Navigation Links
Building better blood vessels could advance tissue engineering
Date:4/4/2013

lls, which make up the vessel lining and supporting cells. Their scaffolding carrier is fibrin, a protein in the human body that helps blood clot.

"The cells know what to do," Putnam said. "You can take these things and mix them and put them in an animal. Literally, it's as easy as a simple injection and over a few days, they spontaneously form new vessels and the animals' own vasculature connects to them."

But it turns out these vessels don't always thrive. The U-M team aimed to figure out why. In reading previously published findings, Putnam noticed that researchers used "a mishmash of support cells," and the field had paid little attention to which ones work best. So that's where he and his colleagues focused.

In their experiments, they mixed three recipes of blood vessel starter solutions, each with a different commonly used supporting cell type: lung fibroblasts, adult stem cells from fat and adult stem cells from bone marrow. They also made a version with no supporting cells at all. They injected each solution under the skin of mice, and allowed the new blood vessels to form over a period of two weeks. At various points in time, they injected a tracer dye into the animals' circulation to help them see how well the engineered capillaries held blood, and whether they were connected to the animals' existing vessel networks.

The researchers found that the solution with no support cells and the one with the lung fibroblasts produced immature, misshapen human capillaries that leaked. They could tell because the tracer dye pooled in the tissue around the new vessels. On the other hand, the solutions with both types of adult stem cells gave rise to robust human capillaries that kept blood and dye inside them.

The paper notes that one popular method biomedical engineers use to check the success of their effortscounting blood vesselsmight not be an ideal measure. The adult stem cell solutions produced fewer blood vessels th
'/>"/>

Contact: Nicole Casal Moore
ncmoore@umich.edu
734-647-7087
University of Michigan
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Building the European Unions Natura 2000 -- the largest ever network of protected areas
2. New study finds a protein combination is best to consume post-workout for building muscle
3. Light weights are just as good for building muscle, getting stronger, researchers find
4. CUNY Energy Institute battery system could reduce buildings electric bills
5. A cells first steps: Building a model to explain how cells grow
6. Stealing lifes building blocks
7. Blood-brain barrier building blocks forged from human stem cells
8. Building global collaboration for biodiversity intelligence
9. Mathematicians find solution to biological building block puzzle
10. Minimally invasive building renovation
11. Natural regeneration building urban forests, altering species composition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... NEW YORK , April 14, 2015 /PRNewswire/ ... Fast IDentity Online (FIDO ® ) Alliance tm ... standards-based specifications. FIDO members commit to share technology ... authentication methods that are interoperable, more secure and ... specifications enable biometric identity verification that protects sensitive ...
(Date:4/13/2015)... -- higi, a leading cloud-based consumer engagement platform that provides ... their communities around health and wellness, announced today the ... ... convenient vehicle to receive validated health information from consumers. ... API will allow higi,s trusted partners, on a user ...
(Date:4/8/2015)... CHARLOTTE, N.C. , April 8, 2015 /PRNewswire/ ... technology solutions and services, and Morpho, a leading ... in partnership to produce the market,s most advanced ... Infinisource,s iSolved NXG time clock is setting ... attendance and labor data for the small and ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... This release is available in Spanish . ... and the onset of depressive disorders is not new in the ... the brain mechanism by which diet can condition mental health to ... at the Faculty of Medicine and Odontology of the University of ...
... JOLLA, CA-The Salk Institute has been awarded a $2.3 ... (CIRM) for translational research focusing on developing a novel ... research will concentrate on studying human induced pluripotent stem ... to replicate the disorder in the lab and investigate ...
... ISRAEL, February 4, 2011 Ben-Gurion University of the ... Ilse Katz Institute for Nanoscale Science and Technology, has ... Scientific Research. Dr. Mokari received the Prize for ... applications. ,Dr. Mokari is a senior lecturer ...
Cached Biology News:Scientific research reveals brain alterations linking omega 3 deficit with depression 2Scientific research reveals brain alterations linking omega 3 deficit with depression 3Stem cell leader awarded $2.3 million grant for Parkinson's 2
(Date:5/22/2015)... Lawrence, MA (PRWEB) May 22, 2015 ... that the U.S. Department of Agriculture (USDA), Grain ... a five year contract to Charm Sciences to ... Aflatoxin Quantitative Test (water-based) and ROSA FAST Aflatoxin ... WET-S5 Aflatoxin Quantitative Test uses Water Extraction ...
(Date:5/21/2015)... Specialty Pharmacy Times has completed ... to BPA Worldwide as a business publication member. ... data for Specialty Pharmacy Times based on business/distribution, ... a member of BPA Worldwide, Specialty Pharmacy Times ... with the most reliable, unequaled data,” said Chris ...
(Date:5/21/2015)... 2015 Imagine being able to ... those of others. Being able to read faces and ... people to anticipate their thoughts and actions like never ... feelings to create unique abstract paintings and video, or, ... inside a first-person-shooter as it creates action, dialog, and ...
(Date:5/21/2015)... , May 20, 2015 Research and ... the addition of the "2015 Global Survey ... their offering. The primary goal of ... flow cytometry instruments and reagents. Key information the ... the selection of flow cytometers, predominantly used applications ...
Breaking Biology Technology:USDA-GIPSA (FGIS) Awards 5 Year Contract for Aflatoxin Tests to Charm Sciences 2Specialty Pharmacy Times Joins BPA Worldwide 25 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2Global Survey on Flow Cytometry Adoption Trends 2015 2
... GROUNDBREAKING RESEARCH ON,ALZHEIMER,S DISEASE, MEMORY AND AGING, ... the new,$30 million Blanchette Rockefeller Neurosciences Institute ... West Virginia University and founded,in honor of ... host to,prominent international scientists who have achieved ...
... Agreement Signed in Third Quarter of 2008 Expands ... Application of Cutting-Edge Influenza Vaccine Technology, GAITHERSBURG, ... has licensed its proprietary reverse genetics intellectual property,to ... support,the development and construction of new vaccine strains ...
... TEMPE, Ariz., Oct. 16 A team of ... novel quantitative mass,spectrometry immunoassay for the detection of ... online on Oct. 14 in the journal of,Circulation: ... in Fremont, Christ Hospital in Cincinnati, and Medivation ...
Cached Biology Technology:Blanchette Rockefeller Neurosciences Institute Hosts First-Ever International Forum on Memory and Memory Disorders and Dedicates New $30 Million Research Facility 2Blanchette Rockefeller Neurosciences Institute Hosts First-Ever International Forum on Memory and Memory Disorders and Dedicates New $30 Million Research Facility 3Blanchette Rockefeller Neurosciences Institute Hosts First-Ever International Forum on Memory and Memory Disorders and Dedicates New $30 Million Research Facility 4MedImmune Licenses Reverse Genetics Technology to Hungary's Omninvest for Use in Influenza Vaccine Development and Production 2Novel Mass Spectrometry-based Assay Reveals Degradation and Low Levels of Bioactive B-type Natriuretic Peptide (BNP) in Patients with Heart Failure 2
Anti-Human IFN-Gamma Receptor Chain 2 (beta chain) [CD119], Rabbit serum, NON-neutralizing polyclonal antibody...
AANAT [Arylalkylamine N-acetyltransferase; EC 2.3.1.87]...
Rac1/2/3 (L129) Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Sheep polyclonal to EBNA 3B ( Abpromise for all tested applications). Antigen: Full length protein....
Biology Products: