Navigation Links
Catching the common cold virus genome
Date:3/16/2009

Catching the common cold virus: BYU researchers coming down with the rhinovirus genome

A new study by Brigham Young University researchers on the virus behind nearly half of all cold infections explains how and where evolution occurs in the rhinovirus genome and what this means for possible vaccines.

The study is reported in the April issue of the academic journal Molecular Biology and Evolution.

"There are a lot of different approaches to treating the cold, none of which seem to be effective," said Keith Crandall, professor of biology and co-author of the study. "This is partly because we haven't spent a lot of time studying the virus and its history to see how it's responding to the human immune system and drugs."

The BYU team studied genomic sequences available online and used computer algorithms to estimate how the rhinovirus is related to other viruses.

According to Nicole Lewis-Rogers, a postdoctoral fellow in the Biology Department and lead author on the study, the rhinovirus is similar to the polio virus, whose vaccine was announced in 1955. But while the polio virus has just three subspecies, the rhinovirus has more than 100 subspecies, which continually evolve.

"These viruses could be under the same constraints and yet change differently," Lewis-Rogers said. "That's why it is so hard to create a vaccine."

Through a computer program developed at BYU, Lewis-Rogers' team was able to identify the parts of the virus genome that enable resistance to drugs and the human immune system.

The immune system does a good job of recognizing viral contaminants and getting rid of them, as do new drugs, but the rhinovirus has responded to these defenses by changing its genome so that it is not so easily recognized.

"The virus is evolving solutions against the immune system and drugs," Crandall said. "The more we can learn about how the virus evolves solutions, the better we can rid the body of these infections
'/>"/>

Contact: Michael Smart
michael_smart@byu.edu
801-422-7320
Brigham Young University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Huntingtons disease: catching it early
2. Computer superpower strengthens attempts to combat common diseases
3. Common gene variants increase risk of hypertension, may lead to new therapies
4. New vaccine developed for preventing uncommon cold virus
5. Genetic testing not cost-effective in guiding initial dosing of common blood thinner
6. Common soil mineral degrades the nearly indestructible prion
7. Scientists uncover evolutionary keys to common birth disorders
8. Mayo Clinic: Brain disorder suggests common mechanism may underlie many neurodegenerative diseases
9. Common food additive found to increase risk and speed spread of lung cancer
10. Hairspray is linked to common genital birth defect, says study
11. GUMC researchers hone in on new strategy to treat common infection
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Catching the common cold virus genome
(Date:5/8/2015)... Calif. , May 8, 2015 Synaptics Inc. ... solutions, today announced that members of the executive management team ... Morgan 43rd Annual Technology, Media and Telecom Conference Date: ... Hotel in Boston, MA ... 27, 2015 Time: 2:45pm ET Location: The New York Palace ...
(Date:4/27/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market, announces that its ... the first week of May, 2015 and will be ... Gino Pereira , Chief Executive ... company as Wocket® enters the consumer market. We would ...
(Date:4/17/2015)... 2015 Increasing adoption ... advancement to drive biometric systems market in ... According to a recently released TechSci ... ", biometric systems market in Saudi ... at CAGR of over 22% through 2020. The ...
Breaking Biology News(10 mins):Synaptics to Present at Upcoming Investor Conferences 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3
... Washington, D.C. (October 5, 2010) -- Carbon nanotubes -- ... in diameter -- have many potential uses in nanotechnology, ... of nanotubes depend on their structure, and scientists as ... determined during the initial formation -- or growth -- ...
... BOZEMAN, Mont. -- Montana State University researchers have discovered a ... geothermal vents at the bottom of Yellowstone Lake. A ... in an area where the water is inky black, about ... poisons, the researchers reported in the September issue of Geobiology. ...
... toxic pollution falling onto Puget Sound,s waters has decreased ... below earlier estimates, according to a region-wide study. Despite ... like Tacoma still have the Puget,s Sound,s highest air-deposited ... of Energy,s Pacific Northwest National Laboratory and Texas A&M ...
Cached Biology News:The effects of hydrogen on growing carbon nanotubes 2Montana State team finds rare oasis of life on floor of Yellowstone Lake 2Montana State team finds rare oasis of life on floor of Yellowstone Lake 3Montana State team finds rare oasis of life on floor of Yellowstone Lake 4The sky is falling (less) onto Puget Sound 2The sky is falling (less) onto Puget Sound 3The sky is falling (less) onto Puget Sound 4
(Date:5/28/2015)... MA (PRWEB) May 28, 2015 In ... director, James L. Sherley, M.D., Ph.D., will present the ... medicine. In a conference talk, he will describe ... cell culture designs with computer simulation to produce the ... cell number and quality over time in culture. ...
(Date:5/27/2015)... May 27, 2015 RXi Pharmaceuticals Corporation ... on discovering and developing innovative therapies primarily in ... it has commenced a public offering of shares ... of its common stock and overallotment purchase rights ... shares of common stock, warrants and overallotment purchase ...
(Date:5/27/2015)... The Academy of Model Aeronautics Foundation would like ... Aviation Day. The third annual celebration will be August 15, ... model aviation hobby nation-wide and to introduce model flying to ... chartered clubs to celebrate the hobby and share it with ... will also be a local event at the AMA headquarters ...
(Date:5/27/2015)... May 27, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) ... 31, 2015. Aviv Boim , ... pre-clinical work to generate functional specific antibodies, targeting identified ... we are encouraged by the development progress. We are ... antibodies which modulate immune checkpoints gain clinical acceptance for ...
Breaking Biology Technology:Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 2Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 3RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 3Academy of Model Aeronautics Foundation to host National Model Aviation Day Motorcycle Rally and Family Fest in Muncie, IN 2Academy of Model Aeronautics Foundation to host National Model Aviation Day Motorcycle Rally and Family Fest in Muncie, IN 3Tikcro Technologies Reports First Quarter 2015 Results 2Tikcro Technologies Reports First Quarter 2015 Results 3
... OREX ), a biopharmaceutical company focused on ... Patent and Trademark Office,(USPTO) has issued a patent for ... (U.S. Patent No. 7,462,626), which provides,coverage for Contrave(R), the ... trials. , The patent broadly ...
... BELGIUM, Wis., Jan. 5 Mach One Corporation,(Pink Sheets: ... a positive long term benefit to the agricultural and ... non-binding letter of,intent dated December 30, 2008 related to ... BioPharm) (the "Seller" or "BioPharm") to,acquire all of the ...
... of Norton & Associates with Divisions in NORTECH ... Carbon Credit Today. The group,s announcement of a ... private equity land investments and the acquisition funding ... commercial market conditions, Norton & Associates Inc. provides ...
Cached Biology Technology:Orexigen(R) Therapeutics Issued a Key Fourth U.S. Patent on Contrave(R) 2Orexigen(R) Therapeutics Issued a Key Fourth U.S. Patent on Contrave(R) 3Mach One Corporation Enters Letter of Intent 2Norton & Associates Inc. Adds $3bnUSD Commercial Real Estate Investment P & L Management Holding Group; US Property Portfolio Inc. 2
... High Throughput Processing of Microarrays Using ... ,FAST Frame multiple slide plate is designed ... the corresponding multi-well incubation chambers in a ... microarrays. The footprint dimensions meet the standards ...
... ProXPRESS 2D Proteomic Imaging System, Professional Package ... a Wide Dynamic Range: The ProXPRESS 2D ... in imaging system for both proteomic and ... provides unparalleled flexibility, enabling the use of ...
... Blot includes 7 ... isolated from Alzheimer's-diseased brain ... postcentral gyrus, frontal lobe, ... occipital lobe and cerebellum. ...
... Progenitors, Rabbit, and media. Cryo-preserved cells in ... at passage 25 (approx), supplied with kit ... is supplied as a long-term culture, and ... months of continuous growth from the date ...
Biology Products: