Navigation Links
Columbia geneticists uncover new gene involved in determining hair texture and density in humans
Date:2/25/2008

live nearby one another, and often intermarry.

To identify a gene involved in controlling hair texture, Dr. Christiano and her team performed a genetic analysis of six families of Pakistani origin, who all shared hereditary woolly hair. The cause of hereditary woolly hair was found to be a mutation in a gene called P2RY5. Until this discovery, the pathogenesis of hereditary woolly hair had been largely unknown.

As the authors write in the paper, "The bulb region of plucked hairs from woolly hair patients showed irregular bending without attachment of the root sheath." They propose that mutations in P2RY5 most likely result in hair follicle disruptions, which then compromise its anchoring to the hair shaft and cause the abnormal bending of the bulb region, leading to woolly hair.

Dr. Christiano's discoveries have led to the identification of several genes controlling human hair growth. It remains to be determined whether common variants on the P2RY5 gene can also contribute to naturally occurring variations in hair texture between different human populations.

According to the researchers, P2RY5 is the first gene of a type known as a G-protein coupled receptor (GPCR) implicated in a human hair disorder thereby making it possible to develop drugs that target this receptor. GPCRs represent the largest known class of molecular targets with proven therapeutic value. It is estimated that more than 40 percent of existing drugs work by targeting GPCR drug targets; this target class represents a large fraction of the total biological targets against which FDA-approved oral drugs are directed. Of the top 200 best-selling prescription drugs more than 20 percent interact with GPCRs, providing worldwide sales of over $20 billion.


'/>"/>

Contact: Elizabeth Streich
eas2125@columbia.edu
212-305-6535
Columbia University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Columbia to award 2007 Horwitz Prize to three generations of teacher-student scientists
2. 3 Columbia University Medical Center faculty elected to Institute of Medicine
3. Columbia researchers: Growth of CT scan use may lead to significant public health problem
4. Plant geneticists find veritas in vino
5. St. Jude influenza survey uncovers key differences between bird flu and human flu
6. 454 Sequencing uncovers a genetic basis for different social behaviors in wasp
7. Joslin researchers uncover potential role of leptin in diabetes
8. Agent that triggers immune response in plants is uncovered
9. UD plant biologists uncover top wetland plants hidden weapon
10. Massive microRNA scan uncovers leads to treating muscle degeneration
11. Scientists uncover how hormones achieve their effects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... , June 17, 2015  Crossmatch™, a leading ... that its U.are.U ® 4500 fingerprint readers ... Eateries, Inc., a San Jose, ... to increase security, improve accountability and reduce fraud ... instant, non-repudiable identity confirmation for employee sign in ...
(Date:6/16/2015)... 2015 Fingerprint Cards has received an ... the company,s portfolio from one of its module partners in ... take place during the third quarter 2015. The sensors will ... . Jörgen Lantto, CEO of FPC, comments: " ... growing interest from smartphone OEMs in integrating touch fingerprint sensors ...
(Date:6/15/2015)... 2015 A new report [ ... majority of US consumers using mobile banking applications want their ... fingerprint and voiceprint, instead of having to prove who they ... " Mobile Identity   -   The Fusion of Financial ... now the primary channel used by Gen X and Gen ...
Breaking Biology News(10 mins):Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 4
... Reasons why you should attend this workshop: , ... players in Assisted Reproduction Technologies (ART) data monitoring in ... ART monitoring: An overview of ART data in ... world what have we learned?, Possibilities and limitations ...
... favours traits that enhance dispersal of populations to ... however, is relatively scarce. A study carried out ... Environmental Sciences of the University of Helsinki, along ... traits facilitating dispersal in an outer archipelago. The ...
... LANSING, Mich. The hellbender salamander known affectionately ... one of America,s unique giant salamander species. For unexplained ... little reproduction has occurred in recent decades. ... Zoo in Belgium, veterinarians from Michigan State University are ...
Cached Biology News:The European IVF Monitoring Group celebrates its 10-year anniversary 2UH: Insular evolution: Large and big-footed voles in an outer archipelago 2Preserving sperm vital to saving 'snot otter' salamanders 2
(Date:7/2/2015)... GLASGOW, Scotland , July 2, 2015 ...   Bio-tech procurement company Amici Procurement has ... IOM) to help it move to Office 365. ... Procurement provides small to medium-sized companies in the ... with all aspects of the purchasing cycle to help ...
(Date:7/1/2015)...   Decision Resources Group finds that ... are its oral administration, alternative mechanism of action, ... rheumatologists. Otezla was the first oral therapy specifically ... psoriatic arthritis in the United States ... conventional oral treatments including disease-modifying antirheumatic drugs (DMARDs), ...
(Date:7/1/2015)... , July 1, 2015 Isagenix International, ... has earned three Gold, three Silver, and three Bronze ... gala held in Chicago this ... the premier business awards program in the U.S. ... our company,s strength in developing leaders, cultivating talent, creating ...
(Date:7/1/2015)... , July 1, 2015  UCB, a ... ), a global leader in designing, transforming, and ... Innovation Award in recognition of their close collaboration ... in UCB,s global business services (GBS) finance organization. ... providers and clients that work together effectively to ...
Breaking Biology Technology:Biotech Procurement Company Moves to Office 365 with iomart 2Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 2Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 3Isagenix Earns Nine American Business Awards 2Isagenix Earns Nine American Business Awards 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 4UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 5
... MultiCell,Technologies, Inc. (OTC Bulletin Board: MCET) has moved into new ... May 1, 2008:, -- the new address is: ... RI 02895. -- new phone number is: ... (401) 762-0098, MultiCell Technologies, Inc. is a biopharmaceutical company ...
... to announce that,Grace Ju, Ph.D., research director, RNA Therapeutics ... of Science" by the New Jersey,Association of Biomedical Research ... held May 1 at the Bridgewater Manor., Dr. ... event, which is also,marking the 20th anniversary of NJABR, ...
... Company with 3 divisions has exciting new and unique products; ... contracts to be announced in near future ..., BOCA ... "Company") announced today that their stock is now,up and trading on ... Filings are complete at PinkSheets.com. From this point,Solei will continue on ...
Cached Biology Technology:MultiCell Technologies Relocates Corporate Headquarters 2Roche Research Director Grace Ju Hailed as NJABR 'Outstanding Woman of Science' 2Roche Research Director Grace Ju Hailed as NJABR 'Outstanding Woman of Science' 3Solei Systems, Inc., Announces That the Company Is Now Publicly Traded 2Solei Systems, Inc., Announces That the Company Is Now Publicly Traded 3Solei Systems, Inc., Announces That the Company Is Now Publicly Traded 4
Peroxidase Protective Buffer is a diluent formulated to stabilize the activity of Chemicon horseradish peroxidase (HRP)-antibody conjugates at high conjugate dilution for extended periods....
... Digest Medium (TSB), USP is a highly ... general laboratory use. Due to the inclusion ... medium will support growth of many fastidious ... , Product conforms to United States Pharmacopeia ...
... cells-directed transfection reagent : jetPEI-RGD ... which allows targeted efficient transfection ... cells. Integrins are adhesion molecules ... adhesion processes. Many integrins, including ...
... software is used to predict ... DNA sequence up to 3,200 ... placement of primers and GC ... denaturing gradient gel electrophoresis (DGGE), ...
Biology Products: