Navigation Links
Cancer scientists link ‘oncometabolite’ to onset of acute myeloid leukemia
Date:7/4/2012

(TORONTO, July 4, 2012) A team of international scientists led by principal investigator Dr. Tak Mak at the Princess Margaret Cancer Centre, University Health Network, has identified a causative link between the product of a mutated metabolic enzyme and the onset of acute myeloid leukemia (AML), one of the most common types of leukemia in adults.

Called an "oncometabolite" for its role in cancer metabolism, the metabolite2-hydroxyglutarate (2HG) is a by-product of a gene mutation of an enzyme known as isocitrate dehydrogenase (IDH).

Says Dr. Tak Mak of the findings published today in Nature: "For the first time, we have demonstrated how a metabolite can cause cancer. This sets the stage for developing inhibitors to block the mutation and prevent the production of this disease-initiating enzyme." The research team included scientists at Weill Cornell Medical College, New York City, and Agios Pharmaceuticals, Cambridge, Massachusetts.

Dr. Mak, Director, The Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital, is an internationally acclaimed immunologist renowned for his 1984 discovery of cloning the human T-cell receptor. He is also Professor, University of Toronto, in the Departments of Medical Biophysics and Immunology.

The connection between cancer and metabolism has fascinated scientists at Agios and Dr. Mak, who were the first to identify the oncometabolite in research published in Nature (2009) and The Journal of Experimental Medicine (2010). The IDH gene mutation was initially discovered in brain cancers in 2008 by American scientists at Johns Hopkins in Baltimore and subsequently also linked to leukemia.

In the lab, Dr. Mak's team genetically engineered a mouse model with the mutation in its blood system to mimic human AML. They discovered that the gene mutation launches the perfect storm for the oncometabolite to trigger the blood system to increase the stem cells p
'/>"/>

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network
Source:Eurekalert

Page: 1 2

Related biology news :

1. The genomics symposium to boost the further development of cancer research
2. Study identifies pathway to enhance usefulness of EGFR inhibitors in lung cancer treatment
3. Regulation of telomerase in stem cells and cancer cells
4. 5th Latin American Conference on Lung Cancer
5. Husband-wife team set out to improve breast cancer exams
6. Double the pain: RUB biologists find the cause of pain in the treatment of fair skin cancer
7. A new indicator for breast cancer relapse identified
8. UCLA scientists discover how key enzyme involved in aging, cancer assembles
9. Researchers identify need to sample multiple tumor zones in breast cancer
10. Groundbreaking discovery of the cellular origin of cervical cancer
11. UC Davis scientists find new role for P53 genetic mutation -- initiation of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... to create colors, nature had already perfected the process ... hues, for example. Now scientists are tapping into those ... make colored plastics. Their paper on using structure ... than dyes, to produce color appears in the ACS ... Anders Kristensen and colleagues point out that currently, plastic ...
(Date:7/30/2014)... Steven Chown has been awarded the Scientific Committee ... in Antarctic Research. , SCAR, an inter-disciplinary international ... international scientific research in the Antarctic region, and ... the Earth system. The organisation also provides scientific ... responsible for governing the region. , The medal ...
(Date:7/30/2014)... pieces is still in its infant stage. But it ... major significance. "Amazingly often, we are findingin addition to ... we found in Baltic amber," explained Bonn paleontologist Professor ... from the Baltic Sea region, which is almost 10,000 ... the coastal regions of Mecklenburg, Poland and Belarus. The ...
Breaking Biology News(10 mins):Chinese mosquitos on the Baltic Sea 2
... Today, the Nankai Trough Seismogenic Zone Experiment (NanTroSEIZE) gets ... Shingu Port with scientists aboard, all ready to log, ... the most active earthquake zones on Earth. The vessel,s ... drilling expeditions that will retrieve geological samples and provide ...
... led by the Smithsonian Institution has completed a new ... hobbit, a 3-foot-tall, 18,000-year-old hominin skeleton, discovered four years ... offers one of the most striking confirmations of the ... of one of the oldest human migrations to Asia. ...
... recently discovered that a chemical chain reaction that controls ... could mean the difference between normal growth and cancer. ... Cell, describes how organs can grow uncontrollably huge and ... This chain reaction, a domino-like chain of events ...
Cached Biology News:Scientists launch deep-sea scientific drilling program to study volatile earthquake zone 2Scientists launch deep-sea scientific drilling program to study volatile earthquake zone 3Scientists launch deep-sea scientific drilling program to study volatile earthquake zone 4New research sheds light on 'Hobbit' 2Controlling for size may also prevent cancer 2
(Date:7/30/2014)... July 30, 2014 Researchers often use ... biology, but such devices can do much more ... As such, researchers have looked to patterned assemblies ... metabolic engineering to characterize – and potentially ... devices are envisioned to recreate animal and human ...
(Date:7/30/2014)... 2014  AtheroNova Inc. (OTCBB: AHRO), a biotech ... compounds to safely regress atherosclerotic plaque and improve ... partner, CardioNova, has accomplished first dosing of subjects ... lead compound, AHRO-001.  This Phase 1b trial will ... safety trial completed in February 2014, in which ...
(Date:7/30/2014)... NCERC at Southern Illinois University ... findings on corn stover pretreatment methods at a ... Washington, D.C. , “Arun’s selection for presentation ... testament to the success of our postdoctoral fellowship ... the foresight and vision of SIUE and the ...
(Date:7/30/2014)... 30, 2014 Vala Sciences was ... Environmental Protection Agency (EPA). This new contract was ... models, including tests designed to assess the effect ... formation of connections between neurons (synapses), which are ... synapse formation by environmental pollutants likely contributes to ...
Breaking Biology Technology:UMD Researchers Bridge Gap between Microelectronics, Biological Systems 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 3UMD Researchers Bridge Gap between Microelectronics, Biological Systems 4AtheroNova Announces Milestone with Initiation of Phase 1b Clinical Trial of AHRO-001 2AtheroNova Announces Milestone with Initiation of Phase 1b Clinical Trial of AHRO-001 3AtheroNova Announces Milestone with Initiation of Phase 1b Clinical Trial of AHRO-001 4NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 2NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 3U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 2U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 3
... Group of representatives,from seven international health-care organizations call ... patients with hypertension, the single,most important cause of ... working group to identify 5 specific concrete practical ... of the Journal of Human,Hypertension(1): Detect and Prevent ...
... Research Will Create Jobs, Attract ... ... government is providing $150,million through the Next Generation Jobs Fund to ... John Wilkinson has announced., "Attracting these investments will create good-paying ...
... Portfolio, - Conference Call Scheduled for 5 February 2008, ... ... BRISBANE, Australia, Feb. 4 Progen,Pharmaceuticals Limited (ASX: PGL; ... Agreement to acquire privately-held U.S.,oncology company CellGate, Inc. The CellGate ...
Cached Biology Technology:Experts and Representatives From Leading International Health-Care Organizations Call to Stop the Hypertension Pandemic, a Worldwide Silent Killer 2Experts and Representatives From Leading International Health-Care Organizations Call to Stop the Hypertension Pandemic, a Worldwide Silent Killer 3Experts and Representatives From Leading International Health-Care Organizations Call to Stop the Hypertension Pandemic, a Worldwide Silent Killer 4Experts and Representatives From Leading International Health-Care Organizations Call to Stop the Hypertension Pandemic, a Worldwide Silent Killer 5Sparking Growth In Ontario's Biopharmaceutical Industry 2Sparking Growth In Ontario's Biopharmaceutical Industry 3Progen Expands Drug Development Pipeline Through Acquisition of CellGate 2Progen Expands Drug Development Pipeline Through Acquisition of CellGate 3Progen Expands Drug Development Pipeline Through Acquisition of CellGate 4Progen Expands Drug Development Pipeline Through Acquisition of CellGate 5
...
... Rabbit Antibody to CRF ... with the ovine CRF sequence ... Cells and fibres are found ... of rat brain in colchicine ...
...
Alexa Fluor 647 anti-mouse Qa-2...
Biology Products: