Navigation Links
Clues to chromosome crossovers
Date:2/13/2013

airs entwined during meiosis. Green spots show the location of RNF212. (Neil Hunter/UC Davis)The latest paper from Hunter's lab, published Feb. 10 in Nature Genetics, shows that Rnf212 is essential for crossing-over in mammalian cells. Crossovers form by a process called homologous recombination, in which chromosomes are first broken and then repaired by coupling with a matching template chromosome. Although hundreds of recombination events are started in each cell, only one or two crossovers will form between any given pair of chromosomes.

"There isn't a special, predetermined site for a crossover. It can occur just about anywhere along a chromosome. But there has to be at least one and there always is," Hunter said.

In a series of experiments in mouse cells, graduate student April Reynolds, Hunter and colleagues found that the RNF212 protein defines where crossovers will occur by binding to just one or two recombination sites per chromosome where it triggers the accumulation of the protein machinery that actually carries out the cutting and splicing of DNA.

Mice that lacked the gene for RNF212 were sterile. Mice that had one working copy of the gene were fertile, but on careful examination there were fewer crossovers formed while sperm and eggs were being made than in normal mice, potentially reducing fertility. It's possible that this might be tied to some causes of infertility in humans.

It remains unclear how each pair of chromosomes always manages to crossover at least once. But Hunter says he is, "convinced that RNF212 holds the key to understanding this unique problem in chromosome biology."


'/>"/>

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Researchers look to relatives for clues in quest to develop sources of bioenergy
2. Relative reference: Foxtail millet offers clues for assembling the switchgrass genome
3. Higher pain tolerance in athletes may hold clues for pain management
4. Clues to nervous system evolution found in nerve-less sponge
5. Preserved frogs hold clues to deadly pathogen
6. Remote Siberian lake holds clues to Arctic -- and Antarctic -- climate change
7. Highlighting molecular clues to the link between childhood maltreatment and later suicide
8. Hunting for autisms chemical clues
9. Salt cress genome yields new clues to salt tolerance
10. Gecko feet hold clues to creating bandages that stick when wet
11. A mechanism providing clues for research into pancreatic diabetes is described
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Clues to chromosome crossovers
(Date:2/5/2015)... , Jan. 30, 2015  It is gratifying ... power and potential for genomic science as a means ... disease prevention and treatment.  I was honored to participate ... government-funded precision medicine program. Since the ... science of genomics—from the first sequenced genome of a ...
(Date:1/22/2015)...  Today, FreeWavz ( www.FreeWavz.com ), the developer of ... Fundable, https://www.fundable.com/freewavz . FreeWavz will be expanding ... meet customer demand. Logo - ... Invented by Dr. Eric ...
(Date:1/22/2015)... Washington , January 20, 2015 Investorideas.com, ... tech stocks, releases video from the CES 2015 (Consumer Electronics ... Apollo Robbins . Apollo shows how easily ... smart wallet, a product of NXT-ID, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3
... that protects metals against corrosion in seawater has ... Sheffield Hallam University. At the Society for General ... Jeanette Gittens and colleagues described how they had ... coating which then protected an aluminium alloy from ...
... Institutes of Health (NIH) researchers have identified a gene that ... cancer. The finding is reported today in the journal ... of a group of enzymes implicated in skin cancer and ... found that one-quarter of human melanoma tumors had changes, or ...
... insight into mechanisms that allow invasive tumor cells to move, ... new understanding about how to stop cancer from spreading. A ... is the process that most often leads to death from ... Nature Cell Biology , researchers say that a molecule ...
Cached Biology News:Skin cancer study uncovers new tumor suppressor gene 2Skin cancer study uncovers new tumor suppressor gene 3Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells 2
(Date:2/27/2015)... (PRWEB) February 27, 2015 Immunovaccine ... and immunotherapy company, today announced that the U.S. ... for Fast Track designation and Phase I clinical ... conjunction with the mutual co-development agreement signed with ... Fast Track designation for the DPX-Survivac. , “We ...
(Date:2/27/2015)... ADELAIDE, Australia , Feb. 27, 2015 ... data from the DisrupTOR-1 trial of BNC105 in patients ... Symposium in Orlando, Florida . The ... of the City of Hope Comprehensive Cancer Center ... presentation. The new data identifies Ferritin ...
(Date:2/27/2015)... Brighton, Illinois (PRWEB) February 27, 2015 ... Matt Sims, General Manager of State Line Farms, received ... Award recognizes a producer, under the age of 35, ... , "It is an honor to win the Tomorrow's ... to discovering who won the Top Producer Award and ...
(Date:2/27/2015)... -- Steep Hill, the industry leader in cannabis testing and ... a full service medical cannabis quality assurance laboratory in ... scientific tools and methodology to the state, for regulatory ... the only laboratory licensed by the New Mexico Department ... order to meet the recently adopted regulatory requirements pertaining ...
Breaking Biology Technology:Immunovaccine Inc. (TSX: IMV) receives Fast Track and Phase I trial approval for Ebola and Anthrax vaccine programs, signs co-development agreement with Gilead Sciences 2Immunovaccine Inc. (TSX: IMV) receives Fast Track and Phase I trial approval for Ebola and Anthrax vaccine programs, signs co-development agreement with Gilead Sciences 3New BNC105 Biomarker Data to be Presented at US Cancer Conference 2New BNC105 Biomarker Data to be Presented at US Cancer Conference 3New BNC105 Biomarker Data to be Presented at US Cancer Conference 4New BNC105 Biomarker Data to be Presented at US Cancer Conference 5Matt Sims Receives the 2015 Tomorrow’s Top Producer Horizon Award 2Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 2
... it not been for the war in Iraq, 2003 might ... forgot. Certainly, in the world of information technology, that may ... happened slowly. Customers took their time. But for some activity ... then, must explain why the predictions I so carefully made ...
... a new device that holds 33% more data than ... after the June 2003 launch of the 1.5 GB ... introduced the 2.0-gigabyte Cornice Storage Element. These storage ... other applications that demand large amounts of reliable, inexpensive ...
... Madison, Wis. During the height of the mad cow ... a story headlined English beef approved for Irish consumption. The ... carried a smidgeon of truth about how choices were made ... imports or changing feed stocks during the British scare were ...
Cached Biology Technology:The Year Ahead in IT 2The Year Ahead in IT 3The Year Ahead in IT 4The Year Ahead in IT 5With Larger Storage Capacity Comes Smaller Devices 2Lets Use Science to Corral Mad Cow Disease and the Public Stampede 2Lets Use Science to Corral Mad Cow Disease and the Public Stampede 3
... have moderate chemiluminescence efficiencies and the chemistry ... have the added benefit that they require ... the background signal. This benefit has been ... immunoassay applications. These compounds can also be ...
Required to perform reference file generation, flatfield calibration and performance verification processes on the GSD-501...
ssDNA from PCR DNA in less than 1 hour. No gels, columns, or slurries. Sequence from high quality ssDNA: clearer reads, longer runs....
... version of Freezerworks Unlimited includes 2 clients and ... facilitates the sharing of freezers by multiple groups ... Network Client/Server version ... in monitor with 256 colors; OS 8.6 & ...
Biology Products: