared laboratory space at QB3@953 was created to ... key obstacle for many early stage organizations - access ... the sponsorship, Amgen launched two "Amgen Golden Ticket" awards, ...
(Date:6/22/2016)... , June 22, 2016 Cell ... will allow them to produce up to one ... one lot within one week. These high-quality, consistent ... laboriously preparing cells and spend more time doing ... through a proprietary, high-volume manufacturing process that produces ...
Breaking Biology Technology: