Navigation Links
Birth control has long-term effect on hormone exposure
Date:10/20/2008

WINSTON-SALEM, N.C. Researchers at Wake Forest University School of Medicine may be one step closer to understanding why past oral contraceptive use dramatically lowers the risk of ovarian and uterine cancers later in life.

While studying the effect of post-menopausal dietary soy consumption on estrogen metabolism in cynomolgus monkeys, Latanya M. Scott, Ph.D., discovered that monkeys who had been given birth control earlier in life had a reduced amount of estrogen excreted in their urine. The research was done in collaboration with Xia Xu, Ph.D., and Timothy Veenstra, Ph.D. at Science Applications International Corporation-Frederick, Inc., in Frederick, Md., who have developed novel methods for analysis of urinary estrogens.

The discovery was particularly noteworthy because it was found three years after oral contraceptive treatment was stopped, roughly the equivalent of a decade of life in a human.

While researchers have known for many years that past oral contraceptive use significantly lowers the risk of ovarian and uterine cancers later in life, this new observation in monkeys may shed light on the mechanism behind the cancer-protective effect of the treatment. Past oral contraceptive use appears to result in a long-term change in the way the monkeys' bodies process hormones. While researchers don't yet understand the precise mechanism by which hormone levels are being affected, they do know that both the level of estrogen in the blood and the amount of estrogen being excreted in urine are lowered with past oral contraceptive use, which may mean that the oral contraceptive use is somehow leading to a diminished synthesis of estrogen.

The study appears in this month's issue of Cancer Epidemiology, Biomarkers and Prevention.

"Hormone exposure has long been known to be important in cancer risk," said J. Mark Cline, D.V.M., Ph.D., and senior researcher on the project. "These effects are robust, and we b
'/>"/>

Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Risk of common vaginal infection linked to preterm birth appears higher for blacks
2. Birth records hold pancreatic cancer clue
3. Researchers find evidence linking stress caused by the Sept. 11 disaster with low birth weights
4. Birth of an iceberg
5. The birth and death of dopamine neurons: A new model for neurodegeneration
6. Certain diseases, birth defects may be linked to failure of protein recycling system
7. New folic acid seal helps women choose enriched grain foods to help prevent birth defects
8. Immunosuppressant further linked to birth defects
9. Northern right whales head south to give birth, leave genetic fingerprints with NOAA researchers
10. Deadly genetic disease prevented before birth in zebrafish
11. Birth of an enzyme
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 16, 2014 Research and Markets ... addition of the "Global Chemical Sensor Market ... http://photos.prnewswire.com/prnh/20130307/600769 One ... increasing demand for medical sensors in biomedical applications. ... for quick and correct diagnosis during surgical procedures. ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced ... India 2015-2019" report to their offering. ... market is the adoption of multimodal biometric systems. ... of an individual for verification and identification purposes. ...
(Date:12/10/2014)... -- Valencell, a leader in performance biometric data sensor technology, ... its licensees for highly accurate, clinically validated biometric technology. ... from fitness and health sectors, but first responders/military and ... only as useful as the biometric data it delivers. ... long-term mass consumer adoption of wearable products," said Dr. ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... have usually quite strong memories of past events like an ... not clear how the brain keeps track of the temporal ... wine before or after Mary left the party? , ... at the University of Lübeck have confirmed the widely held ...
... in the human vagina have been definitively identified in ... of the journal Immunity, published by Cell Press. The ... that will prevent HIV-1 transmission. , "The majority ... HIV infection following sexual contact," explain study authors Dr. ...
... impressive result of a study carried out by a group ... the Mario Negri Institute in Milan, Italy in cooperation with ... The study appears in the April 18th issue of the ... Science, PLoS ONE. , Stroke is the first cause of ...
Cached Biology News:Researchers discover new details about HIV-1 entry and infection 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Once more, ... provide a larger packaged waste water treatment plant to ... Abdullah Economic City (KAEC). Two years ago Bioshaft successfully ... Gate Development, serving two residential towers with an occupancy ... over a quarter million gallons per day and was ...
(Date:12/17/2014)... December 17, 2014 Xeno Diagnostics ... following its most recent COLA inspection. Xeno has ... a national healthcare accreditation organization. Accreditation is earned ... quality in day-to-day operations, demonstrate continued accuracy in ... rigorous on-site laboratory survey. , While ...
(Date:12/17/2014)... 2014 Audacity, a leading California-based health ... of the Huntsworth Health Group, is proud to announce ... In her role, Gonzales will serve as Senior Vice ... honored to welcome a talent of Jamie’s caliber to ... Fraikin. “She is a proven healthcare innovation leader and ...
(Date:12/17/2014)... , Dec. 17, 2014  United Therapeutics Corporation (NASDAQ: ... promotions as well as changes to Martine Rothblatt ... Promotions United Therapeutics announced the promotion ... Co-Chief Executive Officer and David Zaccardelli , Pharm.D. ... connection with these promotions, Dr. Rothblatt,s title will change ...
Breaking Biology Technology:Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4
... International, Inc. (Pink Sheets: DYAI) ("Dyadic"), a leading-edge early-stage biotechnology company, is pleased ... , , , ... , , ... Whitehead as Executive Director of Strategic Alliances . Ms. Whitehead brings to ...
... Tetrahedral dice, which have four triangular sides, ... according to research performed by a collaboration of New ... the result of a series of experiments that involved ... more dice until the containers were completely filled. After ...
... ... , ... 2010 -- Advances in energy conservation, better materials for frontier technologies and new economic engines, ... basic and applied, to be enabled by an upgrade to the Advanced Photon Source (APS) ...
Cached Biology Technology:Dyadic International Strengthens Management Team 2Dyadic International Strengthens Management Team 3Dyadic International Strengthens Management Team 4Dyadic International Strengthens Management Team 5Densest dice packing and computing with molecules 2Upgrade to Advanced Photon Source Announced by DOE 2Upgrade to Advanced Photon Source Announced by DOE 3Upgrade to Advanced Photon Source Announced by DOE 4
... Dyad thermal cycler is a flexible ... chassis accommodates a variety of interchangeable ... hold different types and numbers of ... with point-and-click navigation. Peltier heat pumps, ...
MiniCycler thermal cycler with Hot Bonnet heated lid, holds 25x0.2ml tubes...
For demonstration of Helicobacter pylori...
... SR-101 Labeled Substrates (red fluorescence; Ex=590 ... serine protease activation • No lysing, ... Kits utilize cell-permeable, fluorescently labeled inhibitors ... chymotrypsin-like activity in whole living cells. ...
Biology Products: