Navigation Links
Bugs without borders
Date:12/9/2012

Researchers show that the global epidemic of Clostridium difficile 027/NAP1/BI in the early to mid-2000s was caused by the spread of two different but highly related strains of the bacterium rather than one as was previously thought. The spread and persistence of both epidemics were driven by the acquisition of resistance to a frontline antibiotic.

Unlike many other healthcare-associated bacteria, C. difficile produces highly resistant and infectious spores. These spores can promote the transmission of C. difficile and potentially facilitates its spread over greater geographical distances, even across continents.

This study highlights the ease and rapidity with which the hospital bacterium, C. difficile, can spread throughout the world, emphasising the interconnectedness of the global healthcare system.

"Between 2002 and 2006, we saw highly publicised outbreaks of C. difficile in hospitals across the UK, USA, Canada and Europe," says Dr Miao He, first author from the Wellcome Trust Sanger Institute. "We used advanced DNA sequencing to determine the evolutionary history of this epidemic and the subsequent pattern of global spread.

"We found that this outbreak came from two separate epidemic strains or lineages of C. difficile, FQR1 and FQR2, both emerging from North America over a very short period and rapidly spread between hospitals around the world."

The team used the genetic history to map both epidemic strains of C. difficile using a global collection of samples from hospital patients between 1985 and 2010. They demonstrated that the two C. difficile strains acquired resistance to this antibiotic, fluoroquinolone, separately, a key genetic change that may have instigated the epidemics in the early 2000s.

"Up until the early 2000s, fluoroquinolone was an effective treatment for C. difficile infection," says Professor Brendan Wren, author from
'/>"/>

Contact: Aileen Sheehy
press.office@sanger.ac.uk
0044-012-234-92368
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. How to make high-end perfumes without whale barf
2. Feeding without the frenzy
3. Plant growth without light control
4. Production of chemicals without petroleum
5. NPointer from Neurotechnology Uses Hand Gestures to Control and Navigate Computer Programs Without a Mouse or Touchpad
6. Survival without water: A key trait of an aquatic invader to spread
7. Surviving without ice
8. How bumblebees find efficient routes without a GPS
9. Production of FRP components without release agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... University Mainz (JGU) as a full member, ensuring ... a significant nationwide standing in the field of ... Gutenberg University Mainz as a full member of ... and international competition for the best minds and ... proud that Mainz University has been recognized as ...
(Date:10/15/2014)... Fred Alt will be awarded the 44th Rosenstiel Award ... for his pioneering research exploring the mechanisms of genomic ... cancer cells. Alt is the second alumnus to win ... Nobel Prize in 2003. , Alt is the Charles ... at Harvard Medical School and an investigator at the ...
(Date:10/14/2014)... 2014)—It,s been millions of years since T. rex ... by Ohio University scientists is breathing life back into ... dinosaur snouts. The research has important implications for how ... to enhance the sense of smell and cool their ... Ohio University doctoral student Jason Bourke, lead author of ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3
... Lysmata amboinensis usually live in monogamous pairs, but dark ... Central,s open access journal Frontiers in Zoology shows ... attack and kill each other until only a single pair ... This means that they start out as males but, as ...
... pollination, the number of seeds they produce, or their relative ... of pollen. The number of visits a plant may receive ... plant density. But what if a plant happens to grow ... pollinators visiting its flowers? Will all the effort put into ...
... and depth of the Deepwater Horizon oil spill ... severity of ecological damage and to develop restoration plans for ... report by the National Research Council. A broad approach ... production -- in addition to replacing natural resources damaged by ...
Cached Biology News:Violent passions jealous cleaner shrimp murder their rivals 2How does a plant survive with few mates or pollinators? A European herb has figured out its own way 2How does a plant survive with few mates or pollinators? A European herb has figured out its own way 3New report offers broad approach to assessing impacts of ecological damage 2New report offers broad approach to assessing impacts of ecological damage 3
(Date:10/22/2014)... Oct. 22, 2014 Research and Markets ... Market by Material, by Application, Geography - Global Analysis ... offering. Organic electronics, also called as ... material science which deals with small conductive molecules and ... small molecules and polymers are carbon based, made using ...
(Date:10/20/2014)... MENLO PARK, Calif. , Oct. 20, 2014 ... announced today that the Company has signed a ... Institute of Regenerative Medicine (CIRM), effective October 1, ... of Clinical Development payments and the release of ... $14.3 million CIRM grant award for clinical development ...
(Date:10/20/2014)... October 20, 2014 OncLive® ... Kimmel Cancer Center at Thomas Jefferson University has ... Through the Strategic Alliance Partnership program, the Sidney ... collaborate to raise awareness of the Center’s cutting-edge ... other projects. Clinicians and other health care professionals ...
(Date:10/19/2014)... CAMBRIDGE, Mass. , Oct. 19, 2014 NextCODE ... of the whole genome in real time, today announced the ... the NextCODE Exchange , at the American Society of ... . To learn more, sign up and apply for ... on its unique features and benefits can be viewed ...
Breaking Biology Technology:Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3
... March 14 GHI Medical, a national,leader in ... to,correlate the results of a current test used ... is called the TrichoBioScan(TM)., The TrichoBioScan(TM) consists ... with an in-depth microscopic analysis of a person,s,hair ...
... 14 ,Renovis, Inc. (Nasdaq: RNVS ), a biopharmaceutical ... major medical needs in the areas of,neurological and inflammatory ... year ended December 31, 2007., Revenue for the ... was,$1.3 million and $9.8 million, respectively, compared to $2.2 ...
... Diagnostics,Incorporated (NYSE: DGX ), the nation,s leading ... it is scheduled to speak,at the Lehman Brothers ... 2008, at The Loews Miami Beach Hotel, Miami, ... at 9:00 a.m.,Eastern Time., The presentation will ...
Cached Biology Technology:Renovis Reports Fourth Quarter and Full Year 2007 Financial Results 2Renovis Reports Fourth Quarter and Full Year 2007 Financial Results 3Renovis Reports Fourth Quarter and Full Year 2007 Financial Results 4Renovis Reports Fourth Quarter and Full Year 2007 Financial Results 5Renovis Reports Fourth Quarter and Full Year 2007 Financial Results 6Renovis Reports Fourth Quarter and Full Year 2007 Financial Results 7Quest Diagnostics to Speak at Lehman Brothers 11th Annual Global Healthcare Conference 2
BD BioCoat Collagen IV 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse collagen type IV....
... are designed for sequencing inserts cloned into ... or T3 RNA polymerase promoters, or lambda ... at a concentration of 0.1 µg/µl in ... DNA sequencing reactions using SequiTherm™ EXCEL™ II ...
BD BioCoat Matrigel Matrix 35 mm Culture Dishes Coating : BD MatrigelTM Basement Membrane Matrix ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vo...
BD BioCoat Collagen I 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of rat tail collagen type I....
Biology Products: