Navigation Links
C. difficile vaccine proves safe, 100 percent effective in animal models
Date:7/31/2014

An experimental vaccine protected 100 percent of animal models against the highly infectious and virulent bacterium, Clostridium difficile, which causes an intestinal disease that kills approximately 30,000 Americans annually. The research is published ahead of print in Infection and Immunity.

In the study, the vaccine protected the mice and non-human primates against the purified toxins produced by C. difficile, as well as from an orogastric spore infection, a laboratory model that mimics the human disease, after only two immunizations.

"Animals that received two immunizations did not get sick or show signs of C. difficile-associated disease," says corresponding author Michele Kutzler, of Drexel University College of Medicine, Philadelphia.

"While our research was conducted in animal models, the results are very translatable to the clinic," says Kutzler. "In some cases, patients who acquire C. difficile can develop serious complications including severe diarrhea, toxic megacolon, bowel perforation, multi-organ failure, and death. Once fully developed, our DNA vaccine could prevent the deadly effects of C. difficile infection when administered to hospital patients at risk of acquiring C. difficile."

The protection following just two immunizations is especially important since the time window in humans between colonization with C. difficile and the onset of disease symptoms can be a mere 10-14 days, says Kutzler.

The vaccine protects against the bacterial toxins by mustering anti-toxin neutralizing antibodies, says Kutzler.

The cost of fighting the half million C. difficile infections that occur annually in the US is estimated to be nearly $10 billion, most of which could be saved by a successful preventive vaccine, says Kutzler. Morbidity and mortality have risen over the last decade, likely due to increased prevalence of relapsing disease,
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers create vaccine for dust-mite allergies
2. Nasal mucosal inhalation of AD vaccine attenuates Aβ1-42-induced cytotoxicity
3. First positive results toward a therapeutic vaccine against brain cancer
4. Researchers shut down a SARS cloaking system; findings could lead to SARS, MERS vaccines
5. UNL team explores new approach to HIV vaccine
6. Ebola vaccine success highlights dilemma of testing on captive chimps to save wild apes
7. New experimental vaccine produces immune response against MERS virus
8. New technique brings us closer to HIV and Hepatitis C vaccines
9. Potential lung cancer vaccine shows renewed promise
10. Researchers have identified a novel immunological mechanism of great importance for vaccine developm
11. Can personalized tumor vaccines improve interleukin-2 treated metastatic melanoma?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... The announcement comes as demand for fire vault ... Ireland,s foremost records management company, has secured ... impressive track record of clients within the first 12 months, ... sector in Dubai . As a result, ... a further eight staff members at its Irish headquarters. The ...
(Date:4/14/2015)... NEW YORK , April 14, 2015 /PRNewswire/ ... Fast IDentity Online (FIDO ® ) Alliance tm ... standards-based specifications. FIDO members commit to share technology ... authentication methods that are interoperable, more secure and ... specifications enable biometric identity verification that protects sensitive ...
(Date:4/13/2015)... April 13, 2015 According ... "Global Biometrics Market Forecast & Opportunities, 2020", the global ... of around 14% till 2020. The biometrics market ... scale implementation and review of biometric management systems. ... new products with greater efficiency, are resulting in ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
... follows form" might have been written to describe proteins, ... nature,s workhorse biomolecules enables each to carry out its ... X-ray protein crystallography, in which a beam of x-rays ... protein,s atoms, creating a diffraction pattern of dots that ...
... prescribed drugs for the treatment of heart failure are beta-blockers ... the heart,s workload. The drugs were thought to produce those ... study led by scientists at Temple University School of Medicine, ... counteracting the effects of an enzyme known as GRK2. The ...
... Nov. 5, 2013  The AVS has selected its major award ... to encourage excellence in research and innovation in technical areas ... award winners: Medard W. Welch Award— Dr. ... Barbara, "For seminal contributions to the theory of heterojunctions and ...
Cached Biology News:Bringing out the best in X-ray crystallography data 2Temple researchers uncover clues to how existing heart drugs work 2AVS Announces Its Major Award Winners of 2013 2AVS Announces Its Major Award Winners of 2013 3AVS Announces Its Major Award Winners of 2013 4AVS Announces Its Major Award Winners of 2013 5AVS Announces Its Major Award Winners of 2013 6
(Date:5/5/2015)... 5, 2015 Reprints Desk, Inc., a Research ... access to scientific, technical and medical (STM) content, today ... Association of Southeastern Research Libraries (ASERL) . ... across 11 southeastern states. Founded in 1956, ASERL has ... to address the continually changing needs of its member ...
(Date:5/5/2015)... Franz Inc ., the leading supplier ... its flagship product, AllegroGraph, has been named a Champion by ... report. AllegroGraph is a high performance Semantic Graph ... Graph databases are skyrocketing in popularity and have grown by ... DBMS ranking by DB-Engines. , “We are excited ...
(Date:5/5/2015)... -- Orexigen Therapeutics, Inc. (Nasdaq: OREX ) will announce ... May 8 before the market opens. The announcement will ... at 8:30 a.m. Eastern Time (5:30 a.m. Pacific Time). ... phone by calling (800) 708-4540 (domestic) or (847) 619-6397 ... live on the Investors section of the Orexigen web ...
(Date:5/5/2015)... , May 5, 2015  Indianapolis-based medical ... of its innovative line of products including the ... for atraumatically accessing deep-seated brain abnormalities and then ... been completed at more than 50 institutions throughout ... technology has also been included in 12 abstracts, ...
Breaking Biology Technology:Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 2Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 3Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 4Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 2Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 3NICO Corporation Gains Market Expansion after Multiple Published Clinical Articles Support Access Technology for Deep Brain Lesions 2NICO Corporation Gains Market Expansion after Multiple Published Clinical Articles Support Access Technology for Deep Brain Lesions 3
... Web-based reporting credited with state's top healthcare ranking , , ... the state's web-based quality reporting system with the state's top ... Agency for Healthcare Research and Quality. , ,The ... quality score among all 50 states based on 129 measures ...
... company secrets. He thinks business meetings can be toxic as ... to improve the flow of communication, and he thinks employees ... , ,There is a method to Jason Fried's ... the recent Wisconsin Entrepreneurs' Conference in Milwaukee. , ,The founder ...
... - Using innovation to grow the top line will be ... 7:30 to 9 a.m., at the Butte des Morts Country ... open to the public, will center on innovation and adding value ... by Todd Teske, executive vice president and chief operating officer of ...
Cached Biology Technology:Visions: Chicago software exec Jason Fried breaks (almost) all the rules 2Visions: Chicago software exec Jason Fried breaks (almost) all the rules 3
The VersArray hybridization chamber is used for manual (coverslip) hybridization of microarrays. The chamber accommodates 2 slides and is watertight to allow incubation of slides in a water bath. Dim...
5X StabilCoat Immunoassay Stabilizer is a 5X concentrate solution of StabilCoat Immunoassay Stabilizer. The shelf-life of 5X StabilCoat Immunoassay Stabilizer is 2 years when stored at 4C. Product ...
... solid. PROTECT FROM LIGHT. Useful in cell activation experiments ... ≥98% by TLC. Soluble in DMSO or EtOH. ... 10 mM stock in DMSO is recommended. Microliter amounts ... O with rapid mixing (e.g. 10 μl into 5 ...
Monoclonal antibodies conjugated with rhodamine...
Biology Products: