Navigation Links
Breast cancer heterogeneity no barrier to predictive testing, study shows
Date:5/2/2013

n profiling on their 78 samples using oligonucleotide microarrays. Overall, they found that the gene expression profiles of the cores were variable, and in at least 5 patients this heterogeneity was substantial.

However, when they analysed a number of multi-gene signatures selected from previous studies, this heterogeneity was considerably less significant.

The gene sets differed in their variance between biopsies, the authors found. The most pronounced heterogeneity was observed in immune response-related genes, while the least heterogeneous were the classifiers based on genes selected by advanced bioinformatical methods from both cell culture experiments and patient tissues.

"Overall, the heterogeneity among the potentially predictive genes was small enough and we conclude that this factor should not prohibit their effective use in clinical practice," Dr Jarząb says.

"Our study confirms that it is possible to address tumour heterogeneity when carrying out routine diagnostic procedures in patients. Our results may help to introduce the better tailoring of preoperative treatment."

Commenting on the results, Dr. Angelo Di Leo, Head of the Sandro Pitigliani Medical Oncology Unit and Chair of the Oncology Department at the Hospital of Prato, Istituto Toscano Tumori, Italy, said: "If other studies report similar results to this one, then it could become common practice to evaluate prognostic or predictive breast cancer markers from more than one primary tumour area."

"The study is innovative because it is one of the first to address the question of intratumour heterogeneity. It means that not all the cells from the same tumour have the same characteristics, and if we want to have a clear picture of the tumour biology we should not limit the evaluation of tumour markers to one area of the tumour itself," Dr. Di Leo said.


'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Big data analysis identifies prognostic RNA markers in a common form of breast cancer
2. Cold winters freezing out breast cancer treatment
3. Identified as responsible for breast and ovarian hereditary cancer 3 mutations at BRCA1 gene
4. An important discovery in breast cancer by IRCM researchers
5. UCLA researchers find nanodiamonds could improve effectiveness of breast cancer treatment
6. IMPAKT -- Translational research breast cancer conference
7. LSUHSC research discovers new drug target for metastatic breast cancer
8. AACR news: Studies show increasing evidence that androgen drives breast cancer
9. AACR news: Six2 homeoprotein allows breast cancer cells to detach and metastasize
10. AACR news: Paragazole excels in preclinical models of triple-negative breast cancer
11. Certain breast cancers have a trait that could be attacked by new therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... The announcement comes as demand for fire ... Ireland,s foremost records management company, has ... an impressive track record of clients within the first 12 ... management sector in Dubai . As a ... employ a further eight staff members at its Irish headquarters. ...
(Date:4/13/2015)... , April 13, 2015 ... TechSci Research, "Global Biometrics Market Forecast & Opportunities, 2020", ... a CAGR of around 14% till 2020. The ... for large scale implementation and review of biometric ... launch of new products with greater efficiency, are ...
(Date:4/8/2015)...  Infinisource, a leading provider of SaaS-based Human Capital ... leading supplier of biometric identification and security solutions, ... advanced biometrically-enabled time clock, the companies announced today. ... setting a bold, new standard for the collection ... and mid-size employer. When connected to the iSolved ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... release is available in German . , It ... the fate of individual cells during the early development of ... team of molecular biologists led by Pia Aanstad of the ... accounts for the interpretation of the concentration of the signaling ...
... patient,s body, stem cells intended to treat or cure ... they are no longer under the control of the ... solve this problem, according to a perspective article from ... a recent issue of the journal Cell Stem ...
... the time of the Babylonians to the Incas, terracing ... and hilly croplands. Designing terrace layouts can be time ... are developing a Web-based program that will design multiple ... will help farm experts choose the most efficient and ...
Cached Biology News:Why the thumb of the right hand is on the left hand side 2Gene therapy could expand stem cells' promise 2Web-based program designs more efficient farm terrace layouts 2
(Date:5/22/2015)... May 22, 2015 Baylor Research Institute (BRI) ... Translational Genomics Research Institute (TGen) in Phoenix, ... on accelerating early detection and treatments for patients with a ... institutions will lead to new clinical trials and access to ... the gap from bench to bedside across Baylor Scott ...
(Date:5/21/2015)... 21, 2015  Susan Hedstrom, Executive Director of ... organization dedicated to supporting research to advance the ... today that FPWR has received the organization,s largest ... contributed $1 million in support of the ... "Our gift signifies our ...
(Date:5/21/2015)... , May 21, 2015 ... inner feelings - and those of others. Being able ... senses. Analyze and read people to anticipate their thoughts ... your deepest emotions and feelings to create unique abstract ... of responsive games. Get inside a first-person-shooter as it ...
(Date:5/21/2015)... As part of its philanthropic partnership with Banner ... funded a $3.25 million project to relocate and equip ... up-to-date features and technology. , The new pharmacy is ... members will begin moving from the current location to ... , The current pharmacy has been using a ...
Breaking Biology Technology:Precision Medicine Collaboration to Increase Options for Cancer Patients 2Precision Medicine Collaboration to Increase Options for Cancer Patients 3Precision Medicine Collaboration to Increase Options for Cancer Patients 4The Foundation for Prader-Willi Research Receives $1M Contribution in Support of Clinical Initiatives 25 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 3
... Communications, an,innovator in medical communications, brand development, ... to serve the company,s growing,client base in ... Palmisano, the new vice president of medical ... it integrates creative thinking,and scientific acumen to ...
... Modeling Complex ... Biological Systems for Type 2 Diabetes, CAMBRIDGE, Mass., ... on identifying molecular mechanisms, networks and,biomarkers to better understand ... Sirtris Pharmaceuticals, Inc. (Nasdaq: SIRT ),a biopharmaceutical company ...
... Shandong, China, April 30 /Xinhua-PRNewswire-FirstCall/ --,China Biologic ... or "the,Company"), one of the leading plasma-based ... ("PRC"), today announced that the Company,received approval ... Administration,("SFDA") (1) to start the production of ...
Cached Biology Technology:MedThink Hires Two Executives to Serve its Growing Pharmaceutical Client Base 2Genstruct and Sirtris Pharmaceuticals Win Bio-IT World's Best Practices Award 2China Biologic Products Announces SFDA Approval for the Production of Cryoprecipitate and for the Clinical Trial of Human Prothrombin Complex 2China Biologic Products Announces SFDA Approval for the Production of Cryoprecipitate and for the Clinical Trial of Human Prothrombin Complex 3
...
DryStrip aligners, 4. Category: Electrophoresis Systems & Standards & Reagents, IEF & SDS-PAGE & 2-D Electrophoresis, Multiphor II Kits & Components and Accessories....
Immunogen: Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, alpha1/alpha2-isotype. Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
Biology Products: