Navigation Links
Caught in the act: Researchers capture key moments in cell death
Date:2/2/2013

Scientists at the Walter and Eliza Hall Institute have for the first time visualised the molecular changes in a critical cell death protein that force cells to die.

The finding provides important insights into how cell death occurs, and could lead to new classes of medicines that control whether diseased cells live or die.

Cell death, called apoptosis, is important for controlling the number of cells in the body. Defects in cell death have been linked to the development of diseases such as cancer and neurodegenerative conditions. Insufficient cell death can cause cancer by allowing cells to become immortal while excessive cell death of neurons may be a cause of neurodegenerative conditions.

Dr Peter Czabotar, Professor Peter Colman and colleagues in the institute's Structural Biology division, together with Dr Dana Westphal from the institute's Molecular Genetics of Cancer division, made the discovery which is published in the latest edition of the journal Cell.

Dr Czabotar said activation of the protein Bax had long been known to be an important event leading to apoptosis, but until now it was not known how this activation occurred. "One of the key steps in cell death is that holes are punched into a membrane in the cell, the mitochondrial membrane," Dr Czabotar said. "Once this happens the cell is going to go on and die. Bax is responsible for punching the holes in the mitochondrial membrane and visualising its activation brings us a step closer to understanding the mechanics of cell death."

Using the Australian Synchrotron, Dr Czabotar and colleagues were able to obtain detailed three-dimensional images of Bax changing shape as it moved from its inactive to active form. The active form ruptures mitochondrial membranes, removing the cell's energy supply and causing cell death.

"By using the powerful X-ray beams created by the synchrotron, we obtained structures of Bax that were really exciting," Dr Cza
'/>"/>

Contact: Vanessa Solomon
solomon@wehi.edu.au
61-393-452-971
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caught in the act: Researchers capture key moments in cell death
(Date:8/31/2014)... is developing drugs that are highly effective against a ... patient. Such properties are directly related to the 3D ... have a shape that is perfectly complementary to a ... specificity. Publishing in Nature Chemistry , EPFL scientists ... the 3D structure of bioactive peptides and enhance their ...
(Date:8/31/2014)... is available in French . ... just published in the prestigious Nature Neuroscience journal ... Centre of the Douglas Mental Health University Institute and McGill ... circuitry and dynamic mechanisms controlling memory as well of the ... sub-region named the subiculum. , In 2009, they developed ...
(Date:8/29/2014)... how the repeated climatic shifts over the last ... genetic diversity, a team of researchers led by ... Carnaval developed a new biodiversity metric called "phylogeographic ... the genetic variation within species is restricted in ... of biology, and 14 other researchers from institutions ...
Breaking Biology News(10 mins):A new synthetic amino acid for an emerging class of drugs 2A new synthetic amino acid for an emerging class of drugs 3Memory and Alzheimer's: Towards a better comprehension of the dynamic mechanisms 2CCNY team defines new biodiversity metric 2
... published recently in PLoS One delivers new insight ... rattlesnakes may be engaged in an arms race with opossums, ... long been known to eat venomous snakes, this fact has ... of snake venom. Instead, snake venom is usually seen as ...
... see if you can spot the tallest tree. If you,re in ... there are few and far between, and tend to hunch low ... forests make the exercise a bit more difficult. And in the ... the eye can estimate. Knowing how tall trees can grow ...
... the University of Michigan Comprehensive Cancer Center have found that ... encouraging cancer stem cells to grow. Cancer stem cells ... drive its growth and spread. Traditional cancer treatments do not ... In a study published online in the Journal ...
Cached Biology News:Rapid venom evolution in pit vipers may be defensive 2Rapid venom evolution in pit vipers may be defensive 3MIT: The tallest tree in the land 2MIT: The tallest tree in the land 3Cancer stem cells recruit normal stem cells to fuel ovarian cancer, U-M study finds 2
(Date:9/2/2014)... Australia (PRWEB) September 02, 2014 The ... a cure for chronic tinnitus are seeking support for ... on the Indiegogo platform ( http://igg.me/at/tinaway ), was launched ... be a therapeutic ‘mHealth’ app and is based on ... of a team of biomedical and software engineers, Dr. ...
(Date:8/31/2014)... September 01, 2014 Available spectra ... needs for research and cultivation of a wide ... Valoya’s proprietary LEDs with proven patented and pending ... uncompromised light uniformity in critical applications in contrast ... LEDs. , “Our customers have a large variety ...
(Date:8/29/2014)... Electronic circuits are based on electrons, but one of ... photonic circuits, i.e. circuits based on light (photons) instead ... to create a stream of single photons and control ... sorts of attempts to achieve this control, but now ... creating a steady stream of photons emitted one at ...
(Date:8/29/2014)... Local veterinarian, Dr. Keith Clement, and his ... to participate in an investigational study of donor stem ... of this study is to determine if a single ... arthritically affected joints can help reduce pain and inflammation ... current investigational study must be older than nine months, ...
Breaking Biology Technology:tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 2tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 3tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 4tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 5Breakthrough in light sources for new quantum technology 2Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... Therapeutics S.A.,(Alternext: ALEHT), a drug and diagnostic discovery ... the annual shareholders, meeting of the Company, that ... de Vezin,s appointment as,member of the Supervisory Board, ... has reached the age limit defined in the ...
... 29 ,Anesiva, Inc. (Nasdaq: ANSV ) today ... with Green Vision Company, for,several Middle Eastern countries. ... approved in the U.S. to,provide topical local analgesia ... children three to 18 years of age., ...
... barrier technology from Singapore A*STARs Institute of Materials ... organic light emitting diodes (OLEDs) and solar cells ... other technology available in the market, opening up ... , A team of scientists from Singapores Institute ...
Cached Biology Technology:Frederic Desdouits Appointed Member of the Supervisory Board of ExonHit Therapeutics 2Frederic Desdouits Appointed Member of the Supervisory Board of ExonHit Therapeutics 3Anesiva Announces New Zingo Marketing and Distribution Agreement 2Anesiva Announces New Zingo Marketing and Distribution Agreement 3Nanoengineered barrier invented to protect plastic electronics from water degradation 2Nanoengineered barrier invented to protect plastic electronics from water degradation 3Nanoengineered barrier invented to protect plastic electronics from water degradation 4Nanoengineered barrier invented to protect plastic electronics from water degradation 5
... matrix for the extraction of unwanted ... other macromolecules, Applications: ,Reducing octyl glucoside ... interaction of pure β-adrenergic receptor and ... SDS in 6 M urea/0.05 mM ...
Values of steady state parameters for enzyme activities are determined....
... be used for the identification of potential biomarkers ... and other diseases. Due to the fact that ... it provides an attractive alternative to blood plasma ... ProteoSpin Urine Protein Concentration Micro Kit provides ...
... Antibody Capture Kit eliminates ... optimization steps typically required ... This kit enables the ... multiple antigens based on ...
Biology Products: