Navigation Links
Columbia Engineering and Penn researchers increase speed of single-molecule measurements
Date:3/18/2012

New York, NYMarch 18, 2012As nanotechnology becomes ever more ubiquitous, researchers are using it to make medical diagnostics smaller, faster, and cheaper, in order to better diagnose diseases, learn more about inherited traits, and more. But as sensors get smaller, measuring them becomes more difficultthere is always a tradeoff between how long any measurement takes to make and how precise it is. And when a signal is very weak, the tradeoff is especially big.

A team of researchers at Columbia Engineering, led by Electrical Engineering Professor Ken Shepard, together with colleagues at the University of Pennsylvania, has figured out a way to measure nanoporestiny holes in a thin membrane that can detect single biological molecules such as DNA and proteinswith less error than can be achieved with commercial instruments. They have miniaturized the measurement by designing a custom integrated circuit using commercial semiconductor technology, building the nanopore measurement around the new amplifier chip. Their research will be published in the Advance Online Publication on Nature Methods's website on 18 March at 1400 (2pm) US Eastern time/ 1800 London time.

Nanopores are exciting scientists because they may lead to extremely low-cost and fast DNA sequencing. But the signals from nanopores are very weak, so it is critically important to measure them as cleanly as possible.

"We put a tiny amplifier chip directly into the liquid chamber next to the nanopore, and the signals are so clean that we can see single molecules passing through the pore in only one microsecond," says Jacob Rosenstein, a Ph.D. candidate in electrical engineering at Columbia Engineering and lead author of the paper. "Previously, scientists could only see molecules that stay in the pore for more than 10 microseconds."

Many single-molecule measurements are currently made using optical techniques, which use fluorescent molecules that emit photons
'/>"/>

Contact: Holly Evarts
holly@engineering.columbia.edu
347-453-7408
Columbia University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Columbia engineers map energy use in NYC buildings
2. New Columbia engineering technique diagnoses non-periodic arrhythmias in a single heartbeat
3. Columbia River salmon are adapting to climate change
4. Columbia engineering innovative hand-held lab-on-a-chip could streamline blood testing worldwide
5. Columbia Engineering team makes major step in improving forecasts of weather extremes
6. Columbia engineers develop new method to diagnose heart arrhythmias
7. Columbia researchers find green roof is a cost-effective way to keep water out of sewers
8. Columbia engineers patch a heart
9. Columbia professor to discuss good, bad aspects of choice at NJIT March 23 talk
10. Columbia engineer observes surprising behavior of cells during blood-vessel formation
11. Columbia University uses technological innovation to study bone structure
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Columbia Engineering and Penn researchers increase speed of single-molecule measurements
(Date:8/10/2015)... Germany , August 10, 2015 ... in Eye Tracking Technology for more than two decades, ... Platform for integration into all consumer display formats. The ... seamless integration of eye tracking into consumer tablets, laptops, ... reality smart glasses. Omnivision,s leading sensor technology contributes to ...
(Date:8/6/2015)... and TELTOW, Germany , August 6, ... Conference, SensoMotoric Instruments (SMI) shows the world,s ... , based on Epson,s Moverio BT-200 see-through head ... With this new solution, unprecedented quality and efficiency is ... with context-sensitive displays. For the first time, professionals and ...
(Date:8/5/2015)... , August 5, 2015 ... titled "Facial Recognition Market - Global Industry Analysis, Size, ... global market for facial recognition is forecast to reach ... by increased demand for surveillance systems by civil and ... number of crimes and terrorist activities across the globe ...
Breaking Biology News(10 mins):SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6
... Patients have been known to hug Lauren Gerson, MD, so ... say to them? Go ahead and eat chocolate. Indulge your ... you want it, have that orange juice with breakfast and, ... for most heartburn patients, there's insufficient evidence to support the ...
... has created technology to regrow teeth--the first time scientists ... Using low-intensity pulsed ultrasound (LIPUS), Dr. Tarak El-Bialy from ... Chen and Dr. Ying Tsui from the Faculty of ... non-invasive and novel way to stimulate jaw growth and ...
... dengue fever wax and wane over a period of ... With the incidence and range of the potentially deadly ... epidemics has never been more important. , A new ... that a brief period of cross-immunity conferred by any ...
Cached Biology News:Chocolate, wine, spicy foods may be OK for heartburn, Stanford study finds 2Chocolate, wine, spicy foods may be OK for heartburn, Stanford study finds 3Chocolate, wine, spicy foods may be OK for heartburn, Stanford study finds 4Ultrasound may help regrow teeth 2UGA study explains peaks and troughs of dengue epidemics 2UGA study explains peaks and troughs of dengue epidemics 3
(Date:8/27/2015)... ... 27, 2015 , ... Inc. Magazine released its annual list of the 5,000 ... in growth for the three years through 2014. Being named to the Inc. 5000 ... in the country. , “We are thrilled to make the Inc. 5000 list ...
(Date:8/26/2015)... , Aug. 26, 2015 /PRNewswire/ - iCo Therapeutics ... today reported financial results for the quarter ended ... expressed in Canadian dollars and presented under International ... pre-clinical activities with respect to our Oral Amp ... a contract manufacturer," said Andrew Rae , ...
(Date:8/26/2015)... 26, 2015 Intrexon Corporation (NYSE: XON ... closing of its previously announced public offering of common ... of their option to purchase an additional 731,707 shares ... $41.00 per share.  The exercise of the underwriters, option ... sold by Intrexon to 5,609,756 shares and increased the ...
(Date:8/26/2015)... (PRWEB) , ... August 26, 2015 , ... PRC ... to develop new business relationships with local sponsors in southern California. The Clinical Trial ... their drug development processes and regulatory pathways., , Stem ...
Breaking Biology Technology:iLab Solutions Named to 2015 Inc. 5000 List 2iLab Solutions Named to 2015 Inc. 5000 List 3iCo Therapeutics Announces Second Quarter 2015 Financial Results 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 4PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 3
... acquires Toronto start-up CognoVision ... ... --> ... first_result; // Results are keyed by longUrl, so we need to grab the first one. for (var r in ...
... growing North American presence ... ... --> ... first_result; // Results are keyed by longUrl, so we need to grab the first one. for (var r in ...
... Jiayuan Tong, Chief Financial Officer, Chief Business & Development Officer ... ) is invited to present at CFO China Summit 2011 ... 21 Jianguomenwai Avenue, Beijing 100020, China on January 19, 2011. ... , Implementing Effective Working Capital Management Strategies in China ...
Cached Biology Technology:Intel Corporation acquires Toronto start-up CognoVision 2Intel Corporation acquires Toronto start-up CognoVision 3Intel Corporation acquires Toronto start-up CognoVision 4Intel Corporation acquires Toronto start-up CognoVision 5Intel Corporation acquires Toronto start-up CognoVision 6Intel Corporation acquires Toronto start-up CognoVision 7Enerkem adds two new executive roles to growing North American presence 2Enerkem adds two new executive roles to growing North American presence 3Enerkem adds two new executive roles to growing North American presence 4Enerkem adds two new executive roles to growing North American presence 5Enerkem adds two new executive roles to growing North American presence 6Enerkem adds two new executive roles to growing North American presence 7Tianyin's Dr. James Jiayuan Tong is Invited to Speak at the CFO China Summit 2011 on January 19, 2011 at the St. Regis Hotel, Beijing 2Tianyin's Dr. James Jiayuan Tong is Invited to Speak at the CFO China Summit 2011 on January 19, 2011 at the St. Regis Hotel, Beijing 3
... For real-time or pre-programmed ... biophysics, electrochemistry, or general liquid-handling ... 10 millisecond accuracy. ... unattended Microprocessor-based for accuracy ...
... 10. *SizeSep 400 Spun Columns: For rapid ... in length. - ... distilled water containing 0.15% Kathon CG/IcP Biocide. ... pairs. *Extremely useful in the construction ...
... The Light Diagnostics Universal Amplicon ... for use in the qualitative ... generated by in vitro ... use only; not to be ...
... 25 purifications. Allows rapid purification ... removal of unincorporated CyDye label and ... yields of labeled cDNA probe. ... labeled by either direct incorporation or ...
Biology Products: