Navigation Links
Breast cancer risk gene discovery fast tracked by new technology
Date:3/29/2012

An international team of researchers led by the University of Melbourne has used new technology to fast track the discovery of a breast cancer risk gene and could assist in the discovery of other cancer genes.

Professor Melissa Southey of the Genetic Epidemiology Laboratory, Department of Pathology at the University of Melbourne, who led the study, said it was a significant discovery and the first breast cancer risk gene to be discovered using the latest genetic sequencing technology.

"The mutations in the newly identified gene XRCC2, although rare, explain another proportion of breast cancers that run in families where there is no known genetic cause and that particularly occur at an early age," she said.

"We identified this gene quite quickly using genetic technology called massively parallel sequencing, which enables sequencing of large amounts of human DNA at high speed.'

"Due to these results and our methodology we believe that further risk genes will be identified at a faster rate than before and potentially for other cancers such as colorectal and prostate cancers," she said.

Professor Southey said the discovery could help manage the risk of breast cancer for families with a strong history of the disease and no known genetic cause.

"This discovery will assist some families to determine individual risk and which family members are at high risk of contracting the disease," Professor Southey said.

"Unaffected relatives of people with a mutation in this gene could also be offered predictive testing, subsequent genetic counselling and ongoing clinical management on the basis of their mutation status.'

"People whose breast cancer is associated with XRCC2 mutations could also benefit from specific treatments that target the genetic fault," she said.

Currently, only about 30 per cent of the familial risk for breast cancer has been explained, leaving the substantial majority sti
'/>"/>

Contact: Rebecca Scott
rebeccas@unimelb.edu.au
61-383-440-181
University of Melbourne
Source:Eurekalert

Page: 1 2

Related biology news :

1. Protein jailbreak helps breast cancer cells live
2. Study details on-off switch that promotes or suppresses breast cancer
3. Breast cancer spread triggered by a cleaver-wielding protein on cancer cells surface
4. Some breast cancer spread may be triggered by a protein, study shows
5. Researchers identify possible receptor for key breast cancer regulator
6. ISG15: A novel therapeutic target to slow breast cancer cell motility
7. Cell-CT: A new dimension in breast cancer research
8. Breastfeeding promotes healthy growth
9. Breastfeeding saved babies in 19th century Montreal
10. MRI may be noninvasive method to measure breast cancer prognosis
11. New Achilles heel in breast cancer: Tumor cell mitochondria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... JOSE, Calif. , July 27, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that ... ® touchscreen solution for its stylish smartwatch. ... for its proven reliability, low power and highly ... a wet finger. Huawei designers also required a ...
(Date:7/21/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... on the growing mobile commerce market and creator ... has filed provisional patent 62/192218 for ... This invention highlights next generation payment technology from ... also the user using unique personal identifiers including ...
(Date:7/9/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), a leading ... will report financial results for the fourth quarter and ... the close of market. The company will host a ... p.m. PT (5:00 p.m. ET), during which management may ... the live call, analysts and investors should dial 888-455-2260 ...
Breaking Biology News(10 mins):Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2
... release is available in German . ... strategy for the individual but it can drive the species ... Daniel Rankin from the University of Zurich has demonstrated in ... long debated whether the behavior of the individual is able ...
... Monday, May 16, 2011 A new discovery in mice ... day allow doctors to spare some patients with acute myeloid ... for new therapeutic research. AML, the most common ... form of cancer that primarily affects the elderly. Despite years ...
... Packard and the University of California, Santa Barbara, have ... of an electronic device that computer engineers hope will ... memory resistors, are a newly understood circuit element for ... seek ways of mimicking the behaviour of our own ...
Cached Biology News:Aggressive male mating behavior can endanger species 2Study reveals need for personalized approach in treatment of AML 2Study reveals need for personalized approach in treatment of AML 3'Computer synapse' analyzed at the nanoscale 2
(Date:7/31/2015)... ... 2015 , ... Global Resorcinol Market 2015-2019 is a comprehensive ... global resorcinol industry. The report highlights the various growth prospects and the prevalent ... of primary and secondary inputs from the existing players of the resorcinol market. ...
(Date:7/30/2015)... July 30, 2015   GenoSpace , a ... interpretation and analysis of genomic and other biomedical ... has joined the company as Vice President of ... http://photos.prnewswire.com/prnh/20150730/250931 "GenoSpace partners with ... interpret, analyze and explore complex sets of genomic, ...
(Date:7/30/2015)... 2015   Aratana Therapeutics, Inc . (NASDAQ: ... on the licensing, development and commercialization of innovative ... its strategic partner VetStem Biopharma, Inc. has shared ... AT-016, an adipose-derived allogeneic stem cell product exclusively ... pain in dogs. The double-blinded, multi-site, ...
(Date:7/30/2015)... , July 30, 2015  Discovery Laboratories, Inc. ... has received the second $1.0M tranche under a ... (SBIR) grant valued at up to $3.0 million ... KL4 surfactant as a potential medical countermeasure to ... Labs was awarded an initial $1.0 million under ...
Breaking Biology Technology:Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 2Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 3Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 4GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 5Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3
... ... ... -- Professor Jean M. J. Frchet, a pioneering chemist who has achieved great success ... King Abdullah University of Science and Technology (KAUST) in Saudi Arabia., , , , ...
... ... American Communications Professionals Honors LaVoie Group for Best Industry-Exclusive Agency and Best Business ... ... Group , a life science and pharmaceuticals focused strategic communications agency, announced today ...
... , ... a life science-focused strategic communications agency, announced today that it has been selected by ... develop and execute its corporate communications and public relations program. , ... Salem, MA (Vocus) February 8, 2010 ...
Cached Biology Technology:Frchet Named Vice President for Research at Kaust 2Frchet Named Vice President for Research at Kaust 3Frchet Named Vice President for Research at Kaust 4Frchet Named Vice President for Research at Kaust 5LaVoie Group Honored by LACP with Two Awards 2LaVoie Group Honored by LACP with Two Awards 3LaVoie Group Honored by LACP with Two Awards 4Invida Selects LaVoie Group as Public Relations Agency of Record 2Invida Selects LaVoie Group as Public Relations Agency of Record 3