Navigation Links
Carnegie Mellon researchers develop artificial cells to study molecular crowding and gene expression
Date:7/14/2013

t from a crowd of people, Tan said. If only a few people are in a room, it's easy for people to mingle, or even to become isolated. But in a crowded room where it's hard to move around, individuals will often tend to stay close to each other for extended periods. The same thing happens in a cell. If the intracellular space is crowded, binding between molecules increases.

Notably, the researchers found that the dense environments also made gene transcription less sensitive to environmental changes. When the researchers altered concentrations of magnesium, ammonium and spermidine chemicals that modulate the stability and binding of macromolecules they found higher perturbations of gene expression in low density environments than in high density environments.

"Artificial cellular systems have tremendous potential for applications in drug delivery, bioremediation and cellular computing," Tan said. "Our findings underscore how scientists could harness functioning mechanisms of natural cells to their advantage to control these synthetic cellular systems, as well as in hybrid systems that combine synthetic materials and natural cells."


'/>"/>

Contact: Byron Spice
bspice@cs.cmu.edu
412-268-9068
Carnegie Mellon University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Keck award enables Carnegie Mellon and Stanford to dramatically expand crowdsourced RNA design
2. Carnegies Greg Asner named Energy/Climate Fellow by US State Department
3. Carnegie Mellon fluorescent biosensor reveals mechanism critical to immune system amplification
4. Carnegies Wolf B. Frommer receives Bogorad Award for Excellence in Plant Biology
5. Carnegie Mellon Universitys Biometrics Center Selected To House New Pedo-Biometrics Research and Identity Automation Lab
6. Carnegie Mellon study shows skin-aging radicals age naturally formed particles in the air
7. Carnegies Donald Brown wins Lasker-Koshland Award
8. Carnegie Institution for Science receives Grand Challenges Explorations grant
9. Carnegie debuts revolutionary biosphere mapping capability at AGU
10. Carnegies Greg Asner elected to National Academy of Sciences
11. Carnegie Mellon neuroscientists discover new phase of synaptic development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... read quickly. It involves visual searching for clues ... sentences. Similarly to humans, biological systems are sometimes ... Genes that need to be read quickly are ... the easier it will be to read them ... (IGC, Portugal) and Centre for Molecular and Structural ...
(Date:4/22/2014)... team of Yale researchers will lead a five-year, $3 ... rain events is affecting the transport of dissolved organic ... they say could alter the chemical composition and water ... With funding from the National Science Foundation,s MacroSystems Biology ... across the watershed, which begins in Canada and runs ...
(Date:4/22/2014)... Consortium Ltd.,s nanotechnology expert will present a poster ... at the 7th International Nanotoxicology Congress to ... , Dr. Monita Sharma will outline a strategy consistent ... of Sciences, " Toxicity Testing in the 21st Century: ... of non-animal methods involving human cells and cell lines ...
Breaking Biology News(10 mins):Cell division speed influences gene architecture 2Connecticut River watershed study will assess impacts of extreme rain events 2Connecticut River watershed study will assess impacts of extreme rain events 3
... SPRING HARBOR, N.Y. A new book, ... CSHL,s mix of historic and modern buildings and the striking ... preservationist and tree enthusiast Elizabeth L. Watson, who, together with ... in various homes on the picturesque grounds of CSHL for ...
... ARGONNE, Ill. (June 9, 2008) The Institute for Genomics ... Department of Energy,s (DOE) Argonne National Laboratory and the University ... enhanced ability to sequence genomes more quickly and broadly. ... by searching only on the fairway, but not the rough," ...
... HARBOR, N.Y. The appointment of James Watson ... set off an explosive development of research at Cold ... wisely teams of investigators with diverse scientific interests. ... by the scientists involved tell the stories of research ...
Cached Biology News:Argonne-University of Chicago joint venture bolsters genomic sequencing capabilities 2Watson-inspired innovation in research at Cold Spring Harbor Laboratory 2
(Date:1/14/2014)... Boston, MA (PRWEB) January 14, 2014 iLab ... Michelle Detwiler as the new Director of Product Strategy. In ... as well as iLab sub-teams to guide in the development ... that iLab provides the maximum possible benefit to the scientific ...
(Date:1/14/2014)... Rockville, MD (PRWEB) January 14, 2014 ... dedicated to developing innovative information technology solutions for ... other health care stakeholders, announced today the signing ... the US Food and Drug Administration (FDA). ...
(Date:1/14/2014)... 14, 2014 Kerr Corporation, a leading manufacturer ... additional how-to information about dual arch impressions on its dental ... Arch Impressions,” the blog entry serves up a list of ... a step-by-step demonstration by Dr. David Little as he crafts ...
(Date:1/14/2014)... Research Triangle Park, NC (PRWEB) January 14, 2014 ... diagnostic company focusing on ultra-sensitive POC diagnostic platforms and novel ... on their first round of financing netting a total of ... first outside equity capital in the company. This group of ...
Breaking Biology Technology:iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2BioMedomics, Inc. Closes $690K Round of Financing 2
... ancient and proud history of interstate sports rivalries (especially ... this past New Years Day, the rivalry generates nasty ... marijuana have in common? They both get smoked in ... another interstate rivalry. This one is of keen interest ...
... -RedPrairie announced Wednesday it will support American Musical ... of supply chain execution solutions. AMS , ... a customer distribution network next year and develop ... and enterprise vision products. , ,AMS was ...
... a calm before the storm. The plans are set, the ... spent in quiet preparations by a group of outstanding companies ... producer of the event, I'm bound by the rules that ... at the conference on February 15. And as DEMO has ...
Cached Biology Technology:For Now, Michigan Can Celebrate $150 Million Entrepreneurial VC Fund 2For Now, Michigan Can Celebrate $150 Million Entrepreneurial VC Fund 3For Now, Michigan Can Celebrate $150 Million Entrepreneurial VC Fund 4The Calm Before the Storm: Hot New Firms and Technologies 2The Calm Before the Storm: Hot New Firms and Technologies 3
... Yeast ProtoArray high-density functional protein microarray is ... elucidation of proteinprotein interactions on a proteome ... cerevisiae open reading frames (ORFs) expressed as ... on a 1 inch x 3 inch ...
... is a compact, versatile system that simultaneously ... or 24-well microplates into a solid filter ... scintillation and gamma counter. The FilterMate is ... applications such as cell proliferation, receptor binding, ...
... Corning single use spatulas have been designed ... They are for those interested in eliminating ... spatulas. Each spatula is individually packaged, RNase/DNase ... number is a new product number, created ...
... Competitor Assay Kits are ideal for ... binding compounds using fluorescence polarization (FP) ... of glutathione transferase to the ligand ... [PR-LBD(GST)] and a proprietary, fluorescently-tagged progesterone ...
Biology Products: