Navigation Links
CNIO researchers discover a gene that links stem cells, aging and cancer
Date:7/17/2014

An organism is healthy thanks to a good maintenance system: the normal functioning of organs and environmental exposure cause damage to tissues, which need to be continuously repaired. This process is not yet well understood, but it is known that stem cells in the organs play a key role, and that when repair fails, the organism ages more quickly. Researchers from the Spanish National Cancer Research Centre (CNIO) have "discovered one of the key genes that make up the maintenance mechanism for tissues" says Miguel Foronda, the first author of the manuscript.

The study is published this week in the journal Cell Reports. The authors believe that it adds another piece to the ageing, stem cells and cancer puzzle, made up of three main elements that are known to be related, but no one knows exactly how. By understanding this relationship throughout identification key regulatory genes, we could have a different, perhaps more unified, vision of these three areas with enormous implications for health.

The target of this research, the Sox4 gene, is expressed during embryonic development it contributes, for example, to the development of the pancreas, the bones and the heart, and to the differentiation of lymphocytes. It is also active in the adult organism, but in a very limited way, being mainly restricted to some stem cell compartments.

Furthermore, when Sox4 malfunctions it becomes an oncogene. Practically all human cancers have too much Sox4, which translates into more cellular proliferation and less apoptosisprogrammed cell death; a mechanism that protects against cancer. It is also known that Sox4 plays a role in metastasis.

Both of these factsthat Sox4 is expressed only in some cells in the adult organism, and that it favours cancer development when there is too much of itindicate that Sox4 is a powerful gene, with important consequences if it is not properly regulated. The CNIO group, therefore, wanted to study m
'/>"/>

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Duck migration study reveals importance of conserving wetlands, MU researchers find
2. Researchers advance understanding in immune response to infectious disease
3. Researchers find organic pollutants not factor in turtle tumor disease
4. Largest International Meeting for the Study of Reproductive Biology Attracts Researchers from 36 Countries in Grand Rapids, Michigan
5. Little too late: Researchers identify disease that may have plagued 700-year-old skeleton
6. Researchers declassify dinosaurs as being the great-great-grandparents of birds
7. IPCC must consider alternate policy views, researchers say
8. Science and cookies: Researchers tap into citizen science to shed light on ant diversity
9. Researchers receive $12.6 million NIH grant to study genetics of Alzheimers
10. Researchers uncover new knowledge about our intestines
11. SDSC assists researchers in novel wildlife tracking project
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
CNIO researchers discover a gene that links stem cells, aging and cancer
(Date:9/18/2014)... cycles of carbon and nitrogen comprise all spheres ... environmental systems have caused imbalances and perturbations that ... (GHGs). Increased GHGs result in climate changes which ... oceans and the atmosphere. Understanding these feedback mechanisms ... of environmental science during the past three decades. ...
(Date:9/18/2014)... up to 400 kilometres in search of a home, which ... Clownfish spend their entire adult lives under the protection of ... open ocean, says study co-author, Dr Hugo Harrison from the ... at James Cook University. , "In the past we haven,t ... rare glimpse into how far they can swim, crossing large ...
(Date:9/17/2014)... engineering professor and his doctoral student have designed a ... water collected from fog and dew., The device could ... deserts around the globe., Cheng Luo, professor in the ... candidate in the same College of Engineering department, published ... of ACS, (American Chemical Society) Applied Materials ...
Breaking Biology News(10 mins):Greenhouse gas research enters a new era 2Nemo's epic journey to find a new home 2Shorebird's beak inspires UT Arlington research on water collection 2
... The majority of rare diseases are hereditary. But despite ... exact cause remains unclear. The discovery of the underlying ... diagnosis and the development of innovative approaches to their ... Genetics and the Institute of Medical Genetics at the ...
... The incidence of psychotic disorders varies greatly ... course, and treatment response across individuals. High rates ... cannabis users, and traumatised individuals reflect the causal ... progress in the area of molecular genetics, has ...
... the environment specifically to creatures that live in water ... Carolina State University toxicologists. In a study published in ... NC State researchers show that water fleas take up nitrates ... fertilizers and convert those chemicals into nitric oxide. Nitric ...
Cached Biology News:All genes in 1 go 2Developmental gene-environment interactions: A model for psychosis 2Developmental gene-environment interactions: A model for psychosis 3Developmental gene-environment interactions: A model for psychosis 4Developmental gene-environment interactions: A model for psychosis 5Developmental gene-environment interactions: A model for psychosis 6Fertilizer chemicals linked to animal developmental woes 2
(Date:9/18/2014)... 18, 2014 Leatherwood Plastics has ... material, to stay competitive in the semiconductor, clean ... materials ultimately impact product quality and productivity, according ... , Established in 1980 in Lewisville, TX, ... fabricators have left the business. Much of Leatherwood’s ...
(Date:9/18/2014)... 18, 2014  MEI Pharma, Inc. (Nasdaq: MEIP ... novel therapies for cancer, announced today that Daniel P. ... at BioCentury,s NewsMakers in the Biotech Industry conference ... from the Millennium Broadway Hotel & Conference Center in ... presentation can be accessed at www.meipharma.com . A replay ...
(Date:9/18/2014)... Oncothyreon Inc. (NASDAQ: ONTY ) today announced ... offerings of 10,000,000 shares of its Common Stock at ... for expected gross proceeds of $20 million and 10,000 ... a price to the public of $2,000.00 per share, ... of Series A Convertible Preferred Stock is non-voting and ...
(Date:9/18/2014)... 2014   Sigma-Aldrich Corporation (Nasdaq: ... into a new gene editing partnership with the ... Under the partnership, Sigma-Aldrich will provide the Vector ... and dedicated gene editing bioinformaticians. The ... at the U-M Medical School. One initiative already ...
Breaking Biology Technology:Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 3Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4
... Tips for Better Blood ... Sugar Management, BRIDGEWATER, N.J., ... with diabetes, Emmy nominated actress and,Broadway star Aida Turturro is teaming up ... diabetes to reach,better levels of blood sugar control. Ms. Turturro,s personal story ...
... security guards, police officers and armed forces into Robocops, repelling ... in carbon nanotechnology however could give those in the line ... of damage. , A research paper published in ... Centre for Advanced Materials Technology at the University of Sydney ...
... Dragon Pharmaceutical Inc.,(TSX: DDD; OTCBB: DRUG; BBSE: ... 7ACA production has been successfully implemented on ... validates the Company,s research,and development efforts to ... immediate benefits to production operations by,increasing production ...
Cached Biology Technology:Actress Aida Turturro Tells Americans to Start Now to Talk With Their Healthcare Provider About Taking Control of Their Diabetes 2Actress Aida Turturro Tells Americans to Start Now to Talk With Their Healthcare Provider About Taking Control of Their Diabetes 3Actress Aida Turturro Tells Americans to Start Now to Talk With Their Healthcare Provider About Taking Control of Their Diabetes 4Using nanotech to make Robocops 2Dragon Announces R&D Achievement in Biotech Manufacturing Process 2Dragon Announces R&D Achievement in Biotech Manufacturing Process 3
Collected from sexually mature, mixed sex, mixed breed dogs. Serum from specific breeds available by request....
... EPS 301 Power Supply, 1. ... maximum.Constant voltage or constant current modes.Single-unit ... precision and reproducibility.Suitable for submarine, mini ... as well as semidry and mini ...
Mouse Serpin F1/PEDF MAb (Clone 199315)...
Mouse MMP-24 (MT5-MMP) MAb (Clone 143908)...
Biology Products: