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Coating improves electrical stimulation therapy used for Parkinson's, depression, chronic pain
Date:9/15/2008

DALLAS Sept. 16, 2008 Researchers at UT Southwestern Medical Center have designed a way to improve electrical stimulation of nerves by outfitting electrodes with the latest in chemically engineered fashion: a coating of basic black, formed from carbon nanotubes.

The nanotube sheathing improves the signals received and transmitted by electrodes, which researchers say is a potentially critical step for advancing electrical nerve stimulation therapy. This type of therapy increasingly shows promise for diseases ranging from epilepsy to depression to chronic leg and back pain.

By implanting electronic nerve stimulators, doctors elsewhere have provided a quadriplegic patient with the ability to move a computer cursor at will, and monkeys have been able to move objects in a virtual world with mere mind power. For individuals who lose an arm or leg and rely on prosthetics, implanted stimulators offer promise in restoring feelings of sensation.

"The key to success for these types of brain-machine interfaces is where the electrode meets the nerve tissue," said Dr. Edward Keefer, instructor of plastic surgery at UT Southwestern and lead author of the study appearing in a recent issue of Nature Nanotechnology. "When we coat the electrodes with carbon nanotubes, it improves the stimulation of the nerve and the feedback from the sensors."

Depending on the way the nanotubes are fashioned, researchers were able to bolster either the stimulation or receptive capabilities to improve performance. In some tests, the nanotube coating improved performance by fortyfold, while in others it improved by a factor of as much as 1,600.

Nanotubes look like lattices rolled into a tube on a microscopic scale. Although they are 1/50,000 the width of a human hair, nanotubes are nonetheless among the stiffest and strongest fibers known, as well as excellent conductors of electricity.

Those properties proved to be just the attri
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Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

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