Navigation Links
Cold winters freezing out breast cancer treatment
Date:4/18/2013

LONDON, ON For women diagnosed with a form of breast cancer known as estrogen receptor positive (ER+) breast cancer, tamoxifen is an essential drug used in the treatment and prevention of recurring breast cancer. Currently, tamoxifen is used in a one-size-fits-all approach where the same dose is prescribed for every patient. New research at Lawson Health Research Institute has found that in addition to patient-specific genetic factors, lack of exposure to vitamin D during the long winter months affects the body's ability to metabolize the drug.

The findings, which have been reported in the journal Breast Cancer Research and Treatment, are the first to identify this seasonal effect. Dr. Richard Kim, who is a physician at London Health Sciences Centre (LHSC) and holds the Wolfe Medical Research Chair in Pharmacogenomics at Western University, reports that during the winter months nearly 30 percent of patients are at risk for less than optimal level of the active form of tamoxifen, called endoxifen, and therefore may not benefit as much from the therapy.

In the liver, tamoxifen is converted to the active form of the drug called endoxifen by a protein called CYP2D6. "We know that endoxifen is nearly 100 times more potent against the estrogen receptor relative to tamoxifen," says Dr. Kim. "Our research has shown that patients with normal CYP2D6 activity can easily convert tamoxifen to endoxifen, whereas patients with no CYP2D6 activity have a significantly limited ability to convert tamoxifen to endoxifen."

In addition to the seasonal effect, Dr. Kim found that the simultaneous use of a common antidepressant can also substantially lower the body's ability to metabolize endoxifen levels. "Patients who are either partly or completely deficient in CYP2D6 and who are prescribed the SSRI class of antidepressants are at major risk for subtherapeutic endoxifen levels," says Dr. Kim.

With nearly 10 percent of the population
'/>"/>

Contact: Robert DeLaet
robert.delaet@lawsonresearch.com
519-685-8500 x75616
Lawson Health Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Duck-billed dinosaurs endured long, dark polar winters
2. Extreme winters impact fish negatively
3. Freezing nerves knocks pain out cold
4. Protein jailbreak helps breast cancer cells live
5. Breast cancer risk gene discovery fast tracked by new technology
6. A new breast cancer susceptibility gene
7. Mechanism found connecting metastatic breast cancer and arthritis
8. Detecting breast cancers fingerprint in a droplet of blood
9. Researchers identified a protein useful in predicting the risk of pulmonary metastases in breast cancer patients
10. High levels of TRAIL protein in breast milk might contribute to anticancer activity
11. Fourth IMPAKT Breast Cancer Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... NC Seeds that sprout as soon as they,re planted ... need to be more careful. In the wild, a plant ... day would risk disaster. More than just an insurance policy ... that seed dormancy has long-term advantages too: Plants whose ... rise to more species, finds in a team of researchers ...
(Date:4/17/2014)... under clinical trials to treat tuberculosis could be the ... against various bacteria, fungal infections and parasites, yet evade ... chemists and collaborators. , Led by U. of I. ... ways the drug SQ109 attacks the tuberculosis bacterium, how ... from yeast to malaria and how targeting multiple ...
(Date:4/17/2014)... NJ. April 16, 2014. Kessler Foundation has been ... million from the Department of Defense Spinal Cord ... principal investigator for the randomized, double-blinded, controlled, multi-site ... bone and muscle strength after spinal cord injury. ... & Engineering Research at Kessler Foundation. Two additional ...
Breaking Biology News(10 mins):Plants with dormant seeds give rise to more species 2Multitarget TB drug could treat other diseases, evade resistance 2Kessler Foundation awarded Department of Defense grant for spinal cord injury research 2
... from India,s first genetically modified crop may have been overemphasized, ... expense of sustainable farm management, says a new study by ... by Glenn Stone, PhD, professor of anthropology in Arts & ... World Development . In his paper, Stone compares village ...
... most common mosquito-borne viral disease in the world, has ... in countries such as Argentina, Chile and the continental ... dengue (pronounced DENgee) in the Western Hemisphere, according to ... in the American Journal of Tropical Medicine and ...
... have developed a method of discovering new drugs for ... of biological molecules may predict their effectiveness as medicines. ... drugs that were shown to be effective for fighting ... "The power of this is that it,s a ...
Cached Biology News:New findings in India's Bt cotton controversy: Good for the field, bad for the farm? 2Brandeis study shows economic impact of dengue virus in Americas 2Brandeis study shows economic impact of dengue virus in Americas 3Brandeis study shows economic impact of dengue virus in Americas 4Math may help calculate way to find new drugs for HIV and other diseases 2Math may help calculate way to find new drugs for HIV and other diseases 3
(Date:1/15/2014)... Westlake Village, Calif. (PRWEB) January 15, 2014 ... cancer treatment and management through the genomic analysis of ... will offer Therapy Finder™, a web-based cancer decision support ... a reporting option with Cynvenio’s ClearID™ genomic test, Therapy ...
(Date:1/15/2014)... 15, 2014 ­ RedBrick Health , a fast-growing ... today announces that EmblemHealth , the ... is now providing the RedBrick Compass health assessment, combined ... all of its members. EmblemHealth is among the first ...
(Date:1/15/2014)... January 15, 2014 A study has been ... the Formula 1 track could help to tackle the problem ... (MAT), Stowhealth (a GP surgery based in Stowmarket) and academics ... Simplyhealth. Telemetry technology, which is inspired by equipment ...
(Date:1/15/2014)... VA (PRWEB) January 15, 2014 Two ... have continued their sponsorship of an annual competition for ... in, and access to, innovative STEM study. The competition ... TEAMS: Tests of Engineering Aptitude, Mathematics, and Sciences ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5
... agreed to buy La Crosse-based data quality firm Firstlogic ... expected to close in the second quarter. , ,Firstlogic is ... consulting to help businesses make sure their data is as ... worldwide in places such as call centers, web sites, customer ...
... Associated Bank of Green Bay have joined a new ... companies. , , Tonka Bay Equity Partners of ... of banks from around the country and some individual ... in manufacturing and business services. , ,"They're interested in ...
... He may have just graduated last year, but ... on the heels of his brainstorming service that sells the ... , , Innovation Trip , a seven-day tour, will take ... Stanford campuses with time to sample local culture. Participants are ...
Cached Biology Technology:Brainstorming entrepreneur creates new innovation business 2Brainstorming entrepreneur creates new innovation business 3
DryStrip aligners, 4. Category: Electrophoresis Systems & Standards & Reagents, IEF & SDS-PAGE & 2-D Electrophoresis, Multiphor II Kits & Components and Accessories....
Newborn Calf Serum US Origin...
Immunogen: Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, alpha1/alpha2-isotype. Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
Biology Products: