Navigation Links
Beyond the microscope: Identifying specific cancers using molecular analysis
Date:3/19/2012

SALT LAKE CITY, March 19, 2012Researchers from Huntsman Cancer Institute (HCI) at the University of Utah report they have discovered a method to identify cancer-causing rearrangements of genetic material called chromosomal translocations quickly, accurately, and inexpensively. A description of the method and the research results appear online in this month's issue of the EMBO Molecular Medicine journal.

Many cancers result from chromosomal translocations in tumor cells. Hundreds of cancer-causing translocations have been discovered, but current methods for detecting them have significant shortcomings.

The technique, developed in the lab of Stephen Lessnick, M.D., Ph.D., director of the Center for Children's Cancer Research at HCI, combines microarray technology, which can look for thousands of translocations in a single test, with a novel antibody that is used to detect the presence of the translocation.

"We're moving past the age when a pathologist looking through the microscope at a tumor sample is the best way to diagnose what type of cancer it is," said Lessnick. "The molecular tests currently available are slow, inefficient, and expensive, and one of the biggest issues is that you need high-quality tumor samples, not always available in the clinical setting, to do them." According to Lessnick, his method tolerates real-life specimens much better than the current standard techniques.

"Originally, this method was used in HCI's Cairns lab (headed by Bradley R. Cairns, Ph.D.) to study RNA in yeast. We took their method and applied it to our study of chromosomal translocations in human tissue," Lessnick said. He said the next task is to find a commercial partner to develop this research from a 'proof of principle' into a diagnostic test that doctors can use to help their patients.

"With this method, there's potential to develop a single array that could test for every known cancer-causing translocation simultaneousl
'/>"/>

Contact: Linda Aagard
801-587-7639
University of Utah Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Car tracks beyond the asphalt
2. Beyond Darwin: Evolving new functions
3. Stranglers of the tropics -- and beyond
4. Biodiversity science in Quebec: 2010 and beyond
5. Beyond polar bears? Experts look for a new vision of climate change to combat skepticism
6. Beyond the genome
7. Beyond the corn field: Balancing fuel, food and biodiversity
8. Homebuilding beyond the abyss
9. Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss
10. Beyond genomics, biologists and engineers decode the next frontier
11. Frost & Sullivan Looks at Biometrics Advancement in Civil Security: Exploring Opportunities for Today and Beyond
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... , Nov. 19, 2014  Earlier this year ... York College, and one of the most prolific inventors ... that are transmitted from Smartphones to third party agencies. ... and has one of the earliest known patents in ... usage in the military, child care, elder care and ...
(Date:11/18/2014)... 18, 2014  The Secure Identity & Biometrics ... jointly announce the formation of The Airport Entry ... Identity and Biometric Entry and Exit Solutions ... official support from BORDERPOL, the international non-profit organization ... provide expertise regarding border security, traveler and migration ...
(Date:11/15/2014)... YORK , Nov. 13, 2014  While we may ... technology Doctor McCoy used in "Star Trek" to gain instant ... tools designed to work with smartphones and tablets for monitoring ... of the healthcare world. This may seem a tad Orwellian ... ready to adopt some of these technological opportunities into their ...
Breaking Biology News(10 mins):Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4
... This press release is available in German ... a few nanometers and possess a high luminous potential. Scientists ... in manufacturing silicon-based light-emitting diodes (SiLEDs). They are free of ... team of chemists, materials researchers, nanoscientists, and opto-electronic experts presents ...
... National Science Foundation (NSF) announced the latest round of ... effort. I-Corps is a public-private partnership to help develop ... The three awards, totaling $11,239,921, went to three consortia ... support regional needs for innovation education, infrastructure and research. ...
... University of California, Berkeley, UC San Francisco and Stanford ... commercializing university research and fostering innovation locally and nationally, ... National Science Foundation (NSF). The "I-Corps Node: NSF ... new Innovation Corps (or I-Corps) Nodes that the NSF ...
Cached Biology News:Light from silicon nanocrystal LEDs 2New grants to innovation corps 'nodes' further enhance public-private partnership 2New grants to innovation corps 'nodes' further enhance public-private partnership 3UC Berkeley, UCSF and Stanford join forces to help commercialize university innovations 2UC Berkeley, UCSF and Stanford join forces to help commercialize university innovations 3
(Date:11/26/2014)... Chester, OH (PRWEB) November 25, 2014 ... Holdings, has joined the Graphel Carbon Products team as ... in sales, marketing, and customer service for the graphite ... add Miles to our team,” stated Dave Trinkley, VP ... “His wide range of experience in the graphite ...
(Date:11/26/2014)... , 25 novembre 2014 Theravalues Corporation est ... le marché européen au salon Hi Europe 2014 ... ). Curcumine la plus biodisponible ... amorphe (non-cristalline) à des ingrédients approuvés par les ... pigment jaune présent dans la racine de curcuma ...
(Date:11/24/2014)... N.J. , Nov. 24, 2014  IGI Laboratories, ... based specialty generic pharmaceutical company, today announced ... (ANDA) to the U.S. Food and Drug Administration (FDA), ... in 2014 to seven, with eighteen submissions now pending ... , President and CEO of the Company, commented, "Our ...
(Date:11/24/2014)...   First published articles now available ... , a world-leading provider of scientific, technical and medical information ... the latest title in the Current Opinion journal series ... . Current Opinion in Food ... keep up-to-date with the expanding volume of information published in ...
Breaking Biology Technology:Miles Holder Joins Graphel Corporation as Sales/Marketing Manager 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3IGI Laboratories, Inc. Announces ANDA Submission 2Elsevier Announces Launch of New Journal: Current Opinion in Food Science 2Elsevier Announces Launch of New Journal: Current Opinion in Food Science 3
... child waits for Christmas. Today, PalmOne introduces the ... I buy?" conundrum. , ,I saw the new Treo six weeks ... (Yes, even I take a break from the schmoozing to sneak ... fell in love. This newest handheld communicator takes everything that ...
... is rapidly coming to a close, the fourth quarter represents a ... states. Witness the more important of these events: , , ... lot of biotech activities! This is a good sign and bodes ... annual meeting in Chicago. Its also an indicator that biotech is ...
... Madison, Wis. Angel and venture capitalists looking ... on a few business strategies that make some life-sciences ... panel of experts who spoke at the Wisconsin ... 26. The trade association attracted 300 industry representatives to ...
Cached Biology Technology:Christmas comes early with Treo 650 2Christmas comes early with Treo 650 3Furious pace of Midwest biotech events marks progress 2Furious pace of Midwest biotech events marks progress 3Local biotech startups must compete nationally for investors attention 2Local biotech startups must compete nationally for investors attention 3
Purified anti-SOCS3...
Tumor Suppressor Sampler Kit 10 mu g each...
AMAP Multi Site-directed Mutagenesis Kit Research Focus: other Storage Temperature: -20C Shipping Temperature: dry ice...
Umbilical cord blood eosinophils, For immunohistochemistry (IHC)...
Biology Products: