Navigation Links
Birth control has long-term effect on hormone exposure
Date:10/20/2008

elieve this discovery could be translated fairly quickly into a study in women. If our results are confirmed to also occur in women, they could change the way we look at oral contraceptives and cancer risk," added Cline, a professor of pathology and comparative medicine.

With funding from the National Institutes of Health, researchers began with 181 premenopausal cynomolgus monkeys and followed them for seven years in a study designed to look at hormone effects on many aspects of female health.

Half of the monkeys were given a birth control treatment of triphasic estrogen and progestin, marketed by Wyeth Pharmaceuticals as TriphasilTM, for 26 months. At the end of the premenopausal phase of the study, the animals underwent surgery to have their ovaries removed, making them surgically menopausal.

The postmenopausal monkeys were then divided into three dietary intervention groups to evaluate the effects of soy on hormone metabolism.

Urine samples were collected from each monkey during the 35th and 36th months of the postmenopausal phase of the study and frozen for subsequent analysis of metabolite concentrations.

Lab results showed that the premenopausal use of oral contraceptives resulted in significantly lower levels of most estrogen metabolites three years after surgical menopause. Among the most abundant metabolites, percent changes ranged from a 25 percent reduction in E1 to a 50 percent reduction in 2OHE1 with oral contraceptive administration. Postmenopausal dietary isoflavones induced fewer significant effects on postmenopausal estrogen metabolite concentrations.

"The magnitude and persistence of oral contraceptive effect really surprised us," said Cline, a diplomate of the American College of Veterinary Pathologists. "It tells us that there may be a new and potentially strong cancer-protective mechanism at work. This could open new doors of inquiry in the field."


'/>"/>

Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Risk of common vaginal infection linked to preterm birth appears higher for blacks
2. Birth records hold pancreatic cancer clue
3. Researchers find evidence linking stress caused by the Sept. 11 disaster with low birth weights
4. Birth of an iceberg
5. The birth and death of dopamine neurons: A new model for neurodegeneration
6. Certain diseases, birth defects may be linked to failure of protein recycling system
7. New folic acid seal helps women choose enriched grain foods to help prevent birth defects
8. Immunosuppressant further linked to birth defects
9. Northern right whales head south to give birth, leave genetic fingerprints with NOAA researchers
10. Deadly genetic disease prevented before birth in zebrafish
11. Birth of an enzyme
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... Beaverton, OR) New research presented at the ... in Houston, TX showed for the first time ... in women using a readily available nutritional supplement, ... by Dr. Judith A. Smith, Pharm.D., associate professor ... Sciences at The University of Texas Health Science ...
(Date:10/29/2014)... the rage. Thousands of scientists worldwide are conducting research ... dioxide nanoparticles from sun creams can get through the ... electronic products are as hazardous for the lungs as ... can get into the blood via the intestinal flora, ... flowing – and the number of scientific projects is ...
(Date:10/29/2014)... innovative workflow reveals new research potential of the ... published article in the Biodiversity Data Journal ... in tabular format and imported these into a human-readable ... Tool (PWT). Data were used to study the ... from the Microgastrinae subfamily. , BOLD is originally designed ...
Breaking Biology News(10 mins):HPV infections in women eradicated by AHCC, Japanese mushroom extract 2Nanosafety research: The quest for the gold standard 2Nanosafety research: The quest for the gold standard 3Go straight and publish: From Barcode of Life Data Systems to scholarly publishing systems 2
... Biochemistry and Biophysics Department within the School of Medicine ... awarded the 2012 Paul Ehrlich and Ludwig Darmstaedter Prize ... cell biology." The 100,000 German award specifically ... how cells cope with stressinsight that has profound implications ...
... of our genes is apolipoprotein E ( APOE ), which ... have: APOEε4, the main genetic risk factor for sporadic Alzheimer,s ... itself and which is caused by a combination of hereditary ... of the sporadic patients affected by this disease are carriers ...
... has been mapped in northwest Tasmania, Australia. Both species are ... very little into each other,s territory. The ,mixing zone, where ... 100 m wide where carefully studied. The mapping was ... is a millipede specialist and a research associate at the ...
Cached Biology News:UCSF biochemist wins prestigious prize 2UCSF biochemist wins prestigious prize 3A new way of approaching the early detection of Alzheimer's disease 2Millipede border control better than ours 2
(Date:10/31/2014)... Huge event with 36,000+ global professionals is ... analysis and forecasting   CPhI Worldwide , ... most successful show to date with pre-audit figures estimating ... year in Paris , the show ... countries representing every step of the pharmaceutical supply chain ...
(Date:10/31/2014)... October 31, 2014 Jeffrey T. Manuel, ... Historical Studies within the College of Arts and Sciences, ... record the history of alcohol-based fuels in Illinois. ... others have been working to build Illinois’ biofuels industry ... overlooked aspect of the state's agricultural and business history. ...
(Date:10/31/2014)... ENVIRON , an international ... that Dr. Harvey Clewell III has rejoined the ... closely with senior professionals in ENVIRON’s Health Sciences ... at The Hamner Institutes for Health Sciences (The ... he is Director, Center for Human Health Assessment. ...
(Date:10/30/2014)... , October 30, 2014 Investor-Edge ... Inc. (NYSE MKT: ONVO), Medivation Inc. (NASDAQ: ... Synthetic Biologics Inc. (NYSE MKT: SYN), and Ironwood Pharmaceuticals ... can be accessed at: http://investor-edge.com/register . ... at 4,549.23, down 0.33%, the Dow Jones Industrial Average ...
Breaking Biology Technology:CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 2CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 3CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 4CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 5CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 6SIUE History Prof Manuel Working on Biofuels Book with NCERC 2SIUE History Prof Manuel Working on Biofuels Book with NCERC 3Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5
... proprietary technology to generate antibodies against ... novel research targets provided by Sigma-Aldrich, ... (Nasdaq: SIAL ) and MorphoSys AG (Frankfurt ... a,collaboration agreement to design, produce and distribute unique,recombinant ...
... Problems in VA System for Veterans with PTSD, ... MUSC distinguished university professor and director of the ... Institute of,Psychiatry, testified before Congress Feb 26 and ... PTSD (post-traumatic stress disorder) Compensation Committee,regarding findings in ...
... Relationship Combines Leading Mobile Computing Workstations with ... Nurses More Time with Patients, COLUMBUS, ... developer,of medication management and healthcare technology solutions ... announced an exclusive referral,agreement with McKesson Automation, ...
Cached Biology Technology:Sigma-Aldrich and MorphoSys Enter Into a Collaboration and Licensing Agreement for Recombinant Research Antibodies 2Sigma-Aldrich and MorphoSys Enter Into a Collaboration and Licensing Agreement for Recombinant Research Antibodies 3MUSC's Kilpatrick to Address Congress Regarding PTSD Care 2Artromick Aligns with McKesson to Enhance Medication Safety at the Patient's Bedside 2Artromick Aligns with McKesson to Enhance Medication Safety at the Patient's Bedside 3
... Versatile state of the Art ... flask to dual 38,000 L fermentation. ... scale to production. Aseptic operation ... Batch, Fed-Batch, and Continuous Modes. ...
Competitors to lower non-specific signal...
... Each vial contains 200 g of lyophilized ... sequence (C-terminal amino acids 380-402; GLTPSAWEASSLRSSRHSGLSHF. ... antigen for production of Cayman's EP1 receptor ... be used in conjunction with this antibody ...
Immunogen: VDAC3 Protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: