Navigation Links
Bits of 'junk' RNA aid master tumor-suppressor gene
Date:8/23/2007

Little-known bits of RNA help master tumor-suppressor gene do its job, U-M cancer researchers find

Three micro RNA genes appear to be key partners of protective gene p53; their loss is linked to common type of lung cancer

ANN ARBOR, Mich. Scientists have shown in literally thousands of studies that the p53 gene deserves its reputation as the guardian of the genome. It calls to action an army of other genes in the setting of varied cell stresses, permitting repair of damaged DNA or promoting cell death when the cell damage is too great. A key net effect of p53s action is to prevent development of cancerous cells.

Now, University of Michigan Medical School scientists provide the most thorough evidence yet that p53 also regulates a trio of genes from the realm of so-called junk genes the roughly 97 percent of a cells genetic material whose function is only beginning to be understood.

The study shows that in the junk lies treasure, in terms of critical knowledge about how normal cells stifle cancer or succumb to it, says Guido Bommer, M.D., the lead author of results, published in a recent issue of the journal Current Biology.

The findings in the study offer new insights into specific mechanisms by which the expression of hundreds to thousands of genes and proteins is altered in the roughly 50 percent of cancers that carry mutations in the p53 tumor suppressor gene, says Eric Fearon, M.D., Ph.D., senior author of the study and deputy director of the U-M Comprehensive Cancer Center. Scientists continue to mine for details of what goes wrong when p53 is defective and cannot perform its tumor-fighting duties.

The U-M study is one of four recent studies from labs around the world showing that p53 normally gets support from members of a small family of micro RNA genes. The studies are part of a larger effort to understand the function of micro RNA (miRNA for short).

Scientists have long known the im
'/>"/>

Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Seaweed could make junk food healthier
2. Rodent social behavior encoded in junk DNA
3. Junk DNA may not be so junky after all
4. Evolutionary scrap-heap challenge: Antifreeze fish make sense out of junk DNA
5. University of Iowa scientists explore function of junk DNA
6. Master gene controls healing of skin in fruit flies and mammals
7. UT Southwestern researchers discover master switch in cell death
8. Master regulatory gene found that guides fate of blood-producing stem cells
9. Wisconsin scientists discover a master key to microbes pathogenic lifestyles
10. Master genetic switch found for chronic pain
11. Cuttlefish masters of disguise despite colorblindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... how the bowel lining develops and, in the process, ... , The researchers produced evidence that stem cells are ... a feature of the bowel lining, and believe these ... controversial finding as scientists are still divided on the ... Chin Wee Tan and Professor Tony Burgess from the ...
(Date:10/15/2014)... Oct. 15, 2014 Sandata Technologies, LLC, ... and community-based care, today announced it released a ... Santrax® Electronic Visit Verification™ Solution (EVV™)  for Quality ... home health company founded in 1996 and has ... The study details the challenges ...
(Date:10/15/2014)... have linked increased resistance to bacterial pneumonia in female ... hormone estrogen. , Females are naturally more resistant to ... scientists has shown that increased resistance to bacterial pneumonia ... oxide synthase 3 (NOS3). They also show that this ... female sex hormone estrogen. , The team, lead by ...
Breaking Biology News(10 mins):Cryptic clues drive new theory of bowel cancer development 2Sandata Announces Case Study with Quality Care Services, Inc. 2
... bacteria destroy oil. Might those bacteria lead oil companies to ... while at the same time reducing the carbon dioxide that ... thinks that may be possible. Larter, professor of ... Geology at the University of Calgary, was the keynote speaker ...
... , MADISON Establishing a firm link between environmental ... proposition. Now, however, a team of scientists from ... 16, 2010) online issue of the CDC journal ... to date linking increased incidence of malaria to land-use ...
... found antibiotic-resistant bacteria in seven species of sharks and ... Massachusetts. Most of these wild, free-swimming fish harbored several ... the Journal of Zoo and Wildlife Medicine , ... The researchers also found multidrug-resistant bacteria in fish at ...
Cached Biology News:Incidence of malaria jumps when Amazon forests are cut 2Incidence of malaria jumps when Amazon forests are cut 3Wild sharks, redfish harbor antibiotic-resistant bacteria 2
(Date:10/22/2014)... NEW YORK , Oct. 22, 2014 ... Diabetes Federation, approximately 400 million people worldwide are living ... 552 million people by 2030.  The global market for ... In 2012 approximately 330,000 people worldwide died from pancreatic ... of death due to cancer in the ...
(Date:10/20/2014)... The report “Pharmacy Automation Systems Market ... Labeling Systems, Table-top Counters) by End-user (Inpatient Pharmacy ... Trends to 2019” analyzes and studies the major ... Europe, Asia-Pacific, and the Rest of the World ... figures spread through 300 pages and in-depth TOC ...
(Date:10/20/2014)... Calif. , Oct. 20, 2014 ... that the Company has signed a Notice of ... Regenerative Medicine (CIRM), effective October 1, 2014.  The ... Development payments and the release of additional grant ... CIRM grant award for clinical development of Asterias, ...
(Date:10/20/2014)... , Oct. 20, 2014  GenVec, Inc. (NASDAQ: ... Horovitz , Ph.D., from its board of directors effective on ... August 2003, and served as its chairman from June 2006 ... the Nominating and Corporate Governance and Audit Committees of the ... than a decade of dedicated service to GenVec, and its ...
Breaking Biology Technology:Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Zola P. Horovitz To Retire From GenVec Board 2
... for the first time generated stem cells from one of ... development will help research into the condition as it will ... shed light on why certain nerve cells die. Scientists, ... took skin samples from a patient diagnosed with one of ...
... of researchers from France and Germany has developed a ... to electrical fields at room temperature. Previously this was ... temperatures. Electric fields are technically much easier and cheaper ... power guzzling coils. The researchers have now found a ...
... atomic forces can be exploited to make nanoparticle superclusters ... many nanotech applications but hard to accomplish, University of ... forces are at work bringing the building blocks of ... research are in many ways similar to viruses. ...
Cached Biology Technology:Stem cell study offers hope for Parkinson's patients 2Controlling magnetism with electric fields 2Engineers discover nanoscale balancing act that mirrors forces at work in living systems 2
For removal of the zona pellucida. Sterile, Mouse Embryo tested...
Imject Freund's Complete Adjuvant (FCA)...
... stain was developed specifically for reduced mutagenicity ... DNA in agarose or acrylamide gels. SYBR Safe ... bromide but SYBR Safe stain's detection sensitivity is ... stain comes as a premixed solution that can ...
... nucleic acid gel stain is an exceptionally ... fluorescence when bound to dsDNA and low background ... in gels using laser scanners or standard UV ... also found uses in capillary electrophoresis, real-time PCR ...
Biology Products: