Navigation Links
Bits of 'junk' RNA aid master tumor-suppressor gene
Date:8/23/2007

Little-known bits of RNA help master tumor-suppressor gene do its job, U-M cancer researchers find

Three micro RNA genes appear to be key partners of protective gene p53; their loss is linked to common type of lung cancer

ANN ARBOR, Mich. Scientists have shown in literally thousands of studies that the p53 gene deserves its reputation as the guardian of the genome. It calls to action an army of other genes in the setting of varied cell stresses, permitting repair of damaged DNA or promoting cell death when the cell damage is too great. A key net effect of p53s action is to prevent development of cancerous cells.

Now, University of Michigan Medical School scientists provide the most thorough evidence yet that p53 also regulates a trio of genes from the realm of so-called junk genes the roughly 97 percent of a cells genetic material whose function is only beginning to be understood.

The study shows that in the junk lies treasure, in terms of critical knowledge about how normal cells stifle cancer or succumb to it, says Guido Bommer, M.D., the lead author of results, published in a recent issue of the journal Current Biology.

The findings in the study offer new insights into specific mechanisms by which the expression of hundreds to thousands of genes and proteins is altered in the roughly 50 percent of cancers that carry mutations in the p53 tumor suppressor gene, says Eric Fearon, M.D., Ph.D., senior author of the study and deputy director of the U-M Comprehensive Cancer Center. Scientists continue to mine for details of what goes wrong when p53 is defective and cannot perform its tumor-fighting duties.

The U-M study is one of four recent studies from labs around the world showing that p53 normally gets support from members of a small family of micro RNA genes. The studies are part of a larger effort to understand the function of micro RNA (miRNA for short).

Scientists have long known the im
'/>"/>

Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Seaweed could make junk food healthier
2. Rodent social behavior encoded in junk DNA
3. Junk DNA may not be so junky after all
4. Evolutionary scrap-heap challenge: Antifreeze fish make sense out of junk DNA
5. University of Iowa scientists explore function of junk DNA
6. Master gene controls healing of skin in fruit flies and mammals
7. UT Southwestern researchers discover master switch in cell death
8. Master regulatory gene found that guides fate of blood-producing stem cells
9. Wisconsin scientists discover a master key to microbes pathogenic lifestyles
10. Master genetic switch found for chronic pain
11. Cuttlefish masters of disguise despite colorblindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a biometric authentication ... success of the Wocket™ smart wallet at CES 2015 in ... as one of the "11 Hot Products at CES" in a review ... So Far" by Newseveryday.com and "The top 10 gadgets from CES 2015" ...
(Date:1/22/2015)... NEW YORK , Jan. 21, 2015  Analyst Report Issued ... Credit Card Brands report showed that planet-wide, transactions at merchants ... 2011, while the total number of credit, debit, and prepaid ... the U.S. were victims of fraudulent card usage in 2012, ...
(Date:1/22/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/wxdglm/global_wearable ... "Global Wearable Technologies Market and Applications, Opportunities, Industry ... Forecast 2014-2020" report to their offering. ... that can be worn on the user,s body ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... most comprehensive analysis yet of the genome of childhood acute ... genetic blueprint, suggesting the cancer arises from just a handful ... Research Hospital. The research appears in the July 27 online ... Sciences . "Our data raise the possibility ...
... houses be the buildings of the future? That,s what ... summer by constructing a "BaleHaus" made of prefabricated straw bale ... around the world will be able to watch its progress ... ,- part of a site which will also feature blogs, ...
... first ever overall nation-wide estimate of the tiger population ... figures announced by the Nepal Government,s Department of National ... 121 (100 194) breeding tigers in the wild ... tiger population estimate was jointly implemented by the DNPWC, ...
Cached Biology News:Comprehensive look at rare leukemia finds relatively few genetic changes launch disease 2Comprehensive look at rare leukemia finds relatively few genetic changes launch disease 3University has grand designs to build a house of straw 2University has grand designs to build a house of straw 3121 breeding tigers estimated to be found in Nepal 2
(Date:1/22/2015)... Crystal Diagnostics (CDx) Xpress System, a rapid ... AOAC-PTM Certifications for the six non-O157 Shiga toxin-producing E. coli ... to as STEC or the “Big-6”) as well as Escherichia ... per 325 g of raw ground beef and raw beef ...
(Date:1/22/2015)... 22, 2015 Controlled Substance Compliance Services ... helps companies check the legal requirements around using controlled ... China. , As their international operations expand and ... software solutions built as a result of the first ...
(Date:1/22/2015)... , Jan. 22, 2015   Cypher Genomics, Inc., ... Inc. (NASDAQ: SQNM ), the leading ... for next generation noninvasive prenatal tests (NIPT). Through ... technology, called Mantis™, to advance analysis of clinically-relevant ...
(Date:12/25/2014)... The report “Service Quality Management and ... Provider Type - Global Advancements, Worldwide Forecasts & Analysis ... analysis and forecasting of revenues. , Browse 152 ... and in-depth TOC on “Service Quality Management (SQM) and ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Global Compliance Service for Controlled Substances to Expand to China 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... announced today that Dr. Venki Raman has joined its board ... Energy Technologies , a consultancy service in the field of ... , ,Madison's Virent Energy Systems, Inc., is developing ... fuel gases and other high value chemicals. APR uses ...
... federal Food and Drug Association today approved GE ... system designed to help doctors detect, diagnose and monitor ... mass and increased risk of fracture, more accurately and ... clinicians to simultaneously assess body composition and ascertain fat ...
... Inc., a provider of computerized assessment and progress ... expand its Dallas field sales office and add ... Renaissance product solutions. Renaissance Learning also plans to ... to streamline specific functions to its Wisconsin Rapids ...
Cached Biology Technology:
... Origami host strains are K-12 derivatives that ... (trxB) and glutathione reductase (gor) genes, which ... cytoplasm. Studies have shown that expression in ... in another host even though overall expression ...
... Zero Blunt TOPO PCR ... is designed for cloning ... blunt-end PCR products. The ... TOPO Cloning and greater ...
... CELLection Dynabeads (4.5 m) coated with the ... EpCAM and DNase Releasing Buffer. For ... tumour cells directly from blood, bone marrow ... enriched from bone marrow. Enriched cells are ...
Recombinant Human CCL21/6Ckine (Mucin Stalk Chimera)...
Biology Products: