Navigation Links
Building better blood vessels could advance tissue engineering
Date:4/4/2013

ANN ARBOROne of the major obstacles to growing new organsreplacement hearts, lungs and kidneysis the difficulty researchers face in building blood vessels that keep the tissues alive, but new findings from the University of Michigan could help overcome this roadblock.

"It's not just enough to make a piece of tissue that functions like your desired target," said Andrew Putnam, U-M associate professor of biomedical engineering. "If you don't nourish it with blood by vascularizing it, it's only going to be as big as the head of a pen.

"But we need a heart that's this big," he added, holding up his fist.

More immediately, doctors and researchers believe figuring out how to grow working blood vessels might offer treatments for diseases that affect the circulatory system such as diabetes. Perhaps the right drug or injection could save patients' feet from amputation.

Putnam and his colleagues have revealed why one of the leading approaches to building blood vessels isn't consistently working: It's making leaky tubes. They also demonstrated how adult stem cells could solve this problem. A paper on the findings is published online in Tissue Engineering Part A, and will appear in a forthcoming print edition.

Today, biomedical researchers are taking two main approaches to growing new capillaries, the smallest blood vessels and those responsible for exchanging oxygen, carbon dioxide and nutrients between blood and muscles or organs.

One group of researchers is developing drug compounds that would signal existing vessels to branch into new tributaries. These compoundsgenerally protein growth factorsmimic how cancerous tumor cells recruit blood vessels.

The other group, which includes the U-M team, is using a cell-based method. This technique involves injecting cells within a scaffolding carrier near the spot where you want new capillaries to materialize. In Putnam's approach, they deliver endothelial ce
'/>"/>

Contact: Nicole Casal Moore
ncmoore@umich.edu
734-647-7087
University of Michigan
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Building the European Unions Natura 2000 -- the largest ever network of protected areas
2. New study finds a protein combination is best to consume post-workout for building muscle
3. Light weights are just as good for building muscle, getting stronger, researchers find
4. CUNY Energy Institute battery system could reduce buildings electric bills
5. A cells first steps: Building a model to explain how cells grow
6. Stealing lifes building blocks
7. Blood-brain barrier building blocks forged from human stem cells
8. Building global collaboration for biodiversity intelligence
9. Mathematicians find solution to biological building block puzzle
10. Minimally invasive building renovation
11. Natural regeneration building urban forests, altering species composition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015  A man-made form of insulin delivered by nasal ... in adults with mild cognitive impairment and Alzheimer,s disease ... at Wake Forest Baptist Medical Center. The ... cognitive impairment (MCI) or mild to moderate Alzheimer,s dementia ...
(Date:1/22/2015)... Jan. 22, 2015 Research and Markets ... the "Global Wearable Technologies Market and Applications, ... Trends and Forecast 2014-2020" report to their ... smart devices that can be worn on the ...
(Date:12/22/2014)... Research and Markets ( http://www.researchandmarkets.com/research/fx4bg3/the_global ) ... Global Watermarking and Fingerprinting Markets" report to ... This insight provides an overview ... markets. Watermarking aims to control and monitor piracy ...
Breaking Biology News(10 mins):Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2The Global Watermarking and Fingerprinting Markets 2
... spinal cord injury is receiving attention in the research ... department of biomedical engineering at NJIT, recently has published ... stimulators for individuals with spinal cord injuries. ... of support from a four-year, $1.4 million National Institutes ...
... Inc. (Nasdaq: AWRE ), a global provider ... of the Next-Generation Universal Automated Booking Station, or "Universal ... of Justice. Universal ABS is a biometric enrollment application ... modular, COTS software framework that is far more easily ...
... S.C., Oct. 17, 2011 Integrated Biometrics, a South ... announced today that they have launched a new FBI ... device has been tested by The MITRE Corporation and ... Certified Product List. Watson is the world,s first non-optical ...
Cached Biology News:NJIT researcher testing micro-electronic stimulators for spinal cord injuries 2Aware Develops Next-Generation Biometric Enrollment Application for Department of Justice 2Aware Develops Next-Generation Biometric Enrollment Application for Department of Justice 3Aware Develops Next-Generation Biometric Enrollment Application for Department of Justice 4The World's First Non Optical FBI Appendix F Certified Fingerprint Sensor 2
(Date:1/22/2015)... BRUNSWICK , Nueva Jersey , 22 de ... Award for Biomedical Research abre hoy su llamada a ... personas cuya investigación científica ha hecho, o tiene el ... la salud humana. Las nominaciones se aceptarán hasta el ...
(Date:1/22/2015)... , Jan. 22. 2015  Varian Medical Systems (NYSE: ... has been honored for its commitment to sustainability with inclusion ... Varian is the highest ranked healthcare equipment company among the ... during the World Economic Forum at Davos, Switzerland ...
(Date:1/22/2015)... , Jan. 22, 2015  Derma Sciences, Inc. (Nasdaq: ... focused on advanced wound care, announces that AMNIOEXCEL® ... have been added to the Premier, Inc. Regenerative ... opportunity for the AMNIOEXCEL® and AMNIOMATRIX® product lines, ...
(Date:12/24/2014)... , Dec. 24, 2014  United Therapeutics Corporation (NASDAQ: ... MDT ) has submitted a pre-market approval ... for the use of Medtronic,s SynchroMed ® II ... for use with United Therapeutics, Remodulin ® (treprostinil) ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Varian Honored Among World's 100 Most Sustainable Corporations 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4
... is available in Spanish . , Scientists ... characterized for the first time different antioxidant compounds from foods ... called Teucrium polium. They have used two new techniques, capillary ... to identify and quantify a great part of the phenolic ...
... OMAHA, Neb. , Feb. 5 Transgenomic, Inc. (OTC ... Chief Executive Officer, will be presenting a corporate overview of the company ... take place at 11:30 a.m. EST on Tuesday, February ... City , NY. , About Transgenomic, Inc. ...
... published today in Science , by researchers at ... Office, the Natural Resources Institute, and the Universities of ... flight behaviours that enable insects to undertake long-distance migrations, ... , Many insects avoid cold British winters by migrating ...
Cached Biology Technology:New antioxidant compounds have been identified in foods such as olive oil, honey and nuts 2Transgenomic Presents at 12th Annual BIO CEO & Investor Conference 2Migrating insects fly in the fast lane 2
... deuterium atoms at the 9, 10, 12, and ... an internal standard for the quantification of 9(S)-HODE ... by the lipoxygenation of linoleic acid in both ... atherosclerotic plaques, as an esterified component of membrane ...
5(S)-HETE-d8 is used as an internal standard for the quantification of 5(S)-HETE by stable isotope dilution mass spectrometry....
...
All-in-one mix, removes primers and dNTPs from PCR product for following direct sequencing...
Biology Products: