Navigation Links
Beyond the microscope: Identifying specific cancers using molecular analysis
Date:3/19/2012

SALT LAKE CITY, March 19, 2012Researchers from Huntsman Cancer Institute (HCI) at the University of Utah report they have discovered a method to identify cancer-causing rearrangements of genetic material called chromosomal translocations quickly, accurately, and inexpensively. A description of the method and the research results appear online in this month's issue of the EMBO Molecular Medicine journal.

Many cancers result from chromosomal translocations in tumor cells. Hundreds of cancer-causing translocations have been discovered, but current methods for detecting them have significant shortcomings.

The technique, developed in the lab of Stephen Lessnick, M.D., Ph.D., director of the Center for Children's Cancer Research at HCI, combines microarray technology, which can look for thousands of translocations in a single test, with a novel antibody that is used to detect the presence of the translocation.

"We're moving past the age when a pathologist looking through the microscope at a tumor sample is the best way to diagnose what type of cancer it is," said Lessnick. "The molecular tests currently available are slow, inefficient, and expensive, and one of the biggest issues is that you need high-quality tumor samples, not always available in the clinical setting, to do them." According to Lessnick, his method tolerates real-life specimens much better than the current standard techniques.

"Originally, this method was used in HCI's Cairns lab (headed by Bradley R. Cairns, Ph.D.) to study RNA in yeast. We took their method and applied it to our study of chromosomal translocations in human tissue," Lessnick said. He said the next task is to find a commercial partner to develop this research from a 'proof of principle' into a diagnostic test that doctors can use to help their patients.

"With this method, there's potential to develop a single array that could test for every known cancer-causing translocation simultaneousl
'/>"/>

Contact: Linda Aagard
801-587-7639
University of Utah Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Car tracks beyond the asphalt
2. Beyond Darwin: Evolving new functions
3. Stranglers of the tropics -- and beyond
4. Biodiversity science in Quebec: 2010 and beyond
5. Beyond polar bears? Experts look for a new vision of climate change to combat skepticism
6. Beyond the genome
7. Beyond the corn field: Balancing fuel, food and biodiversity
8. Homebuilding beyond the abyss
9. Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss
10. Beyond genomics, biologists and engineers decode the next frontier
11. Frost & Sullivan Looks at Biometrics Advancement in Civil Security: Exploring Opportunities for Today and Beyond
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... that cells are more resilient in taking care of ... critical components, cells can adapt and make copies of ... study published in this week,s Cell Reports , ... that cells can grow normally without a crucial component ... is stored in DNA, which has to be continuously ...
(Date:4/24/2014)... the Scientific Reports journal. , CSIC researcher Carles ... of CSIC and Pompeu Fabra University-UPF), explains: "When the Y ... that it did not match with the DNA recovered from ... genome and to make a functional interpretation in order to ... , The functional genome analysis was based on two ...
(Date:4/24/2014)... Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have identified ... system to discriminate between viral and endogenous RNAs ... they take control of cellular metabolism and hijack ... This process is dependent on viral RNA molecules ... of RNA viruses) and/or newly synthesized in the ...
Breaking Biology News(10 mins):Cell resiliency surprises scientists 2The blood preserved in the pumpkin did not belong to Louis XVI 2Viral infections: Identifying the tell-tale patterns 2Viral infections: Identifying the tell-tale patterns 3
... is on track to become only the second disease ever ... The Journal of Infectious Diseases, now available online, scientists are ... gone. One study reduces concerns that people whose immune systems ... The other study looks at the how switching forms ...
... there has been great controversy about the ubiquitous vegetable's ... National Academies of Sciences, a team led by a ... has for the first time demonstrated a single origin ... scientists analyzed DNA markers in 261 wild and 98 ...
... into the chest to maintain circulation can significantly extend ... failure who are not candidates for heart transplantation, according ... Duke University Medical Center cardiologists. , The pumps, known ... the heart's left ventricle ?the chamber of the heart ...
Cached Biology News:Polio vaccination strategies assessed as eradication nears 2Polio vaccination strategies assessed as eradication nears 3Finding rewrites the evolutionary history of the origin of potatoes 2Implantable pumps extend lives of patients too sick for transplant 2Implantable pumps extend lives of patients too sick for transplant 3
(Date:1/15/2014)... January 15, 2014 A study has been ... the Formula 1 track could help to tackle the problem ... (MAT), Stowhealth (a GP surgery based in Stowmarket) and academics ... Simplyhealth. Telemetry technology, which is inspired by equipment ...
(Date:1/15/2014)... NY (PRWEB) January 15, 2014 The Microcompetition ... a major disease. One of these latent viruses is the ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic inflammatory ... theory, a study found that RA patients have high concentrations ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Freeslate, ... solutions, today announced that Lupin Limited, one of India’s ... CM Protégé PharmD System for high throughput ... India, is focused on a wide range of quality, ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. – ... Warrington, Pa. , Details: The Hepatitis B Foundation, ... cure for hepatitis B and improving the quality of life ... on Friday, April 11 at Warrington Country Club in Warrington, ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... Madison, Wis. - TomoTherapy, Inc. , producer ... reach to Germany. , , The University Clinic Heidelberg ... treat cancer patients with the Hi-Art System, a machine that ... cells with limited damage to healthy tissue. , ,Dr. Jrgen ...
... the third major storm of the 2006 Atlantic ... low-pressure system recently, apprehensions about impending natural and ... , ,A Wisconsin telecommunications company has been enlisted ... ,To address concerns of a large-scale crisis once ...
... tool that misrepresented something simple about more than 90 ... basing their health plan buying decisions on the often ... have to imagine such a scenario because they have ... ,Now a Wisconsin software developer believes it has come ...
Cached Biology Technology:Wisconsin firm leads testing of alerts by cell phone 2Wisconsin firm leads testing of alerts by cell phone 3Healthcare software addresses "90 million" misclassified Americans 2Healthcare software addresses "90 million" misclassified Americans 3
... and other fluid sources for 8 vessels ... of each individual pump is controlled electronically. ... exactly maintained. ,High-precision controlled miniature pumps ... which allows flow rates between 0 and ...
... excellent ion chromatography system . The ... from 0.01S to 5000S, houses the measuring cell ... CE 4715, is available. Data processing is ... Solvent delivery is by the high pressure CE ...
Fujifilm Pictro-Color Process for sharp, clear reproduction comparable to silver-halide photography. Photorealistic 400 dpi quality. A4 and A5 output....
... and other fluid sources for 4 vessels ... of each individual pump is controlled electronically. ... exactly maintained. ,High-precision controlled peristaltic pumps ... which allows flow rates between 0.01 to ...
Biology Products: