Navigation Links
Cleveland Clinic researchers discover neuroprotective role of immune cell
Date:7/22/2014

July 22, 2014, Cleveland: A type of immune cell widely believed to exacerbate chronic adult brain diseases, such as Alzheimer's disease and multiple sclerosis (MS), can actually protect the brain from traumatic brain injury (TBI) and may slow the progression of neurodegenerative diseases, according to Cleveland Clinic research published today in the online journal Nature Communications.

The research team, led by Bruce Trapp, PhD, Chair of the Department of Neurosciences at Cleveland Clinic's Lerner Research Institute, found that microglia can help synchronize brain firing, which protects the brain from TBI and may help alleviate chronic neurological diseases. They provided the most detailed study and visual evidence of the mechanisms involved in that protection.

"Our findings suggest the innate immune system helps protect the brain after injury or during chronic disease, and this role should be further studied," Dr. Trapp said. "We could potentially harness the protective role of microglia to improve prognosis for patients with TBI and delay the progression of Alzheimer's disease, MS, and stroke. The methods we developed will help us further understand mechanisms of neuroprotection."

Microglias are primary responders to the brain after injury or during illness. While researchers have long believed that activated microglia cause harmful inflammation that destroys healthy brain cells, some speculate a more protective role. Dr. Trapp's team used an advanced technique called 3D electron microscopy to visualize the activation of microglia and subsequent events in animal models.

They found that when chemically activated, microglia migrate to inhibitory synapses, connections between brain cells that slow the firing of impulses. They dislodge the synapse (called "synaptic stripping"), thereby increasing neuronal firing and leading to a cascade of events that enhance survival of brain cells.

Trapp is internationall
'/>"/>

Contact: Laura Ambro
ambrol@ccf.org
216-636-5876
Cleveland Clinic
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
2. Cleveland Clinic develops clinical screening program for no.1 genetic cause of colon cancer
3. Cleveland Clinic research shows anemia drug does not improve health of anemic heart failure patients
4. Cleveland Clinic researchers discover new link between heart disease and red meat
5. Cleveland Clinic research shows gut bacteria byproduct predicts heart attack and stroke
6. Cleveland Clinics 2013 Obesity Summit explores causes, prevention and treatment of obesity
7. 2 Cleveland Clinic researchers honored for contribution to science
8. Cleveland Clinic identifies mechanism in Alzheimers-related memory loss
9. Cleveland Clinic researchers discover process that turns good cholesterol bad
10. Collaborative preclinical efficacy studies suggest a new target for drug addiction treatment
11. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2015)... May 20, 2015 NXT-ID, Inc. (NASDAQ: ... wholly owned subsidiary, 3D-ID LLC, a company engaged in ... for the biometrics technology portion of the recently awarded ... the Department of the Army. 3D-ID LLC ... for government, law enforcement and security agencies. ...
(Date:5/19/2015)... May 19, 2015  Technology is rapidly advancing, outpacing ... in the cloud. Passwords and their management are soon ... and standards-based specifications such as those developed by the ... of passwords presents for BYOD, COPE, IoT, and mobile ... identity protocol. In response to the ...
(Date:5/18/2015)... Fingerprint Cards (FPC) has received an order for ... from one if its module partners. Deliveries are planned to ... the sensors will be used by smartphone manufacturers in ... amount to 740 MSEK to date. In addition to previously ... number of smaller orders not separately communicated amounting to more ...
Breaking Biology News(10 mins):NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
... Atlantic right whale's future looks grim if the current ... professor of oceanography Douglas Nowacek and a group of ... co-authored a paper titled "North Atlantic Right Whales in ... the journal Science. , In it, Nowacek and his ...
... well-respected researcher who is now a chief of an immunology ... the boat in the past few years for the experts ... Matzinger has developed the "danger model," suggesting that the immune ... of a biological cell's death than with the introduction of ...
... new muscle complete with its own network of blood ... in a living mouse. The accomplishment is a first ... June 19 issue of Nature Biotechnology. , Lead researcher ... along with scientists from the Massachusetts Institute of Technology, ...
Cached Biology News:Scientists to mimic nature for newest cancer drugs 2Researchers seek to discover what really happens when a virus enters the body 2Researchers seek to discover what really happens when a virus enters the body 3New complete muscle grown in the lab 2
(Date:5/21/2015)... - SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: ... commercializes proprietary technologies and products for advanced microarray diagnostics, ... second fiscal quarter ended March 31, 2015. ... business with our existing customers and to develop new ... of SQI. "The delivery of a fully automated sqidlite™ ...
(Date:5/21/2015)... 2015 Specialty Pharmacy Times has ... admitted to BPA Worldwide as a business publication ... audience data for Specialty Pharmacy Times based on ... becoming a member of BPA Worldwide, Specialty Pharmacy ... clients with the most reliable, unequaled data,” said ...
(Date:5/21/2015)... 21, 2015  Prima Biomed Ltd. (NASDAQ: PBMD ... to become a leader in the development of immunotherapeutic ... the final CVac data from the Phase II CAN-003 ... for a clinically meaningful improvement in Overall Survival ("OS") ... In the group of second remission patients ...
(Date:5/21/2015)... , May 21, 2015  The EveryLife ... Hatch (R-UT) and Amy Klobuchar ... Now Accelerating Cures & Treatments, or OPEN ACT. ... disease patient advocacy organizations, this bipartisan legislation promises ... affordable medicines to rare disease patients by incentivizing ...
Breaking Biology Technology:SQI Diagnostics Reports Second Quarter Financial Results 2SQI Diagnostics Reports Second Quarter Financial Results 3SQI Diagnostics Reports Second Quarter Financial Results 4SQI Diagnostics Reports Second Quarter Financial Results 5SQI Diagnostics Reports Second Quarter Financial Results 6SQI Diagnostics Reports Second Quarter Financial Results 7SQI Diagnostics Reports Second Quarter Financial Results 8Specialty Pharmacy Times Joins BPA Worldwide 2Correction Continues after Big Move - BrokerBank Securities, Inc. 2Advocates Cheer Senate Leaders for Introducing Bipartisan Bill to Increase Number of Rare Disease Treatments 2
... of Yeshiva University have shown for the first time ... common form of the disease) in an animal model. ... of Clinical Investigation. , Hemophilia A affects one in ... that can cause disability or death. It has, most ...
... to ... Broaden Product Portfolio, WAYNE, Pa., Feb. 14 Escalon ... second quarter and,six months ended December 31, 2007., For the ... Company,s Drew, Vascular and Escalon Digital Solutions (EMI),business units, which increased ...
... Calif., Feb. 14 Telik, Inc.,(Nasdaq: TELK ) ... held on Thursday, February 21, 2008 at 4:30 p.m. ... that day of the company,s,financial results for the fourth ... conference call will be accessible via Telik,s website at, ...
Cached Biology Technology:Transplanted cells may hold the key to curing hemophilia A, Einstein scientists report 2Escalon(R) Reports Second Quarter Fiscal 2008 Results 2Escalon(R) Reports Second Quarter Fiscal 2008 Results 3Escalon(R) Reports Second Quarter Fiscal 2008 Results 4Escalon(R) Reports Second Quarter Fiscal 2008 Results 5Escalon(R) Reports Second Quarter Fiscal 2008 Results 6Escalon(R) Reports Second Quarter Fiscal 2008 Results 7Escalon(R) Reports Second Quarter Fiscal 2008 Results 8
Fast, sensitive quantitation of Mouse IgM concentration....
Request Info...
... anti-rabbit IgG FITC is used as ... staining on tissues or culture cells ... in rabbits. It is highly recommended ... omitting the primary antibody, be included ...
1000X solution used for inducing CopyControl™ based vectors to high copy numbers...
Biology Products: