Navigation Links
Cleverly designed vaccine blocks H5 avian influenza in models
Date:3/25/2013

ne slowed its function, interfering with the virus' replication. That makes the vaccine safer.

The next step was to engineer the H5 gene into the vaccine. It was inserted into segment 8, where the NS2 gene had been.

Another aspect of the new vaccine's design makes it safer still, by rendering successful reassortment less likely. Both NS1 and NS2 are needed for viral replication. Since the two genes are now separated into different segments, any reassortment will have to include both segments, instead of just segment 8, in order for a reassortant virus to be viable. This greatly reduced the probability of successful reassortment.

The World Health Organization (WHO) recognizes avian influenza subtypes H5, H7, and H9 as potential pandemic viruses, because they all have in rare instances infected humans, and because they circulate in wild birds. Single reassortants could be sufficient to breach the species barrier, and since they do not circulate among us, we lack any immunity. Moreover, H5 is unusually lethal, having killed roughly half of those few it is confirmed to have infected.


'/>"/>

Contact: Garth Hogan
ghogan@asmusa.org
202-942-9389
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. A new type of data papers designed to publish online interactive keys identifying biodiversity
2. Faster, cheaper gas and liquid separation using custom designed and built mesoscopic structures
3. MIT-designed cooler preserves tuberculosis drugs, records doses
4. Portable diagnostics designed to be shaken, not stirred
5. Research is ensuring stormwater systems are designed for the future
6. HPV vaccine trends point to failures in patient education, vaccine programs
7. Cancer vaccines self-sabotage, channel immune attack to injection site
8. Human trials for Streptococcus A vaccine
9. Novel aptamer boosts T cell-based immune response to therapeutic vaccines
10. Designer bacteria may lead to better vaccines
11. UMMS experts seek better flu vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... 2014 NexID Biometrics , a ... solutions for the biometric authentication industry, has recently ... online authentication with standards for strong authentication. According ... decision to join FIDO Alliance stems from NexID,s ... use. We believe the FIDO Alliance is a ...
(Date:7/30/2014)... CHAMPAIGN, Ill. Scientists are searching through a massive ... more than 50 years ago, and the effort is ... world they inhabited. , When the collection is fully ... will be the largest unbiased Dominican amber collection in ... most striking discovery thus far is that of a ...
(Date:7/30/2014)... of iodine-125 (125I) in cancer treatment has been ... ganglia are critical for neural transmission between the ... and colleagues from Institute of Radiation Medicine, Chinese ... could be implanted into rat dorsal root ganglia ... seeds with different radioactivity (0, 14.8, 29.6 MBq) ...
Breaking Biology News(10 mins):NexID Biometrics Joins the FIDO Alliance 2Decades-old amber collection offers new views of a lost world 2
... The National Science Foundation (NSF) today announced Science ... collaboration among scientists and educators around the globe ... common interests and goals, SAVI can better leverage ... society,s most vexing problems. Building on beneficial ...
... distribution models for revealing the response of animals ... the endangered marsupial, the Northern Bettong. The research, ... weather events, rather than the gradual changes of ... Bettong,s movements, range boundaries and likely contact with ...
... tropical parasitic disease that can lead to life-threatening heart ... than previously thought, according to research from The University ... for four years now, and this year the number ... professor of integrative biology and philosophy at The University ...
Cached Biology News:Virtual institutes to support the scientific collaborations of the future 2Virtual institutes to support the scientific collaborations of the future 3Australia's endangered bettong reveals how weather effects species distribution 2Chagas disease may be a threat in South Texas, says researcher 2
(Date:7/30/2014)... July 30, 2014 Selexis SA ... biologic drug discovery and mammalian cell line development, announced ... Libraries ™ will be presented at the 10th Annual ... held, September 8 – 10, 2014 at the Double ... , The following abstract will be presented during an ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 With ... increase of personal health expenditure as well as ... care system, China diagnostic reagent industry has been ... over 90%. In 2013, Chinese in vitro diagnostics ... billion came from in vitro diagnostic reagents. ...
(Date:7/30/2014)... 2014 Vycom announces the addition of ... to meet Factory Mutual (FM) 4910 fire propagation and ... wet benches, process tools, fume hoods, furniture and cabinetry. ... to semiconductor wafers used in electronic chip manufacturing. ... solution with excellent workability and superior aesthetics. It is ...
(Date:7/30/2014)... , July 30, 2014  Dyadic International, ... company whose patented and proprietary technologies are used ... other proteins for the bioenergy, bio-based chemical, biopharmaceutical ... of Thomas "Tom" Dubinski as Vice President and ... leading the financial and information technology operations for ...
Breaking Biology Technology:Selexis SA to Present New Data and a Case Study at IBC’s Cell Line Development and Engineering Conference 2Selexis SA to Present New Data and a Case Study at IBC’s Cell Line Development and Engineering Conference 3China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 2China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 3Vycom Announces Flametec® Thermax PVC (FM4910 Listed) For a Variety of Clean Room Applications with Excellent Workability and Aesthetics 2Thomas Dubinski joins Dyadic as Chief Financial Officer 2Thomas Dubinski joins Dyadic as Chief Financial Officer 3Thomas Dubinski joins Dyadic as Chief Financial Officer 4
... ... ... Therapeutic Proteins Inc. (TPI) today announced the completion of the nation’s first independent, ... Administration (FDA) requirements. The Chicago facility is located at University Technology Park at ...
... ... and Existing Partnerships , ... April 21, 2010 -- HealthTalker , the leader in word of mouth (WOM) marketing ... Core Leadership Team as the Senior Director of Strategic Partnerships. , , , ...
... situations, a split second can make the difference between ... of new "smart sensors" that allow for faster response ... new research from NC State that will help ensure ... those faced in Afghanistan or elsewhere. "We,ve taken ...
Cached Biology Technology:Therapeutic Proteins Inc. Completes First Independent, Dedicated Biosimilars Manufacturing Facility in U.S. 2Therapeutic Proteins Inc. Completes First Independent, Dedicated Biosimilars Manufacturing Facility in U.S. 3Therapeutic Proteins Inc. Completes First Independent, Dedicated Biosimilars Manufacturing Facility in U.S. 4HealthTalker Adds Industry Expert Collie Turner to Its Executive Team 2
... The thermostable dUTPase(pyrococcus fruriosus) maximizes the ... DNA polymerases). It removes contaminating ... dNTP solutions. The presence of ... reaction can prevent dUTP misincorporation by ...
... the D-2000, but comes with a shutter (controlled ... The D-2000 Deuterium Light Source produces a ... deep-UV versions of the light source are available, ... powerful and stable lamp provides peak-to-peak stability of ...
... product for cell-based kinetic assays and research ... of expensive HTS equipment, which lead to ... development stage. The NOVOstar offers the right ... as any other assay suitable for the ...
... The kit measures mitochondria intactness ... mitochondrial membrane potential. Features and Benefits: ... method for staining isolated mitochondria and ... Contains all the reagents required for ...
Biology Products: