Navigation Links
Cancer risk for African-American women with benign breast disease factors Wayne State finds
Date:2/11/2013

DETROIT A Wayne State University researcher has identified characteristics in benign breast disease associated with future cancer risk in African-American women.

Michele Cote, Ph.D., associate professor of oncology in the School of Medicine and the Barbara Ann Karmanos Cancer Institute, recently reviewed data from about 1,400 20- to 84-year-old African-American women who underwent breast biopsies between 1997 and 2000. Researchers identified biopsies that showed benign breast disease (BBD) and also tracked subsequent breast cancers.

BBD is an established risk factor for breast cancer among Caucasian women, Cote said, but less is known about it in African-American women, who tend to get breast cancer earlier, in more aggressive forms and die more frequently from it.

In "Benign Breast Disease and the Risk of Subsequent Breast Cancer in African American Women," published recently in the journal Cancer Prevention Research, she said 68 percent of women studied showed nonproliferative BBD, and 29 percent had the proliferative form of the disease without atypia, a state in which cells are not growing normally but are not cancerous.

The remaining 3 percent showed proliferative BBD with atypia, a percentage similar to a group of Caucasian women studied recently by the Mayo Clinic. Women in Cote's study with the proliferative form of the disease with atypia were three times as likely to develop breast cancer as women without proliferative disease.

A number of pathological characteristics are associated with BBD and breast cancer. Her group examined several of those, including the presence of cysts, fibrosis and atrophy of breast components, known clinically as lobular involution.

Another characteristic, columnar alteration, a variation in the way cells are structured, was shown to be associated with increased breast cancer risk. Cote said because columnar alterations are highly correlated with proliferative disease, further study of the independent effects of both could be valuable.

Her team wanted to see if characteristics Mayo researchers found in white women increase or decrease risk in the same ways in black women.

"Hopefully, this eventually means the risk models that will be developed will be similar if not identical for white and black women, which simplifies usage," Cote said. "The question is, what are those pathological features that actually increase risk, because not all benign biopsies are the same."

She said her study marks a successful collaboration between Wayne State, Karmanos and the Mayo Clinic that helps identify those at greatest risk for breast cancer and lays the groundwork for studying additional pathological characteristics.

"Better characterization of the risk of breast cancer among women with BBD, considering both ethnicity and detailed molecular findings, can lead to better surveillance, earlier diagnosis and, potentially, improved survival," Cote said.

Cote received funding in 2012 from Susan G. Komen for the Cure to continue her research in the Detroit area on benign breast disease and the risk of breast cancer in African-American women.


'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert  

Related biology news :

1. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
2. Embryonic development protein active in cancer growth
3. BRG1 mutations confer resistance to hormones in lung cancer
4. Genetic variation in East Asians found to explain resistance to cancer drugs
5. Beyond the microscope: Identifying specific cancers using molecular analysis
6. Marshall University study may lead to new treatments for prostate cancer
7. Salk scientists open new window into how cancers override cellular growth controls
8. Penn research points to new way of preserving fertility for boys undergoing cancer treatment
9. Genetic abnormality offers diagnostic hope for childrens cancer
10. Protein jailbreak helps breast cancer cells live
11. Breast cancer risk gene discovery fast tracked by new technology
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer risk for African-American women with benign breast disease factors Wayne State finds
(Date:4/14/2016)... 14, 2016 BioCatch ™, ... today announced the appointment of Eyal Goldwerger ... Goldwerger,s leadership appointment comes at a time ... the deployment of its platform at several of the ... which discerns unique cognitive and physiological factors, is a ...
(Date:3/31/2016)... 2016  Genomics firm Nabsys has completed a financial ... Bready , M.D., who returned to the company in ... leadership team, including Chief Technology Officer, John Oliver ... Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys from ...
(Date:3/22/2016)... 2016 According to ... for Consumer Industry by Type (Image, Motion, Pressure, ... & IT, Entertainment, Home Appliances, & Wearable ... 2022", published by MarketsandMarkets, the market for ... USD 26.76 Billion by 2022, at a ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... While the ... such as the Cary 5000 and the 6000i models are higher end machines that ... the height of the spectrophotometer’s light beam from the bottom of the cuvette holder. ...
(Date:6/23/2016)... , June 23, 2016   Boston Biomedical ... novel compounds designed to target cancer stemness pathways, ... been granted Orphan Drug Designation from the U.S. ... of gastric cancer, including gastroesophageal junction (GEJ) cancer. ... designed to inhibit cancer stemness pathways by targeting ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... and Mold) microbial test has received AOAC Research Institute approval 061601. , “This ... introduced last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. ...
Breaking Biology Technology: