Navigation Links
Cat and mouse: A single gene matters
Date:4/29/2013

When a mouse smells a cat, it instinctively avoids the feline or risks becoming dinner. How? A Northwestern University study involving olfactory receptors, which underlie the sense of smell, provides evidence that a single gene is necessary for the behavior.

A research team led by neurobiologist Thomas Bozza has shown that removing one olfactory receptor from mice can have a profound effect on their behavior. The gene, called TAAR4, encodes a receptor that responds to a chemical that is enriched in the urine of carnivores. While normal mice innately avoid the scent marks of predators, mice lacking the TAAR4 receptor do not.

The study, published April 28 in the journal Nature, reveals something new about our sense of smell: individual genes matter.

Unlike our sense of vision, much less is known about how sensory receptors contribute to the perception of smells. Color vision is generated by the cooperative action of three light-sensitive receptors found in sensory neurons in the eye. People with mutations in even one of these receptors experience color blindness.

"It is easy to understand how each of the three color receptors is important and maintained during evolution," said Bozza, an author of the paper, "but the olfactory system is much more complex."

In contrast to the three color receptors, humans have 380 olfactory receptor genes, while mice have more than 1,000. Common smells like the fragrance of coffee and perfumes typically activate many receptors.

"The general consensus in the field is that removing a single olfactory receptor gene would not have a significant effect on odor perception," said Bozza, an assistant professor of neurobiology in the Weinberg College of Arts and Sciences.

Bozza and his colleagues tested this assumption by genetically removing a specific subset of olfactory receptors called trace amine-associated receptors, or TAARs, in mice. Mice have 15 TAARs. One is
'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Dartmouth researchers find there is no single sexy chin
2. Sleator lab identifies single point mutation in Listeria monocytogenes
3. Single gene might explain dramatic differences among people with schizophrenia
4. Extremely high estrogen levels may underlie complications of single-birth IVF pregnancies
5. Little did we know about beetle diversity: Astonishing 138 new species in a single genus
6. Light-emitting bioprobe fits in a single cell
7. They hunt, they kill, they cheat: Single-celled algae shed light on social lives of microbes
8. NIH awards Penn scientists $10 million over 5 years for innovative research on single cells
9. Single protein targeted as the root biological cause of several childhood psychiatric disorders
10. New study reveals that every single junk food meal damages your arteries
11. Columbia researchers report novel approach for single molecule electronic DNA sequencing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... -- According to a new market research ... Emotion, Forensic), by Software (Middleware, Databases), by Hardware (Cameras, Integrated ... Home) - Global Forecast to 2020", published by MarketsandMarkets, ... 2015 to $6.19 Billion by 2020, at a CAGR ... Tables and   43 Figures spread through 140 Pages ...
(Date:5/20/2015)... 2015 Research ... the addition of the  "5-year Opportunity ... Market"  report to their offering.  ,     ... analyses trends in the iris recognition ... sectors, globally. Despite hardware pricing and ...
(Date:5/19/2015)...  Technology is rapidly advancing, outpacing enterprises, ability to ... Passwords and their management are soon to be rendered ... such as those developed by the FIDO Alliance™. With ... for BYOD, COPE, IoT, and mobile payments, the interconnected ... In response to the call for seamless, ...
Breaking Biology News(10 mins):Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3
... to wonder how a fruit fly is able to locate ... summer evening, especially since its flight path seems to be ... Andy Reynolds at Rothamsted Research in the United Kingdom have ... their environment using a series of straight flight paths punctuated ...
... unique protein from jellyfish that could be inserted into ... them to radiate a brilliant green color. This green ... new discoveries regarding how living cells function. But one ... plants harbor tough cell walls and enormous subcellular ...
... the University of East Anglia have discovered exactly what makes ... The age-old mystery was unlocked thanks to some novel bacteria ... Johnston and his team at UEA isolated this microbe from ... single gene responsible for the emission of the strong-smelling gas, ...
Cached Biology News:Flies don't buzz about aimlessly! 2Cloning the smell of the seaside 2
(Date:5/27/2015)... The Medical Innovation Impact Index (MI3), a ... medical innovation, has been developed at the Initiative ... University’s ( FDU ) Rothman Institute of Innovation and ... new FDA (Food & Drug Administration) draft guidance documents ... certain medical devices. , “The main impediment to ...
(Date:5/26/2015)... May 26, 2015 Innovacyn, a ... in the human and animal health industries, announced ... Future Innovators of Agriculture College Scholarship Award. The ... who exhibits a passionate commitment to the agriculture ... This year’s winners, Alexis Pedrow from Anderson County ...
(Date:5/26/2015)... 26, 2015  Alere Inc. (NYSE: ALR ) (the ... to timely file its Quarterly Report on Form 10-Q for ... it has received a notice from the New York Stock ... with the NYSE,s continued listing requirements under the timely filing ... Manual. The reason for the delay relates ...
(Date:5/26/2015)...  A simple blood test developed at the University ... Alzheimer,s disease is a step closer to being used ... that are needed before a blood test could be ... & Dementia . The guidelines establish protocols and reflect ... includes UNT Health Science Center. "If we ...
Breaking Biology Technology:Medical Innovation Impact Index Launched at Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) under the Rothman Institute 2Innovacyn Announces Winners Of This Year’s Vetericyn® College Scholarship Award 2Innovacyn Announces Winners Of This Year’s Vetericyn® College Scholarship Award 3Guidelines bring UNT Health Science Center's blood test for Alzheimer's one step closer 2
... 1 Sidec announces the first,Protein Tomography(TM) ... This Award,is set up to enable research ... yet collaborated with Sidec on a Protein ... technology successfully used in,cancer drug research., ...
... Highlights 140 Doctors Changing the Face of ... ... of BLACK ENTERPRISE (BE),unveils its 2008 report on the best and brightest ... millions of lives through the revolutionary treatment of,diseases, from cancer and diabetes ...
... CryoLife, Inc., (NYSE: CRY ) a,biomaterials, ... Harvey Morgan has been elected to the Company,s ... Managing Director at Bentley,Associates L.P., an investment banking ... years of investment banking experience with,significant expertise in ...
Cached Biology Technology:Sidec Announces the First Protein Tomography(TM) Award at Sidec's Executive Forum at PEGS 2Black Enterprise Unveils America's Leading Doctors 2Black Enterprise Unveils America's Leading Doctors 3Harvey Morgan Joins CryoLife Board of Directors 2
Superior homology search software - in all the flavours of blast, with increased sensitivity and speed...
Protein 3D structure prediction, via threading. Easy to use....
... (3 per pack), 1. One ... processing.Automated staining of Coomassie Blue or ... acid analysis.Prepares blots for high sensitivity ... of protocol, solution, volume, and processing ...
DITHIOTHREITOL, 150UMOL, 1 EA. Dithiothreitol (DTT), 0.1 M Solution:, *0.1 M solution of DTT in high purity dH2O., *0.2 m filtered., *Storage: -20C. Category: SEQUENASE....
Biology Products: