Navigation Links
Biomarker predicts malignancy potential of HG-PIN lesions in the prostate
Date:4/30/2008

prostate cancer cells.

HG-PIN is defined as a pre-malignant lesion present in most cancerous prostates. Although a pre-malignant lesion shows many of the typical cellular changes observed in cancer, the lesion has not yet progressed fully to disease. Since HG-PIN lesions are also associated with the presence of cancer in many patients, men whose biopsies show HG-PIN are often re-biopsied until cancer is detected, Paciucci says.

In most recent studies, the average risk of cancer following a diagnosis of isolated HG-PIN in biopsy ranged from 20 percent to 30 percent, the researchers say. And while other researchers have found markers in HG-PIN lesions, none have been able to discriminate between lesions that will progress to cancer, the researchers say.

In this study, the research team analyzed HG-PIN lesions from 140 patients: the positive control group comprised 79 patients diagnosed with prostate cancer who had their prostate glands surgically removed and who had been earlier diagnosed with HG-PIN; the negative control group included 11 patients with bladder cancer who had both their diseased bladder and healthy prostate removed; and the study group comprised 50 patients diagnosed with HG-PIN but not prostate cancer. The study group had an average of 2.5 biopsies each between 2000 and 2004.

Finding that PTOV1 gene expression was elevated in HG-PIN associated with cancer, the investigators used tissue microarray and immunohistochemical analyses to see whether PTOV1 protein levels could discriminate these pre-malignant lesions from HG-PIN that did not develop into prostate cancer.

They considered both the number of cells that express the protein and the intensity of the expression, and derived a quantitative score (Hscore) that ranged from 0 to 300. From this, they calculated that an Hscore of 100 represented a highly sensitive malignancy threshold. This means that when PTOV1 Hscore is equal or above 100 the possibility
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A search for biomarkers for early detection of colorectal cancer
2. Singulex Teams With Wyeth Pharmaceuticals to Translate Pre-Clinical Biomarker Research Into Clinical Study Design
3. Genetic Engineering & Biotechnology News reports on cancer biomarkers
4. Biomarkers allow doctors to match therapy to patient
5. Cell response to stress signals predicts tumors in women with common pre-breast cancer
6. Built-in exercise monitor predicts fitness
7. Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
8. How and where fat is stored predicts disease risk better than weight
9. New study predicts where corals can thrive
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. Neuronal conduction of excitation without action potentials based on ceramide production
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... stress and stress-related psychiatric disorders are associated ... the molecular mechanisms underlying this relation are ... the development of targeted preventive strategies and ... diseases. This work is presented at the ... Now an international group of researchers from ...
(Date:10/17/2014)... regarding Ebola is critical and pertinent for practicing physicians ... outbreak and epidemic. The Journal, Disaster Medicine and ... Ebola Virus and Public Health, to surround the public, ... critical societal moment. , On October 17, the ... . The primer was prepared by Dr. Eric Toner, ...
(Date:10/17/2014)... available in German . ... few drugs. When treating overdoses, doctors are often limited to ... if there is a combination of drugs involved. So what ... swallows his grandmother,s pills? ETH professor Jean-Christophe Leroux from the ... an answer to this question. "The task was to develop ...
Breaking Biology News(10 mins):Researchers find why depression and aging linked to increased disease risk 2Emergency aid for overdoses 2Emergency aid for overdoses 3
... Miss. Treating chronic migraines with behavioral approaches ... can make financial sense compared to prescription-drug ... new study found. Longtime behavioral therapy researcher ... Medical Center professor of psychiatry, coauthored the study. ...
... Professor Michael Davies will tell the annual meeting of ... (Wednesday) that the "vanishing twin" phenomenon, in which only ... starts as a multiple pregnancy, is linked to a ... to a nearly three-fold risk of multiple malformations. ...
... German . FRANKFURT. A newly synthesized protein is ... into its correct three dimensional structure if it was not ... of membrane proteins chaperones do not only pre-vent their aggregation, ... membrane insertion. The underlying molecular mechanism of how a certain ...
Cached Biology News:Behavioral treatment for migraines a cost-effective alternative to meds, study finds 2Behavioral treatment for migraines a cost-effective alternative to meds, study finds 3'Vanishing twin' explains increased risk of birth defects 2'Vanishing twin' explains increased risk of birth defects 3'Vanishing twin' explains increased risk of birth defects 4A chaperone system guides tail-anchored membrane proteins to their destined membrane 2
(Date:10/20/2014)... Local veterinary surgeon, Dr. Tim McCarthy is seeking ... stem cells for dogs with osteoarthritis. Dr. McCarthy has ... clinical stem cell therapy for 7 years. The ultimate ... single injection of donor stem cells into one or ... inflammation in the treated joints. , Candidates for ...
(Date:10/19/2014)... October 20, 2014 OCTOBER ... Meeting (ABIM). ABIM will take place ... information about ABIM 2014 is now available ... Delegates representing companies and organizations from all ... obtain information on the latest products and ...
(Date:10/19/2014)... The Asia-Pacific Bromine Market report defines and ... and forecast of revenue. , Browse through the ... to get an idea of the in-depth analysis ... segmentation in the Asia-Pacific bromine market, and is ... http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is a volatile ...
(Date:10/19/2014)... The Asia-Pacific Speech Analytics market report ... with analysis and forecast of revenue. This market is ... $208 million by 2019, at a Compound Annual Growth ... Browse through the TOC of the Asia-Pacific Speech Analytics ... analysis provided. It also provides a glimpse of the ...
Breaking Biology Technology:Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4
... Webb Space Telescope is its new technology. Much of the ... built specifically to enable it to see farther back in ... innovations are being used to benefit humankind in many other ... observatory and successor to the Hubble Space Telescope. The most ...
... Syndax Pharmaceuticals, Inc. , an oncology company moving into ... studies, announced the appointment of Arlene M. Morris as ... president.  "Syndax is leading the field ... unmet needs in cancer due to the problem of ...
... 2012 The following is being released by SENS Foundation: ... debate on Wednesday, 25th April, 2012. The debate will begin ... Eastern) in the University of Oxford,s Sheldonian Theatre; doors open ... propose the motion "This house wants to defeat ageing entirely" ...
Cached Biology Technology:Webb Telescope spinoff technologies already seen in some industries 2Webb Telescope spinoff technologies already seen in some industries 3Webb Telescope spinoff technologies already seen in some industries 4Syndax Pharmaceuticals Appoints Arlene Morris as CEO 2Syndax Pharmaceuticals Appoints Arlene Morris as CEO 3Leading Scientists to Debate Views on Rejuvenation Biotechnologies 2
... in Refrigerated Vapor Trap Models RVT100, RVT400, ... Models UVS400, UVS400A and UVS800DDA., A non-corrosive, ... use for temperatures ranging from -105 to ... stability and does not evaporate. Far superior ...
... 10X Automation Buffer is a concentrated formulation ... autostainers employing capillary action technology, as well ... in collaboration with David Brigati M.D., Department ... OK. This buffer is recommended for all ...
... MALDI O-TOF creates a new category for ... platform that has been licensed to the ... Manitoba. , As the first single MALDI-TOF ... collisional cooling, the prOTOF 2000 represents a ...
... miVac DNA is an ideal small concentrator ... concentrator capable of removing water and organic ... including tubes, microplates, vials and round bottom ... for the busy lab. ,The built-in special ...
Biology Products: