Navigation Links
Children with autism more likely to have mitochondrial defects impacting cellular energy production
Date:11/30/2010

NEW YORK, N.Y. (December 1, 2010) A new study published in the Journal of the American Medical Association (JAMA) and partially funded by Autism Speaks, found that children with autism have more trouble fueling the energy demands of their cells due to dysfunctional mitochondria. These new findings from UC Davis reveal several different types of mitochondrial dysfunction and suggest a novel way of screening for these deficits using blood samples.

Mitochondria, the "powerhouses" of cells, provide energy for cell functions through a cascade of enzyme complexes. Together, those enzyme complexes create energy through a process called oxidative phosphorylation. Previous studies have shown that mitochondrial dysfunction can lead to a host of disorders particularly affecting brain cells which are characterized by high energy demands. Although mitochondrial dysfunction has previously been suspected in some individuals with autism spectrum disorders, the evaluation was difficult, and typically required a sample from muscle cells.

For the study, blood samples were taken from ten children with autism and ten unrelated typically developing children, all aged 2-5 years. The researchers analyzed mitochondria in children's white blood cells. Mitochondria in the samples from children with autism were less efficient at creating energy through oxidative phosphorylation. In some, there was a genetic mutation that affected mitochondrial function. In others, the researchers observed that one or more enzyme complexes were dysfunctional. In most of the children with autism, there were many extra copies of mitochondria, which may partially compensate for each one not working optimally.

"It is remarkable that evidence of mitochondrial dysfunction and changes in mitochondrial DNA were detected in the blood of these young children with autism," said Geraldine Dawson, Ph.D., Autism Speaks chief science officer. "We look forward to seeing oth
'/>"/>

Contact: Jane E. Rubinstein
jrubinstein@rubenstein.com
212-843-8287
Autism Speaks
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Gene links to anorexia found by Childrens Hospital of Philadelphia researchers
2. Childrens Hospital of Philadelphia collaborates in gene therapy success in an immune disorder
3. Study shows young, unsupervised children most at risk for dog bites
4. Fearless children show less empathy, more aggression
5. Overweight children have different eating patterns than normal weight children
6. Comprehensive nutrition services vital to childrens health
7. OHSU Doernbecher Childrens Hospital conducts second phase of landmark Batten study
8. Center to study effects of plastics chemicals on childrens health
9. Childrens agitation after surgery may be preventable
10. NIH funds Center of Excellence for Molecular Hematology at Cincinnati Childrens
11. Childrens Hospital LA discovers growth factor essential to epicardial cell function
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Children with autism more likely to have mitochondrial defects impacting cellular energy production
(Date:10/15/2014)... VILNIUS, Lithuania , Oct. 15, 2014 /PRNewswire/ ... identification technologies, today announced the availability of the ... . VeriLook Surveillance 3.0 provides real-time biometric face ... multiple high-resolution digital surveillance cameras. The new version ... detects and differentiates people from objects while they ...
(Date:10/14/2014)... have sequenced the house fly genome for the first ... from an insect that thrives in pathogen-rich dung piles ... in the journal Genome Biology , will increase ... how flies quickly adapt to resist insecticides, which could ... (Musca domestica) carry and transmit more than 100 human ...
(Date:10/14/2014)... 2014 – Scientists from The Scripps Research Institute (TSRI) ... of Health (NIH) to lead an investigation of Lassa ... in Africa. The study aims to understand how Lassa ... while others survive the inflection. , "The ultimate ... of how Lassa fever virus causes disease and develop ...
Breaking Biology News(10 mins):VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3House fly genome reveals expanded immune system 2Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
... scientific detective story that uncovers a previously unrecognized ... of air pollutants. Incardona of the National ... from the U.S. government, Canadian government and academia ... Ocean Basins: Emerging Chemical Contaminants and Human Health. ...
... turtles ensnared in tuna nets are a heart-wrenching reminder ... in fisheries science as by-catch, this killing of non-target ... answers. One possible solution, advanced by NSERC grantee ... British Columbia involves digital maps and mathematical analysis to ...
... in the midst of a seething, breathing microbial world. ... from the surface of the human skin, to rainforest ... Despite the powerful and pervasive role of microbes ... a mystery. This is the subject of The Uncharted ...
Cached Biology News:New tool for resolving fisheries conflicts 2Unexplored microbes hold incredible potential for science and industry 2Unexplored microbes hold incredible potential for science and industry 3
(Date:10/18/2014)... The report "1,6-Hexanediol Market by Application and By ... the global market on the basis of its ... such as the key drivers, current trends and ... 81 Market Data Tables and 29 Figures spread ... Market by Application and by Geography - Trends ...
(Date:10/18/2014)... October 18, 2014 The Asian Electronic Medical ... in Asian with analysis and forecast of revenue. The electronic ... grow to $2,328.0 million by 2018, at a CAGR of ... of the Asian Electronic Medical Record (EMR) market, to get ... a glimpse of the segmentation of the market in the ...
(Date:10/18/2014)... The “Global Diagnostic Electrocardiograph (ECG) Market ... (Hospitals, Home/Ambulatory, Research Center, Physician Office, Nursing Homes), ... to 2020” provides a detailed overview of the ... and strategies impacting the global diagnostic ECG market ... revenue and share analysis. , The global diagnostic ...
(Date:10/17/2014)... DE (PRWEB) October 17, 2014 ... among top employers, as published in today’s print ... Science Careers’ annual Top Employers Survey polled employees ... determine the 20 best employers. Rankings were ... were asked to rate their companies on 23 ...
Breaking Biology Technology:1,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 2The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 3The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 4The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 5DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3
... ... , ... August 13, 2009 -- Inc. magazine announced on Wednesday its 2009 Inc. 5000 ranking ... solutions company and a leader in web-database solutions, healthcare intelligence and specialized job boards, ...
... in Teddington have developed imaging technology to be used in ... an impending labour shortage for UK farmers. Annual waste ... can mean up to 100,000 of lost revenue for an ... during research. Falling number of migrant labourers means that healthy ...
... , , OMAHA, Neb., Aug. 12 Transgenomic, ... June 30, 2009. The Company,s financial results are presented in the tables that ... Company reported a net loss of $730,000 or $0.01 per share for the ... per share for the second quarter of 2008. , , ...
Cached Biology Technology:Massachusetts Technology Corporation Named to Inc. 5000 List of Fastest Growing Private Companies 2UK scientists developing intelligent harvesting robot to save farms up to 100,000 a year 2Transgenomic, Inc. Reports Second Quarter 2009 Results 2Transgenomic, Inc. Reports Second Quarter 2009 Results 3Transgenomic, Inc. Reports Second Quarter 2009 Results 4Transgenomic, Inc. Reports Second Quarter 2009 Results 5Transgenomic, Inc. Reports Second Quarter 2009 Results 6Transgenomic, Inc. Reports Second Quarter 2009 Results 7Transgenomic, Inc. Reports Second Quarter 2009 Results 8
... PureLink PCR Purification Kits provide rapid ... enzymes, short-failed PCR products, and salts from ... bind/wash/elute procedure:, provides two Binding Buffer ... bp* , can be performed in either ...
... Zero Blunt TOPO PCR ... fastest and easiest method ... or equal to95%) cloning ... amplified with proofreading thermostable ...
Quartz-Halogen, 100 W, High Intensity...
... System with Gateway™ Technology is designed ... the polyhedrin promoter. The expression cassette ... (bacmid DNA) by site-specific transposition (Tn7) ... recombinant bacmid DNA is then used ...
Biology Products: