Navigation Links
CSI-style DNA fingerprinting tracks down cause of cancer spread
Date:7/15/2013

The University of Colorado Cancer Center along with Yale University and the Denver Crime Lab report in the journal PLOS ONE the first proof of cancer's ability to fuse with blood cells in a way that gives cancer the ability to travel, allowing previously stationary cancer cells to enter the bloodstream and seed sites of metastasis around the body. The work used DNA fingerprinting of a bone marrow transplant patient with cancer, along with DNA fingerprinting of the patient's bone marrow donor, to show that subsequent metastatic cancer cells in the patient's body carried parts of both genomes, fused together into a hybrid cancer cell.

Metastasis is responsible for the overwhelming majority of cancer deaths and there are many theories as to how it occurs, but the problem remains yet unsolved. John Pawelek, PhD, at Yale has pointed out that the combination of a cancer cell with a blood cell could explain how a cancer cell acquires the ability to move through the body. The problem is there has been no way to prove this through genetic analyses of the tumor cells they are too similar to the patient's non-tumor cells and so you can't tell if the mutations that allow a cancer cell to travel arose in the cell itself or through fusion with another source.

"One night on a bus ride returning from a conference, John pointed out that, in a patient with a bone marrow transplant, the blood cells come from someone else one person with two genomes," says Richard Spritz, MD, investigator at the CU Cancer Center and professor of pediatrics at the CU School of Medicine. "He had received a pathology specimen of a melanoma tumor that had metastasized to the brain of a patient who had previously received a bone marrow transplant from his brother, and he asked me whether, as a collaboration, we could distinguish between the donor and patient genomes in a cancer cell? I knew that one of the best ways to accomplish this was by DNA fingerprinting."

And
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Metabolic fingerprinting: Using proteomics to identify proteins in gymnosperm pollination drops
2. Chemical fingerprinting tracks the travels of little brown bats
3. lobSTR algorithm rolls DNA fingerprinting into 21st century
4. Geology tracks eruptions, earthquakes, erosion, extinctions & more
5. Sequencing tracks animal-to-human transmission of bacterial pathogens
6. New DNA-method tracks fish and whales in seawater
7. Molecular spectroscopy tracks living mammalian cells in real time as they differentiate
8. New technology tracks sparrow migration for first time from California to Alaska
9. U of T-led study cracks universal RNA code, suggests a new cause for autism
10. H7N9 influenza: History of similar viruses gives cause for concern
11. Less haze in Singapore as the cause becomes clearer and more complex
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... Toronto Scarborough research shows that male black widow spiders ... a rare example of mate preference by male spiders. ... Emily MacLeod and Maydianne Andrade, a professor in UTSC,s ... studies and the wild that males overwhelmingly chose to ... black widows can tell whether a potential mate is ...
(Date:4/23/2014)... Scientists have conclusive evidence that the source of a ... Ocean and called the "bio-duck," is the Antarctic minke ... by submarine personnel in the 1960s who thought it ... recorded at various locations in the Southern Ocean, but ... In February 2013, an international team of researchers deployed ...
(Date:4/23/2014)... accurate group decision increases with the abundance of brains ... a variety of factors as often happens in ... smaller groups actually tend to make more accurate decisions ... certain pieces of information. , The findings present a ... or the "wisdom of crowds," wherein individual observations ...
Breaking Biology News(10 mins):Picky male black widow spiders prefer well-fed virgins 2Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3Too many chefs: Smaller groups exhibit more accurate decision-making 2Too many chefs: Smaller groups exhibit more accurate decision-making 3
... ARBOR, Mich. Researchers from the University of Michigan ... overexpressed in 90 percent of pancreatic cancers, the most ... Ataxia Telangiectasia Group D Complementing gene, called ATDC, is ... than in cells from a normal pancreas. What,s more, ...
... Germany March 2, 2009 >> Genomatix Software, a ... Next Generation Sequencing (NGS) data, announced today that Boehringer ... Mining Station and a Genomatix Genome Analyzer at its ... the only complete and integrated analysis solution for NGS ...
... of Illinois plant geneticist Stephen Moose has developed a corn ... that would make good silage, Moose said, due to a ... make it a good energy crop. The gene known ... giving corn seedlings a waxy coating that acts like a ...
Cached Biology News:U-M researchers ID gene involved in pancreatic cancer 2Boehringer Ingelheim uses Genomatix' Next Generation Sequencing data analysis systems 2Doubling a gene in corn results in giant biomass 2
(Date:1/15/2014)... , Jan. 15, 2014 TaiGen Biotechnology Company, Limited ... agreement with R-Pharm, a leading Russian pharmaceutical company, to ... Russian Federation , Turkey ... States (CIS). Nemonoxacin is a novel antibiotic for the treatment ...
(Date:1/14/2014)... Jan. 14, 2014  3D Communications, a leading provider of strategic communications ... and media events in the United States ... Virginia Cox , JD, is returning to the firm,s ... re-joins 3D after more than two years of service as ...
(Date:1/14/2014)... and BETHESDA, Md. , Jan. 14, ... with two institutes from the National Institutes of Health ... bringing safer, more effective treatments to patients on a ... for Advancing Translational Sciences (NCATS) and the National Eye ...
(Date:1/14/2014)... Rockville, MD (PRWEB) January 14, 2014 ... dedicated to developing innovative information technology solutions for ... other health care stakeholders, announced today the signing ... the US Food and Drug Administration (FDA). ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Former FDA Associate Commissioner Returns To 3D Communications 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... Mass. and SYDNEY, Sept. 14, 2011 HeartWare International, ... a leading innovator of less invasive, miniaturized circulatory support ... failure, today announced that CEO Doug Godshall is scheduled ... at 10:30 a.m. ET on Wednesday, September 21, 2011. ...
... Sept. 14, 2011 Tengion, Inc. (NASDAQ: TNGN ... Davis, Vice President Finance and Chief Financial Officer of Tengion, ... on Monday, September 19, 2011, at 1:30 pm EDT. ... accessed under "Calendar of Events" in the Investors section of ...
... 13Researchers at Vanderbilt University have developed a new technique that ... tissue at multiple points simultaneously, a method that could help ... and change shape. UV lasers are a commonly-used ... incisions by vaporizing one point at a time in a ...
Cached Biology Technology:HeartWare to Present at the UBS Global Life Sciences Conference 2Tengion to Present at UBS Global Life Sciences Conference 2
... purified from egg white. The extinction coefficient , ... in 10 mM phosphate-buffered saline, pH ... sodium azide and 50% glycerol. Avidin (from egg ... is purified by molecular sieving and ...
Request Info...
Request Info...
... CELLection Dynabeads (4.5 m) coated with the ... EpCAM and DNase Releasing Buffer. For ... tumour cells directly from blood, bone marrow ... enriched from bone marrow. Enriched cells are ...
Biology Products: