Navigation Links
Colon cancer researchers target stem cells, discover viable new therapeutic path
Date:12/1/2013

(TORONTO, Canada Dec. 1, 2013) - Scientists and surgeons at Princess Margaret Cancer Centre have discovered a promising new approach to treating colorectal cancer by disarming the gene that drives self-renewal in stem cells that are the root cause of disease, resistance to treatment and relapse. Colorectal cancer is the third leading cause of cancer-related death in the Western world.

"This is the first step toward clinically applying the principles of cancer stem cell biology to control cancer growth and advance the development of durable cures," says principal investigator Dr. John Dick about the findings published online today in Nature Medicine.

He talks about the research in this video - click the link to watch: https://www.youtube.com/watch?v=QK7JquljkBc.

Dr. Dick pioneered the cancer stem cell field by first identifying leukemia stem cells (1994) and colon cancer stem cells (2007). He is also renowned for isolating a human blood stem cell in its purest form as a single stem cell capable of regenerating the entire blood system paving the way for clinical use (2011). Dr. Dick holds a Canada Research Chair in Stem Cell Biology and is a Senior Scientist at University Health Network's Princess Margaret Cancer Centre and McEwen Centre for Regenerative Medicine. He is also a Professor in the Department of Molecular Genetics, University of Toronto, and Director of the Cancer Stem Cell Program at the Ontario Institute for Cancer Research.

In pre-clinical experiments, the research team replicated human colon cancer in mice to determine if specifically targeting the stem cells was clinically relevant. First, the researchers identified that the gene BMI-1, already implicated in maintaining stem cells in other cancers, is the pivotal regulator of colon cancer stem cells and drives the cycle of self-renewal, proliferation and cell survival. Ne
'/>"/>

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Hardworking sisters enable insect colonies to thrive
2. Colon cancer screening guidelines may miss 10 percent of colon cancers
3. Research shows how aspirin may act on blood platelets to improve survival in colon cancer patients
4. Scientists learn how soy foods protect against colon cancer
5. New 3-D colonoscopy eases detection of precancerous lesions
6. Scientists discover thriving colonies of microbes in ocean plastisphere
7. University of Tennessee professor links massive prehistoric bird extinction to human colonization
8. Researchers id queens, mysterious disease syndrome as key factors in bee colony deaths
9. Cleveland Clinic develops clinical screening program for no.1 genetic cause of colon cancer
10. Two-faced cells discovered in colon cancer
11. E. coli adapts to colonize plants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Colon cancer researchers target stem cells, discover viable new therapeutic path
(Date:11/7/2014)...  In conjunction with the Glendale ... Foundation of the Verdugos has announced the " GLENDALE ... $250,000 initiative to keep the Verdugo Regional Crime Lab operational ... months of existence, the Lab has processed more than 400 ... enforcement. "Because our number one priority is the ...
(Date:11/6/2014)... occur because of metastasis, yet progress in preventing ... , "It,s been particularly challenging to design drugs ... fellow in systems biology at Harvard Medical School. ... after they,ve already metastasized." , Gujral and colleagues ... help researchers better understand how metastasis begins. Their ...
(Date:11/5/2014)... of biology in the UTSA College of Sciences, ... selected to receive a two-year $300,00 National Science ... (EAGER). The funding supports President Obama,s BRAIN Initiative, ... new technology that will demystify complex brain processes. ... neuroscience are broken into the interactions of multiple ...
Breaking Biology News(10 mins):Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Migration negation 2Migration negation 3UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3
... has placed increasing demands on available water resources. In ... Nevada, where the population approached two million people. The ... that features frequent severe drought conditions has created an ... to meet resident and visitor demand., Las Vegas operates ...
... The National Institute of Child Health and Development (NICHD) of ... of Medicine of Yeshiva University a $7.5 million grant to ... Research (SCCPIR).One of only 13 such centers in the country ... center will focus on a wide range of diseases of ...
... World Water Day on Sunday, 22 March aims ... clean drinking water on our planet. In a densely ... than ever before. Helmholtz scientists in the research ... precisely these problems. In cooperation with partners from other ...
Cached Biology News:Keeping golf courses green when fresh water is limited 2Keeping golf courses green when fresh water is limited 3NIH funds research center for women's reproductive health at Einstein 2NIH funds research center for women's reproductive health at Einstein 3Research to secure a safe water supply 2Research to secure a safe water supply 3Research to secure a safe water supply 4
(Date:11/22/2014)... Frederick, MD (PRWEB) November 21, 2014 ... sample management solutions provider, has released Limfinity® version ... more installation projects of Limfinity® than ever in ... majority configuration and minority framework enhancement. Limfinity® version ... goes far above and beyond bug fixes! , ...
(Date:11/22/2014)... LAVAL, Quebec , November 21, 2014 ... Martensen wechselt als Chief Commercial Officer zu KLOX ... zum SVP der Unternehmensentwicklung und Chief Financial Officer bestellt ... in Europa mit der Vermarktung seines jüngst zugelassenen Behandlungssystems ... Technologies Inc. ("KLOX" bzw. das "Unternehmen") ist sehr erfreut, ...
(Date:11/21/2014)... 20, 2014 Author Matthew J. Pallamary’s ... the Other Side” published as a tribute to ... the “Fiction: Short Story” category of the 2014 ... and CEO of USA Book News, said this year’s ... publishers, including Simon & Schuster, Penguin, John Wiley & ...
(Date:11/21/2014)... 21, 2014 Why did Stephen Hawking ... Einstein so instantly recognizable? Why have they become icons ... and author Hilton Ratcliffe seeks out the answers to ... all to do with science. In " Stephen Hawking ... November 21, 2014), Ratcliffe puts it plainly: , ...
Breaking Biology Technology:RURO Announces Limfinity® version 5.1.4 2KLOX Technologies meldet Neubesetzung von Führungspositionen 2KLOX Technologies meldet Neubesetzung von Führungspositionen 3KLOX Technologies meldet Neubesetzung von Führungspositionen 4KLOX Technologies meldet Neubesetzung von Führungspositionen 5Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4
... DIEGO, Feb. 10 ADVENTRX Pharmaceuticals, Inc.,(NYSE Alternext ... written,indications of interest from numerous companies representing a ... evaluating all proposals and,options. In December 2008, ... range,of strategic options, including the sale or disposition ...
... OrthoCare Innovations, LLC is pleased,to announce that former ... Nelson, MD have joined its board of medical ... former Medicare directors to the,Centers for Medicare and ... Carrier), will also consult with the,Company on issues ...
... Feb. 10 /PRNewswire-Asia/ -- Sundia MediTech, a CRO,company ... based in Florida,U.S.A. jointly announced their 2 year ... International Conference yesterday in San Diego,USA. So far ... 2,more candidates to be identified within the next ...
Cached Biology Technology:ADVENTRX Provides Update on Strategic Transaction Process 2ADVENTRX Provides Update on Strategic Transaction Process 3ADVENTRX Provides Update on Strategic Transaction Process 4Former SADMERC Medical Directors Join OrthoCare Innovations as Medical and Scientific Advisory Board Members and Strategic Advisors 2Sundia MediTech and Xcovery Announce Big Success in Drug Discovery 2
... Polystyrene covers can be used ... Ridged covers for stacking of ... covers for use with automated ... ridged and non-ridged, are available ...
Designed for use with all 96-well SPRI reagent kits. Used with round bottom 96-well microplates, and 96-well thermal cycling plates....
... HistoMark Biotin Streptavidin-HRP Systems provide rapid, ... intracellular antigens in frozen or paraffin-embedded ... These systems also facilitate double or ... be performed simultaneously with primary antibodies ...
... 96- or 384-well PCR plates Dimples on both ... 96-tube plates End tabs on Thermo-Mat™ 384 fit ... Efficient sealing is achieved with either Thermo-Mat™ 96 or ... hot lid thermal cyclers Fully autoclavable ...
Biology Products: