Navigation Links
CSI-style DNA fingerprinting tracks down cause of cancer spread
Date:7/15/2013

The University of Colorado Cancer Center along with Yale University and the Denver Crime Lab report in the journal PLOS ONE the first proof of cancer's ability to fuse with blood cells in a way that gives cancer the ability to travel, allowing previously stationary cancer cells to enter the bloodstream and seed sites of metastasis around the body. The work used DNA fingerprinting of a bone marrow transplant patient with cancer, along with DNA fingerprinting of the patient's bone marrow donor, to show that subsequent metastatic cancer cells in the patient's body carried parts of both genomes, fused together into a hybrid cancer cell.

Metastasis is responsible for the overwhelming majority of cancer deaths and there are many theories as to how it occurs, but the problem remains yet unsolved. John Pawelek, PhD, at Yale has pointed out that the combination of a cancer cell with a blood cell could explain how a cancer cell acquires the ability to move through the body. The problem is there has been no way to prove this through genetic analyses of the tumor cells they are too similar to the patient's non-tumor cells and so you can't tell if the mutations that allow a cancer cell to travel arose in the cell itself or through fusion with another source.

"One night on a bus ride returning from a conference, John pointed out that, in a patient with a bone marrow transplant, the blood cells come from someone else one person with two genomes," says Richard Spritz, MD, investigator at the CU Cancer Center and professor of pediatrics at the CU School of Medicine. "He had received a pathology specimen of a melanoma tumor that had metastasized to the brain of a patient who had previously received a bone marrow transplant from his brother, and he asked me whether, as a collaboration, we could distinguish between the donor and patient genomes in a cancer cell? I knew that one of the best ways to accomplish this was by DNA fingerprinting."

And
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Metabolic fingerprinting: Using proteomics to identify proteins in gymnosperm pollination drops
2. Chemical fingerprinting tracks the travels of little brown bats
3. lobSTR algorithm rolls DNA fingerprinting into 21st century
4. Geology tracks eruptions, earthquakes, erosion, extinctions & more
5. Sequencing tracks animal-to-human transmission of bacterial pathogens
6. New DNA-method tracks fish and whales in seawater
7. Molecular spectroscopy tracks living mammalian cells in real time as they differentiate
8. New technology tracks sparrow migration for first time from California to Alaska
9. U of T-led study cracks universal RNA code, suggests a new cause for autism
10. H7N9 influenza: History of similar viruses gives cause for concern
11. Less haze in Singapore as the cause becomes clearer and more complex
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2014)... to monitor seals, every movement, researchers have shown for ... to offshore wind farms and pipelines. Those man-made structures ... according to a study published in the Cell Press ... , "I was shocked when I first saw the ... Shoal," an offshore wind farm in the United Kingdom, ...
(Date:7/21/2014)... Want to conserve water and save on your utility ... and published in the current issue of the journal ... List: The Most Effective Actions U.S. Households Can Take ... water use substantially by simple actions such as installing ... consumption. While the suggestions may be familiar, the researchers ...
(Date:7/21/2014)... Dysfunction in dopamine signaling profoundly changes the ... brain,s prefrontal cortex and may be an underlying ... schizophrenia, according to UC Irvine scientists. , This ... that receive this neurotransmitter showed for the first ... of behavioral and physiological functions regulated in the ...
Breaking Biology News(10 mins):Seals forage at offshore wind farms 2Researchers provide guide to household water conservation 2Researchers provide guide to household water conservation 3UCI researchers find epigenetic tie to neuropsychiatric disorders 2
... things that suffer from stress. Trees must deal with stress ... too much water, from scarcity of a needed nutrient, from ... to stress quickly and efficiently is a pressing goal of ... University scientists has identified the molecular mechanism that Populusthe scientific ...
... A recent research study has shown that food ... food due to resource constraints, can lead to greater ... "Prior studies have shown that women living ... health complications," said Craig Gundersen, a University of Illinois ...
... scientists have analysed the temperature and salt levels of the ... evolution of each variable. Their research shows that, since at ... and saltier, and that, since the 1990s, this process has ... layer of the Western Mediterranean increases by 0.002C, and its ...
Cached Biology News:Feeling stressed? So is the poplar 2Food insecurity increases risk of weight gain and complications during pregnancy 2Temperature and salt levels of the Western Mediterranean are on the increase 2
(Date:7/22/2014)... Biofeedback – When a ... diagnosed, selecting medication to best treat it can become ... by using electroencephalography (EEG) can help predict which medicine ... risk of adverse drug events. , The article ... the current issue of the journal Biofeedback offers evidence ...
(Date:7/21/2014)... Hills, IL (PRWEB) July 21, 2014 ... control, and simple programming, the new Cole-Parmer® ... Head is easy to operate for automated ... cycles for hands-free dispensing. The batch count function ... cumulative volume or totalizer tracks amount dispensed across ...
(Date:7/21/2014)... , July 21, 2014  Mike Patterson, ... of $1.6 million in Series Seed B funding ... chemical sensors for the life science, defense, intelligence, ... Capital Partners led the round and was joined ... Angels.  Said Patterson , "This round of ...
(Date:7/20/2014)... July 20, 2014 NSG Precision ... glass optics, and spectrophotometer calibration standards ... NSG has released many products that have transformed ... has been their solid-state calibration standards. , NSG’s ... since their release in 2008. NSG started ...
Breaking Biology Technology:Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 2Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 3New Easy-View Cole-Parmer Digital Gear Pump Drive Makes Performance Monitoring Effortless 2Global Graphene Manufacturing Leader, Graphene Frontiers, Receives Series Seed B Funding To Assure Production Of The Next Generation Of Biological And Chemical Sensor Technology 2How NSG Precision Cells Spectrophotometer Calibration Standards Makes NIR Work Easier 2How NSG Precision Cells Spectrophotometer Calibration Standards Makes NIR Work Easier 3
... May 28 CV Therapeutics,Inc. (Nasdaq: CVTX ... rule 4350, the Company issued new inducement stock ... primarily in connection,with its commercialization efforts in the ... an aggregate 151,800 shares of,common stock and are ...
... May 28 Abt Associates announced that,it has ... Officer.,Small most recently served as Senior Vice President, ... Inc., a $700 million,provider of factory and tool ... Prior to joining Brooks Automation he held the,position ...
... Ohio, May 28 NanoLogix, Inc. (Pink,Sheets: NNLX) ... updates:, NanoLogix personnel will showcase company technology ... Exhibition in Boston, June 1-5 2008. The ASM,meeting ... NanoLogix will be Dr. Sergey Gazenko and CEO ...
Cached Biology Technology:CV Therapeutics Reports Option Grants Under Nasdaq Marketplace Rule 4350 2Abt Associates Names Richard Small Vice President and Chief Financial Officer 2NanoLogix Inc. to Present at The American Society for Microbiology (ASM) General Meeting in Boston; Announces Product Line and Provides Operations Update 2
Anti-Rsk2/MAPKAP Kinase 1b, #0 SK2/MAPKAP K1 beta Smartpool&t 3T3 cell lysate Non-specific Control Pool , #D 1X Universal Buffer...
TNF-R2 (L-20)...
... The PowerEase 500 Power ... mini-gel electrophoresis. It offers extensive ... and four custom methods for ... own preferences. The simple intuitive ...
Eliminate electrical interference from any analog signal, without filtering. Ideal for electrophysiology applications like EKG, EMG, and EEGs. Removes 50/60hz noise and harmonics caused by grounding ...
Biology Products: