Navigation Links
Columbia University scientist devises new way to more rapidly generate bone tissue
Date:12/15/2008

NEW YORK (Dec. 15, 2008) Using stem cell lines not typically combined, researchers at Columbia University Medical Center have designed a new way to "grow" bone and other tissues.

The inability to foster angiogenesis a physiological process involving the growth of new blood vessels from pre-existing vessels has been a major roadblock in tissue regeneration. Previous approaches have included the use of angiogenic growth factors and the fabrication of artificial blood vessels. However, there are problems associated with these approaches. Among these problems: artificially fabricated blood vessels do not readily branch out and network with host blood vessels, and blood vessels induced by angiogenic growth factors tend to be immature and "leaky."

To overcome these obstacles, a team of Columbia researchers has co-transplanted hematopoietic and mesenchymal stem/progenitor cells to promote the regeneration of vascularized tissues. What they found was that the tissue regenerated in bone more rapidly than when either type of stem cell was used alone.

The work by Jeremy Mao, DDS, Ph.D., published today in the Public Libraries of Science, takes a new approach: rarely have mesenchymal and hematopoietic cells been delivered in combination for the healing of defects and the treatment of diseases partially due to the separate research communities in which these two cell groups are studied.

"Dr. Mao's research in tissue engineering represents the fruits of interdisciplinary science. His work has relevance for oral health care, as well as many other health care disciplines," said Dr. Ira Lamster, Dean of the Columbia University College of Dental Medicine.

Dr. Mao and colleagues demonstrated that when human mesenchymal stem/progenitor cells were seeded in micropores of 3D calcium phosphate scaffolds, followed by infusion of gel-suspended CD34+ hematopoietic cells, greater vascularization was seen in mice than when mesenchymal cells were used alone.

Furthermore, Dr. Mao's team found that the number of vessels and the diameter of the vessels produced by the co-transplantation of hematopoietic and mesenchymal to create vascularized tissue were dramatically increased when combined with Vascular Endothelial Growth Factor or VEGF.

"The work has potential beyond bones and may have implications for the growth of muscle, nerve and organs," Dr. Mao said. "The synergistic action of mesenchymal cells and hematopoietic cells provide an alternative approach for regrowing a host of vascular tissues."


'/>"/>

Contact: Alex Lyda
mal2133@columbia.edu
212-305-0820
Columbia University Medical Center
Source:Eurekalert

Related biology news :

1. Salmon smolt survival similar in Columbia and Fraser rivers
2. Similar survival rates for Pacific salmon in Fraser, Columbia Rivers raises new questions
3. Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding
4. Columbia geneticists uncover new gene involved in determining hair texture and density in humans
5. Columbia researchers: Growth of CT scan use may lead to significant public health problem
6. 3 Columbia University Medical Center faculty elected to Institute of Medicine
7. Columbia to award 2007 Horwitz Prize to three generations of teacher-student scientists
8. Queens University Belfast plays leading role in Europe-wide tests for safer food
9. Wii bit of fun at Rice University has serious intent
10. Rice University study finds possible clues to epilepsy, autism
11. World Energy Outlook to be presented at Rice University Dec. 9
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... LONDON , March 2, 2017 Who ... infringement lawsuits? Download the full report: https://www.reportbuyer.com/product/4313699/ ... ON THE FINGERPRINT SENSOR FIELD? Fingerprint sensors using ... smartphones. The fingerprint sensor vendor Idex forecasts an increase ... in mobile devices and of the fingerprint sensor market ...
(Date:2/28/2017)... LOS ANGELES , Feb. 28, 2017   ... identity verification software globally, announces significant enhancements to new ... in May 2016. New products include mobile and desktop ... and DocX TM - a real time manual ... Acuant,s core idScan® technology provides the fastest and most ...
(Date:2/27/2017)... WASHINGTON , Feb. 27, 2017   Strategic ... fund, today announced it has led a $3.5 million investment ... collaboration platform. Strategic Cyber Ventures is DC based and ... and Hank Thomas . Ron Gula , ... Tech Ventures, also participated in this series A round ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... YORK , March 29, 2017 "Surging ... programs deployed by the government are expected to drive ... The gesture recognition market is expected to ... a CAGR of 29.63% between 2017 and 2022. The ... 15.27 billion by 2022, growing at a CAGR of ...
(Date:3/29/2017)... 2017 WuXi Biologics, a leading open-access ... biologics and a WuXi AppTec Affiliate, today announced ... Bioprocessing Excellence Award from IMAPAC, a leading consulting ... to recognize outstanding leaders and trend-setters of today, ... and biomanufacturing experts in the industry, along with ...
(Date:3/29/2017)... ... March 29, 2017 , ... (March 29, 2017) — ... approved as an active member of the Mexican Direct Selling Association A.C. ... consumers in relationship marketing. This professional organization fosters loyal and fair competition among ...
(Date:3/29/2017)... , March 29, 2017  Applied ... applying mechanistic modeling to drug research and ... collaboration with Zymeworks Inc. for quantitative systems ... therapeutics intended for the treatment of cancer. ... Zymeworks previously for GLP toxicology studies and ...
Breaking Biology Technology: