Navigation Links
Clemson University study points to possible treatment for brain disorders
Date:10/22/2013

CLEMSON, S.C. Clemson University scientists are working to determine how neurons are generated, which is vital to providing treatment for neurological disorders like Tuberous Sclerosis Complex (TSC).

TSC is a rare genetic disease that causes the growth of tumors in the brain and other vital organs and may indicate such disorders as autism, epilepsy and cognitive impairment that may arise from the abnormal generation of neurons.

"Current medicine is directed at inhibiting the mammalian target of rapamycin (mTOR), a common feature within these tumors that have abnormally high activity," said David M Feliciano, assistant professor of biological sciences. "However, current treatments have severe side effects, likely due to mTOR's many functions and playing an important role in cell survival, growth and migration."

Feliciano and colleagues published their findings in journal Cell Reports.

"Neural stem cells generate the primary communicating cells of the brain called neurons through the process of neurogenesis, yet how this is orchestrated is unknown," said Feliciano.

The stem cells lie at the core of brain development and repair, and alterations in the cells' self-renewal and differentiation can have major consequences for brain function at any stage of life, according to researchers.

To better understand the process of neurogenesis, the researchers used a genetic approach known as neonatal electroporation to deliver pieces of DNA into neural stem cells in young mice, which allowed them to express and control specific components of the mTOR pathway.

The researchers found that when they increase activity of the mTOR pathway, neural stem cells make neurons at the expense of making more stem cells. They also found that this phenomenon is linked to a specific mTOR target known as 4E-BP2, which regulates the production of proteins.

Ultimately, this study points to a possible new treatment,
'/>"/>

Contact: David M. Feliciano
dfelici@clemson.edu
864-656-0435
Clemson University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Clemson plant breeders roll out new oat variety
2. Clemson, Coastal Carolina universities to set hundreds of sensors in Savannah River
3. Clemson scholar receives top agriculture science award
4. Clemson plant pathologist working to raise cucurbit yields, lower production costs
5. Clemson University researchers: What happens to peaches when the chill is gone?
6. Clemson University researchers to study oil and gas operations impact on Gulf Coast pelicans
7. Clemson researchers: Different forage affects beef cattle weight, taste
8. University of Houston study shows BP oil spill hurt marshes, but recovery possible
9. University of Alberta led research may have discovered how memories are encoded in our brains
10. BGI, University of Helsinki and Wuhan University sign a MOU concerning cooperation on genomics
11. Marshall University study may lead to new treatments for prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Clemson University study points to possible treatment for brain disorders
(Date:11/18/2014)... , Nov. 18, 2014  The Secure Identity ... Association today jointly announce the formation of The ... of its Identity and Biometric Entry and ... Framework received official support from BORDERPOL, the international ... improve and provide expertise regarding border security, traveler ...
(Date:11/18/2014)... BETHESDA, Md. , Nov. 17, 2014 The ... European and U.S. regulatory agencies will speak and at least ... Quality Metrics Conference at the Omni Shoreham Hotel in ... is pleased once again to have significant support from the ... and Europe in our effort to ...
(Date:11/15/2014)... , Nov. 13, 2014  While we may still be ... McCoy used in "Star Trek" to gain instant access to ... to work with smartphones and tablets for monitoring and measuring ... healthcare world. This may seem a tad Orwellian to some, ... adopt some of these technological opportunities into their healthcare regime. ...
Breaking Biology News(10 mins):Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4
... available in French . , Dopamine replacement ... with Parkinson,s disease, can, at times, adversely affect cognition. ... Head of the Neurophysiological and Neuroimaging Research theme at ... de Montral (IUGM), which is affiliated with the Universit ...
... , Birds with high levels of stress hormones have ... to their brood, according to new biology research at ... stress hormone is often thought to indicate an individual ... mating success. However, our research indicates that tree swallows ...
... and new research by University of California, Berkeley, neuroscientists ... and other highly emotional experiences lead to incredibly strong ... 14) in advance of publication in the journal ... report a new way for emotions to affect memory: ...
Cached Biology News:Researchers identify why dopamine replacement therapy has a paradoxical effect on cognition 2Stress may lead to better bird parenting 2Fear boosts activation of young, immature brain cells 2Fear boosts activation of young, immature brain cells 3
(Date:12/19/2014)... REDWOOD CITY, Calif. , Dec. 19, 2014 ... , USA) announced today that they have been ... Technologies 1,2 is a privately held company that ... processing of next generation sequencing (NGS) data for the ... into the Roche Sequencing Unit, and will continue to ...
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/fhh9rj/technology ... "Technology Innovations in Smart Fabrics (Technical Insights)" ... http://photos.prnewswire.com/prnh/20130307/600769 The Research Service ... detailed assessment on technological advancements and market for ... 1. The Smart Fabrics market is expected ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 Today, ... locate its pilot production facility and future company ... and produce innovative new materials that safely and ... not only because of its historic, strong support ... efforts to attract leading edge, technology-based companies such ...
(Date:12/19/2014)... Ed Bilsky, Ph.D., vice president for Research and ... the Neurosciences (CEN), and professor of pharmacology at the ... member of the prestigious Dana Alliance for Brain Initiatives ... receive this honor. , The Dana Alliance ... Foundation. Its mission is to advance public education ...
Breaking Biology Technology:Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3Technology Innovations in Smart Fabrics (Technical Insights) 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 3
... CARLSBAD, Calif., Jan. 6 AutoGenomics, a leader in ... company has been invited and has accepted to present ... January 12-15, 2009 at the Westin St. Francis Hotel ... President & CEO will provide an overview of the ...
... Jan. 6 /PRNewswire-FirstCall/ - SemBioSys Genetics Inc. (TSX:SBS), ... plants, today announced it has received US$2,500,000 from ... for the option agreement and issuance of 2,400,000 ... 2008. The transaction provides MannKind with the option ...
... ST. LOUIS, Mo., Jan. 6 Sigma-Aldrich,(Nasdaq: ... with the acquisition of,Seppro(R) affinity depletion technology and ... Inc. Seppro depletion products enable,scientists to measure ... range of mammalian and plant biological samples. ...
Cached Biology Technology:SemBioSys receives US$2.5 million from option agreement with MannKind for plant-produced insulin 2SemBioSys receives US$2.5 million from option agreement with MannKind for plant-produced insulin 3Sigma-Aldrich Acquires Seppro(R) Depletion Technology From GenWay Biotech 2Sigma-Aldrich Acquires Seppro(R) Depletion Technology From GenWay Biotech 3