Navigation Links
Certain breast cancers have a trait that could be attacked by new therapies
Date:3/27/2013

More than 100 women per day die from breast cancer in the United States. The odds of developing breast cancer increase for women taking hormone replacement therapy to avoid the effects of menopause. New research by University of Missouri scientist Salman Hyder may lead to treatments for breast cancers associated with taking these synthetic hormones. Hyder, along with an international team, found that hormone-therapy-related breast cancer cells have a physical feature that could be attacked by cancer therapies.

"We identified a specific cell membrane protein that blocks cell death in breast cancer cells and allows these cells to grow in response to hormone replacement therapy," said Hyder. "Others have observed an over-abundance of these proteins in a population of breast cancer cells which may explain increased risk of breast cancer in women who consume hormone replacement therapy. Therapies could be developed that would block the activity of these cell membrane proteins, which would make cancer cells more likely to die. The membrane protein is known as PGRMC1."

The proteins identified by Hyder and his colleagues were affected by progestin, one of the hormones given to women to stave off the effects of menopause. Progestin is a synthetic chemical which mimics the hormone progesterone. In hormone replacement therapy, doctors prescribe progestin along with synthetic replicas of the hormone, estrogen.

"Every progestin type that we have tested has negative effects," said Hyder. "A growing body of evidence suggests women should be wary before taking progestin. However, if women take only synthetic estrogens, such as estradiol, it leads to a higher risk of uterine cancer. Hence, the two must be taken together, but even then they seem to still increase cancer risks in post-menopausal women."


'/>"/>

Contact: Tim Wall
walltj@missouri.edu
573-882-3346
University of Missouri-Columbia
Source:Eurekalert

Page: 1

Related biology news :

1. Progesterone may be why pregnant women are more vulnerable to certain infections
2. Mutant champions save imperiled species from almost-certain extinction
3. In an uncertain world, Navy needs science and technology collaboration, chief says
4. TLR1 protein drives immune response to certain food-borne illness in mice
5. NOAA: Gulf of Mexico dead zone predictions feature uncertainty
6. Financial tool considered climate change uncertainty to select land for conservation
7. Signalling pathways meeting targeting the HER/EGFR family: Focus on breast, lung and colorectal cancers
8. Omega-3s inhibit breast cancer tumor growth, study finds
9. Research improving breast cancer treatment by targeting tumor initiating cells
10. Cancer risk for African-American women with benign breast disease factors Wayne State finds
11. Triple-negative breast cancer subtypes identified using microRNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
(Date:3/23/2017)... March 23, 2017 The report "Gesture Recognition and Touchless ... and Geography - Global Forecast to 2022", published by MarketsandMarkets, the market is ... of 29.63% between 2017 and 2022. Continue Reading ... ... ...
(Date:3/20/2017)... , March 20, 2017 At this year,s CeBIT ... -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG stand together ... is this year,s CeBIT partner country. At the largest German biometrics company ... use: fingerprint, face and iris recognition as well as DERMALOG´s multi-biometrics system.   ... ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 22, 2017 , ... A new ... San Diego, California, this August will feature high-level speakers on quantum devices, graphene ... SPIE Optics and Photonics, the largest multidisciplinary optical sciences meeting in North America, ...
(Date:5/23/2017)... ... May 23, 2017 , ... Energetiq Technology, a world ... facility expansion to accommodate its rapid growth. , The renovations at the company’s ... of the existing areas. The expansion includes, a state-of-the-art engineering facility, and a ...
(Date:5/23/2017)... ... ... Bacterial biofilms, surface adherent communities of bacteria that are encased in a ... and catheter infections to gum disease and the rejection of medical implants. Though ... year, there is currently a paucity of means for preventing their formation or treating ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... to re-engineer their control technology again and again. METTLER TOLEDO has released two ... manufacturers. The videos illustrate how integration of the ACT350 into Siemens and Allen ...
Breaking Biology Technology: