Navigation Links
Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding
Date:10/14/2008

tely our bodies actions such as moving, thinking and other biological processes.

Prior to their work, it was thought that proteins, which at "birth" resemble a line of beads on a string, spontaneously fold themselves into their final, three-dimensional structures. Drs. Hartl and Horwich discovered that inside cells, proteins need assistance from other proteins, known as chaperones, to guide the process and ensure they fold into the proper shape. In independent and often complementary work, they also established the pathway and molecular mechanisms involved in this process.

The work of Drs. Hartl and Horwich demonstrated that when the protein folding pathway is imperfect, protein can accumulate in cells, leading to disease. Protein misfolding has been associated with approximately 20 diseases, including Alzheimer's, Huntington's and cystic fibrosis. Targeting the activity of the chaperones to correct misfolded proteins is a therapeutic goal currently under development.

"The selection of Arthur Horwich and Ulrich Hartl for this year's Horwitz Prize recognizes their scientific contribution began in part by Rosalind Franklin on the role of shape in human biology; and as the pathway has been replicated in bacteria, fungi, plants, animals and humans, their work has been seminal in understanding the protein folding as vital to biological function," said Andrew R. Marks, M.D., chair of the Horwitz Prize Committee at Columbia University. Dr. Marks is the Clyde and Helen Wu Professor of Molecular Cardiology and chairman of the Department of Physiology and Cellular Biophysics at Columbia University College of Physicians and Surgeons.

"We are delighted to highlight the contributions of women in science by honoring the work of Rosalind Franklin," added Dr. Marks. "It is particularly important that her key role in unraveling the structure of DNA is widely recognized so that she can serve as a role model for young women in science and for al
'/>"/>

Contact: Elizabeth Streich
eas2125@columbia.edu
212-305-6535
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Columbia to award 2007 Horwitz Prize to three generations of teacher-student scientists
2. 3 Columbia University Medical Center faculty elected to Institute of Medicine
3. Columbia researchers: Growth of CT scan use may lead to significant public health problem
4. Columbia geneticists uncover new gene involved in determining hair texture and density in humans
5. ESF EURYI award winner aims to stop cancer cells reading their own DNA
6. The American Society of Plant Biologists announces 2007 awards
7. Minimally invasive heart surgery research wins NIH award
8. 12 McGill researchers awarded Canada Research Chairs
9. Herr receives Heinz Award for Technology, the Economy and Employment
10. Singapore National Science and Technology Awards
11. RSC Project Prospect scoops prestigious award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... researchers have identified a gene that could help scientists ... protein in the cell membrane of plants that senses ... conservation machinery accordingly. , "It,s similar to a ... at Duke. , The findings, which appear Aug. ... it easier to feed the world,s growing population in ...
(Date:8/27/2014)... requires nerve cells to rearrange existing patterns of activity ... patterns, a study of monkeys has found. The scientists ... electrical activity of brain cell networks. The study was ... "We looked into the brain and may have seen ... said Aaron Batista, Ph.D., an assistant professor at the ...
(Date:8/27/2014)... invasive grass species frequently found in forests has created ... on American toads, a new University of Georgia study ... to the U.S. in the early 1900s, is one ... to more than a dozen states in the past ... and in forests, it can survive in widely diverse ...
Breaking Biology News(10 mins):Water 'thermostat' could help engineer drought-resistant crops 2Scientists plug into a learning brain 2Scientists plug into a learning brain 3More wolf spiders feasting on American toads due to invasive grass, UGA study shows 2More wolf spiders feasting on American toads due to invasive grass, UGA study shows 3
... One fifth of the standard dose of a commonly ... the full dose. This new finding should allow scarce ... in Africa. In a study initiated by the ... research arm of Doctors Without Borders/Mdecins Sans Frontires), and ...
... Institute,s Linheng Li Lab has identified the precise location of ... today in the Advance Online Publication of Nature . ... Institute,s support facilities to develop a new technology ex ... the dynamic behavior of stem cells. This technology enabled the ...
... University,s School of Biomedical Engineering and Science,s Center for Injury ... 2008. The Office of the Deputy Chief of ... the award for research that could ultimately help save eyesight ... The center was selected from 57 applicants from around ...
Cached Biology News:Stowers Institute's Linheng Li Lab expands understanding of bone marrow stem cell niche 2New dummy design and development wins US Department of Defense award 2
(Date:8/27/2014)... 27, 2014 Budding Biomedical Scientists ... University School participated in the Scientific Enrichment ... University’s School of Medicine . , ... unparalleled professional experience in the sciences and brings ... faculty and students for both academic and career ...
(Date:8/26/2014)... , Aug. 26, 2014  NeuroSigma, Inc., a ... to develop bioelectronic technologies, today announced that it has ... U.S. Securities and Exchange Commission relating to a proposed ... of shares to be offered and the price range ... Jefferies LLC will act as the book-running ...
(Date:8/26/2014)... Aug. 26, 2014 An analysis by Replikins, ... all Mers CoV virus strains has revealed ... to 2012.  This conservation and sharing of specific Replikin ... CoV Blocker-Vaccine™ candidate, as it did for the H5N1 ... of which have been found to be effective (1,2). ...
(Date:8/26/2014)... engineers from Singapore has successfully piloted the world,s ... communications. , With the weight of payloads being ... lightweight, low power-consuming, wireless communication system to do ... been a challenge for system designers. , The ... Nanyang Technological University in Singapore launched VELOX-I, which ...
Breaking Biology Technology:Students at Cleveland's University School Conduct Biomedical Research at Case Western Reserve University’s School of Medicine 2ZigBee in the Sky 2
... /PRNewswire/ - Cytochroma today announced that it,has appointed ... Affairs and Quality Assurance. Dr. Engel brings to ... and quality assurance,and will be responsible for directing ... that the Company has appropriate quality,systems in place. ...
... VLP vaccines gains momentum with launch of a Phase ... IIa study of Seasonal Influenza Vaccine, ... ) announced today vaccination of healthy volunteers in a Phase,II ... The Phase IIa randomized, placebo controlled clinical trial will,evaluate the ...
... Sept. 16 Accuray,Incorporated (Nasdaq: ARAY ), a ... its president and chief executive officer, Euan S.,Thomson, Ph.D., ... Sciences,Conference in New York City, on Thursday, September 25, ... live webcast of the presentation will be available online ...
Cached Biology Technology:Cytochroma appoints Steven I. Engel as Vice President of Regulatory Affairs and Quality Assurance 2Novavax Commences Clinical Testing of its Seasonal Influenza VLP Vaccine Candidate 2Novavax Commences Clinical Testing of its Seasonal Influenza VLP Vaccine Candidate 3Novavax Commences Clinical Testing of its Seasonal Influenza VLP Vaccine Candidate 4Novavax Commences Clinical Testing of its Seasonal Influenza VLP Vaccine Candidate 5Accuray Incorporated's CEO to Speak at UBS Global Life Sciences Conference 2
...
... Digital Sight DS-U2 camera controller is the successor ... designed to interface any of the cameras in ... computer through a USB2.0 interface. The DS-U2 transmits ... cumbersome installation by equipping both hub and mass ...
This unique buffer provides a gentle method for removal of primary and secondary antibodies to allow several reprobings on the same membrane. Gentle buffer will not alter the antigen for subsequent i...
...
Biology Products: