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Certain anticancer agents could be harmful to patients with heart disease
Date:6/23/2008

rgy-hungry cells of heart muscle."

The researchers say that the role of hedgehog signaling in the vasculature of the heart means that it could be a target for new drugs that could be used to treat heart disease. Ornitz says the study also suggests that hedgehog signaling could be required to maintain blood vessels elsewhere in the body. That means it could also be uniquely important in the brain, which has a very dense capillary network, and that drugs that increase hedgehog signaling could possibly be useful to treat strokes. Lavine, who has just graduated from the Washington University Medical Scientist Training Program will begin an internal medicine cardiology residency and cardiovascular diseases fellowship. He plans to investigate the contribution of hedgehog signaling in other forms of heart disease such as diabetic cardiovascular disease.


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Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert

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