Navigation Links
Building better blood vessels could advance tissue engineering
Date:4/4/2013

ANN ARBOROne of the major obstacles to growing new organsreplacement hearts, lungs and kidneysis the difficulty researchers face in building blood vessels that keep the tissues alive, but new findings from the University of Michigan could help overcome this roadblock.

"It's not just enough to make a piece of tissue that functions like your desired target," said Andrew Putnam, U-M associate professor of biomedical engineering. "If you don't nourish it with blood by vascularizing it, it's only going to be as big as the head of a pen.

"But we need a heart that's this big," he added, holding up his fist.

More immediately, doctors and researchers believe figuring out how to grow working blood vessels might offer treatments for diseases that affect the circulatory system such as diabetes. Perhaps the right drug or injection could save patients' feet from amputation.

Putnam and his colleagues have revealed why one of the leading approaches to building blood vessels isn't consistently working: It's making leaky tubes. They also demonstrated how adult stem cells could solve this problem. A paper on the findings is published online in Tissue Engineering Part A, and will appear in a forthcoming print edition.

Today, biomedical researchers are taking two main approaches to growing new capillaries, the smallest blood vessels and those responsible for exchanging oxygen, carbon dioxide and nutrients between blood and muscles or organs.

One group of researchers is developing drug compounds that would signal existing vessels to branch into new tributaries. These compoundsgenerally protein growth factorsmimic how cancerous tumor cells recruit blood vessels.

The other group, which includes the U-M team, is using a cell-based method. This technique involves injecting cells within a scaffolding carrier near the spot where you want new capillaries to materialize. In Putnam's approach, they deliver endothelial ce
'/>"/>

Contact: Nicole Casal Moore
ncmoore@umich.edu
734-647-7087
University of Michigan
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Building the European Unions Natura 2000 -- the largest ever network of protected areas
2. New study finds a protein combination is best to consume post-workout for building muscle
3. Light weights are just as good for building muscle, getting stronger, researchers find
4. CUNY Energy Institute battery system could reduce buildings electric bills
5. A cells first steps: Building a model to explain how cells grow
6. Stealing lifes building blocks
7. Blood-brain barrier building blocks forged from human stem cells
8. Building global collaboration for biodiversity intelligence
9. Mathematicians find solution to biological building block puzzle
10. Minimally invasive building renovation
11. Natural regeneration building urban forests, altering species composition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2015)... 2015 ACT Genomics Co., Ltd., a ... transform cancer genomic information into precision diagnosis and ... raised US$ 8 million in the its first private ... Taipei, Taiwan , ACT Genomics has developed ... aim to implement next generation sequencing (NGS) and ...
(Date:2/11/2015)... According to a ... Product (Cards and Readers, Biometrics, Controllers, Management Software), ... Healthcare, Education) and By Geography - Global Forecast and Analysis to ... Control Market is expected to reach $10.4 ... of 10.6% between 2014 and 2020. ...
(Date:2/5/2015)... North Carolina , 5. Februar 2015 ... Jahr als spezialisiertes Logistikunternehmen und hat eine ... einzige klinische Logistikfirma (Clinical Logistics Organization – ... der neuen Kampagne lautet First , ... Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
Breaking Biology News(10 mins):ACT Genomics Raises $8 Million in its First Private Funding Round 2Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3
... has been the inspiration for countless books and movies, ... engineers. Researchers at the California Institute of Technology (Caltech) ... intelligencenot in a robot or a silicon chip, but ... to have made an artificial neural network out of ...
... Mobile devices have become as common as the stethoscope in ... read test results, access diagnostic tools and take patient notes, ... smartphone or using a flash drive. These mobile devices are ... huge security risks to patient information. In less ...
... LOS ALAMOS, New Mexico, July 20, 2011Researchers at the ... Great Lakes Bioenergy Research Center have found a potential ... materials such as corn leaves and stalks, or switch ... Journal of the American Chemical Society , Los Alamos ...
Cached Biology News:Caltech researchers create the first artificial neural network out of DNA 2Caltech researchers create the first artificial neural network out of DNA 3Caltech researchers create the first artificial neural network out of DNA 4Mobile Devices Pose New Security Risks for Patients; Five Experts Share Insights on mHealth 2Mobile Devices Pose New Security Risks for Patients; Five Experts Share Insights on mHealth 3Mobile Devices Pose New Security Risks for Patients; Five Experts Share Insights on mHealth 4Mobile Devices Pose New Security Risks for Patients; Five Experts Share Insights on mHealth 5Researchers find potential key for unlocking biomass energy 2
(Date:3/2/2015)... Resilinc released online today its ... summarizes and analyzes nearly 700 unique supply chain notifications ... global event monitoring and alert reporting service. Supply chain ... period of the email service to receive early warnings ... impact revenue, market share, customer satisfaction, and shareholder value. ...
(Date:3/2/2015)... 2015  Pfenex Inc. (NYSE MKT: PFNX), a ... biosimilar therapeutics, today announced that it will be ... in Miami, FL at the Loews Miami Beach Hotel.  Dr. ... Pfenex, will provide an overview of the company,s ... ET. A live audio webcast and archive of ...
(Date:3/2/2015)... BARBARA, Calif. , March 2, 2015 /PRNewswire/ ... biotechnology company developing therapies for autoimmune and infectious ... Office (USPTO) has issued an important new composition ... system function through the targeting of CLIP. ... targeted peptide technology underlying VG Life Sciences, VG1177, ...
(Date:3/1/2015)... London, UK (PRWEB) March 01, 2015 ... a partnership agreement for quality market research promotion ... and sell research reports worked out by DataGroup ... Department at Market Publishers Ltd, commented on the ... to have DataGroup Booksellers in our team of ...
Breaking Biology Technology:Resilinc Publishes 2014 EventWatch™ Supply Chain Disruption Annual Report 2Resilinc Publishes 2014 EventWatch™ Supply Chain Disruption Annual Report 3VG Life Sciences Granted Key Composition Of Matter Patent 2VG Life Sciences Granted Key Composition Of Matter Patent 3Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 2Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 3
... AMEX: SNT ) announced that that Leslie J. ... DATE: December 1, 2011 TIME: 10:00 AM EST LINK: ... now" button. This will be a live, interactive ... questions in real-time both in the presentation hall as well ...
... Molecular Devices, LLC, the prominent source of powerful ... release of a much-anticipated customizable extension to its suite ... (Logo:  http://photos.prnewswire.com/prnh/20100406/SF82092LOGO ) Version ... the 51st annual meeting of the American Society for ...
... lead roles in a study that identified a portion ... embryonic stem cells (hESCs). The study was a worldwide ... of Sheffield (UK), Paul Robson of the Genome Institute ... Institute (BTI), and Barbara Knowles and others in the ...
Cached Biology Technology:Senesco Technologies, Inc. to Webcast, Live, at RetailInvestorConferences.com on December 1st 2Senesco Technologies, Inc. to Webcast, Live, at RetailInvestorConferences.com on December 1st 3Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow 2Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow 3Singapore scientists lead human embryonic stem cell study 2Singapore scientists lead human embryonic stem cell study 3
... PGE2 is one of several isoprostanes produced from ... potent renal vasoconstrictor in the rat. 8-iso PGE2 ... values of 0.5 and 5 µM, respectively. When ... at a concentration of 4 mg/kg/min, 8-iso PGE2 ...
... Source: Tritirachium album Description: Proteinase ... used in a wide range of applications purified ... bonds mainly following the carboxyl group of N-substituted ... and is classified as a serine protease. Proteinase ...
Proliferin (C-14)...
Porcine Pulmonary Artery Endothelial Cells (PPAEC) (>500,000 cells)...
Biology Products: