Navigation Links
Cancer-causing gene discovery suggests new therapies
Date:1/23/2009

Scientists have discovered a novel way by which a much-studied cancer-promoting gene accelerates the disease. The finding suggests a new strategy to halt cancer's progress.

Up to now, research has largely focused on how the mutated gene, Myc, disrupts the ability of DNA to be "transcribed" into RNA the first step in making proteins that are essential for cell growth and function. But the new research shows that this altered Myc gene, called an oncogene, can also act directly on the final stage of protein production.

The finding in mice suggests that drugs already available to counter this increased protein production could slow or stop cancer's runaway growth induced by Myc. Rapamycin, for example, an immunosuppressant drug already in clinical trials for cancer, might help treat cancers where Myc is over active, the scientists suggest.

The discovery was led by Davide Ruggero, PhD, and Maria Barna, PhD, faculty scientists at the University of California San Francisco (UCSF).

Study findings were published in the journal "Nature" (December 18, 2008).

"Control of protein production rapidly affects cell behavior, and in a robust manner," explains Ruggero, assistant professor of urology at the UCSF Helen Diller Family Comprehensive Cancer Center and co-senior author on the paper with Barna. "The ability of the Myc oncogene to directly alter this process may well explain the rapid progression of cancer formation."

Scientists have known for some time that when the Myc gene is mutated and becomes an oncogene, it interferes with the early steps in DNA activity in the cell nucleus. But how the oncogene affected the subsequent production of proteins, a step known as translation, was unknown.

"A cancer causing gene, such as Myc, regulates many distinct cellular processes, and that can make it very difficult to tease apart which ones are the most important for the cancer to progress," says Barna,
'/>"/>

Contact: Kirsten Michener
kmichener@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cancer-causing gut bacteria exposed
2. Researchers identify cancer-causing gene in many colon cancers
3. Rare cancer-causing syndrome found, for the first time, in Singapore
4. Jumbo-sized discovery made in Malaysia
5. UC Davis discovery offers hope for treating kidney cancer
6. Life Sciences Discovery Fund awards health research program grants
7. In just 5 years, gene discovery to clinical trial of potential treatment
8. Discovery of new gene associated with diabetes risk suggests link with body clock
9. Kidney function discovery sheds light on genetic complexity of disease
10. New discovery may enhance MRI scans, lead to portable MRI machines
11. Discovery of giant roaming deep sea protist provides new perspective on animal evolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... Gutenberg University Mainz (JGU) as a full member, ... maintain a significant nationwide standing in the field ... Johannes Gutenberg University Mainz as a full member ... national and international competition for the best minds ... be proud that Mainz University has been recognized ...
(Date:10/15/2014)... linked increased resistance to bacterial pneumonia in female mice ... estrogen. , Females are naturally more resistant to respiratory ... has shown that increased resistance to bacterial pneumonia in ... synthase 3 (NOS3). They also show that this enzyme ... sex hormone estrogen. , The team, lead by Professor ...
(Date:10/15/2014)... Geneticist Fred Alt will be awarded the 44th Rosenstiel ... University for his pioneering research exploring the mechanisms of ... and cancer cells. Alt is the second alumnus to ... the Nobel Prize in 2003. , Alt is the ... Genetics at Harvard Medical School and an investigator at ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2
... bonds that tie a mother to her newborn may be ... deliver by cesarean section, according to a study published by ... Journal of Child Psychology and Psychiatry . ... James Swain, M.D., recruited two groups of parents from postpartum ...
... This press release is available in German . ... checks above all at airports has been increased ... protection of passengers. Possibilities for new and safe methods of ... can be used for this purpose, however, it has to ...
... into the mating and nesting practices of a common ... males sequentially the highest recorded of any vertebrate. ... Biological Sciences, has researched the frog species Bibron,s toadlet ... field trip, discovered a new behaviour undetected in a ...
Cached Biology News:Natural childbirth linked to stronger baby bonding than C-sections 2Checking people at airports -- with terahertz radiation 2Australian frog species chooses not to put eggs in 1 basket 2
(Date:10/22/2014)... -- Research and Markets  has announced the addition ... Application, Geography - Global Analysis and Forecast (2014 - ... Organic electronics, also called as polymer electronics or plastic ... with small conductive molecules and electrically conductive polymers. It ... are carbon based, made using synthetic strategies developed in ...
(Date:10/20/2014)... Convey Computer , the leader ... Iowa State University won first place in the ... HC-2ex, the team’s solution achieved the highest overall performance ... second place finisher. , Experts from all segments of ... long challenge, using a variety of design tools, hardware ...
(Date:10/20/2014)... -- GenVec, Inc. (NASDAQ: GNVC ) today announced the ... board of directors effective on October 24, 2014.   Dr. Horovitz ... its chairman from June 2006 to November 2013.  During his ... and Audit Committees of the board.  "We ... service to GenVec, and its stockholders," said Wayne T. ...
(Date:10/20/2014)... 20, 2014 Local veterinary surgeon, Dr. ... investigational study of donor stem cells for dogs with ... therapy and has performed clinical stem cell therapy for ... to determine if a single injection of donor stem ... help reduce pain and inflammation in the treated joints. ...
Breaking Biology Technology:Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Zola P. Horovitz To Retire From GenVec Board 2Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... INDIANAPOLIS, Feb. 8 Semafore Pharmaceuticals Inc.,today announced ... and Ullrich Schwertschlag, M.D., Ph.D., chief medical officer,will ... programs at,2:45 p.m. EST on Wednesday, Feb. 13, ... New York City., The update will include ...
... onTargetjobs, the leading,niche Internet job ... of,RegionalHelpWanted.com, a network of over 350 ... is the parent company of BioSpace.com, ... career services to the biotechnology, pharmaceutical,hospitality, ...
... Remain as Advisor to Company, FRAZER, Pa., Feb. ... Executive Vice President, General Counsel &,Secretary, John E. Osborn, ... March 31. Mr. Osborn has agreed to remain as ... matters., "John has been an invaluable member of ...
Cached Biology Technology:Semafore to Present at BIO CEO & Investor Conference 2onTargetjobs Announces Acquisition of RegionalHelpWanted.com 2Cephalon General Counsel John E. Osborn to Resign Position 2Cephalon General Counsel John E. Osborn to Resign Position 3
A Highly Purified, Cost-Effective Taq DNA Polymerase...
... , Ellman's reagent *M: ... *Storage: RT, When an enzyme-catalyzed reaction ... present in the substrate, it may be possible ... with the product to form a chromophore. The ...
Cag-A (IgG) -Ab EIA Sample Size: 10 l...
... a recombinant human protein produced in E. coli ... RNase A type enzymes. The mode of ... in a 1:1 ratio. The enzyme has been ... and cell types. Addition of the ribonuclease inhibitor ...
Biology Products: