Navigation Links
Biomarker predicts malignancy potential of HG-PIN lesions in the prostate
Date:4/30/2008

prostate cancer cells.

HG-PIN is defined as a pre-malignant lesion present in most cancerous prostates. Although a pre-malignant lesion shows many of the typical cellular changes observed in cancer, the lesion has not yet progressed fully to disease. Since HG-PIN lesions are also associated with the presence of cancer in many patients, men whose biopsies show HG-PIN are often re-biopsied until cancer is detected, Paciucci says.

In most recent studies, the average risk of cancer following a diagnosis of isolated HG-PIN in biopsy ranged from 20 percent to 30 percent, the researchers say. And while other researchers have found markers in HG-PIN lesions, none have been able to discriminate between lesions that will progress to cancer, the researchers say.

In this study, the research team analyzed HG-PIN lesions from 140 patients: the positive control group comprised 79 patients diagnosed with prostate cancer who had their prostate glands surgically removed and who had been earlier diagnosed with HG-PIN; the negative control group included 11 patients with bladder cancer who had both their diseased bladder and healthy prostate removed; and the study group comprised 50 patients diagnosed with HG-PIN but not prostate cancer. The study group had an average of 2.5 biopsies each between 2000 and 2004.

Finding that PTOV1 gene expression was elevated in HG-PIN associated with cancer, the investigators used tissue microarray and immunohistochemical analyses to see whether PTOV1 protein levels could discriminate these pre-malignant lesions from HG-PIN that did not develop into prostate cancer.

They considered both the number of cells that express the protein and the intensity of the expression, and derived a quantitative score (Hscore) that ranged from 0 to 300. From this, they calculated that an Hscore of 100 represented a highly sensitive malignancy threshold. This means that when PTOV1 Hscore is equal or above 100 the possibility
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A search for biomarkers for early detection of colorectal cancer
2. Singulex Teams With Wyeth Pharmaceuticals to Translate Pre-Clinical Biomarker Research Into Clinical Study Design
3. Genetic Engineering & Biotechnology News reports on cancer biomarkers
4. Biomarkers allow doctors to match therapy to patient
5. Cell response to stress signals predicts tumors in women with common pre-breast cancer
6. Built-in exercise monitor predicts fitness
7. Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
8. How and where fat is stored predicts disease risk better than weight
9. New study predicts where corals can thrive
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. Neuronal conduction of excitation without action potentials based on ceramide production
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... German . ... the oldest form of communication. Acting as messenger molecules, ... sexual attraction between males and females. Fish rely on ... behavior in males and females. Scientists at the Marine ... Faro, Portugal, and at the Max Planck Institute for ...
(Date:8/29/2014)... The rise of the Tibetan plateau -- the largest ... important for both its profound effect on climate and ... in GSA Bulletin , Katharine Huntington and colleagues ... -- using modern and fossil snail shells to investigate ... Tibet. , Views range widely on the timing ...
(Date:8/28/2014)... that an expansion of marine protected areas is needed ... According to investigators from the Wildlife Conservation Society ... focused on saving the largest numbers of species, often ... and difficult-to-replace ecological functions. , Many vital ... species that also are food for millions of people. ...
Breaking Biology News(10 mins):Ready for mating at the right time 2Ready for mating at the right time 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7Study finds marine protected areas inadequate for protecting fish and ocean ecology 2
... right shape might be just as important in a biology ... important role in the effectiveness of cells grown to repair ... new structures that enable cells to "shape up," researchers at ... up with a way to measure, and more importantly, classify, ...
... mountains of Ecuador have described a new plant species, a ... mini biodiversity hotspot. The new species, Piper kelleyi , ... most of which are entirely dependent on this plant species ... which focuses on the influence of plant-produced chemical compounds on ...
... shock is caused by excessive and systemic reaction of ... of bacterial origin. The number of deaths by septic ... is still increasing, despite numerous large scale clinical trials. ... demonstrated in a mouse study that a potential novel ...
Cached Biology News:Shape-sifting: NIST categorizes bio scaffolds by characteristic cell shapes 2New plant species a microcosm of biodiversity 2Researchers at UGent and VIB, discovered potential novel treatment against septic shock 2
(Date:8/28/2014)... 2014   SunTrust Robinson Humphrey (STRH) ... to its equity research team in biotechnology and ... in equity research demonstrates our commitment to providing ... enhance their investment decision making," said Biff ... continue to make significant investments in differentiated content ...
(Date:8/28/2014)... MENLO PARK, Calif. , Aug. 28, 2014 ... company focused on developing novel mid- to late-stage ... raised $7.0 million in its first round of ... AshHill Biomedical Investments and Hercules Bioventures with participation ... biotech entrepreneur and pharmaceutical executive, Dr. Larry ...
(Date:8/28/2014)... 2014 Scientists, researchers, and technologists will ... Laser Damage 2014 symposium. Marking its 46th year, ... will run 14-17 September. The event is sponsored by ... . , The premier conference for basic and applied ... optical materials will engage researchers and engineers from numerous ...
(Date:8/28/2014)... Earlier this month, a report was created ... U.S. Air Force on the performance of vehicles using ... type of fuel made from mustard seeds, offered great ... America’s Eco friendly future. In fact, every branch of ... independent of foreign oil over the next few years. ...
Breaking Biology Technology:SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5
... Help Advance Technology to Find a Faster, ... SizingPITTSBURGH, April 1 ChemImage, ( www.chemimage.com ... with Next Breath, LLC ( www.nextbreath.net ), ... further validate ChemImage,s Raman Chemical Imaging for ...
... Today at 5:00 p.m. EDT - SOUTH SAN ... SNSS ) today reported financial results for ... 2008.Total revenue for the year ended December 31, 2008 ... million. As of December 31, 2008, cash, cash equivalents ...
... of Technology and Saint Joseph,s Hospital Team UpATLANTA, ... Joseph,s Hospital have joined together to begin the first ... biology of pancreatic cancer. Tissue and serum samples ... the differences in genetic and cellular features between normal ...
Cached Biology Technology:ChemImage and Next Breath Structure Partnership to Validate Bioequivalence Testing for Nasal Spray Suspensions 2ChemImage and Next Breath Structure Partnership to Validate Bioequivalence Testing for Nasal Spray Suspensions 3Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 2Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 3Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 4Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 5Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 6Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 7Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 8Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 9Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 10Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 11Groundbreaking Research Begins for Pancreatic and Lung Cancers 2Groundbreaking Research Begins for Pancreatic and Lung Cancers 3
... provides a fast and simple procedure for the ... detergents from small samples of protein. The kit ... as an ion exchanger. Each column is capable ... or basic protein.A complete kit for acidic and ...
... hematopoietic stem cells called monocytes. Osteoclasts resorb ... and lowering the surrounding pH to an ... mineral is then solubilized and the collagen ... primarily by Macrophage Colony-Stimulating Factor (M-CSF) and ...
... Receptor-gamma (PPAR) is a member of ... transcription factors that heterodimerize with retinoic ... in the regulation of glucose and ... class of anti-diabetic agents called thiazolidinediones ...
... hybridization Preparation Reconstitution: one vial ... mg ficoll and 50 mg ... of water yields a 50concentrate ... Density: 1.00 g/mL (20 C) ...
Biology Products: