Navigation Links
CNIO researchers discover a gene that links stem cells, aging and cancer
Date:7/17/2014

An organism is healthy thanks to a good maintenance system: the normal functioning of organs and environmental exposure cause damage to tissues, which need to be continuously repaired. This process is not yet well understood, but it is known that stem cells in the organs play a key role, and that when repair fails, the organism ages more quickly. Researchers from the Spanish National Cancer Research Centre (CNIO) have "discovered one of the key genes that make up the maintenance mechanism for tissues" says Miguel Foronda, the first author of the manuscript.

The study is published this week in the journal Cell Reports. The authors believe that it adds another piece to the ageing, stem cells and cancer puzzle, made up of three main elements that are known to be related, but no one knows exactly how. By understanding this relationship throughout identification key regulatory genes, we could have a different, perhaps more unified, vision of these three areas with enormous implications for health.

The target of this research, the Sox4 gene, is expressed during embryonic development it contributes, for example, to the development of the pancreas, the bones and the heart, and to the differentiation of lymphocytes. It is also active in the adult organism, but in a very limited way, being mainly restricted to some stem cell compartments.

Furthermore, when Sox4 malfunctions it becomes an oncogene. Practically all human cancers have too much Sox4, which translates into more cellular proliferation and less apoptosisprogrammed cell death; a mechanism that protects against cancer. It is also known that Sox4 plays a role in metastasis.

Both of these factsthat Sox4 is expressed only in some cells in the adult organism, and that it favours cancer development when there is too much of itindicate that Sox4 is a powerful gene, with important consequences if it is not properly regulated. The CNIO group, therefore, wanted to study m
'/>"/>

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Duck migration study reveals importance of conserving wetlands, MU researchers find
2. Researchers advance understanding in immune response to infectious disease
3. Researchers find organic pollutants not factor in turtle tumor disease
4. Largest International Meeting for the Study of Reproductive Biology Attracts Researchers from 36 Countries in Grand Rapids, Michigan
5. Little too late: Researchers identify disease that may have plagued 700-year-old skeleton
6. Researchers declassify dinosaurs as being the great-great-grandparents of birds
7. IPCC must consider alternate policy views, researchers say
8. Science and cookies: Researchers tap into citizen science to shed light on ant diversity
9. Researchers receive $12.6 million NIH grant to study genetics of Alzheimers
10. Researchers uncover new knowledge about our intestines
11. SDSC assists researchers in novel wildlife tracking project
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
CNIO researchers discover a gene that links stem cells, aging and cancer
(Date:7/21/2015)... , July 21, 2015  NXT-ID, Inc. ... a biometric authentication company focused on the growing ... smart wallet, announces that it has filed provisional ... and Method. This invention highlights ... only authorizes an account, but also the user ...
(Date:7/13/2015)... , Jul. 13, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... provisional patent 62/188684 for BEHAVIORAL-DIRECTED AUTHENTIATION ... new convenient and secure method to make payments.  ... payment methods, introduced with its groundbreaking voice-direct payment ...
(Date:7/9/2015)... , July 9, 2015  Synaptics Inc. ... of human interface solutions, today announced a ... first fully hardware encapsulated fingerprint sensor and ... technology is literally off the grid, isolating ... matching within the fingerprint sensor to provide ...
Breaking Biology News(10 mins):NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
... people are biologically more susceptible to drug addiction than others, ... In the August 15, 2007 issue of the Journal of ... study that may help answer this question. ... had a particular receptor in the brain that is more ...
... August 15, 2007) A prominent problem in AIDS ... to concentrate and perform normal movements. Scientists at ... how HIV/AIDS disrupts the normal replication of stem cells ... forming. Drs. Stuart Lipton, Marcus Kaul, Shu-ichi Okamoto ...
... reported new insight into the pathology underlying a ... that is caused by alterations in the same ... tremor/ataxia syndrome (FXTAS) overwhelmingly affects males, usually in ... In contrast, fragile X syndrome manifests itself from ...
Cached Biology News:Nicotinic receptors may be important targets for treatment of multiple addictions 2AIDS interferes with stem cells in the brain 2AIDS interferes with stem cells in the brain 3Deep into the machinery of adult fragile X 2Deep into the machinery of adult fragile X 3
(Date:7/27/2015)... , July 27, 2015 /PRNewswire/ - Quest PharmaTech ... company developing and commercializing products for the treatment of ... Quest announces that it has closed a $1,000,000 unit ... placement of 16,666,667 units of the Company at a ... of one common share and one common share purchase ...
(Date:7/27/2015)...   Inocucor Technologies Inc ., the agriculture ... farmers, has received a notice of allowance from ... patent application to protect Inocucor consortia and unique ... yields on farms and in greenhouses. ... microbial consortium and its fermentation byproducts, which are ...
(Date:7/27/2015)... The Brain & Behavior Research ... annual Klerman and Freedman Prizes, recognizing exceptional clinical ... supported by NARSAD Young Investigator Grants. The grants ... in neurobiological and psychosocial research, garner pilot data ... detection, treatment, prevention and cure of mental illnesses. ...
(Date:7/26/2015)... ... July 26, 2015 , ... Maine ... calibration verification / linearity test kit. The VALIDATE® ANEMIA kit contains Ferritin, Folate, ... is prepared using the CLSI recommended “equal delta” method for linearity testing and ...
Breaking Biology Technology:Quest PharmaTech Closes $1,000,000 Private Placement 2Inocucor Technologies Receives Groundbreaking U.S. Patent for Proprietary Biological Processes that Stimulate Plant Growth 2Inocucor Technologies Receives Groundbreaking U.S. Patent for Proprietary Biological Processes that Stimulate Plant Growth 3Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 2Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 3Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 4Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 5Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 6Maine Standards Company, LLC Announces Release of VALIDATE® ANEMIA Calibration Verification / Linearity Test Kit 2
... YORK, March 5 Bristol-Myers Squibb,Company (NYSE: ... of Directors,has elected Jean-Marc Huet senior vice president ... this role, Mr. Huet will be,responsible for directing ... the global financial operations of the organization and ...
... projects ONOM@TOPIC and SilOnIS shared ... the most innovative and sustainable project in ... European smartcard platform for,citizenship and mobile multimedia ... secure for users,while adding value for network ...
... March 4 On Wednesday, March 5, 2008,at 8:30 a.m. Eastern/2:30 p.m. Central European/5:30 ... CTIC),management team will host a conference call to discuss the company,s recent,transactions targeting cleaning ... ... ...
Cached Biology Technology:Bristol-Myers Squibb Board Elects Jean-Marc Huet Senior Vice President and Chief Financial Officer 2Bristol-Myers Squibb Board Elects Jean-Marc Huet Senior Vice President and Chief Financial Officer 3MEDEA+ Noblanc award highlights improvements in microelectronics 2MEDEA+ Noblanc award highlights improvements in microelectronics 3Cell Therapeutics, Inc. to Hold Conference Call to Update on Recent Transactions and Upcoming Milestones 2