Navigation Links
Circadian rhythms have profound influence on metabolic output, UCI study reveals
Date:3/19/2012

Irvine, Calif., March 19, 2012 By analyzing the hundreds of metabolic products present in the liver, researchers with the UC Irvine Center for Epigenetics & Metabolism have discovered that circadian rhythms our own body clock greatly control the production of such key building blocks as amino acids, carbohydrates and lipids.

They identified more than 600 liver-originated metabolites, which are the chemical substances created by metabolism that sustain and promote cell health and growth. Approximately 60 percent of these metabolites were found to be dependent on the endogenous circadian clock many more than expected, as only about 15 percent of the body's genes are regulated by it.

Circadian rhythms over 24 hours govern fundamental biological and physiological processes in almost all organisms. They anticipate environmental changes and adapt certain bodily functions to the appropriate time of day. Disruption of these cycles can seriously affect human health.

Center for Epigenetics & Metabolism director Paolo Sassone-Corsi, lead author on the study and one of the world's preeminent researchers on circadian rhythms, said the liver metabolites reveal how the body clock through the main circadian gene, CLOCK orchestrates the interplay between metabolites and signaling proteins in much the same way a conductor leads a symphony.

"Metabolites and signaling proteins like the horns and strings in an orchestra need to be perfectly coordinated, and we've found that CLOCK provides that direction," he said.

Since external cues such as day-night lighting patterns and nutrition influence the circadian machinery, metabolites and their relationship to signaling proteins in cells seem to be acutely tied to circadian disruptions. This may help explain, Sassone-Corsi added, some of the primary physiological factors underlying obesity, high cholesterol and metabolic-based diseases like diabetes.

"This interplay has far-rea
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related biology news :

1. How exposure to irregular light affects plant circadian rhythms
2. Differences in jet lag severity could be rooted in how circadian clock sets itself
3. Circadian clocks in a blind fish
4. Manipulating plants circadian clock may make all-season crops possible
5. A sleep strategy commonly used by night nurses throws off their circadian clocks
6. Circadian rhythms spark plants ability to survive freezing weather
7. UNC scientists pinpoint link between light signal and circadian rhythms
8. Circadian rhythms: Their role and dysfunction in affective disorder
9. Light, circadian rhythms affect vast range of physiological, behavioral functions
10. Texas A&M researchers find new mechanism for circadian rhythm
11. MicroRNAs grease the cells circadian clockwork
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... led by the Australian National University (ANU), have ... and deep-sea temperature variability over the past 5.3 ... understand the climate surrounding ice ages over the ... the relationship between carbon dioxide levels, global temperatures ... University of Southampton (UoS) and the National Oceanography ...
(Date:4/16/2014)... Nicaragua,s legal, artisanal green sea turtle fishery has uncovered ... turtles in what may have become an unsustainable take, ... and University of Florida. , During the research period, ... were killed between 1991 and 2011, with catch rates ...
(Date:4/16/2014)... leaf looks like one seamless surface; however, up close, ... patchwork of cells in a variety of shapes and ... their own unique forms, Caltech biologist Elliot Meyerowitz, postdoctoral ... shape-controlling factors in pavement cells, which are puzzle-piece-shaped epithelial ...
Breaking Biology News(10 mins):Ancient sea-levels give new clues on ice ages 2Declining catch rates in Caribbean green turtle fishery may be result of overfishing 2Declining catch rates in Caribbean green turtle fishery may be result of overfishing 3For cells, internal stress leads to unique shapes 2
... firing in a brain reward circuit instantly rendered mice ... a study supported by the National Institutes of Health ... mimic the pattern, previously resilient mice instantly succumbed to ... they avoided other animals and lost their sweet ...
... of Cladophora in the Great Lakes, including phosphorus-rich ... way back onto the radar of scientists, including Mercyhurst University ... fouling, concerns that incidences of avian botulism are linked to ... and human pathogens have sparked renewed attention in the nuisance ...
... MINNEAPOLIS / ST. PAUL (12/12/2012) The National Science ... $720,000 grant to the University of Minnesota to ... study of Earth-surface systems, with a special emphasis ... Future Earth (LIFE) is a new collaborative network ...
Cached Biology News:Stress-resilience/susceptibility traced to neurons in reward circuit 2Stress-resilience/susceptibility traced to neurons in reward circuit 3Stress-resilience/susceptibility traced to neurons in reward circuit 4Grant furthers Mercyhurst research for human pathogens in Great Lakes 2U of M to lead international virtual institute studying climatic and human effects on Earth 2U of M to lead international virtual institute studying climatic and human effects on Earth 3
(Date:1/14/2014)... PA (PRWEB) January 14, 2014 Date: Friday, ... , Location: Warrington Country Club, 1360 Almshouse Road, Warrington, Pa. ... national nonprofit organization solely dedicated to finding a cure for ... affected worldwide, will host its annual Crystal Ball on Friday, ...
(Date:1/14/2014)... As pet owners drew up their lists of New Year,s ... better care of my furry companion." Nowadays there are pet salons, ... cases to take the little canine or feline darlings along wherever ... buy some pricey toys at the pet store. But anyone who ...
(Date:1/14/2014)... 2014 iLab Solutions, the leader in core ... Director of Product Strategy. In this role, Michelle will work ... to guide in the development of iLab products. Her main ... possible benefit to the scientific community by offering the most ...
(Date:1/14/2014)... , Jan. 14, 2014   Kinaxis ®, provider of ... and sales and operations planning ( S&OP ) service, is ... Summit , which will be held at the Hilton San ... join Kinaxis customer Elisabeth Kaszas , Director of Supply ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... ... And Improved Website. The New Site Provides Users With A Comprehensive Overview Of Pace ... Site Also Offers An Expanded Service Description For Each Of Its Three Major Business ... ...
... , REDWOOD CITY, Calif., Aug. 6 ... that target cancer stem cells, today announced the publication in ... activity in colon and breast cancer models for the company,s ... cancer stem cells to treat solid tumors. OMP-21M18 is ...
... ANNAPOLIS, Md., Aug. 6 PharmAthene, Inc. (NYSE Amex: ... biological and chemical threats, announced today that its financial results for ... 13, 2009. , , PharmAthene management will be ... results. The call is scheduled to begin at 11:00 a.m. ...
Cached Biology Technology:One of the Nation's Leading Analytical Testing Laboratories is Now Easier to Access -- Pace Analytical Launches New Web Site to Showcase Its Three Business Divisions 2Data Published in Cell Stem Cell Demonstrates Potent Anti-Cancer Activity for OncoMed Pharmaceuticals' Lead Antibody 2Data Published in Cell Stem Cell Demonstrates Potent Anti-Cancer Activity for OncoMed Pharmaceuticals' Lead Antibody 3Data Published in Cell Stem Cell Demonstrates Potent Anti-Cancer Activity for OncoMed Pharmaceuticals' Lead Antibody 4PharmAthene to Host Second Quarter 2009 Conference Call and Webcast on Thursday, August 13, 2009 2
MarrowMAX Bone Marrow Medium...
... recognizes murine IRF7 protein, and ... related IRF proteins. Reactivity of ... protein was confirmed by western ... cells transfected with IRF7. Reactivity ...
Rabbit anti-phospho-EGFr (Tyr992) - Concentrate...
Contains L-glutamine...
Biology Products: