Navigation Links
CNIO researchers discover a gene that links stem cells, aging and cancer
Date:7/17/2014

An organism is healthy thanks to a good maintenance system: the normal functioning of organs and environmental exposure cause damage to tissues, which need to be continuously repaired. This process is not yet well understood, but it is known that stem cells in the organs play a key role, and that when repair fails, the organism ages more quickly. Researchers from the Spanish National Cancer Research Centre (CNIO) have "discovered one of the key genes that make up the maintenance mechanism for tissues" says Miguel Foronda, the first author of the manuscript.

The study is published this week in the journal Cell Reports. The authors believe that it adds another piece to the ageing, stem cells and cancer puzzle, made up of three main elements that are known to be related, but no one knows exactly how. By understanding this relationship throughout identification key regulatory genes, we could have a different, perhaps more unified, vision of these three areas with enormous implications for health.

The target of this research, the Sox4 gene, is expressed during embryonic development it contributes, for example, to the development of the pancreas, the bones and the heart, and to the differentiation of lymphocytes. It is also active in the adult organism, but in a very limited way, being mainly restricted to some stem cell compartments.

Furthermore, when Sox4 malfunctions it becomes an oncogene. Practically all human cancers have too much Sox4, which translates into more cellular proliferation and less apoptosisprogrammed cell death; a mechanism that protects against cancer. It is also known that Sox4 plays a role in metastasis.

Both of these factsthat Sox4 is expressed only in some cells in the adult organism, and that it favours cancer development when there is too much of itindicate that Sox4 is a powerful gene, with important consequences if it is not properly regulated. The CNIO group, therefore, wanted to study m
'/>"/>

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Duck migration study reveals importance of conserving wetlands, MU researchers find
2. Researchers advance understanding in immune response to infectious disease
3. Researchers find organic pollutants not factor in turtle tumor disease
4. Largest International Meeting for the Study of Reproductive Biology Attracts Researchers from 36 Countries in Grand Rapids, Michigan
5. Little too late: Researchers identify disease that may have plagued 700-year-old skeleton
6. Researchers declassify dinosaurs as being the great-great-grandparents of birds
7. IPCC must consider alternate policy views, researchers say
8. Science and cookies: Researchers tap into citizen science to shed light on ant diversity
9. Researchers receive $12.6 million NIH grant to study genetics of Alzheimers
10. Researchers uncover new knowledge about our intestines
11. SDSC assists researchers in novel wildlife tracking project
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
CNIO researchers discover a gene that links stem cells, aging and cancer
(Date:4/20/2015)... DUBAI , April 20, 2015 ... soars   Glenbeigh Records Management (GRM), ... contract with Dubai Islamic Bank. Having built up an impressive ... is now a leading player within the records management sector ... company expects to double is GCC staffbase and employ a ...
(Date:4/14/2015)... 2015  HYPR Corp. today announced it has ... Alliance tm , an industry consortium transforming online ... share technology and collaborate to deliver open specifications ... secure and private, and easier to use. ... protects sensitive user information and eliminates the dependency ...
(Date:4/13/2015)... According to a recently ... & Opportunities, 2020", the global biometrics market is ... till 2020. The biometrics market is garnering attention ... review of biometric management systems. The constant development ... greater efficiency, are resulting in increasing installation of ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
... December Highlights: LEADS: (top news ... Improvements Volcanoes can be catastrophic. Lava flows ... and devastate natural areas. Scientists from the USGS work ... world,s volcanoes. They use seismometers to detect and monitor ...
... Los Angeles, London, New Delhi, Singapore and Washington DC (Dec ... how individual,s identify with political parties , according to ... Quarterly , the official journal of the Western Political Science ... among the most studied concepts in modern political science. Scholars ...
... protein complex mutated in human disease removes excess signaling molecules ... Medical School. The study will be published in the December ... ( www.jcb.org ). Defective cilia cause a range of ... to mutations in 12 different proteins. Seven of these form ...
Cached Biology News:USGS science picks 2USGS science picks 3USGS science picks 4USGS science picks 5USGS science picks 6USGS science picks 7
(Date:5/22/2015)... 22, 2015 Charm Sciences, Inc. ... of Agriculture (USDA), Grain Inspection, Packers and Stockyards ... to Charm Sciences to monitor aflatoxin in grains ... and ROSA FAST Aflatoxin Quantitative Test (solvent-based). , ... uses Water Extraction Technology to extract aflatoxin ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 Seventh Wave ... safety and efficacy of pharmaceutical products and medical devices, ... Heights, MO 63043, a 50,000 sq. ft. building more ... to enable strategic growth. Facility renovations will begin immediately ... new space will occur in September. , “We ...
(Date:5/21/2015)... San Francisco, CA (PRWEB) May 21, 2015 ... microbiome sequencing, has announced a partnership with PicnicHealth, ... records for patients. Participants diagnosed with Inflammatory Bowel ... as well as a complementary uBiome research kit. ... Summer 2014. , For more ...
(Date:5/21/2015)... Patent Offering, The patent’s technology pertains ... therapeutic imaging within a body lumen (open space). ... a low cost, single-use disposable illumination and camera module ... 18, 2013 and the patent approval was received on ... to customize the lighting and magnification of the endoscope ...
Breaking Biology Technology:USDA-GIPSA (FGIS) Awards 5 Year Contract for Aflatoxin Tests to Charm Sciences 2Seventh Wave Laboratories Purchases Building for Expansion, Upcoming Move 2Seventh Wave Laboratories Purchases Building for Expansion, Upcoming Move 3uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 3IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3
... Aug. 24 ACCESS PHARMACEUTICALS, INC. (OTC ... specializing in products for cancer and supportive care, announced ... Zarzycki will give an invited presentation today on the ... held at the American Chemical Society,s ("ACS") ...
... in French . , The generation of an ... is known as the piezoelectric effect, and it has a ... watches, motion sensors and precise positioning systems. Researchers at McGill ... this effect in nanoscale semiconductors called "quantum dots," enabling the ...
... ORANGEBURG, S.C., Aug. 23 Zeus, Inc., a global ... it is now publishing its catalog in 6 languages: ... also increased its number of bilingual Technical Account Managers ... in Asia. All six catalogs are available for download ...
Cached Biology Technology:Access Pharmaceuticals Presents at American Chemical Society Annual Fall Meeting in Boston, MA 2Access Pharmaceuticals Presents at American Chemical Society Annual Fall Meeting in Boston, MA 3Access Pharmaceuticals Presents at American Chemical Society Annual Fall Meeting in Boston, MA 4Good vibrations: New atom-scale products on horizon 2Zeus Catalog Available in Six Languages 2
MHC. Sections include: the isolation and functional properties of antigen-presenting cells analysis of MHC class II endocytosis and peptide turnover analysis of signalling via MHC class II molecu...
... The 1-D PAGE ... Kit for Targeted Protein ... SDS PolyAcrylamide Gel Electrophoresis ... chemistry, and cleavable-linker technology ...
Supplemental reagent for annexin V assay....
Antibody Purification Specificity: Antibody Purification ...
Biology Products: