Navigation Links
Clemson University study points to possible treatment for brain disorders
Date:10/22/2013

CLEMSON, S.C. Clemson University scientists are working to determine how neurons are generated, which is vital to providing treatment for neurological disorders like Tuberous Sclerosis Complex (TSC).

TSC is a rare genetic disease that causes the growth of tumors in the brain and other vital organs and may indicate such disorders as autism, epilepsy and cognitive impairment that may arise from the abnormal generation of neurons.

"Current medicine is directed at inhibiting the mammalian target of rapamycin (mTOR), a common feature within these tumors that have abnormally high activity," said David M Feliciano, assistant professor of biological sciences. "However, current treatments have severe side effects, likely due to mTOR's many functions and playing an important role in cell survival, growth and migration."

Feliciano and colleagues published their findings in journal Cell Reports.

"Neural stem cells generate the primary communicating cells of the brain called neurons through the process of neurogenesis, yet how this is orchestrated is unknown," said Feliciano.

The stem cells lie at the core of brain development and repair, and alterations in the cells' self-renewal and differentiation can have major consequences for brain function at any stage of life, according to researchers.

To better understand the process of neurogenesis, the researchers used a genetic approach known as neonatal electroporation to deliver pieces of DNA into neural stem cells in young mice, which allowed them to express and control specific components of the mTOR pathway.

The researchers found that when they increase activity of the mTOR pathway, neural stem cells make neurons at the expense of making more stem cells. They also found that this phenomenon is linked to a specific mTOR target known as 4E-BP2, which regulates the production of proteins.

Ultimately, this study points to a possible new treatment,
'/>"/>

Contact: David M. Feliciano
dfelici@clemson.edu
864-656-0435
Clemson University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Clemson plant breeders roll out new oat variety
2. Clemson, Coastal Carolina universities to set hundreds of sensors in Savannah River
3. Clemson scholar receives top agriculture science award
4. Clemson plant pathologist working to raise cucurbit yields, lower production costs
5. Clemson University researchers: What happens to peaches when the chill is gone?
6. Clemson University researchers to study oil and gas operations impact on Gulf Coast pelicans
7. Clemson researchers: Different forage affects beef cattle weight, taste
8. University of Houston study shows BP oil spill hurt marshes, but recovery possible
9. University of Alberta led research may have discovered how memories are encoded in our brains
10. BGI, University of Helsinki and Wuhan University sign a MOU concerning cooperation on genomics
11. Marshall University study may lead to new treatments for prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Clemson University study points to possible treatment for brain disorders
(Date:8/21/2014)... tube connectors, designed by an international standards process, will ... According to an invited review published in the OnlineFirst ... NCP ), the official journal of the American Society ... will greatly reduce the occurrence of misconnection that can ... connectors, which are used to join medical devices, components, ...
(Date:8/21/2014)... from North Carolina State University have developed a novel ... model has applications for creating new materials as well ... "Our new technique allows us to model much larger ... much more quickly," says Nan Li, lead author of ... in NC State,s Department of Materials Science and Engineering. ...
(Date:8/20/2014)... a study of 158 pregnant teenagers in Rochester, NY, ... intentional consumption of ice, cornstarch, vacuum dust, baby powder ... Cornell study. , Moreover, such teens had significantly lower ... eat nonfood substances. , Pregnant teens, regardless of pica, ... lead to iron deficiency and anemia. Low iron in ...
Breaking Biology News(10 mins):New feeding tube connectors will improve patient safety 2Researchers develop models to study polyelectrolytes, including DNA and RNA 2Pica in pregnant teens linked to low iron 2
... WASHINGTON, D.C. (March 7, 2011) -- All our daily activities, ... on signals carried along the body,s vast network of neurons. ... small molecules within nerve cells -- receptors, ion channels, and ... recently, the study of these molecules in real time has ...
... gene that causes Hajdu-Cheney syndrome, a disorder of the ... The study, published in Nature Genetics today, ... highlights the gene as a potential target for treating ... reported cases of Hajdu-Cheney syndrome (HCS), of which severe ...
... separates from Greenland, is the calving due to typical ... called the Scalable, Efficient, and Accurate Community Ice Sheet ... Ridge National Laboratory, aims to use state-of-the-art simulation to ... climate. ORNL computational Earth scientist Kate Evans leads ...
Cached Biology News:Gene responsible for severe osteoporosis disorder discovered 2
(Date:8/20/2014)... 20, 2014 The 6th Annual ... held on October 29-30 in San Francisco, CA. This ... and government researchers and clinicians focused on addressing and ... , In the twelve years since the sequencing of ... been introduced with pharmacogenetic information in the label and ...
(Date:8/20/2014)... SAN JOSE, Calif. , Aug. 20, 2014 ... UCSD highlights the transformative collaboration between the school,s ... (IoT).  As part of the Intel® Software Academic ... between computer sciences and the human body.  ... The study exhibits the work of ...
(Date:8/20/2014)... Cranford, NJ (PRWEB) August 20, 2014 ... solutions, announced today that it has expanded its myPROpad™ ... of the EQ-5D-5L, one of the most widely ... for measuring general health status. The EQ-5D is used ... to generate a measure that can be used to ...
(Date:8/19/2014)... (PRWEB) August 20, 2014 One ... regenerative medicine is an inadequate vascular supply. Nutrient ... and decellularized tissues is critical for successful regeneration ... attempted to mitigate deficiencies in vascularization and promote ... scaffold bioactivity, optimizing scaffold design and architecture, and ...
Breaking Biology Technology:6th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2EQ-5D™ Assessment Now Available for iPad 2Vascularization in Tissue Engineering Highlighted at 12th New Jersey Symposium on Biomaterials Science 2
... LA JOLLA, Calif., Jan. 13 Burnham ... an assay development and license agreement with ... L.L.C. (J&JPRD). The agreement is Burnham,s ... company.Under this multi-year agreement, Burnham will provide ...
... - GeneNews Limited (TSX: GEN), a company focused ... detection of diseases and personalized health management, today ... 7,473,528 entitled "Method for the detection of Chagas ... protects the Company,s discovery of a blood biomarker-based ...
... Datafarm, Inc. a leading provider of Electronic Document Publishing Solutions and ... announce the appointment of Mr. Daniel F. Orfe to Vice President, ... will oversee Datafarm,s Regulatory Services Group. , ... Marlborough, ...
Cached Biology Technology:Burnham Announces Assay Development and License Agreement with Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 2GeneNews granted U.S. patent for Chagas disease based on Sentinel Principle(TM) platform 2Datafarm, Inc., Announces the Appointment of Daniel F. Orfe to Vice President, Global Regulatory Submission Services 2Datafarm, Inc., Announces the Appointment of Daniel F. Orfe to Vice President, Global Regulatory Submission Services 3Datafarm, Inc., Announces the Appointment of Daniel F. Orfe to Vice President, Global Regulatory Submission Services 4
... of Tracker, plus software to note when the ... a food reward.The Spatial Behavior line is a ... camera, frame grabber, and feature extraction software and ... up to 6 moving animals. Software automatically ...
... Behavior System. Enables replay of a reorded ... parts, and scoring events and duration by button ... Behavior line is a family of instruments all ... feature extraction software and that can track two ...
... fermentation systems for cultivation of microorganisms and ... of bio-pharmaceutical products maximum performance and economy ... and cell fermentation 10 L 1,500 ... ,*Fully automated control system ,*High-quality ...
... technology, SilenceMag is the most efficient ... and easy to use, SilenceMag is ... designed for siRNA delivery, SilenceMag allows ... doses of siRNA.,SilenceMag formulation gives reliable ...
Biology Products: