Navigation Links
Birth control has long-term effect on hormone exposure
Date:10/20/2008

elieve this discovery could be translated fairly quickly into a study in women. If our results are confirmed to also occur in women, they could change the way we look at oral contraceptives and cancer risk," added Cline, a professor of pathology and comparative medicine.

With funding from the National Institutes of Health, researchers began with 181 premenopausal cynomolgus monkeys and followed them for seven years in a study designed to look at hormone effects on many aspects of female health.

Half of the monkeys were given a birth control treatment of triphasic estrogen and progestin, marketed by Wyeth Pharmaceuticals as TriphasilTM, for 26 months. At the end of the premenopausal phase of the study, the animals underwent surgery to have their ovaries removed, making them surgically menopausal.

The postmenopausal monkeys were then divided into three dietary intervention groups to evaluate the effects of soy on hormone metabolism.

Urine samples were collected from each monkey during the 35th and 36th months of the postmenopausal phase of the study and frozen for subsequent analysis of metabolite concentrations.

Lab results showed that the premenopausal use of oral contraceptives resulted in significantly lower levels of most estrogen metabolites three years after surgical menopause. Among the most abundant metabolites, percent changes ranged from a 25 percent reduction in E1 to a 50 percent reduction in 2OHE1 with oral contraceptive administration. Postmenopausal dietary isoflavones induced fewer significant effects on postmenopausal estrogen metabolite concentrations.

"The magnitude and persistence of oral contraceptive effect really surprised us," said Cline, a diplomate of the American College of Veterinary Pathologists. "It tells us that there may be a new and potentially strong cancer-protective mechanism at work. This could open new doors of inquiry in the field."


'/>"/>

Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Risk of common vaginal infection linked to preterm birth appears higher for blacks
2. Birth records hold pancreatic cancer clue
3. Researchers find evidence linking stress caused by the Sept. 11 disaster with low birth weights
4. Birth of an iceberg
5. The birth and death of dopamine neurons: A new model for neurodegeneration
6. Certain diseases, birth defects may be linked to failure of protein recycling system
7. New folic acid seal helps women choose enriched grain foods to help prevent birth defects
8. Immunosuppressant further linked to birth defects
9. Northern right whales head south to give birth, leave genetic fingerprints with NOAA researchers
10. Deadly genetic disease prevented before birth in zebrafish
11. Birth of an enzyme
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... , May 5, 2015, NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, reminds investors ... Chief Technology Officer, is presenting  at CARTES SECURE CONNEXIONS AMERICA ... 5-7, 2015. The three-day conference is organized ... is speaking in is themed Global Fraud: Where is ...
(Date:4/27/2015)... 27, 2015 Profile Solutions, Inc. (OTC: PSIQ), ... systems is pleased to announce that Dr Gerry ... and member of its scientific advisory board. ... a thought leader in technology-enhanced learning models. He was ... has published studies and books focused on online student ...
(Date:4/20/2015)... , April 20, 2015 ...   Glenbeigh Records Management (GRM), Ireland,s ... with Dubai Islamic Bank. Having built up an impressive track ... now a leading player within the records management sector in ... expects to double is GCC staffbase and employ a further ...
Breaking Biology News(10 mins):NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... 12, 2012 The California Institute for Regenerative Medicine ... Vincent Chen, Ph.D., associate professor at Sanford-Burnham Medical Research ... projects funded as part of CIRM,s Basic Biology IV ... our understanding of stem cells and how to work ...
... for the synthesis of proteins, interspersed with noncoding regions ... in a new and unannotated genome is one of ... the Indian Institute of Technology in Delhi have used ... exons an order of magnitude faster than previously developed ...
... the body of a dead jay, according to new research ... can last for up to half an hour. Anecdotal ... birds in the crow family, react to dead of their ... carried out the work. But few experimental studies have explored ...
Cached Biology News:California's stem cell agency boosts heart disease research at Sanford-Burnham 2Scrub jays react to their dead 2
(Date:5/5/2015)... TORONTO, May 5, 2015 /PRNewswire/ - Aptose Biosciences Inc. (NASDAQ: ... financial results for the three months ended March 31, ... all amounts are in Canadian dollars. ... year end from May 31 to December 31. As ... being reported is for the three months ended March ...
(Date:5/5/2015)... 5, 2015  23andMe, Inc., the leading personal genetics ... Research Study in collaboration with Pfizer Inc. The ... erythematosus, more commonly known as lupus, into the study ... effort is also in collaboration with the Lupus Research ... May. Approximately 1.5 million people in the ...
(Date:5/5/2015)... Mich. (PRWEB) May 05, 2015 ... publishing services to develop custom course materials for smaller ... annual enrollments as low as 200 students. , ... a broader range of higher education instructors,” said Jeff ... the country, we can do our part to make ...
(Date:5/5/2015)... -- Psyche Systems Corporation and Luminate Health have recently ... that helps labs comply with new federal HHS legislation ... patients engage with these results, and improves provider workflow. ... HIPAA-compliant digital platform that gives labs an easy way ... results, and uniquely connects labs, physicians, and patients with ...
Breaking Biology Technology:Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 2Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 3Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 4Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 5Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 6Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 7Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 823andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 223andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 3Hayden-McNeil Expands Publishing Program to Service Lower Enrollment Courses 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 3
... Quarter and Year End 2009 Financial Results , VANCOUVER , ... will host a conference call discussing its financial results for the fourth ... March 4, 2010 at 9:00 AM ET ( 6:00 ... March 4, 2010 is as follows: , North America ...
... RICHMOND, Calif. , Feb. 3 Sangamo BioSciences, Inc. (Nasdaq: ... and accomplishments and provided an outlook for 2010. , For the fourth ... of $2.4 million , or $0.05 per share, compared to ... share, for the same period in 2008. As of December 31, 2009 ...
... , ... Label Printer powers low cost label and barcode printing for RURO lab management software. ... (PRWEB) February ... announced support for the newly available Brady BBP™11 Label Printer, a compact, budget friendly ...
Cached Biology Technology:Angiotech Pharmaceuticals Announces Conference Call and Webcast 2Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 2Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 3Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 4Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 5Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 6Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 7Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 8Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 9Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 10Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 11Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 12Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 13RURO and Brady Team to Deliver Solutions for Mid-market Laboratory Applications 2RURO and Brady Team to Deliver Solutions for Mid-market Laboratory Applications 3
Request Info...
Mouse monoclonal [3G131] to Desmoglein 1 ( Abpromise for all tested applications). entrezGeneID: 1828 SwissProtID: Q02413...
TCP-1 alpha (H-110)...
Synphilin 1 Immunogen: Synthetic peptide corresponding to residues S(829) L E L N G E K D K D K G R T L Q R T(847) of human Synphilin 1. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: