Navigation Links
Carnegie Mellon researchers develop artificial cells to study molecular crowding and gene expression
Date:7/14/2013

t from a crowd of people, Tan said. If only a few people are in a room, it's easy for people to mingle, or even to become isolated. But in a crowded room where it's hard to move around, individuals will often tend to stay close to each other for extended periods. The same thing happens in a cell. If the intracellular space is crowded, binding between molecules increases.

Notably, the researchers found that the dense environments also made gene transcription less sensitive to environmental changes. When the researchers altered concentrations of magnesium, ammonium and spermidine chemicals that modulate the stability and binding of macromolecules they found higher perturbations of gene expression in low density environments than in high density environments.

"Artificial cellular systems have tremendous potential for applications in drug delivery, bioremediation and cellular computing," Tan said. "Our findings underscore how scientists could harness functioning mechanisms of natural cells to their advantage to control these synthetic cellular systems, as well as in hybrid systems that combine synthetic materials and natural cells."


'/>"/>

Contact: Byron Spice
bspice@cs.cmu.edu
412-268-9068
Carnegie Mellon University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Keck award enables Carnegie Mellon and Stanford to dramatically expand crowdsourced RNA design
2. Carnegies Greg Asner named Energy/Climate Fellow by US State Department
3. Carnegie Mellon fluorescent biosensor reveals mechanism critical to immune system amplification
4. Carnegies Wolf B. Frommer receives Bogorad Award for Excellence in Plant Biology
5. Carnegie Mellon Universitys Biometrics Center Selected To House New Pedo-Biometrics Research and Identity Automation Lab
6. Carnegie Mellon study shows skin-aging radicals age naturally formed particles in the air
7. Carnegies Donald Brown wins Lasker-Koshland Award
8. Carnegie Institution for Science receives Grand Challenges Explorations grant
9. Carnegie debuts revolutionary biosphere mapping capability at AGU
10. Carnegies Greg Asner elected to National Academy of Sciences
11. Carnegie Mellon neuroscientists discover new phase of synaptic development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... Sweden , July 2, 2015 ... sensors FPC1025, FPC1035, FPC1145 and FPC1155 from the distributor World ... one of FPC,s distributors in Asia . ... 2015. The sensors will be used by smartphone manufacturers in ... MSEK is included in the communicated revenue guidance of approximately ...
(Date:6/30/2015)... Pa. , June 30, 2015 ... the company as CEO to help further develop Genisphere,s ... wealth of partnering experience, having spent much of the ... including Therakine, Amgen, Baxter Bioscience, and Johnson & Johnson. ... focus on Technology and Biotech Corporate Finance. He graduated ...
(Date:6/26/2015)... -- ATL Technology, LLC, a top provider of electromechanical contract ... solutions, headquartered in Springville, Utah , has ... corporation with locations in Santa Clara, ... ). This acquisition will incorporate MedConx,s manufacturing ... Technology,s existing facility in Costa Rica , ...
Breaking Biology News(10 mins):FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2
... smallest species of snake, with adults averaging just under four ... of Barbados. The species -- which is as thin ... on a U.S. quarter --was discovered by Blair Hedges, an ... also are the discoverers of the world,s smallest frog and ...
... history of science and technology, there is an ... developments converge that make it possible to recognize ... biomechanics and astrobiology with more recent developments of ... now well established in the lexicon of modern ...
... neuroradiologists and neurologists of the University hospitals of Heidelberg ... damage, most of which had remained unrecognized up to ... Gadofluorine M, in magnetic resonance imaging. The scientists have ... renowned medical journal Brain . In ...
Cached Biology News:World's smallest snake found in Barbados 2World's smallest snake found in Barbados 3The emerging scientific discipline of aeroecology 2Multiple Sclerosis: new MRI contrast medium enables early diagnosis in animal model 2
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... ... of benzene. Benzene is processed to get such derivatives as ethylbenzene, a precursor ... are principally used within the automotive industry for the production of tyres and ...
(Date:8/3/2015)... , ... August 03, 2015 , ... Nine field days ... Illinois and Indiana. Hosted by the Soil Health Partnership , the field days ... environmental benefits while potentially increasing farm productivity and income. , Brent Bible has practiced ...
(Date:8/3/2015)... E-QURE Corp. (OTCQB: EQUR), a ... Signal Therapy device ("BST Device"), a new and novel ... chronic wounds, today announced that the Company has signed ... specializing in medical devices, for the marketing and distribution ... 70 years old, sales, marketing and distribution company in ...
(Date:8/3/2015)... 3, 2015 According to a ... Cell Culture: Asia to Witness ... the global 3D cell culture market was valued at US$ 586.1 ... a CAGR of 29.1% to account for US$ 2,717.6 ... TOC:  http://www.persistencemarketresearch.com/market-research/3d-cell-cultures-market.asp 3D cell culture refers ...
Breaking Biology Technology:World Benzene Market to Surpass 46 MMT by 2020, According to TechSci Research Report Published at MarketPublishers.com 2World Benzene Market to Surpass 46 MMT by 2020, According to TechSci Research Report Published at MarketPublishers.com 3Soil Health Field Days Kick Off Throughout Midwest 2Soil Health Field Days Kick Off Throughout Midwest 3E-QURE Corp Signs Second Distribution Agreement in Israel 2E-QURE Corp Signs Second Distribution Agreement in Israel 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 2Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 4
... today are WWWno further explanation is required , ,There are ... alphabet, W, as in WWI or WWII, and ... the WWF and WWF. The match between the World Wildlife ... losing to cuddly pandas, and the wrestlers became the WWE, ...
... manufacturing company: time or money? , ,At the University ... down the time it takes to get products developed and ... and end up with more you guessed it ... Rath, associate director of the center, said at a seminar ...
... more. MADISON, Wis. My UW Madison the ... faculty for online organizational and scheduling tasksis migrating to ... project, Arizona-based Unicon, was also announced. , ,The migration, ... complete by August 2005. According to Brian Rust, spokesman ...
Cached Biology Technology:The global power of WWW 2The global power of WWW 3University center offers speed boost to manufacturers 2"My UW Madison" portal migrating to uPortal 2
... are custom designed to meet your needs. ... 8,455 features per array (2 arrays/1" x ... array (1 array/slide). Features ... - This extended length delivers higher sensitivity ...
... for pathway studies, protein-protein interaction studies, ... built on the flexible and powerful ... microarrays are available as part of ... Custom Probe Content ...
... human adult normal Mega Western Protein Array ... The Mega Western Protein Arrays are manufactured ... documented tissue sources. A protein sample from ... along with a Protein molecular weight marker ...
... ProXPRESS 2D Multi-User Applications Package ... Wide Dynamic Range: The ProXPRESS 2D Proteomic ... system for both proteomic and general life ... flexibility, enabling the use of all dyes ...
Biology Products: