Navigation Links
Cancer biologists find DNA-damaging toxins in common plant-based foods
Date:3/27/2013

laboratory dishes for 18 hours.

Measuring and comparing p53 activity with baseline levels, the scientists found that liquid smoke flavoring, black and green teas and coffee showed up to nearly 30-fold increases in p53 activity, which was on par with their tests of p53 activity caused by a chemotherapy drug called etoposide.

Previous studies have shown that liquid smoke flavoring damages DNA in animal models, so Kern's team analyzed p53 activity triggered by the chemicals found in liquid smoke. Postdoctoral fellow Zulfiquer Hossain tracked down the chemicals responsible for the p53 activity. The strongest p53 activity was found in two chemicals: pyrogallol and gallic acid. Pyrogallol, commonly found in smoked foods, is also found in cigarette smoke, hair dye, tea, coffee, bread crust, roasted malt and cocoa powder, according to Kern. Gallic acid, a variant of pyrogallol, is found in teas and coffees.

Kern says that more studies are needed to examine the type of DNA damage caused by pyrogallol and gallic acid, but there could be ways to remove the two chemicals from foods and flavorings.

"We found that Scotch whiskey, which has a smoky flavor and could be a substitute for liquid smoke, had minimal effect on p53 activity in our tests," says Kern.

Liquid smoke, produced from the distilled condensation of natural smoke, is often used to add smoky flavor to sausages, other meats and vegan meat substitutes. It gained popularity when sausage manufacturers switched from natural casings to smoke-blocking artificial casings.

Other flavorings like fish and oyster sauces, tabasco and soy sauces, and black bean sauces showed minimal p53 effects in Kern's tests, as did soybean paste, kim chee, wasabi powder, hickory smoke powders and smoked paprika.


'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
2. Embryonic development protein active in cancer growth
3. BRG1 mutations confer resistance to hormones in lung cancer
4. Genetic variation in East Asians found to explain resistance to cancer drugs
5. Beyond the microscope: Identifying specific cancers using molecular analysis
6. Marshall University study may lead to new treatments for prostate cancer
7. Salk scientists open new window into how cancers override cellular growth controls
8. Penn research points to new way of preserving fertility for boys undergoing cancer treatment
9. Genetic abnormality offers diagnostic hope for childrens cancer
10. Protein jailbreak helps breast cancer cells live
11. Breast cancer risk gene discovery fast tracked by new technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... Some manufacturers are turning away from using triclosan as ... over health concerns. And now scientists are reporting new ... published in the ACS journal Chemical Research in ... commercial substance called octylphenol, promoted the growth of human ... tumors in mice. , Kyung-Chul Choi and colleagues note ...
(Date:4/23/2014)... Exeter researcher has shed light on how an estimated ... remote outback have become reviled as pests and culled ... Environment and Sustainability Institute at the University of Exeter,s ... Australia, from their historic role helping to create the ... "invader." , The deserts of the Australian outback are ...
(Date:4/23/2014)... think one can argue that if we were to follow ... that we canthen we can solve the climate problem without ... foremost climate researchers, in the current issue of Bulletin ... take significant action on climate change now makes it more ... problem, Wigley explains in an exclusive Bulletin interview. ...
Breaking Biology News(10 mins):In lab tests, the antimicrobial ingredient triclosan spurs growth of breast cancer cells 2How Australia got the hump with 1 million feral camels 2How Australia got the hump with 1 million feral camels 3Is nuclear power the only way to avoid geoengineering? 2
... Kam Tang of the Virginia Institute of Marine Science ... play an important role in carrying hitchhiking bacteria to ... "Bacteria dispersal by hitchhiking on zooplankton," appeared in the ... National Academy of Sciences . It was co-authored by ...
... variant which increases susceptibility to tuberculosis (TB) in African ... (GWA) study. This is the first novel disease variant ... demonstrates that such studies are viable in African populations, ... Over the past few years, GWA studies, such as ...
... Joseph Nadeau, PhD, of Case Western Reserve University School ... Health (NIH) Director,s Pioneer Award. One of ... will investigate transgenerational genetic effects, where the biological features ... to depend as much on the genetics of ancestral ...
Cached Biology News:Study shows that hitchhiking bacteria can go against the flow 2Study shows that hitchhiking bacteria can go against the flow 3Genome study identifies genetic variant linked to TB susceptibility in Africans 2Genome study identifies genetic variant linked to TB susceptibility in Africans 3Case Western Reserve geneticist receives prestigious NIH Director's Pioneer Award 2
(Date:1/14/2014)... Bellingham, Washington, USA, and Cardiff, UK (PRWEB) January 13, ... and photonics technology development leader with more than 20 ... international society for optics and photonics . Hainsey will ... “We are delighted to have Dr. Hainsey join SPIE ...
(Date:1/14/2014)... Rochester, NY (PRWEB) January 14, 2014 During ... is now known as “The Doctor’s Plague.” In this time ... their hands. This led, at times, to the death of ... staff today don’t know that they may be unwittingly transmitting ...
(Date:1/14/2014)... BioMedomics, Inc. , a Point of ... and novel disease specific POC tests, announced today that it ... total of $690,000. The investment is from private investors and ... group of private investors has significant successful experience in early ...
(Date:1/14/2014)... City, Panama (PRWEB) January 14, 2014 ... has received the county’s first clinical trial approval ... umbilical cord-derived mesenchymal stem cells (MSC) from the ... Review Board (IRB). , Rheumatoid Arthritis (RA) is ...
Breaking Biology Technology:Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3BioMedomics, Inc. Closes $690K Round of Financing 2Panama’s First Umbilical Cord Stem Cell Clinical Trial for Rheumatoid Arthritis Approved by Comité Nacional de Bioética de la Investigación Institutional Review Board 2Panama’s First Umbilical Cord Stem Cell Clinical Trial for Rheumatoid Arthritis Approved by Comité Nacional de Bioética de la Investigación Institutional Review Board 3
... Critical Path Immunology created to discover and develop ... for immune system-related diseases -, SAN FRANCISCO, March 31 ... with Beckman Coulter, Inc. to,establish a Center for Critical Path ... disease. This facility, which will be managed by,ITI and located ...
... (PHPG) today reported its consolidated, audited, financial,results for its ... in fiscal year 2007 were a record at $15,100,000 ... the year was our,highest ever at $17,802,000 as was ... 2006, respectively., Pre-tax income for the year was ...
... 31 BioMarin,Pharmaceutical Inc. (Nasdaq and SWX: BMRN) ... and distribution partner in Japan, has,received approval for ... Ministry of Health, Labour and Welfare,(MHLW) for the ... "We are proud to work with AnGes ...
Cached Biology Technology:The Immune Tolerance Institute Announces Collaboration with Beckman Coulter Establishing a Multiplatform Immunophenotyping/Immunogenotyping Laboratory 2The Immune Tolerance Institute Announces Collaboration with Beckman Coulter Establishing a Multiplatform Immunophenotyping/Immunogenotyping Laboratory 3Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 2Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 3Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 4Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 5Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 6Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 7Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 8Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 9Naglazyme Approved by Japanese Ministry of Health 2Naglazyme Approved by Japanese Ministry of Health 3Naglazyme Approved by Japanese Ministry of Health 4
... BioGenex Super Sensitive Polymer-HRP ... a novel product based ... polymeric technology. This system ... to noise ratio and ...
... unit is an inexpensive personal or mini thermal ... process. Lightweight, with a small footprint, it can ... the researcher's desk. , The Gene Cycler thermal ... not have access to a large laboratory thermal ...
... Leu-CMK FLISP Assay with SR-101 ... Em=620 nm) • Accurately measure serine ... or permeabilization • B-Bridge's FLISP Kits ... serine proteases (FLISPs) to measure chymotrypsin-like ...
... He biolistic system enables 7-10 times more cells ... fits into the shocking chamber of the PDS-1000 ... wave over 7 microcarriers. By uniformly spreading the ... area, the system maximizes the number of cells ...
Biology Products: