Navigation Links
Boston University biomedical engineers find chink in bacteria's armor
Date:9/6/2007

Biomedical researchers at Boston Universitys College of Engineering may have discovered the path toward developing better drugs capable of defeating so-called superbugs, bacteria that have developed resistance to common antibiotics. The researchers have discovered a previously unknown chain of events occurring in bacteria that opens to door to new avenues of research.

Currently, three classes of bactericidal antibiotics are used to target different bacterial functions: inhibiting DNA replication; blocking protein-building; or halting construction of cell walls. Research from the laboratory of Professor James Collins found the three classes more alike than anyone realized, and the commonalities may be the bugs downfall.

Collins and colleagues article, A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics, appears in the September 7 issue of Cell.

The researchers discovered a common process, or pathway, that was triggered by all three types of antibiotics. Theres an underlying pathway beyond the drug interacting with the target, said graduate student and lead author Michael Kohanski, and the endpoint of this pathway is excessive free radical production.

Free radicals -- such as hydroxyl or superoxide radicals -- are molecules that carry a free, or unpaired, electron like a weapon. Theyll damage DNA, proteins, lipids in the membrane, pretty much anything. Theyre equal opportunity damagers, said Kohanski.

This hidden pathway and resultant free radical overload appears to help current antibiotics do their job, but is not always enough to kill all bacteria by itself. Collins group theorizes that if this effect can be amplified, or if the cells genetic defense against it can be weakened, no bacteria could withstand its effect and the emergence of antibiotic-resistant bacteria could be limited.

Importantly, we showed that if you can inhibit or block the bacterial defense mechanisms to hydrox
'/>"/>

Contact: Mike Seele
mseele@bu.edu
617-353-9766
Boston University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Boston University biomedical engineers win major grant for pursuit of the $1,000 Genome
2. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
3. New protein discovered by Hebrew University researchers
4. Next Generation Body Scanner Launched By The University Of Manchester
5. Roundup®highly lethal to amphibians, finds University of Pittsburgh researcher
6. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
7. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
8. Carnegie Mellon University research reveals how cells process large genes
9. University of Delaware researchers develop cancer nanobomb
10. University of Arizona plant scientists to unravel maize genome
11. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/10/2015)... March 10, 2015  NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the ... smart wallet has been named the "Number One ... Rethink Modern ( http://www.rethinkmodern.com/ ) is ... your home and lifestyle that have a unique function ...
(Date:3/3/2015)... , March 3, 2015 ... provider of advanced cryogenic logistics solutions for ... immunotherapies, stem cells, cell lines, clinical research ... medicine, today announced the expansion of its ... Centers, ("Fred Hutch") Clinical Research Division ...
(Date:3/2/2015)... , March 2, 2015   Neurotechnology , a ... introduced the SentiGaze Software Development Kit (SDK). ... applications that use off-the-shelf webcams to track eye movements ... at a monitor. Heatmaps can be used for applications ... of online advertising. The SDK can also be used ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3
... October 2009, Springer will publish Symbiosis , the ... The journal was previously published by Balaban International Science ... 49, Issue 1. Symbiosis publishes results ... symbiotic interactions at the molecular, cellular and organismal levels. ...
... University of North Carolina at Chapel Hill has been awarded ... as part of the National Institutes of Health,s Rare Diseases ... us continue our discovery of rare disease-causing gene mutations, which ... needs to be expanded and improved," said Michael Knowles, M.D., ...
... CLEVELAND Futuristic plans to grow replacement organs, bones or ... suffering from debilitating disease or injury won,t be anything ... into that tissue. Without blood vessels delivering oxygen ... would starve. Holding out stimulus money as ...
Cached Biology News:Springer to publish Symbiosis 2UNC awarded $6.2 million renewal grant by NIH Rare Diseases Research Network 2Blood vessel builders 2
(Date:3/31/2015)... Today, Cryos International, the world’s largest international ... facilities and inventory from New York City to Orlando, ... relocation is a reflection of their increasing growth and ... completed during the first weekend of spring, March 21 ... April 6. The new facility in the Central Florida ...
(Date:3/30/2015)... Francisco, CA (PRWEB) March 30, 2015 ... tax incentives provided you the government, major companies are ... and local governments setting future mandates for renewable energy ... as an option. , Solara Power is a new ... several incentive programs available that allow qualifying homeowners to ...
(Date:3/30/2015)... 30, 2015  Heidrick & Struggles (Nasdaq: HSII ), ... consulting and culture shaping worldwide, today  announced ... lead its global Healthcare and Life Sciences practice. ... Mitchell will lead a team of more than 80 partners, ... and Asia serving clients in ...
(Date:3/30/2015)... SYDNEY , March 30, 2015 US-Australian ... ) and its subsidiary, CanTx, Inc., and Yale University, ... drug, Cantrixil. The data was presented as an oral ... of Yale Medical School to the 62 nd ... in San Francisco, CA. ...
Breaking Biology Technology:Cryos International Completes Groundbreaking Sperm Migration to Orlando, Florida 2Solara Power Announces Residential Solar Power with No Up-Front Fees 2Heidrick & Struggles Strengthens Leadership of Healthcare - Life Sciences Practice 2Yale University and Novogen Release Data on Cantrixil Mode of Action 2Yale University and Novogen Release Data on Cantrixil Mode of Action 3Yale University and Novogen Release Data on Cantrixil Mode of Action 4
... Transgenomic Inc. (OTC Bulletin Board: TBIO) announces the following Webcast: , , ... Conference Call, ... Where: http://www.transgenomic.com/events.asp?id=6 , ... at the, ...
... Establishing Wholly-owned Subsidiary to Enable BBK Worldwide to ... March 18 BBK Worldwide, a global leader ... the opening of BBK Worldwide -- Osaka, G.K., ... to supporting Japanese pharmaceutical, biotechnology, and medical device ...
... handheld digital force gauge (measures various push-pull forces), used by ergonomic ... made to the interface and the force capacities have been doubled ... ... Salt Lake City, Utah (PRWEB) March 18, 2009 -- HOGGAN Ergo, ...
Cached Biology Technology:Reminder - Webcast Alert: Transgenomic Inc. Announces Fourth Quarter 2008 Earnings Release Conference Call Webcast 2Forward-Thinking Patient Recruitment Company Poised to Create Bridges Between Japanese Clinical R&D Industry and Global Clinical Trial Marketplace 2Forward-Thinking Patient Recruitment Company Poised to Create Bridges Between Japanese Clinical R&D Industry and Global Clinical Trial Marketplace 3HOGGAN Ergo Announces Highly Anticipated Enhancements to the ergoFET Handheld Digital Force Gauge, Greatly Impacting the Field of Ergonomic Research and Application 2HOGGAN Ergo Announces Highly Anticipated Enhancements to the ergoFET Handheld Digital Force Gauge, Greatly Impacting the Field of Ergonomic Research and Application 3
... are intended for laboratory research use only. ... neutral buffered formalin and embedded in paraffin. ... by certified pathologists. Tissue cores were ... into a new recipient paraffin block, in ...
... Equine EIA Principle: ... and LTE4 are products of ... and glutathione-S-transferase. In the past, ... Reacting Substances of Anaphylaxis (SRS-A)". ...
... Endogens Screening Sets contain the ... develop five colorimetric sandwich ELISA plates ... in 100 l/well of cell culture ... and Detection Antibodies, Recombinant Standard (5 ...
... critical to the maintenance of appropriate ... as important and diverse as those ... and stress response, antigen presentation, modulation ... channels, cell cycle regulation, transcription, and ...
Biology Products: