Navigation Links
Clues to chromosome crossovers
Date:2/13/2013

airs entwined during meiosis. Green spots show the location of RNF212. (Neil Hunter/UC Davis)The latest paper from Hunter's lab, published Feb. 10 in Nature Genetics, shows that Rnf212 is essential for crossing-over in mammalian cells. Crossovers form by a process called homologous recombination, in which chromosomes are first broken and then repaired by coupling with a matching template chromosome. Although hundreds of recombination events are started in each cell, only one or two crossovers will form between any given pair of chromosomes.

"There isn't a special, predetermined site for a crossover. It can occur just about anywhere along a chromosome. But there has to be at least one and there always is," Hunter said.

In a series of experiments in mouse cells, graduate student April Reynolds, Hunter and colleagues found that the RNF212 protein defines where crossovers will occur by binding to just one or two recombination sites per chromosome where it triggers the accumulation of the protein machinery that actually carries out the cutting and splicing of DNA.

Mice that lacked the gene for RNF212 were sterile. Mice that had one working copy of the gene were fertile, but on careful examination there were fewer crossovers formed while sperm and eggs were being made than in normal mice, potentially reducing fertility. It's possible that this might be tied to some causes of infertility in humans.

It remains unclear how each pair of chromosomes always manages to crossover at least once. But Hunter says he is, "convinced that RNF212 holds the key to understanding this unique problem in chromosome biology."


'/>"/>

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Researchers look to relatives for clues in quest to develop sources of bioenergy
2. Relative reference: Foxtail millet offers clues for assembling the switchgrass genome
3. Higher pain tolerance in athletes may hold clues for pain management
4. Clues to nervous system evolution found in nerve-less sponge
5. Preserved frogs hold clues to deadly pathogen
6. Remote Siberian lake holds clues to Arctic -- and Antarctic -- climate change
7. Highlighting molecular clues to the link between childhood maltreatment and later suicide
8. Hunting for autisms chemical clues
9. Salt cress genome yields new clues to salt tolerance
10. Gecko feet hold clues to creating bandages that stick when wet
11. A mechanism providing clues for research into pancreatic diabetes is described
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Clues to chromosome crossovers
(Date:7/24/2014)... Scientists at The New York Stem Cell Foundation ... creating a viable cell replacement therapy for multiple ... For the first time, NYSCF scientists generated induced ... of patients with primary progressive multiple sclerosis and ... these stem cells into becoming oligodendrocytes, the myelin-forming ...
(Date:7/24/2014)... how wildlife loss leads to conflict among people around ... Conservation Society (WCS) Health & Ecosystems: Analysis of Linkages ... interdisciplinary approach to tackle global biodiversity decline. , The ... the world,s people and provides protein for more than ... as no surprise that today,s unprecedented loss of wildlife, ...
(Date:7/24/2014)... NY - July 24, 2014 -- Keryx Biopharmaceuticals, Inc. ... the long-term, randomized, active control Phase 3 study of ... phosphate binder, for the treatment of hyperphosphatemia in patients ... study (PhosphatE binding and iRon delivery with FErric CiTrate ... Journal of the American Society of Nephrology ( ...
Breaking Biology News(10 mins):NYSCF scientists one step closer to cell therapy for multiple sclerosis patients 2New study draws links between wildlife loss and social conflicts 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4
... lost from West Antarctica and the Antarctic peninsula over the ... Bristol and published online this week in Nature Geoscience. ... roughly stable, with neither loss nor accumulation over the past ... and colleagues estimated the flux of ice from the ice ...
... a survey across the entire human genome, an international ... Health (NIH) has found evidence that common genetic variants ... role in human height. The findings were released today ... Genetics. The variants most strongly associated with height ...
... Bering Sea. But during this century, the seas ... adapt to greenhouse conditions. All the fish that ends ... USC marine ecologist Dave Hutchins, whose former student at the ... in Marine Ecology Progress Series, a leading journal in the ...
Cached Biology News:Antarctic ice loss 2Researchers uncover new piece to the puzzle of human height 2Researchers uncover new piece to the puzzle of human height 3Researchers uncover new piece to the puzzle of human height 4Greenhouse ocean may downsize fish 2Greenhouse ocean may downsize fish 3
(Date:7/24/2014)... , July 24, 2014  Now available is ... home. Rehealth Regenerative Therapies , located in ... other physically active people a new health option: ... Regardless of age, countless patients suffer from joint and ... such as muscle tears, torn rotator cuff, tennis elbow, ...
(Date:7/24/2014)... Calif. , July 24, 2014  Asterias ... in the emerging field of regenerative medicine, announced ... of a presentation to investors on Tuesday, July ... PDT.  The presentation will include an overview of ... access the webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics at ...
(Date:7/24/2014)... , July 24, 2014  ECC West Africa, ... Colorado with University College Hospital (UCH) Ibadan ... development project to finance, design, construct, and operate and ... Nigeria . Under the first of the ... scoping documents and funding applications. UCH Ibadan intends to ...
(Date:7/24/2014)... on sophisticated equipment, trained personnel, and detection dogs ... terrorist attacks. A revolutionary new electronic chip with ... job much easier. , The groundbreaking nanotechnology-inspired sensor, ... University ,s School of Chemistry and Center for ... company Tracense, picks up the scent of explosives ...
Breaking Biology Technology:Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2Nano-sized chip 'sniffs out' explosives far better than trained dogs 2
... device and technology industries are a major strength of ... the economic health of the state. These industries ... to healthcare technologies and devices. Concentration of this ... producing products and services in the device and technology ...
... I recently traveled to an event in Madison, Wis. that ... Network. It was designed to bring together three geographic locations ... , ,Now ePrairies third eXtreme Networking event (but ... derived from a methodology for dating where men and women ...
... Summit started today. It will be interesting to see if ... Summits. My hunch is that it will not and we ... nothing about high technology. As in the past, the hall will ... are clueless about what to do. , ,If Governor ...
Cached Biology Technology:Mike Rosen Reviews - eXtreme Networking in Madison 2Mike Rosen Reviews - eXtreme Networking in Madison 3Create a Governors Technology Summit 2
... presents PsiPort Mass Directed Auto Purification ... data acquisition system designed for automated ... life science and pharmaceutical discovery programs. ... to simplify high throughput mass directed ...
SP6 RNA Polymerase, 50 l, 20 U/l ,Cap Scribe Buffer, 100 l, 5x conc....
... catalyzes the transfer of the ... 5-terminus of polynucleotides or to ... The enzyme, purified from recombinant ... to phosphorylate RNA, DNA and ...
... Ascent is the first nephelometer ... microplates. Nepheloskan measures light scattering ... for particle quantification. This makes ... in drug discovery, immunoprecipitation, and ...
Biology Products: