Navigation Links
Bleeding, not inflammation, is major cause of early lung infection death
Date:8/27/2007

Researchers believe they have discovered why a bacterial lung infection is so lethal in the early stages, and its not what medical authorities had thought, according to research published August 23 in the journal Immunity. The study reveals for the first time that a toxin released by bacteria causes severe bleeding in the lungs by patients with pneumococcal pneumonia. It is the bleeding, the authors argue, not inflammation as once thought, which makes the infections deadly. The same study also reveals why antibiotics often fail to help prevent early death.

Also called pneumococcus, the bacteria Streptococcus pneumoniae infects the upper respiratory tracts of the elderly and young children mostly. There are 500,000 cases of pneumococcal pneumonia annually in the United States, with about 40,000 of them fatal, according to the Centers of Disease Control and Prevention. Those numbers would be worse in children younger than 2 years if not for the 2000 introduction of the pneumococcal vaccine (Prevnar), according to one report. The picture remains far more serious outside of the United States, however, where pneumococcal infections take the lives of at least one million children each year, according to the World Health Organization

Our finding provides a better understanding of what makes a major global bacterial infection deadly, and marks the beginning of realistic efforts to save lives worldwide, said Jian-Dong Li, M.D., Ph.D., professor of Microbiology & Immunology at the University of Rochester Medical Center and an author on the Immunity paper. The power of understanding this mechanism is that it not only suggests how better to treat this disease, but also that we should think twice about whether standard drug treatments are doing more harm than good, said Li, also senior and corresponding author on the paper.

A Medical Mystery

Recognizing molecules as self, versus foreign invaders to be labeled for destruction, is
'/>"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Columbia research lifts major hurdle to gene therapy for cancer
2. Researchers uncover sequence of major rice pathogen
3. Emergence of cancer as major cause of childhood death in developing countries is not being adequately addressed
4. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
5. Virologists make major step towards understanding the process of HIV infection
6. Major new UNC-based drinking water study suggests pregnancy fears may be overstated
7. Major breakthrough in the treatment of cancers and infectious diseases
8. Major advance made on DNA structure
9. Major link in brain-obesity puzzle found
10. Biota makes major antiviral discovery
11. New gene scanning technology marks a major advance in disease research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... In the most densely forested and most densely populated ... of human needs, values and practices. Disturbances associated with ... agriculture and development, have set the stage for management ... study reports. , The report Five anthropogenic factors ... in the Northern United States was published ...
(Date:4/17/2014)... of stem cell therapies to cure a variety of ... populations based on cell surface markers. Researchers from the ... is highly expressed in a type of stem cells ... in an article in BioResearch Open Access , ... The article is available free on the ...
(Date:4/17/2014)... detection cartridge developed at Sandia National Laboratories and recently ... faster and cheaper. , Bacillus anthracis , ... soils all over the world and can cause serious, ... The bacteria can survive in harsh conditions for decades. ... occur through skin contact, inhalation of spores or eating ...
Breaking Biology News(10 mins):Five anthropogenic factors that will radically alter northern forests in 50 years 2Five anthropogenic factors that will radically alter northern forests in 50 years 3Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3
... men prefer beer when they drink alcohol, taking in at ... of the beverage. Far fewer (around five percent) prefer wine. ... beverages and a riskier approach to alcohol or other substances? ... Preventive Medicine at the University of Zurich and Lausanne University ...
... has shown for the first time evidence of ... bipolar disorder, major depressive disorder and schizophrenia and ... attention deficit-hyperactivity disorder (ADHD), according to a study ... Advance Online publication. The root cause of ...
... NEW YORK CITY Morning sickness, shiny hair, and ... what expectations do pregnant women impose on their ... perspectives on pregnancy? Danielle Bessett, an assistant ... present her research on this issue at the 108th ...
Cached Biology News:Young beer-drinkers binge-drink more frequently 2New patterns found in the genetic relationship of 5 major psychiatric disorders 2Cultural mythologies strongly influence women's expectations about being pregnant 2Cultural mythologies strongly influence women's expectations about being pregnant 3
(Date:1/15/2014)... Jan. 15, 2014  Bill Jacobs Automotive, a group of car ... up with the Heartland Blood Center and offering free oil ... drive takes place Saturday, Jan. 18 at the Bill Jacobs ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The ...
(Date:1/15/2014)... 2014 Look inside the new Preferred ... the lab, from fluid handling to instruments to supplies. ... when you order. , Preferred Solutions features a ... the L/S® model for precise flow control and dispensing ...
(Date:1/15/2014)... RedBrick Health , a fast-growing leader in consumer health ... EmblemHealth , the New York -based ... RedBrick Compass health assessment, combined with the RedBrick Journeys ... EmblemHealth is among the first health plans in the ...
(Date:1/15/2014)... January 15, 2014 More than 5 ... about 1 in 3 seniors will die with Alzheimer’s ... These jaw-dropping figures have shocked many Americans into looking ... help prevent these tragic age-related cognitive disorders. Jonathan Weisman, ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2
... it not been for the war in Iraq, 2003 might ... forgot. Certainly, in the world of information technology, that may ... happened slowly. Customers took their time. But for some activity ... then, must explain why the predictions I so carefully made ...
... robotic rover Spirit, which bounced to a near pinpoint ... 3) after a seven-month flight, promises a trove of ... , ,John Valley, a UW-Madison professor of geology and ... to be from Mars, expects the latest mission to ...
... - Fiserv Health, an operating group of Fiserv, ... a care management company targeting the self-funded health care ... health plan management, claims processing and administration services for ... addition of Avidyn Health, Fiserv Health now has an ...
Cached Biology Technology:The Year Ahead in IT 2The Year Ahead in IT 3The Year Ahead in IT 4The Year Ahead in IT 5Fiserv Launches Avidyn Health to Target Healthcare Costs 2
... The Freedom EVO series offers versatile liquid ... successfully automate a wide variety of life ... four different base sizes (75, 100, 150 ... access to a platform that will advance ...
... and conveniently controls the temperature at your lab ... levels up to 99 C*, with the "plus" ... as 5 C. The thermoblocks for 0.2 ml**, ... microplates enable a high degree of flexibility for ...
384 Well PCR Plate Carrier for Thermo-Sealer...
... Cell Cultures (ECACC) has been offering training ... government institutes for over seven years. We ... introduce candidates to cell culture and a ... specialist areas such as planning and management ...
Biology Products: