Navigation Links
Blame it on the astrocytes
Date:7/11/2014

Rio de Janeiro, Brazil- In the brains of all vertebrates, information is transmitted through synapses, a mechanism that allows an electric or chemical signal to be passed from one brain cell to another. Chemical synapses, which are the most abundant type of synapse, can be either excitatory or inhibitory. Synapse formation is crucial for learning, memory, perception and cognition, and the balance between excitatory and inhibitory synapses critical for brain function. For instance, every time we learn something, the new information is transformed into memory through synaptic plasticity, a process in which synapses are strengthened and become more responsive to different stimuli or environmental cues. Synapses may change their shape or function in a matter of seconds or over an entire lifetime. In humans, a number of disorders are associated with dysfunctional synapses, including autism, epilepsy, substance abuse and depression.

Astrocytes, named for their star-like shape, are ubiquitous brain cells known for regulating excitatory synapse formation through cells. Recent studies have shown that astrocytes also play a role in forming inhibitory synapses, but the key players and underlying mechanisms have remained unknown until now.

A new study just published in the journal Glia and available online on July 11th, details the newly discovered mechanism by which astrocytes are involved in inhibitory synapse formation and presents strong evidence that Transforming Growth Factor Beta 1 (TGF β1), a protein produced by many cell types (including astrocytes) is a key player in this process. The team led by Flvia Gomes of the Rio de Janeiro Institute of Biomedical Sciences at the Federal University of Rio de Janeiro investigated the process in both mouse and human tissues, first in test tubes, then in living brain cells.

Previous evidence has shown that TGF β1, a molecule associated with essential functions in nervous system d
'/>"/>

Contact: Flávia Gomes
fgomes@icb.ufrj.br
55-219-980-22770
Publicase Comunicao Cientfica
Source:Eurekalert

Page: 1 2

Related biology news :

1. Sick from stress? Blame your mom… and epigenetics
2. Viruses not to blame for chronic fatigue syndrome after all
3. Scientists conclude high fructose corn syrup should not be blamed for obesity
4. Gene sequencing project finds new mutations to blame for a majority of brain tumor subtype
5. Blame your parents for bunion woes
6. Rainfall to blame for decline in Arctic peregrines
7. Wetlands likely to blame for greenhouse gas increases: Study
8. History to blame for slow crop taming: Study
9. Climate not to blame for the disappearance of large mammals
10. Astrocytes control the generation of new neurons from neural stem cells
11. Who reprograms rat astrocytes into neurons?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/7/2014)... by Dr. Debra Auguste, associate professor, biomedical engineering, ... City College of New York, have identified a ... one of the most aggressive forms of breast ... a high mortality rate owing to aggressive proliferation ... options. However, Professor Auguste,s team, discovered the overexpression ...
(Date:11/6/2014)... groundbreaking paper from a team of Florida State University ... plants could adapt to and survive environmental swings such ... the latest issue of the journal The Plant ... of DNA and proteins) is organized in a cell ... genes are turned on and others are turned off. ...
(Date:11/6/2014)... Insilico Medicine, Inc, a Baltimore-based bioinformatics company focused ... announced a research collaboration with the international leader ... (OTC: CSBR). , "There are many companies utilizing ... Oncology,s TumorGraft technology is unique in a way ... generating vast amounts of valuable data. Our bioinformatic ...
Breaking Biology News(10 mins):Maize analysis yields whole new world of genetic science 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2
... from the U.S. Armed Forces, as well as federal, ... first-responder personnel from throughout the United States, and defense ... 2009 Force Protection Equipment Demonstration (FPED VII). The event ... Corps Base, Quantico, VA, during May 19-21.The demonstration, which ...
... High Volume Transaction Solution Enabling Paperless Processing for ... May 11 Communication Intelligence Corporation (" CIC ... of electronic signature solutions for business process automation ... in biometric signature verification and Striata, the leading ...
... Paperless eCharging Saves Time and Increases EfficiencyWALL, ... (OTC Bulletin Board: BKYI), a leader in ... solutions, today announced that Minnesota counties are ... part of a new paperless criminal charging, ...
Cached Biology News:Demonstration Features Commercial Technology for Combating Terrorism 2Striata and CIC Launch Integrated eSignature, eDelivery, and eBilling for the Financial Services Industry 2Striata and CIC Launch Integrated eSignature, eDelivery, and eBilling for the Financial Services Industry 3Striata and CIC Launch Integrated eSignature, eDelivery, and eBilling for the Financial Services Industry 4Striata and CIC Launch Integrated eSignature, eDelivery, and eBilling for the Financial Services Industry 5Minnesota Counties Secure New Criminal Charging System With BIO-key(R) Fingerprint Biometrics 2Minnesota Counties Secure New Criminal Charging System With BIO-key(R) Fingerprint Biometrics 3
(Date:11/21/2014)... 2014 Deep Research Report on Global ... report on the transformer market. The report provides ... industry chain structure as well as industry overview. ... China’s domestic market as well as global industry ... The report also covers information on policy, plans ...
(Date:11/21/2014)... 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today ... September 30, 2014.  Biorem,s complete 2014 third quarter financial statements and ... Financial Summary:Three-months ended September 30, , Nine-months ended ... , 2014 , 2013 , 2014 ... 5,281 , 6,715 , 14,476 Gross profit ...
(Date:11/18/2014)... 17, 2014 pH measurement and control ... the pharmaceutical, chemical, and food and beverage industries. But ... and how do pH sensors work? METTLER TOLEDO has ... in process industries with these questions and more. , ... in the process industries. The actual sensor, the pH ...
(Date:11/18/2014)... FL (PRWEB) November 18, 2014 Brothers ... announced the launch of PAWSitively Curing Cancer, Inc ... This new 501(c) (3) non-profit organization is dedicated to ... donated goes directly to the University of Florida ... partner with PAWSitively Curing Cancer as the recipient of ...
Breaking Biology Technology:International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 2International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 3Biorem Reports Third Quarter Results 2Biorem Reports Third Quarter Results 3pH Guide from METTLER TOLEDO Explains Measurement, Theory and Practice of pH Applications 2PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 2PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 3
... 2, 2011 This September, during Prostate Cancer Awareness ... cancer screening method that may change the face of ... Cleveland hospitals and one Boston hospital, analyzed by the National ... urine screening. Dr. David Samadi, Vice Chairman, Department of ...
...  Sept. 2, 2011  PTC Therapeutics, Inc. and ... of their collaboration. Under the original agreement, PTC ... and Genzyme held commercial rights in all other ... rights to ataluren and Genzyme retains an option ...
... This release is available in German . ... and MIT professor Ron Weiss have successfully incorporated a ... recognizes certain cancer cells using logic combinations of five ... (Kobi) Benenson, Professor of Synthetic Biology at ETH Zurich, ...
Cached Biology Technology:More Precise Prostate Cancer Screening on Horizon 2More Precise Prostate Cancer Screening on Horizon 3PTC Therapeutics and Genzyme Announce Restructuring of Collaboration 2PTC Therapeutics and Genzyme Announce Restructuring of Collaboration 3Profiler at the cellular level 2Profiler at the cellular level 3
... 2010 Class II Biological Safety Cabinets ... of comfort while incorporating the latest ... operator, environment and product protection with ... recirculated air.,Bottom filters are safely exchanged ...
... latest SpeedVac Concentrator, the SPD series takes ... new modern twist., The SPD121P SpeedVac comes ... for optimizing runs; preventing samples from freezing; ... at the end-users preset level., Standard features ...
... Oven with circular clear acrylic chamber for ... HybriCycler Oven features microprocessor operation for precise ... the unit., Carousel rotates at 11 ... ,easily removable , Bottle Capacity - ...
... KingFisher magnetic particle based purification systems provide ... from any sample. They offer increased throughput ... three systems- KingFisher, KingFisher mL and KingFisher ... 1000 l. Each system consists of an ...
Biology Products: