Navigation Links
Bone marrow mononuclear stem cells show no new gains in heart function says TIME study
Date:11/18/2013

MINNEAPOLIS, MN November 18, 2013 New data reported by the Cardiovascular Cell Therapy Research Network (CCTRN) at the 2013 Scientific Sessions of the American Heart Association in Dallas showed that the use of bone marrow mononuclear stem cells (BMCs) did not improve heart function significantly more at one year than at six months. While there was measurable decrease in the size of scar tissue at six and 12 months, stem cells administered as a part of the TIME (Transplantation In Myocardial Infarction Evaluation) study did not improve overall heart functionality. The results were presented by Jay Traverse, MD of the Minneapolis Heart Institute Foundation on Monday, Nov. 18.

"While there are no safety issues with BMC's, the resulting reduction in scar tissue (infarct size) at six months and at one year and the small improvement in left-ventricular function was no different than a placebo, suggesting that these types of stem cells would appear to be of low therapeutic efficacy, " stated Jay Traverse, MD, of the Minneapolis Heart Institute Foundation. "At this early stage of stem cell therapy research investigating viable post-heart attack strategies, our study and others suggest that we should look at other, more potent stem cells as a means to improving functionality following a heart attack." Traverse noted that this is one of the largest serial cardiac MRI studies examining the changes in left-ventricular function following a heart attack.

In this analysis, the administration of BMC's following moderate to large anterior STelevated myocardial infarction (STEMIs) was not associated with improved recovery of global and regional left ventricular (LV) function at one year compared to placebo. Levels of left ventricular ejection fraction (LVEF) increased from baseline to six months but did not improve further between six months and one year in either the BMC or the placebo group. On average, infarct size decreased in the BMC and placebo groups between baseline and six months by 30% with a smaller reduction between six months and one year. The reduction in infarct size was accompanied by a similarly significant reduction in LV mass through one year. There were no differences in the reduction in infarct size and LV mass between the BMC and placebo groups at any time.

TIME, and a previous, related study (LateTIME), were carried out by the CCTRN, sponsored by the NIH's National Heart, Lung, and Blood Institute. Both used autologous bone marrow mononuclear cells in randomized treatment of patients at different intervals following a heart attack. Together, TIME and Late TIME have shown that stem cell therapy is safe, but both studies noted a lack of effectiveness delivered by BMC therapy on left-ventricular function.

TIME was developed to examine the role of timing of cell delivery post-STEMI and enrolled 120 patients (avg. age 57) between July 2008 and February 2011; the participants all had moderate to severe reduction of their left ventricular ejection fraction (37%) and had undergone coronary stent placement as treatment for their heart attack. The participants were randomly assigned to stem cell delivery or placebo at three or seven days following their heart attack. Researchers utilized an automated method of processing and purifying the stem cells from the bone marrow of each volunteer to ensure that everyone received a uniform dose (150 million stem cells).


'/>"/>

Contact: Steve Goodyear
sgoodyear@mhif.org
612-863-1654
Minneapolis Heart Institute Foundation
Source:Eurekalert

Related biology news :

1. Newly identified bone marrow stem cells reveal markers for ALS
2. Type 2 diabetes patients transplanted with own bone marrow stem cells reduces insulin use
3. Researchers discover brain cancer treatment using genetic material from bone marrow cells
4. Scientists find bone-marrow environment that helps produce infection-fighting T and B cells
5. Bone marrow cells used in bladder regeneration
6. Bone marrow stem cells do not improve short-term recovery after heart attack
7. Study results: Adult stem cells from bone marrow
8. Autologous bone marrow-derived mononuclear cell transplants can reduce diabetic amputations
9. Cell therapy using patients own bone marrow may present option for heart disease
10. Bone marrow transplant arrests symptoms in model of Rett syndrome
11. Salk scientists for the first time generate mini-kidney structures from human stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... 18, 2017  Socionext Inc., a global expert in SoC-based imaging ... server, the M820, which features the company,s hybrid codec technology. A ... Tera Probe, Inc., will be showcased during the upcoming Medtec Japan ... at the Las Vegas Convention Center April ... Click here for ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, a ... authentication solutions, today announced that it has been ... Research Projects Activity (IARPA) to develop next-generation Presentation ... "Innovation has been a driving force ... program will allow us to innovate and develop ...
(Date:4/6/2017)... April 6, 2017 Forecasts by ... Document Readers, by End-Use (Transportation & Logistics, Government & ... Gas & Fossil Generation Facility, Nuclear Power), Industrial, Retail, ... Are you looking for a definitive report ... ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... FirstHand program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand ... Excellence in Volunteer Experience from US2020. , US2020’s mission is to change the ...
(Date:10/10/2017)... , Oct. 10, 2017 International research firm Parks ... Strategy, will speak at the TMA 2017 Annual Meeting , October ... trends in the residential home security market and how smart safety and ... Parks ... "The residential ...
(Date:10/10/2017)... BARBARA, CALIFORNIA (PRWEB) , ... October 10, 2017 ... ... management, technological innovation and business process optimization firm for the life sciences and ... BoxWorks conference in San Francisco. , The presentation, “Automating GxP Validation ...
(Date:10/9/2017)...  BioTech Holdings announced today identification and patenting ... stem cell therapy prevents limb loss in animal ... that treatment with ProCell resulted in more than ... to standard bone marrow stem cell administration.  Interestingly, ... of therapeutic effect.  ...
Breaking Biology Technology: