Navigation Links
Blame it on the astrocytes
Date:7/11/2014

Rio de Janeiro, Brazil- In the brains of all vertebrates, information is transmitted through synapses, a mechanism that allows an electric or chemical signal to be passed from one brain cell to another. Chemical synapses, which are the most abundant type of synapse, can be either excitatory or inhibitory. Synapse formation is crucial for learning, memory, perception and cognition, and the balance between excitatory and inhibitory synapses critical for brain function. For instance, every time we learn something, the new information is transformed into memory through synaptic plasticity, a process in which synapses are strengthened and become more responsive to different stimuli or environmental cues. Synapses may change their shape or function in a matter of seconds or over an entire lifetime. In humans, a number of disorders are associated with dysfunctional synapses, including autism, epilepsy, substance abuse and depression.

Astrocytes, named for their star-like shape, are ubiquitous brain cells known for regulating excitatory synapse formation through cells. Recent studies have shown that astrocytes also play a role in forming inhibitory synapses, but the key players and underlying mechanisms have remained unknown until now.

A new study just published in the journal Glia and available online on July 11th, details the newly discovered mechanism by which astrocytes are involved in inhibitory synapse formation and presents strong evidence that Transforming Growth Factor Beta 1 (TGF β1), a protein produced by many cell types (including astrocytes) is a key player in this process. The team led by Flvia Gomes of the Rio de Janeiro Institute of Biomedical Sciences at the Federal University of Rio de Janeiro investigated the process in both mouse and human tissues, first in test tubes, then in living brain cells.

Previous evidence has shown that TGF β1, a molecule associated with essential functions in nervous system d
'/>"/>

Contact: Flávia Gomes
fgomes@icb.ufrj.br
55-219-980-22770
Publicase Comunicao Cientfica
Source:Eurekalert

Page: 1 2

Related biology news :

1. Sick from stress? Blame your mom… and epigenetics
2. Viruses not to blame for chronic fatigue syndrome after all
3. Scientists conclude high fructose corn syrup should not be blamed for obesity
4. Gene sequencing project finds new mutations to blame for a majority of brain tumor subtype
5. Blame your parents for bunion woes
6. Rainfall to blame for decline in Arctic peregrines
7. Wetlands likely to blame for greenhouse gas increases: Study
8. History to blame for slow crop taming: Study
9. Climate not to blame for the disappearance of large mammals
10. Astrocytes control the generation of new neurons from neural stem cells
11. Who reprograms rat astrocytes into neurons?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... , Sept. 2, 2015 About hand ... for enterprises, banks, government organizations, telecommunication and hospitals as ... Keys, identity badges, and numeric keypads are used to ... structure of palm and fingers of an individual, width ... geometry scanners with infrared light and reflectors can be ...
(Date:9/2/2015)... Sept. 2, 2015 Security of data ... enterprises, banks, government organizations, telecommunications, hospitals, as well ... were previously being used to prevent unauthorised access. ... authentication, wherein individuals could gain access to secure ... such as hardware devices and numeric codes. However, ...
(Date:9/2/2015)... September 2, 2015 ... implied in a system which uses identical human ... iris, vein, DNA and finger print. Increasing number ... develop such system which provides high level of ... Patterns and tokens are vulnerable to attacks. Furthermore, ...
Breaking Biology News(10 mins):Global Hand Geometry Biometrics Market 2015-2019 2Global Hand Geometry Biometrics Market 2015-2019 3Global Biometrics Spending Market in the Government Sector 2015-2019 2Global Biometrics Spending Market in the Government Sector 2015-2019 3Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 2Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 3Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 4
... Shakespeare. In humans, nature may be less than half of ... researchers has found. In the first study of its ... explain why human birds of a feather flock together, but ... upon the social environment in which individuals interact with one ...
... Stanford University scientists have built the first solar cell made ... used in photovoltaic devices today. The results are ... ACS Nano . "Carbon has the potential to ... author Zhenan Bao, a professor of chemical engineering at Stanford. ...
... stem cells such as regenerating damaged tissues or organs ... past decade. While these types of applications are exciting, it ... immediate impact of stem cells on human health will most ... drugs. , The ability to generate stem cells by reprogramming ...
Cached Biology News:Social factors trump genetic forces in forging friendships, CU-led study finds 2Stanford scientists build the first all-carbon solar cell 2Stanford scientists build the first all-carbon solar cell 3The role of stem cells in developing new drugs 2
(Date:9/4/2015)... ... , ... Canadian astronomer David Levy — who discovered or co-discovered 22 comets ... years to the Linda Hall Library . , Levy is internationally known ... an episode that produced the first collision between two solar system bodies ever observed. ...
(Date:9/4/2015)... Sep. 04, 2015 ... addition of the "Biopreservation Market by Product, ... to 2020" report to their offering. ... reach USD 3,731.03 Million by 2020 from USD ... of 11.65% between 2015 and 2020. ...
(Date:9/4/2015)... ... September 04, 2015 , ... ... bioprinter, the BioBot 1, at the 2015 TERMIS World Congress in Boston. The ... and biomedical engineering institutions around the world. The printer is revolutionary for its ...
(Date:9/4/2015)... CA (PRWEB) , ... September 04, 2015 , ... ... delivery of product safety and pharmacovigilance services and software tools to pharmaceutical and ... PRIMO Mobile by Allergan Japan. PRIMO Mobile is a mobile data intake solution ...
Breaking Biology Technology:Renowned Astronomer David Levy To Donate Night Sky Observation Logs to the Linda Hall Library 2Renowned Astronomer David Levy To Donate Night Sky Observation Logs to the Linda Hall Library 3Global Biopreservation Market 2015-2020 - Product, Biospecimen, Application and End User Analysis of the $3.73 Billion Industry 2Global Biopreservation Market 2015-2020 - Product, Biospecimen, Application and End User Analysis of the $3.73 Billion Industry 3BioBots to Debut Desktop 3D Bioprinter for Living Tissue at TERMIS Global Tissue Engineering Conference in Boston 2BioBots to Debut Desktop 3D Bioprinter for Living Tissue at TERMIS Global Tissue Engineering Conference in Boston 3BioBots to Debut Desktop 3D Bioprinter for Living Tissue at TERMIS Global Tissue Engineering Conference in Boston 4November Research Group’s PRIMO Mobile Goes Live at Allergan Japan 2
... YORK, April 7, 2008 Medicsight PLC, a,subsidiary ... ), and an industry,leader in the development of ... in the early detection and diagnosis of,disease, announces ... the,world,s leading medical imaging and picture archiving and ...
... 2008 Ardea Biosciences,Inc. (Nasdaq: RDEA ) ... its,second generation non-nucleoside reverse transcriptase inhibitors (NNRTIs),at the ... on two of the Company,s mitogen-activated ERK kinase,(MEK) ... the American,Association for Cancer Research (AACR) annual meeting., ...
... 2008 Sangamo,BioSciences, Inc. (Nasdaq: SGMO ) ... Agreement with Open Monoclonal Technologies (OMT), a private,company ... Sangamo will,provide a non-exclusive, worldwide license to OMT ... Sangamo,s proprietary zinc finger,DNA-binding protein (ZFP) technology. OMT ...
Cached Biology Technology:Medicsight Announces New Marketing Partnership with INFINITT 2Medicsight Announces New Marketing Partnership with INFINITT 3Ardea to Present Data on HIV Non-Nucleoside Reverse Transcriptase Inhibitor and Two MEK Inhibitors at Upcoming Medical Conferences 2Ardea to Present Data on HIV Non-Nucleoside Reverse Transcriptase Inhibitor and Two MEK Inhibitors at Upcoming Medical Conferences 3Sangamo BioSciences Announces License Agreement For the Use of ZFP Technology For Generation of Transgenic Animals 2Sangamo BioSciences Announces License Agreement For the Use of ZFP Technology For Generation of Transgenic Animals 3
... one of the smallest thermal cyclers on the ... either the 0.5ml (20 samples) or 0.2ml microtube ... Fast heating and cooling rate of 3.6C/sec and ... performance Fast track programming with new quick ...
... Conjugate Stabilizer is an aqueous solution that ... non-toxic stabilizing chemicals in a MOPS buffer ... This product contains a combination of ... Proclin 300 (Rohm and Haas Company) as ...
Preparation Note: Prepared by method of Wimmer, E., et al., Biochemistry, 7, 2623 (1968). Quality Clarifier: Acceptor Activity: approx. 1000 picomoles phenylalanine per A 260 unit (not determined b...
This buffer is Specifically formulated to be used with Endogen's Poly-HRP Streptavidin...
Biology Products: